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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KRT27
Full Name:
Keratin, type I cytoskeletal 27
Alias:
K1C27; Keratin 25C; Keratin 27; KRT25C; Type I inner root sheath specific keratin 25 irs3
Type:
Cytoskeletal, Intermediate filament protein
Mass (Da):
49823
Number AA:
459
UniProt ID:
Q7Z3Y8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
V
R
F
S
S
T
S
R
R
L
G
Site 2
S7
_
M
S
V
R
F
S
S
T
S
R
R
L
G
S
Site 3
T8
M
S
V
R
F
S
S
T
S
R
R
L
G
S
C
Site 4
S9
S
V
R
F
S
S
T
S
R
R
L
G
S
C
G
Site 5
S14
S
T
S
R
R
L
G
S
C
G
G
T
G
S
V
Site 6
T18
R
L
G
S
C
G
G
T
G
S
V
R
L
S
S
Site 7
S20
G
S
C
G
G
T
G
S
V
R
L
S
S
G
G
Site 8
S24
G
T
G
S
V
R
L
S
S
G
G
A
G
F
G
Site 9
S53
S
C
A
F
G
G
T
S
S
A
G
G
Y
G
G
Site 10
Y58
G
T
S
S
A
G
G
Y
G
G
G
L
G
G
G
Site 11
S81
G
N
E
H
G
L
L
S
G
N
E
K
V
T
M
Site 12
S97
N
L
N
D
R
L
A
S
Y
L
E
N
V
R
A
Site 13
Y98
L
N
D
R
L
A
S
Y
L
E
N
V
R
A
L
Site 14
Y120
E
Q
K
I
K
G
W
Y
E
K
F
G
P
G
S
Site 15
S127
Y
E
K
F
G
P
G
S
C
R
G
L
D
H
D
Site 16
Y135
C
R
G
L
D
H
D
Y
S
R
Y
F
P
I
I
Site 17
Y138
L
D
H
D
Y
S
R
Y
F
P
I
I
D
K
L
Site 18
S151
K
L
K
N
Q
I
I
S
A
T
T
S
N
A
H
Site 19
T169
Q
N
D
N
A
R
L
T
A
D
D
F
R
L
K
Site 20
S186
N
E
L
A
L
H
Q
S
V
E
A
D
I
N
G
Site 21
T202
R
R
V
L
D
E
L
T
L
C
R
T
D
L
E
Site 22
Y221
T
L
S
E
E
L
A
Y
L
K
K
N
H
E
E
Site 23
Y264
L
N
N
M
R
A
E
Y
E
A
L
A
E
Q
N
Site 24
S283
E
A
W
F
N
E
K
S
A
S
L
Q
Q
Q
I
Site 25
S285
W
F
N
E
K
S
A
S
L
Q
Q
Q
I
S
D
Site 26
S291
A
S
L
Q
Q
Q
I
S
D
D
A
G
A
T
T
Site 27
S299
D
D
A
G
A
T
T
S
A
R
N
E
L
T
E
Site 28
T310
E
L
T
E
M
K
R
T
L
Q
T
L
E
I
E
Site 29
T313
E
M
K
R
T
L
Q
T
L
E
I
E
L
Q
S
Site 30
S320
T
L
E
I
E
L
Q
S
L
L
A
T
K
H
S
Site 31
T324
E
L
Q
S
L
L
A
T
K
H
S
L
E
C
S
Site 32
S327
S
L
L
A
T
K
H
S
L
E
C
S
L
T
E
Site 33
S331
T
K
H
S
L
E
C
S
L
T
E
T
E
S
N
Site 34
T333
H
S
L
E
C
S
L
T
E
T
E
S
N
Y
C
Site 35
T335
L
E
C
S
L
T
E
T
E
S
N
Y
C
A
Q
Site 36
T364
L
H
Q
V
R
T
E
T
E
G
Q
K
L
E
Y
Site 37
Y388
L
E
K
E
I
E
T
Y
C
L
L
I
D
G
E
Site 38
S398
L
I
D
G
E
D
G
S
C
S
K
S
K
G
Y
Site 39
S400
D
G
E
D
G
S
C
S
K
S
K
G
Y
G
G
Site 40
S402
E
D
G
S
C
S
K
S
K
G
Y
G
G
P
G
Site 41
Y405
S
C
S
K
S
K
G
Y
G
G
P
G
N
Q
T
Site 42
T412
Y
G
G
P
G
N
Q
T
K
D
S
S
K
T
T
Site 43
S415
P
G
N
Q
T
K
D
S
S
K
T
T
I
V
K
Site 44
T419
T
K
D
S
S
K
T
T
I
V
K
T
V
V
E
Site 45
T423
S
K
T
T
I
V
K
T
V
V
E
E
I
D
P
Site 46
S436
D
P
R
G
K
V
L
S
S
R
V
H
T
V
E
Site 47
S437
P
R
G
K
V
L
S
S
R
V
H
T
V
E
E
Site 48
T441
V
L
S
S
R
V
H
T
V
E
E
K
S
T
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation