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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KRT25
Full Name:
Keratin, type I cytoskeletal 25
Alias:
K1C25; Keratin-25; KRT25A; Type I inner root sheath-specific keratin-K25irs1
Type:
Mass (Da):
49318
Number AA:
450
UniProt ID:
Q7Z3Z0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
L
R
L
S
S
A
S
R
R
S
C
Site 2
S7
_
M
S
L
R
L
S
S
A
S
R
R
S
C
P
Site 3
S9
S
L
R
L
S
S
A
S
R
R
S
C
P
R
P
Site 4
S12
L
S
S
A
S
R
R
S
C
P
R
P
T
T
G
Site 5
T17
R
R
S
C
P
R
P
T
T
G
S
L
R
L
Y
Site 6
T18
R
S
C
P
R
P
T
T
G
S
L
R
L
Y
G
Site 7
S20
C
P
R
P
T
T
G
S
L
R
L
Y
G
G
G
Site 8
Y24
T
T
G
S
L
R
L
Y
G
G
G
T
S
F
G
Site 9
S29
R
L
Y
G
G
G
T
S
F
G
T
G
N
S
C
Site 10
T32
G
G
G
T
S
F
G
T
G
N
S
C
G
I
S
Site 11
S46
S
G
I
G
S
G
F
S
S
A
F
G
G
S
S
Site 12
S47
G
I
G
S
G
F
S
S
A
F
G
G
S
S
S
Site 13
S53
S
S
A
F
G
G
S
S
S
G
G
N
T
G
G
Site 14
S54
S
A
F
G
G
S
S
S
G
G
N
T
G
G
G
Site 15
T58
G
S
S
S
G
G
N
T
G
G
G
N
P
C
A
Site 16
T68
G
N
P
C
A
G
F
T
V
N
E
R
G
L
L
Site 17
S76
V
N
E
R
G
L
L
S
G
N
E
K
V
T
M
Site 18
S92
N
L
N
D
R
L
A
S
Y
L
D
S
V
H
A
Site 19
Y93
L
N
D
R
L
A
S
Y
L
D
S
V
H
A
L
Site 20
S96
R
L
A
S
Y
L
D
S
V
H
A
L
E
E
A
Site 21
Y115
E
Q
K
I
K
G
W
Y
E
K
F
G
P
G
S
Site 22
S122
Y
E
K
F
G
P
G
S
C
R
G
L
D
H
D
Site 23
Y130
C
R
G
L
D
H
D
Y
S
R
Y
F
P
I
I
Site 24
Y133
L
D
H
D
Y
S
R
Y
F
P
I
I
D
D
L
Site 25
T164
Q
I
D
N
A
R
L
T
A
D
D
F
R
L
K
Site 26
Y172
A
D
D
F
R
L
K
Y
E
N
E
L
A
L
H
Site 27
S181
N
E
L
A
L
H
Q
S
V
E
A
D
V
N
G
Site 28
T197
R
R
V
L
D
E
I
T
L
C
R
T
D
L
E
Site 29
Y207
R
T
D
L
E
I
Q
Y
E
T
L
S
E
E
M
Site 30
T215
E
T
L
S
E
E
M
T
Y
L
K
K
N
H
K
Site 31
Y216
T
L
S
E
E
M
T
Y
L
K
K
N
H
K
E
Site 32
Y259
L
N
N
M
R
A
E
Y
E
A
L
A
E
Q
N
Site 33
S278
E
A
W
F
N
E
K
S
A
S
L
Q
Q
Q
I
Site 34
S280
W
F
N
E
K
S
A
S
L
Q
Q
Q
I
S
E
Site 35
S294
E
D
V
G
A
T
T
S
A
R
N
E
L
T
E
Site 36
T305
E
L
T
E
M
K
R
T
L
Q
T
L
E
I
E
Site 37
T308
E
M
K
R
T
L
Q
T
L
E
I
E
L
Q
S
Site 38
S315
T
L
E
I
E
L
Q
S
L
L
A
T
K
H
S
Site 39
T319
E
L
Q
S
L
L
A
T
K
H
S
L
E
C
S
Site 40
S322
S
L
L
A
T
K
H
S
L
E
C
S
L
T
E
Site 41
S326
T
K
H
S
L
E
C
S
L
T
E
T
E
S
N
Site 42
T328
H
S
L
E
C
S
L
T
E
T
E
S
N
Y
C
Site 43
T330
L
E
C
S
L
T
E
T
E
S
N
Y
C
A
Q
Site 44
T359
L
H
Q
V
R
T
E
T
E
G
Q
K
L
E
Y
Site 45
S396
G
D
D
G
A
C
K
S
G
G
Y
K
S
K
D
Site 46
S401
C
K
S
G
G
Y
K
S
K
D
Y
G
S
G
N
Site 47
Y404
G
G
Y
K
S
K
D
Y
G
S
G
N
V
G
S
Site 48
S406
Y
K
S
K
D
Y
G
S
G
N
V
G
S
Q
V
Site 49
S411
Y
G
S
G
N
V
G
S
Q
V
K
D
P
A
K
Site 50
S433
L
E
E
V
D
Q
R
S
K
I
L
T
T
R
L
Site 51
T437
D
Q
R
S
K
I
L
T
T
R
L
H
S
L
E
Site 52
S442
I
L
T
T
R
L
H
S
L
E
E
K
S
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation