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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIM46
Full Name:
Tripartite motif-containing protein 46
Alias:
FLJ23229; Gene Y protein; GeneY; TRIFIC; Tripartite motif-containing 46; Tripartite, fibronectin type-III and C-terminal SPRY motif protein
Type:
Mass (Da):
83405
Number AA:
759
UniProt ID:
Q7Z4K8
International Prot ID:
IPI00376002
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
E
G
E
D
M
Q
T
F
T
S
I
M
D
A
Site 2
S21
M
D
A
L
V
R
I
S
T
S
M
K
N
M
E
Site 3
T22
D
A
L
V
R
I
S
T
S
M
K
N
M
E
K
Site 4
Y66
E
V
L
G
Q
Q
G
Y
I
G
H
G
G
D
P
Site 5
S74
I
G
H
G
G
D
P
S
S
E
P
T
S
P
A
Site 6
S75
G
H
G
G
D
P
S
S
E
P
T
S
P
A
S
Site 7
T78
G
D
P
S
S
E
P
T
S
P
A
S
T
P
S
Site 8
S79
D
P
S
S
E
P
T
S
P
A
S
T
P
S
T
Site 9
S82
S
E
P
T
S
P
A
S
T
P
S
T
R
S
P
Site 10
T83
E
P
T
S
P
A
S
T
P
S
T
R
S
P
R
Site 11
S85
T
S
P
A
S
T
P
S
T
R
S
P
R
L
S
Site 12
T86
S
P
A
S
T
P
S
T
R
S
P
R
L
S
R
Site 13
S88
A
S
T
P
S
T
R
S
P
R
L
S
R
R
T
Site 14
S92
S
T
R
S
P
R
L
S
R
R
T
L
P
K
P
Site 15
T95
S
P
R
L
S
R
R
T
L
P
K
P
D
R
L
Site 16
S108
R
L
D
R
L
L
K
S
G
F
G
T
Y
P
G
Site 17
T112
L
L
K
S
G
F
G
T
Y
P
G
R
K
R
G
Site 18
Y113
L
K
S
G
F
G
T
Y
P
G
R
K
R
G
A
Site 19
T152
A
G
L
F
R
N
L
T
L
E
R
V
V
E
R
Site 20
Y160
L
E
R
V
V
E
R
Y
R
Q
S
V
S
V
G
Site 21
S165
E
R
Y
R
Q
S
V
S
V
G
G
A
I
L
C
Site 22
T214
Q
K
A
Q
H
E
P
T
L
P
T
L
S
F
R
Site 23
T217
Q
H
E
P
T
L
P
T
L
S
F
R
P
K
G
Site 24
S219
E
P
T
L
P
T
L
S
F
R
P
K
G
L
M
Site 25
Y237
H
K
E
E
V
T
H
Y
C
K
T
C
Q
R
L
Site 26
T254
Q
L
C
R
V
R
R
T
H
S
G
H
K
I
T
Site 27
S256
C
R
V
R
R
T
H
S
G
H
K
I
T
P
V
Site 28
T261
T
H
S
G
H
K
I
T
P
V
L
S
A
Y
Q
Site 29
T275
Q
A
L
K
D
K
L
T
K
S
L
T
Y
I
L
Site 30
S277
L
K
D
K
L
T
K
S
L
T
Y
I
L
G
N
Site 31
T279
D
K
L
T
K
S
L
T
Y
I
L
G
N
Q
D
Site 32
T302
L
E
E
A
V
R
H
T
E
V
S
G
Q
Q
A
Site 33
S305
A
V
R
H
T
E
V
S
G
Q
Q
A
K
E
E
Site 34
S314
Q
Q
A
K
E
E
V
S
Q
L
V
R
G
L
G
Site 35
S330
V
L
E
E
K
R
A
S
L
L
Q
A
I
E
E
Site 36
S347
Q
E
R
L
A
R
L
S
A
Q
I
Q
E
H
R
Site 37
S355
A
Q
I
Q
E
H
R
S
L
L
D
G
S
G
L
Site 38
Y365
D
G
S
G
L
V
G
Y
A
Q
E
V
L
K
E
Site 39
T393
H
N
R
I
A
R
A
T
E
A
L
Q
T
F
R
Site 40
T398
R
A
T
E
A
L
Q
T
F
R
P
A
A
S
S
Site 41
S405
T
F
R
P
A
A
S
S
S
F
R
H
C
Q
L
Site 42
S406
F
R
P
A
A
S
S
S
F
R
H
C
Q
L
D
Site 43
T422
G
R
E
M
K
L
L
T
E
L
N
F
L
R
V
Site 44
T437
P
E
A
P
V
I
D
T
Q
R
T
F
A
Y
D
Site 45
T463
S
P
P
A
W
H
Y
T
V
E
F
R
R
T
D
Site 46
T469
Y
T
V
E
F
R
R
T
D
V
P
A
Q
P
G
Site 47
T489
R
R
E
E
V
R
G
T
S
A
L
L
E
N
P
Site 48
S490
R
E
E
V
R
G
T
S
A
L
L
E
N
P
D
Site 49
S500
L
E
N
P
D
T
G
S
V
Y
V
L
R
V
R
Site 50
Y502
N
P
D
T
G
S
V
Y
V
L
R
V
R
G
C
Site 51
Y514
R
G
C
N
K
A
G
Y
G
E
Y
S
E
D
V
Site 52
S518
K
A
G
Y
G
E
Y
S
E
D
V
H
L
H
T
Site 53
T525
S
E
D
V
H
L
H
T
P
P
A
P
V
L
H
Site 54
S537
V
L
H
F
F
L
D
S
R
W
G
A
S
R
E
Site 55
S557
K
D
Q
R
A
V
R
S
V
P
G
L
P
L
L
Site 56
Y593
A
V
T
Q
G
R
S
Y
W
A
C
A
V
D
P
Site 57
S613
K
V
G
V
G
L
E
S
K
L
Q
E
S
F
Q
Site 58
S618
L
E
S
K
L
Q
E
S
F
Q
G
A
P
D
V
Site 59
S627
Q
G
A
P
D
V
I
S
P
R
Y
D
P
D
S
Site 60
Y630
P
D
V
I
S
P
R
Y
D
P
D
S
G
H
D
Site 61
S634
S
P
R
Y
D
P
D
S
G
H
D
S
G
A
E
Site 62
S638
D
P
D
S
G
H
D
S
G
A
E
D
A
T
V
Site 63
T644
D
S
G
A
E
D
A
T
V
E
A
S
P
P
F
Site 64
S669
L
L
G
S
G
A
S
S
N
A
G
L
T
G
R
Site 65
T674
A
S
S
N
A
G
L
T
G
R
D
G
P
T
A
Site 66
T684
D
G
P
T
A
G
C
T
V
P
L
P
P
R
L
Site 67
Y697
R
L
G
I
C
L
D
Y
E
R
G
R
V
S
F
Site 68
S703
D
Y
E
R
G
R
V
S
F
L
D
A
V
S
F
Site 69
T751
T
K
P
E
R
K
V
T
I
G
G
F
A
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation