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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAVS
Full Name:
Mitochondrial antiviral-signaling protein
Alias:
CARD adapter inducing interferon-beta; CARD adaptor inducing IFN-beta; Cardif; IFN-B promoter stimulator 1; Interferon-beta promoter stimulator 1; Interferon-beta promoter stimulator protein 1; IPS1; IPS-1; KIAA1271; Mitochondrial antiviral signaling; Mitochondrial antiviral signaling protein; Mitochondrial anti-viral signaling protein; NF-kappa-B-activating 031N; Virus-induced signaling adapter; Virus-induced signaling adaptor; VISA
Type:
Adapter/scaffold protein
Mass (Da):
56528
Number AA:
540
UniProt ID:
Q7Z434
International Prot ID:
IPI00020719
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005741
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004871
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0042742
GO:0045087
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
P
F
A
E
D
K
T
Y
K
Y
I
C
R
N
F
Site 2
Y11
A
E
D
K
T
Y
K
Y
I
C
R
N
F
S
N
Site 3
T35
L
P
Y
L
P
C
L
T
A
R
D
Q
D
R
L
Site 4
T45
D
Q
D
R
L
R
A
T
C
T
L
S
G
N
R
Site 5
T47
D
R
L
R
A
T
C
T
L
S
G
N
R
D
T
Site 6
S49
L
R
A
T
C
T
L
S
G
N
R
D
T
L
W
Site 7
T54
T
L
S
G
N
R
D
T
L
W
H
L
F
N
T
Site 8
Y71
R
R
P
G
W
V
E
Y
F
I
A
A
L
R
G
Site 9
S90
D
L
A
D
E
V
A
S
V
Y
Q
S
Y
Q
P
Site 10
Y92
A
D
E
V
A
S
V
Y
Q
S
Y
Q
P
R
T
Site 11
S94
E
V
A
S
V
Y
Q
S
Y
Q
P
R
T
S
D
Site 12
Y95
V
A
S
V
Y
Q
S
Y
Q
P
R
T
S
D
R
Site 13
S100
Q
S
Y
Q
P
R
T
S
D
R
P
P
D
P
L
Site 14
S111
P
D
P
L
E
P
P
S
L
P
A
E
R
P
G
Site 15
T121
A
E
R
P
G
P
P
T
P
A
A
A
H
S
I
Site 16
S127
P
T
P
A
A
A
H
S
I
P
Y
N
S
C
R
Site 17
S132
A
H
S
I
P
Y
N
S
C
R
E
K
E
P
S
Site 18
S139
S
C
R
E
K
E
P
S
Y
P
M
P
V
Q
E
Site 19
Y140
C
R
E
K
E
P
S
Y
P
M
P
V
Q
E
T
Site 20
T147
Y
P
M
P
V
Q
E
T
Q
A
P
E
S
P
G
Site 21
S152
Q
E
T
Q
A
P
E
S
P
G
E
N
S
E
Q
Site 22
S157
P
E
S
P
G
E
N
S
E
Q
A
L
Q
T
L
Site 23
T163
N
S
E
Q
A
L
Q
T
L
S
P
R
A
I
P
Site 24
S165
E
Q
A
L
Q
T
L
S
P
R
A
I
P
R
N
Site 25
S180
P
D
G
G
P
L
E
S
S
S
D
L
A
A
L
Site 26
S182
G
G
P
L
E
S
S
S
D
L
A
A
L
S
P
Site 27
S188
S
S
D
L
A
A
L
S
P
L
T
S
S
G
H
Site 28
S192
A
A
L
S
P
L
T
S
S
G
H
Q
E
Q
D
Site 29
T200
S
G
H
Q
E
Q
D
T
E
L
G
S
T
H
T
Site 30
T205
Q
D
T
E
L
G
S
T
H
T
A
G
A
T
S
Site 31
S213
H
T
A
G
A
T
S
S
L
T
P
S
R
G
P
Site 32
T215
A
G
A
T
S
S
L
T
P
S
R
G
P
V
S
Site 33
S217
A
T
S
S
L
T
P
S
R
G
P
V
S
P
S
Site 34
S222
T
P
S
R
G
P
V
S
P
S
V
S
F
Q
P
Site 35
S224
S
R
G
P
V
S
P
S
V
S
F
Q
P
L
A
Site 36
S226
G
P
V
S
P
S
V
S
F
Q
P
L
A
R
S
Site 37
S233
S
F
Q
P
L
A
R
S
T
P
R
A
S
R
L
Site 38
T234
F
Q
P
L
A
R
S
T
P
R
A
S
R
L
P
Site 39
S238
A
R
S
T
P
R
A
S
R
L
P
G
P
T
G
Site 40
T244
A
S
R
L
P
G
P
T
G
S
V
V
S
T
G
Site 41
S246
R
L
P
G
P
T
G
S
V
V
S
T
G
T
S
Site 42
S249
G
P
T
G
S
V
V
S
T
G
T
S
F
S
S
Site 43
T250
P
T
G
S
V
V
S
T
G
T
S
F
S
S
S
Site 44
T252
G
S
V
V
S
T
G
T
S
F
S
S
S
S
P
Site 45
S253
S
V
V
S
T
G
T
S
F
S
S
S
S
P
G
Site 46
S255
V
S
T
G
T
S
F
S
S
S
S
P
G
L
A
Site 47
S256
S
T
G
T
S
F
S
S
S
S
P
G
L
A
S
Site 48
S257
T
G
T
S
F
S
S
S
S
P
G
L
A
S
A
Site 49
S258
G
T
S
F
S
S
S
S
P
G
L
A
S
A
G
Site 50
S263
S
S
S
P
G
L
A
S
A
G
A
A
E
G
K
Site 51
S275
E
G
K
Q
G
A
E
S
D
Q
A
E
P
I
I
Site 52
S293
G
A
E
A
P
A
N
S
L
P
S
K
V
P
T
Site 53
T300
S
L
P
S
K
V
P
T
T
L
M
P
V
N
T
Site 54
S318
K
V
P
A
N
P
A
S
V
S
T
V
P
S
K
Site 55
S320
P
A
N
P
A
S
V
S
T
V
P
S
K
L
P
Site 56
T321
A
N
P
A
S
V
S
T
V
P
S
K
L
P
T
Site 57
S324
A
S
V
S
T
V
P
S
K
L
P
T
S
S
K
Site 58
T328
T
V
P
S
K
L
P
T
S
S
K
P
P
G
A
Site 59
S329
V
P
S
K
L
P
T
S
S
K
P
P
G
A
V
Site 60
S330
P
S
K
L
P
T
S
S
K
P
P
G
A
V
P
Site 61
T342
A
V
P
S
N
A
L
T
N
P
A
P
S
K
L
Site 62
S347
A
L
T
N
P
A
P
S
K
L
P
I
N
S
T
Site 63
S353
P
S
K
L
P
I
N
S
T
R
A
G
M
V
P
Site 64
T365
M
V
P
S
K
V
P
T
S
M
V
L
T
K
V
Site 65
S373
S
M
V
L
T
K
V
S
A
S
T
V
P
T
D
Site 66
T379
V
S
A
S
T
V
P
T
D
G
S
S
R
N
E
Site 67
S382
S
T
V
P
T
D
G
S
S
R
N
E
E
T
P
Site 68
S383
T
V
P
T
D
G
S
S
R
N
E
E
T
P
A
Site 69
T388
G
S
S
R
N
E
E
T
P
A
A
P
T
P
A
Site 70
T393
E
E
T
P
A
A
P
T
P
A
G
A
T
G
G
Site 71
T398
A
P
T
P
A
G
A
T
G
G
S
S
A
W
L
Site 72
S401
P
A
G
A
T
G
G
S
S
A
W
L
D
S
S
Site 73
S402
A
G
A
T
G
G
S
S
A
W
L
D
S
S
S
Site 74
S407
G
S
S
A
W
L
D
S
S
S
E
N
R
G
L
Site 75
S408
S
S
A
W
L
D
S
S
S
E
N
R
G
L
G
Site 76
S409
S
A
W
L
D
S
S
S
E
N
R
G
L
G
S
Site 77
S416
S
E
N
R
G
L
G
S
E
L
S
K
P
G
V
Site 78
S419
R
G
L
G
S
E
L
S
K
P
G
V
L
A
S
Site 79
S426
S
K
P
G
V
L
A
S
Q
V
D
S
P
F
S
Site 80
S430
V
L
A
S
Q
V
D
S
P
F
S
G
C
F
E
Site 81
S433
S
Q
V
D
S
P
F
S
G
C
F
E
D
L
A
Site 82
Y460
H
G
P
E
E
N
E
Y
K
S
E
G
T
F
G
Site 83
S462
P
E
E
N
E
Y
K
S
E
G
T
F
G
I
H
Site 84
S512
E
V
P
C
H
R
P
S
P
G
A
L
W
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation