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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPHP3
Full Name:
Nephrocystin-3
Alias:
FLJ30691; FLJ36696; KIAA2000; Nephronophthisis 3; Nephronophthisis 3 (adolescent); NPH3
Type:
Mass (Da):
150860
Number AA:
UniProt ID:
Q7Z494
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0048496
GO:0045494
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
G
G
E
V
I
E
D
T
Y
G
A
G
G
G
E
Site 2
Y20
G
E
V
I
E
D
T
Y
G
A
G
G
G
E
A
Site 3
S44
K
A
R
L
L
R
N
S
F
R
R
G
A
G
A
Site 4
S76
L
L
G
A
S
F
K
S
T
G
S
S
V
P
E
Site 5
T77
L
G
A
S
F
K
S
T
G
S
S
V
P
E
L
Site 6
S79
A
S
F
K
S
T
G
S
S
V
P
E
L
E
Y
Site 7
S80
S
F
K
S
T
G
S
S
V
P
E
L
E
Y
A
Site 8
Y91
L
E
Y
A
A
A
E
Y
E
R
L
R
K
E
Y
Site 9
Y98
Y
E
R
L
R
K
E
Y
E
I
F
R
V
S
K
Site 10
S104
E
Y
E
I
F
R
V
S
K
N
Q
E
L
L
S
Site 11
S111
S
K
N
Q
E
L
L
S
M
G
R
R
E
A
K
Site 12
T121
R
R
E
A
K
L
D
T
E
N
K
R
L
R
A
Site 13
Y152
E
S
A
L
E
A
K
Y
Q
A
M
E
R
A
A
Site 14
T160
Q
A
M
E
R
A
A
T
F
E
H
D
R
D
K
Site 15
T178
Q
F
K
I
F
R
E
T
K
E
N
E
I
Q
D
Site 16
S215
F
D
P
G
E
S
D
S
D
D
N
C
T
D
V
Site 17
T220
S
D
S
D
D
N
C
T
D
V
T
A
A
G
T
Site 18
Y231
A
A
G
T
Q
C
E
Y
W
T
G
G
A
L
G
Site 19
S239
W
T
G
G
A
L
G
S
E
P
S
I
G
S
M
Site 20
S245
G
S
E
P
S
I
G
S
M
I
Q
L
Q
Q
S
Site 21
S252
S
M
I
Q
L
Q
Q
S
F
R
G
P
E
F
A
Site 22
S261
R
G
P
E
F
A
H
S
S
I
D
V
E
G
P
Site 23
S262
G
P
E
F
A
H
S
S
I
D
V
E
G
P
F
Site 24
S292
L
Q
V
T
P
L
F
S
H
S
L
W
S
N
T
Site 25
S294
V
T
P
L
F
S
H
S
L
W
S
N
T
V
R
Site 26
Y303
W
S
N
T
V
R
C
Y
L
I
Y
T
D
E
T
Site 27
Y306
T
V
R
C
Y
L
I
Y
T
D
E
T
Q
P
E
Site 28
Y321
M
D
L
F
L
K
D
Y
S
P
K
L
K
R
M
Site 29
S322
D
L
F
L
K
D
Y
S
P
K
L
K
R
M
C
Site 30
Y349
P
I
D
V
E
N
Q
Y
L
T
V
R
K
W
E
Site 31
T351
D
V
E
N
Q
Y
L
T
V
R
K
W
E
I
E
Site 32
S405
L
E
D
G
K
V
S
S
D
S
V
Q
Q
L
I
Site 33
S407
D
G
K
V
S
S
D
S
V
Q
Q
L
I
D
Q
Site 34
S416
Q
Q
L
I
D
Q
V
S
N
L
N
K
T
S
K
Site 35
S430
K
A
K
I
I
D
H
S
G
D
P
A
E
G
V
Site 36
S467
L
E
T
K
D
L
G
S
E
D
S
I
P
E
E
Site 37
S470
K
D
L
G
S
E
D
S
I
P
E
E
D
D
F
Site 38
T493
D
E
Q
E
Q
M
E
T
F
Q
Q
A
S
N
S
Site 39
S500
T
F
Q
Q
A
S
N
S
A
H
E
L
G
F
E
Site 40
Y509
H
E
L
G
F
E
K
Y
Y
Q
R
L
N
D
L
Site 41
Y510
E
L
G
F
E
K
Y
Y
Q
R
L
N
D
L
V
Site 42
S537
G
G
P
G
S
G
K
S
L
L
L
S
K
W
I
Site 43
S541
S
G
K
S
L
L
L
S
K
W
I
Q
L
Q
Q
Site 44
S551
I
Q
L
Q
Q
K
N
S
P
N
T
L
I
L
S
Site 45
T554
Q
Q
K
N
S
P
N
T
L
I
L
S
H
F
V
Site 46
S566
H
F
V
G
R
P
M
S
T
S
S
E
S
S
L
Site 47
T567
F
V
G
R
P
M
S
T
S
S
E
S
S
L
I
Site 48
S568
V
G
R
P
M
S
T
S
S
E
S
S
L
I
I
Site 49
S569
G
R
P
M
S
T
S
S
E
S
S
L
I
I
K
Site 50
S572
M
S
T
S
S
E
S
S
L
I
I
K
R
L
T
Site 51
S588
K
L
M
Q
H
S
W
S
V
S
A
L
T
L
D
Site 52
S590
M
Q
H
S
W
S
V
S
A
L
T
L
D
P
A
Site 53
S611
P
R
W
L
E
K
L
S
A
R
H
Q
G
S
I
Site 54
T666
P
A
W
R
L
W
P
T
L
H
L
D
P
L
S
Site 55
S673
T
L
H
L
D
P
L
S
P
K
D
A
K
S
I
Site 56
S706
K
L
E
R
H
C
R
S
A
T
T
C
N
A
L
Site 57
T708
E
R
H
C
R
S
A
T
T
C
N
A
L
Y
V
Site 58
S754
L
Y
R
L
V
L
H
S
I
R
E
S
M
A
N
Site 59
S758
V
L
H
S
I
R
E
S
M
A
N
D
V
D
K
Site 60
S785
S
H
N
G
V
S
E
S
E
L
M
E
L
Y
P
Site 61
Y791
E
S
E
L
M
E
L
Y
P
E
M
S
W
T
F
Site 62
T829
Q
H
L
Q
A
W
E
T
V
R
L
E
Y
L
E
Site 63
Y834
W
E
T
V
R
L
E
Y
L
E
G
P
T
V
T
Site 64
T839
L
E
Y
L
E
G
P
T
V
T
S
S
Y
R
Q
Site 65
S843
E
G
P
T
V
T
S
S
Y
R
Q
K
L
I
N
Site 66
Y851
Y
R
Q
K
L
I
N
Y
F
T
L
Q
L
S
Q
Site 67
T853
Q
K
L
I
N
Y
F
T
L
Q
L
S
Q
D
R
Site 68
S857
N
Y
F
T
L
Q
L
S
Q
D
R
V
T
W
R
Site 69
T862
Q
L
S
Q
D
R
V
T
W
R
S
A
D
E
L
Site 70
S865
Q
D
R
V
T
W
R
S
A
D
E
L
P
W
L
Site 71
Y896
L
F
V
S
Q
N
L
Y
K
R
G
H
F
A
E
Site 72
Y907
H
F
A
E
L
L
S
Y
W
Q
F
V
G
K
D
Site 73
S916
Q
F
V
G
K
D
K
S
A
M
A
T
E
Y
F
Site 74
T920
K
D
K
S
A
M
A
T
E
Y
F
D
S
L
K
Site 75
Y922
K
S
A
M
A
T
E
Y
F
D
S
L
K
Q
Y
Site 76
S925
M
A
T
E
Y
F
D
S
L
K
Q
Y
E
K
N
Site 77
Y929
Y
F
D
S
L
K
Q
Y
E
K
N
C
E
G
E
Site 78
T975
R
S
L
E
I
R
E
T
A
L
D
P
D
H
P
Site 79
S987
D
H
P
R
V
A
Q
S
L
H
Q
L
A
S
V
Site 80
S993
Q
S
L
H
Q
L
A
S
V
Y
V
Q
W
K
K
Site 81
Y995
L
H
Q
L
A
S
V
Y
V
Q
W
K
K
F
G
Site 82
Y1008
F
G
N
A
E
Q
L
Y
K
Q
A
L
E
I
S
Site 83
Y1019
L
E
I
S
E
N
A
Y
G
A
D
H
P
Y
T
Site 84
Y1025
A
Y
G
A
D
H
P
Y
T
A
R
E
L
E
A
Site 85
T1026
Y
G
A
D
H
P
Y
T
A
R
E
L
E
A
L
Site 86
T1035
R
E
L
E
A
L
A
T
L
Y
Q
K
Q
N
K
Site 87
Y1037
L
E
A
L
A
T
L
Y
Q
K
Q
N
K
Y
E
Site 88
Y1043
L
Y
Q
K
Q
N
K
Y
E
Q
A
E
H
F
R
Site 89
S1053
A
E
H
F
R
K
K
S
F
K
I
H
Q
K
A
Site 90
Y1068
I
K
K
K
G
N
L
Y
G
F
A
L
L
R
R
Site 91
T1089
E
L
T
L
G
K
D
T
P
D
N
A
R
T
L
Site 92
Y1103
L
N
E
L
G
V
L
Y
Y
L
Q
N
N
L
E
Site 93
Y1104
N
E
L
G
V
L
Y
Y
L
Q
N
N
L
E
T
Site 94
S1119
A
D
Q
F
L
K
R
S
L
E
M
R
E
R
V
Site 95
S1137
D
H
P
D
C
A
Q
S
L
N
N
L
A
A
L
Site 96
Y1151
L
C
N
E
K
K
Q
Y
D
K
A
E
E
L
Y
Site 97
Y1158
Y
D
K
A
E
E
L
Y
E
R
A
L
D
I
R
Site 98
S1175
A
L
A
P
D
H
P
S
L
A
Y
T
V
K
H
Site 99
Y1187
V
K
H
L
A
I
L
Y
K
K
M
G
K
L
D
Site 100
S1210
A
V
E
I
R
Q
K
S
F
G
P
K
H
P
S
Site 101
S1217
S
F
G
P
K
H
P
S
V
A
T
A
L
V
N
Site 102
T1220
P
K
H
P
S
V
A
T
A
L
V
N
L
A
V
Site 103
S1230
V
N
L
A
V
L
Y
S
Q
M
K
K
H
V
E
Site 104
Y1242
H
V
E
A
L
P
L
Y
E
R
A
L
K
I
Y
Site 105
Y1249
Y
E
R
A
L
K
I
Y
E
D
S
L
G
R
M
Site 106
S1252
A
L
K
I
Y
E
D
S
L
G
R
M
H
P
R
Site 107
S1271
L
K
N
L
A
V
L
S
Y
E
G
G
D
F
E
Site 108
Y1284
F
E
K
A
A
E
L
Y
K
R
A
M
E
I
K
Site 109
S1296
E
I
K
E
A
E
T
S
L
L
G
G
K
A
P
Site 110
S1304
L
L
G
G
K
A
P
S
R
H
S
S
S
G
D
Site 111
S1307
G
K
A
P
S
R
H
S
S
S
G
D
T
F
S
Site 112
S1308
K
A
P
S
R
H
S
S
S
G
D
T
F
S
L
Site 113
S1309
A
P
S
R
H
S
S
S
G
D
T
F
S
L
K
Site 114
T1312
R
H
S
S
S
G
D
T
F
S
L
K
T
A
H
Site 115
S1314
S
S
S
G
D
T
F
S
L
K
T
A
H
S
P
Site 116
S1320
F
S
L
K
T
A
H
S
P
N
V
F
L
Q
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation