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Updated November 2019
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Protein Info
Short Name:
CLASP1
Full Name:
CLIP-associating protein 1
Alias:
CLAP1; Cytoplasmic linker associated protein 1; Cytoplasmic linker-associated protein 1; KIAA0622; MAST1; Multiple asters 1; Multiple asters homologue 1
Type:
Cell cycle regulation
Mass (Da):
169451
Number AA:
1538
UniProt ID:
Q7Z460
International Prot ID:
IPI00396279
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0031592
GO:0000777
Uniprot
OncoNet
Molecular Function:
GO:0043515
GO:0051010
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007163
GO:0010458
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y30
V
G
Q
E
L
I
D
Y
F
S
D
K
Q
K
S
Site 2
S32
Q
E
L
I
D
Y
F
S
D
K
Q
K
S
A
D
Site 3
S37
Y
F
S
D
K
Q
K
S
A
D
L
E
H
D
Q
Site 4
T45
A
D
L
E
H
D
Q
T
M
L
D
K
L
V
D
Site 5
S57
L
V
D
G
L
A
T
S
W
V
N
S
S
N
Y
Site 6
S106
R
L
G
D
A
K
D
S
V
R
E
Q
D
Q
T
Site 7
T113
S
V
R
E
Q
D
Q
T
L
L
L
K
I
M
D
Site 8
Y127
D
Q
A
A
N
P
Q
Y
V
W
D
R
M
L
G
Site 9
S181
N
L
L
G
D
P
N
S
Q
V
R
D
A
A
I
Site 10
S190
V
R
D
A
A
I
N
S
L
V
E
I
Y
R
H
Site 11
S207
E
R
V
R
A
D
L
S
K
K
G
L
P
Q
S
Site 12
S214
S
K
K
G
L
P
Q
S
R
L
N
V
I
F
T
Site 13
S229
K
F
D
E
V
Q
K
S
G
N
M
I
Q
S
A
Site 14
S246
K
N
F
D
D
E
D
S
V
D
G
N
R
P
S
Site 15
S253
S
V
D
G
N
R
P
S
S
A
S
S
T
S
S
Site 16
S254
V
D
G
N
R
P
S
S
A
S
S
T
S
S
K
Site 17
S256
G
N
R
P
S
S
A
S
S
T
S
S
K
A
P
Site 18
S257
N
R
P
S
S
A
S
S
T
S
S
K
A
P
P
Site 19
T258
R
P
S
S
A
S
S
T
S
S
K
A
P
P
S
Site 20
S259
P
S
S
A
S
S
T
S
S
K
A
P
P
S
S
Site 21
S260
S
S
A
S
S
T
S
S
K
A
P
P
S
S
R
Site 22
S265
T
S
S
K
A
P
P
S
S
R
R
N
V
G
M
Site 23
S266
S
S
K
A
P
P
S
S
R
R
N
V
G
M
G
Site 24
T274
R
R
N
V
G
M
G
T
T
R
R
L
G
S
S
Site 25
T275
R
N
V
G
M
G
T
T
R
R
L
G
S
S
T
Site 26
S280
G
T
T
R
R
L
G
S
S
T
L
G
S
K
S
Site 27
S281
T
T
R
R
L
G
S
S
T
L
G
S
K
S
S
Site 28
T282
T
R
R
L
G
S
S
T
L
G
S
K
S
S
A
Site 29
S285
L
G
S
S
T
L
G
S
K
S
S
A
A
K
E
Site 30
S287
S
S
T
L
G
S
K
S
S
A
A
K
E
G
A
Site 31
S288
S
T
L
G
S
K
S
S
A
A
K
E
G
A
G
Site 32
S316
V
P
V
V
Q
I
Y
S
S
R
D
L
E
E
S
Site 33
S317
P
V
V
Q
I
Y
S
S
R
D
L
E
E
S
I
Site 34
S323
S
S
R
D
L
E
E
S
I
N
K
I
R
E
I
Site 35
S332
N
K
I
R
E
I
L
S
D
D
K
H
D
W
E
Site 36
S376
L
D
G
A
F
K
L
S
A
K
D
L
R
S
Q
Site 37
S382
L
S
A
K
D
L
R
S
Q
V
V
R
E
A
C
Site 38
T450
P
R
L
I
P
V
I
T
S
N
C
T
S
K
S
Site 39
S455
V
I
T
S
N
C
T
S
K
S
V
A
V
R
R
Site 40
S457
T
S
N
C
T
S
K
S
V
A
V
R
R
R
C
Site 41
S479
L
Q
E
W
Q
T
H
S
L
E
R
H
I
S
V
Site 42
S485
H
S
L
E
R
H
I
S
V
L
A
E
T
I
K
Site 43
S500
K
G
I
H
D
A
D
S
E
A
R
I
E
A
R
Site 44
Y525
S
R
E
A
E
H
L
Y
H
T
L
E
S
S
Y
Site 45
T527
E
A
E
H
L
Y
H
T
L
E
S
S
Y
Q
K
Site 46
S538
S
Y
Q
K
A
L
Q
S
H
L
K
N
S
D
S
Site 47
S543
L
Q
S
H
L
K
N
S
D
S
I
V
S
L
P
Site 48
S545
S
H
L
K
N
S
D
S
I
V
S
L
P
Q
S
Site 49
S548
K
N
S
D
S
I
V
S
L
P
Q
S
D
R
S
Site 50
S552
S
I
V
S
L
P
Q
S
D
R
S
S
S
S
S
Site 51
S555
S
L
P
Q
S
D
R
S
S
S
S
S
Q
E
S
Site 52
S556
L
P
Q
S
D
R
S
S
S
S
S
Q
E
S
L
Site 53
S557
P
Q
S
D
R
S
S
S
S
S
Q
E
S
L
N
Site 54
S558
Q
S
D
R
S
S
S
S
S
Q
E
S
L
N
R
Site 55
S559
S
D
R
S
S
S
S
S
Q
E
S
L
N
R
P
Site 56
S562
S
S
S
S
S
Q
E
S
L
N
R
P
L
S
A
Site 57
S568
E
S
L
N
R
P
L
S
A
K
R
S
P
T
G
Site 58
S572
R
P
L
S
A
K
R
S
P
T
G
S
T
T
S
Site 59
T574
L
S
A
K
R
S
P
T
G
S
T
T
S
R
A
Site 60
S576
A
K
R
S
P
T
G
S
T
T
S
R
A
S
T
Site 61
T578
R
S
P
T
G
S
T
T
S
R
A
S
T
V
S
Site 62
S579
S
P
T
G
S
T
T
S
R
A
S
T
V
S
T
Site 63
S582
G
S
T
T
S
R
A
S
T
V
S
T
K
S
V
Site 64
T583
S
T
T
S
R
A
S
T
V
S
T
K
S
V
S
Site 65
S585
T
S
R
A
S
T
V
S
T
K
S
V
S
T
T
Site 66
T586
S
R
A
S
T
V
S
T
K
S
V
S
T
T
G
Site 67
S588
A
S
T
V
S
T
K
S
V
S
T
T
G
S
L
Site 68
S590
T
V
S
T
K
S
V
S
T
T
G
S
L
Q
R
Site 69
T592
S
T
K
S
V
S
T
T
G
S
L
Q
R
S
R
Site 70
S594
K
S
V
S
T
T
G
S
L
Q
R
S
R
S
D
Site 71
S598
T
T
G
S
L
Q
R
S
R
S
D
I
D
V
N
Site 72
S600
G
S
L
Q
R
S
R
S
D
I
D
V
N
A
A
Site 73
S609
I
D
V
N
A
A
A
S
A
K
S
K
V
S
S
Site 74
S612
N
A
A
A
S
A
K
S
K
V
S
S
S
S
G
Site 75
S615
A
S
A
K
S
K
V
S
S
S
S
G
T
T
P
Site 76
S616
S
A
K
S
K
V
S
S
S
S
G
T
T
P
F
Site 77
S617
A
K
S
K
V
S
S
S
S
G
T
T
P
F
S
Site 78
S618
K
S
K
V
S
S
S
S
G
T
T
P
F
S
S
Site 79
T620
K
V
S
S
S
S
G
T
T
P
F
S
S
A
A
Site 80
T621
V
S
S
S
S
G
T
T
P
F
S
S
A
A
A
Site 81
S624
S
S
G
T
T
P
F
S
S
A
A
A
L
P
P
Site 82
S625
S
G
T
T
P
F
S
S
A
A
A
L
P
P
G
Site 83
S633
A
A
A
L
P
P
G
S
Y
A
S
L
G
R
I
Site 84
Y634
A
A
L
P
P
G
S
Y
A
S
L
G
R
I
R
Site 85
S636
L
P
P
G
S
Y
A
S
L
G
R
I
R
T
R
Site 86
T642
A
S
L
G
R
I
R
T
R
R
Q
S
S
G
S
Site 87
S646
R
I
R
T
R
R
Q
S
S
G
S
A
T
N
V
Site 88
S647
I
R
T
R
R
Q
S
S
G
S
A
T
N
V
A
Site 89
S649
T
R
R
Q
S
S
G
S
A
T
N
V
A
S
T
Site 90
T651
R
Q
S
S
G
S
A
T
N
V
A
S
T
P
D
Site 91
S655
G
S
A
T
N
V
A
S
T
P
D
N
R
G
R
Site 92
T656
S
A
T
N
V
A
S
T
P
D
N
R
G
R
S
Site 93
S663
T
P
D
N
R
G
R
S
R
A
K
V
V
S
Q
Site 94
S669
R
S
R
A
K
V
V
S
Q
S
Q
R
S
R
S
Site 95
S671
R
A
K
V
V
S
Q
S
Q
R
S
R
S
A
N
Site 96
S674
V
V
S
Q
S
Q
R
S
R
S
A
N
P
A
G
Site 97
S676
S
Q
S
Q
R
S
R
S
A
N
P
A
G
A
G
Site 98
S684
A
N
P
A
G
A
G
S
R
S
S
S
P
G
K
Site 99
S686
P
A
G
A
G
S
R
S
S
S
P
G
K
L
L
Site 100
S687
A
G
A
G
S
R
S
S
S
P
G
K
L
L
G
Site 101
S688
G
A
G
S
R
S
S
S
P
G
K
L
L
G
S
Site 102
S695
S
P
G
K
L
L
G
S
G
Y
G
G
L
T
G
Site 103
Y697
G
K
L
L
G
S
G
Y
G
G
L
T
G
G
S
Site 104
T701
G
S
G
Y
G
G
L
T
G
G
S
S
R
G
P
Site 105
S704
Y
G
G
L
T
G
G
S
S
R
G
P
P
V
T
Site 106
S705
G
G
L
T
G
G
S
S
R
G
P
P
V
T
P
Site 107
T711
S
S
R
G
P
P
V
T
P
S
S
E
K
R
S
Site 108
S713
R
G
P
P
V
T
P
S
S
E
K
R
S
K
I
Site 109
S714
G
P
P
V
T
P
S
S
E
K
R
S
K
I
P
Site 110
S718
T
P
S
S
E
K
R
S
K
I
P
R
S
Q
G
Site 111
S723
K
R
S
K
I
P
R
S
Q
G
C
S
R
E
T
Site 112
S727
I
P
R
S
Q
G
C
S
R
E
T
S
P
N
R
Site 113
T730
S
Q
G
C
S
R
E
T
S
P
N
R
I
G
L
Site 114
S731
Q
G
C
S
R
E
T
S
P
N
R
I
G
L
A
Site 115
S740
N
R
I
G
L
A
R
S
S
R
I
P
R
P
S
Site 116
S741
R
I
G
L
A
R
S
S
R
I
P
R
P
S
M
Site 117
S747
S
S
R
I
P
R
P
S
M
S
Q
G
C
S
R
Site 118
S749
R
I
P
R
P
S
M
S
Q
G
C
S
R
D
T
Site 119
S753
P
S
M
S
Q
G
C
S
R
D
T
S
R
E
S
Site 120
T756
S
Q
G
C
S
R
D
T
S
R
E
S
S
R
D
Site 121
S757
Q
G
C
S
R
D
T
S
R
E
S
S
R
D
T
Site 122
S760
S
R
D
T
S
R
E
S
S
R
D
T
S
P
A
Site 123
S761
R
D
T
S
R
E
S
S
R
D
T
S
P
A
R
Site 124
T764
S
R
E
S
S
R
D
T
S
P
A
R
G
F
P
Site 125
S765
R
E
S
S
R
D
T
S
P
A
R
G
F
P
P
Site 126
S787
Q
P
G
R
I
P
G
S
V
N
A
M
R
V
L
Site 127
S795
V
N
A
M
R
V
L
S
T
S
T
D
L
E
A
Site 128
T796
N
A
M
R
V
L
S
T
S
T
D
L
E
A
A
Site 129
S797
A
M
R
V
L
S
T
S
T
D
L
E
A
A
V
Site 130
T798
M
R
V
L
S
T
S
T
D
L
E
A
A
V
A
Site 131
Y816
K
K
P
V
R
R
R
Y
E
P
Y
G
M
Y
S
Site 132
Y819
V
R
R
R
Y
E
P
Y
G
M
Y
S
D
D
D
Site 133
S823
Y
E
P
Y
G
M
Y
S
D
D
D
A
N
S
D
Site 134
S829
Y
S
D
D
D
A
N
S
D
A
S
S
V
C
S
Site 135
S832
D
D
A
N
S
D
A
S
S
V
C
S
E
R
S
Site 136
S833
D
A
N
S
D
A
S
S
V
C
S
E
R
S
Y
Site 137
S836
S
D
A
S
S
V
C
S
E
R
S
Y
G
S
R
Site 138
S839
S
S
V
C
S
E
R
S
Y
G
S
R
N
G
G
Site 139
Y840
S
V
C
S
E
R
S
Y
G
S
R
N
G
G
I
Site 140
S842
C
S
E
R
S
Y
G
S
R
N
G
G
I
P
H
Site 141
Y850
R
N
G
G
I
P
H
Y
L
R
Q
T
E
D
V
Site 142
T854
I
P
H
Y
L
R
Q
T
E
D
V
A
E
V
L
Site 143
S866
E
V
L
N
H
C
A
S
S
N
W
S
E
R
K
Site 144
S870
H
C
A
S
S
N
W
S
E
R
K
E
G
L
L
Site 145
S885
G
L
Q
N
L
L
K
S
Q
R
T
L
S
R
V
Site 146
T888
N
L
L
K
S
Q
R
T
L
S
R
V
E
L
K
Site 147
S890
L
K
S
Q
R
T
L
S
R
V
E
L
K
R
L
Site 148
T966
V
Q
K
A
L
D
V
T
R
D
S
F
P
F
D
Site 149
S969
A
L
D
V
T
R
D
S
F
P
F
D
Q
Q
F
Site 150
T987
M
R
F
I
V
D
Q
T
Q
T
P
N
L
K
V
Site 151
T989
F
I
V
D
Q
T
Q
T
P
N
L
K
V
K
V
Site 152
S1004
A
I
L
K
Y
I
E
S
L
A
R
Q
M
D
P
Site 153
T1012
L
A
R
Q
M
D
P
T
D
F
V
N
S
S
E
Site 154
T1029
L
A
V
S
R
I
I
T
W
T
T
E
P
K
S
Site 155
T1031
V
S
R
I
I
T
W
T
T
E
P
K
S
S
D
Site 156
T1032
S
R
I
I
T
W
T
T
E
P
K
S
S
D
V
Site 157
S1036
T
W
T
T
E
P
K
S
S
D
V
R
K
A
A
Site 158
S1037
W
T
T
E
P
K
S
S
D
V
R
K
A
A
Q
Site 159
T1068
L
L
G
A
L
P
K
T
F
Q
D
G
A
T
K
Site 160
S1084
L
H
N
H
L
K
N
S
S
N
T
S
V
G
S
Site 161
S1085
H
N
H
L
K
N
S
S
N
T
S
V
G
S
P
Site 162
T1087
H
L
K
N
S
S
N
T
S
V
G
S
P
S
N
Site 163
S1088
L
K
N
S
S
N
T
S
V
G
S
P
S
N
T
Site 164
S1091
S
S
N
T
S
V
G
S
P
S
N
T
I
G
R
Site 165
S1093
N
T
S
V
G
S
P
S
N
T
I
G
R
T
P
Site 166
T1095
S
V
G
S
P
S
N
T
I
G
R
T
P
S
R
Site 167
T1099
P
S
N
T
I
G
R
T
P
S
R
H
T
S
S
Site 168
S1101
N
T
I
G
R
T
P
S
R
H
T
S
S
R
T
Site 169
T1104
G
R
T
P
S
R
H
T
S
S
R
T
S
P
L
Site 170
S1105
R
T
P
S
R
H
T
S
S
R
T
S
P
L
T
Site 171
S1106
T
P
S
R
H
T
S
S
R
T
S
P
L
T
S
Site 172
T1108
S
R
H
T
S
S
R
T
S
P
L
T
S
P
T
Site 173
S1109
R
H
T
S
S
R
T
S
P
L
T
S
P
T
N
Site 174
T1112
S
S
R
T
S
P
L
T
S
P
T
N
C
S
H
Site 175
S1113
S
R
T
S
P
L
T
S
P
T
N
C
S
H
G
Site 176
T1115
T
S
P
L
T
S
P
T
N
C
S
H
G
G
L
Site 177
S1118
L
T
S
P
T
N
C
S
H
G
G
L
S
P
S
Site 178
S1123
N
C
S
H
G
G
L
S
P
S
R
L
W
G
W
Site 179
S1125
S
H
G
G
L
S
P
S
R
L
W
G
W
S
A
Site 180
S1131
P
S
R
L
W
G
W
S
A
D
G
L
A
K
H
Site 181
S1143
A
K
H
P
P
P
F
S
Q
P
N
S
I
P
T
Site 182
S1147
P
P
F
S
Q
P
N
S
I
P
T
A
P
S
H
Site 183
S1153
N
S
I
P
T
A
P
S
H
K
A
L
R
R
S
Site 184
S1160
S
H
K
A
L
R
R
S
Y
S
P
S
M
L
D
Site 185
Y1161
H
K
A
L
R
R
S
Y
S
P
S
M
L
D
Y
Site 186
S1162
K
A
L
R
R
S
Y
S
P
S
M
L
D
Y
D
Site 187
S1164
L
R
R
S
Y
S
P
S
M
L
D
Y
D
T
E
Site 188
Y1168
Y
S
P
S
M
L
D
Y
D
T
E
N
L
N
S
Site 189
T1170
P
S
M
L
D
Y
D
T
E
N
L
N
S
E
E
Site 190
S1175
Y
D
T
E
N
L
N
S
E
E
I
Y
S
S
L
Site 191
Y1179
N
L
N
S
E
E
I
Y
S
S
L
R
G
V
T
Site 192
S1181
N
S
E
E
I
Y
S
S
L
R
G
V
T
E
A
Site 193
T1186
Y
S
S
L
R
G
V
T
E
A
I
E
K
F
S
Site 194
S1193
T
E
A
I
E
K
F
S
F
R
S
Q
E
D
L
Site 195
S1196
I
E
K
F
S
F
R
S
Q
E
D
L
N
E
P
Site 196
S1216
K
K
E
C
D
I
V
S
R
D
G
G
A
A
S
Site 197
S1223
S
R
D
G
G
A
A
S
P
A
T
E
G
R
G
Site 198
T1226
G
G
A
A
S
P
A
T
E
G
R
G
G
S
E
Site 199
S1232
A
T
E
G
R
G
G
S
E
V
E
G
G
R
T
Site 200
S1246
T
A
L
D
N
K
T
S
L
L
N
T
Q
P
P
Site 201
T1250
N
K
T
S
L
L
N
T
Q
P
P
R
A
F
P
Site 202
Y1264
P
G
P
R
A
R
D
Y
N
P
Y
P
Y
S
D
Site 203
Y1267
R
A
R
D
Y
N
P
Y
P
Y
S
D
A
I
N
Site 204
Y1269
R
D
Y
N
P
Y
P
Y
S
D
A
I
N
T
Y
Site 205
T1275
P
Y
S
D
A
I
N
T
Y
D
K
T
A
L
K
Site 206
Y1276
Y
S
D
A
I
N
T
Y
D
K
T
A
L
K
E
Site 207
T1279
A
I
N
T
Y
D
K
T
A
L
K
E
A
V
F
Site 208
S1312
A
D
L
L
K
E
L
S
N
H
N
E
R
V
E
Site 209
S1336
L
K
I
T
R
E
D
S
L
G
V
W
E
E
H
Site 210
T1354
I
L
L
L
L
L
E
T
L
G
D
K
D
H
S
Site 211
Y1384
Q
P
A
R
F
K
N
Y
A
E
L
T
I
M
K
Site 212
T1392
A
E
L
T
I
M
K
T
L
E
A
H
K
D
S
Site 213
S1412
R
A
A
E
E
A
A
S
T
L
A
S
S
I
H
Site 214
T1413
A
A
E
E
A
A
S
T
L
A
S
S
I
H
P
Site 215
S1416
E
A
A
S
T
L
A
S
S
I
H
P
E
Q
C
Site 216
Y1473
I
P
G
L
L
Q
G
Y
D
N
T
E
S
S
V
Site 217
S1478
Q
G
Y
D
N
T
E
S
S
V
R
K
A
S
V
Site 218
S1479
G
Y
D
N
T
E
S
S
V
R
K
A
S
V
F
Site 219
Y1517
K
M
K
L
L
N
L
Y
I
K
R
A
Q
T
T
Site 220
T1523
L
Y
I
K
R
A
Q
T
T
N
S
N
S
S
S
Site 221
T1524
Y
I
K
R
A
Q
T
T
N
S
N
S
S
S
S
Site 222
S1526
K
R
A
Q
T
T
N
S
N
S
S
S
S
S
D
Site 223
S1528
A
Q
T
T
N
S
N
S
S
S
S
S
D
V
S
Site 224
S1530
T
T
N
S
N
S
S
S
S
S
D
V
S
T
H
Site 225
S1531
T
N
S
N
S
S
S
S
S
D
V
S
T
H
S
Site 226
S1532
N
S
N
S
S
S
S
S
D
V
S
T
H
S
_
Site 227
S1535
S
S
S
S
S
D
V
S
T
H
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation