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Updated November 2019
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Protein Info
Short Name:
RGPD4
Full Name:
RanBP2-like and GRIP domain-containing protein 4
Alias:
RGP4
Type:
Intracellular protein
Mass (Da):
198196
Number AA:
1766
UniProt ID:
Q7Z3J3
International Prot ID:
IPI00375793
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0046907
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
S
K
A
Y
G
E
R
Y
V
A
S
V
Q
G
S
Site 2
S14
Y
G
E
R
Y
V
A
S
V
Q
G
S
A
P
S
Site 3
S18
Y
V
A
S
V
Q
G
S
A
P
S
P
R
K
K
Site 4
S21
S
V
Q
G
S
A
P
S
P
R
K
K
S
T
R
Site 5
S26
A
P
S
P
R
K
K
S
T
R
G
F
Y
F
A
Site 6
Y31
K
K
S
T
R
G
F
Y
F
A
K
L
Y
Y
E
Site 7
Y36
G
F
Y
F
A
K
L
Y
Y
E
A
K
E
Y
D
Site 8
Y42
L
Y
Y
E
A
K
E
Y
D
L
A
K
K
Y
I
Site 9
Y48
E
Y
D
L
A
K
K
Y
I
C
T
Y
I
N
V
Site 10
Y52
A
K
K
Y
I
C
T
Y
I
N
V
R
E
M
D
Site 11
Y70
H
R
F
L
G
L
L
Y
E
L
E
E
N
T
E
Site 12
S86
A
V
E
C
Y
R
R
S
V
E
L
N
P
T
Q
Site 13
T92
R
S
V
E
L
N
P
T
Q
K
D
L
V
L
K
Site 14
Y116
V
T
D
G
R
A
K
Y
W
V
E
R
A
A
K
Site 15
S128
A
A
K
L
F
P
G
S
P
A
I
Y
K
L
K
Site 16
Y132
F
P
G
S
P
A
I
Y
K
L
K
E
Q
L
L
Site 17
Y159
D
L
I
Q
S
E
L
Y
V
R
P
D
D
V
H
Site 18
Y175
N
I
R
L
V
E
L
Y
R
S
T
K
R
L
K
Site 19
S177
R
L
V
E
L
Y
R
S
T
K
R
L
K
D
A
Site 20
T178
L
V
E
L
Y
R
S
T
K
R
L
K
D
A
V
Site 21
S199
E
R
N
I
A
L
R
S
S
L
E
W
N
S
C
Site 22
S200
R
N
I
A
L
R
S
S
L
E
W
N
S
C
V
Site 23
S205
R
S
S
L
E
W
N
S
C
V
V
Q
T
L
K
Site 24
S217
T
L
K
E
Y
L
E
S
L
Q
C
L
E
S
D
Site 25
S223
E
S
L
Q
C
L
E
S
D
K
S
D
W
R
A
Site 26
S226
Q
C
L
E
S
D
K
S
D
W
R
A
T
N
T
Site 27
T231
D
K
S
D
W
R
A
T
N
T
D
L
L
L
A
Site 28
S248
N
L
M
L
L
T
L
S
T
R
D
V
Q
E
S
Site 29
S255
S
T
R
D
V
Q
E
S
R
E
L
L
E
S
F
Site 30
S261
E
S
R
E
L
L
E
S
F
D
S
A
L
Q
S
Site 31
S264
E
L
L
E
S
F
D
S
A
L
Q
S
A
K
S
Site 32
S268
S
F
D
S
A
L
Q
S
A
K
S
S
L
G
G
Site 33
S271
S
A
L
Q
S
A
K
S
S
L
G
G
N
D
E
Site 34
S272
A
L
Q
S
A
K
S
S
L
G
G
N
D
E
L
Site 35
S280
L
G
G
N
D
E
L
S
A
T
F
L
E
M
K
Site 36
T282
G
N
D
E
L
S
A
T
F
L
E
M
K
G
H
Site 37
S353
M
M
A
C
D
R
L
S
Q
S
G
H
M
L
L
Site 38
S355
A
C
D
R
L
S
Q
S
G
H
M
L
L
N
L
Site 39
S363
G
H
M
L
L
N
L
S
R
G
K
Q
D
F
L
Site 40
S381
V
E
T
F
A
N
K
S
G
Q
S
A
L
Y
D
Site 41
Y387
K
S
G
Q
S
A
L
Y
D
A
L
F
S
S
Q
Site 42
S393
L
Y
D
A
L
F
S
S
Q
S
P
K
D
T
S
Site 43
S395
D
A
L
F
S
S
Q
S
P
K
D
T
S
F
L
Site 44
T399
S
S
Q
S
P
K
D
T
S
F
L
G
S
D
D
Site 45
S400
S
Q
S
P
K
D
T
S
F
L
G
S
D
D
I
Site 46
S404
K
D
T
S
F
L
G
S
D
D
I
G
N
I
D
Site 47
S434
A
I
R
A
H
N
G
S
L
Q
H
L
T
W
L
Site 48
T474
Q
E
T
S
R
L
E
T
N
A
P
E
S
I
C
Site 49
S506
Q
L
K
E
K
C
N
S
H
H
S
S
Y
Q
P
Site 50
S588
K
C
L
Q
K
M
G
S
G
L
N
S
F
Y
D
Site 51
S592
K
M
G
S
G
L
N
S
F
Y
D
Q
R
E
Y
Site 52
Y594
G
S
G
L
N
S
F
Y
D
Q
R
E
Y
I
G
Site 53
Y599
S
F
Y
D
Q
R
E
Y
I
G
R
S
V
H
Y
Site 54
Y606
Y
I
G
R
S
V
H
Y
W
K
K
V
L
P
L
Site 55
Y647
Q
A
S
E
I
V
E
Y
E
E
D
A
H
V
T
Site 56
T670
G
N
I
E
D
A
M
T
A
F
E
S
I
K
S
Site 57
S701
D
I
A
N
D
A
L
S
P
E
E
Q
E
E
C
Site 58
Y711
E
Q
E
E
C
K
N
Y
L
R
K
T
R
G
Y
Site 59
T715
C
K
N
Y
L
R
K
T
R
G
Y
L
I
K
I
Site 60
Y718
Y
L
R
K
T
R
G
Y
L
I
K
I
L
D
D
Site 61
S728
K
I
L
D
D
S
D
S
N
L
S
V
V
K
K
Site 62
S731
D
D
S
D
S
N
L
S
V
V
K
K
L
P
V
Site 63
S742
K
L
P
V
P
L
E
S
V
K
E
M
L
K
S
Site 64
S749
S
V
K
E
M
L
K
S
V
M
Q
E
L
E
N
Site 65
Y757
V
M
Q
E
L
E
N
Y
S
E
G
D
P
L
Y
Site 66
Y764
Y
S
E
G
D
P
L
Y
K
N
G
S
L
R
N
Site 67
S768
D
P
L
Y
K
N
G
S
L
R
N
A
D
S
E
Site 68
S774
G
S
L
R
N
A
D
S
E
I
K
H
S
T
P
Site 69
S779
A
D
S
E
I
K
H
S
T
P
S
P
T
K
Y
Site 70
T780
D
S
E
I
K
H
S
T
P
S
P
T
K
Y
S
Site 71
S782
E
I
K
H
S
T
P
S
P
T
K
Y
S
L
S
Site 72
T784
K
H
S
T
P
S
P
T
K
Y
S
L
S
P
S
Site 73
Y786
S
T
P
S
P
T
K
Y
S
L
S
P
S
K
S
Site 74
S787
T
P
S
P
T
K
Y
S
L
S
P
S
K
S
Y
Site 75
S789
S
P
T
K
Y
S
L
S
P
S
K
S
Y
K
Y
Site 76
S791
T
K
Y
S
L
S
P
S
K
S
Y
K
Y
S
P
Site 77
S793
Y
S
L
S
P
S
K
S
Y
K
Y
S
P
K
T
Site 78
Y796
S
P
S
K
S
Y
K
Y
S
P
K
T
P
P
R
Site 79
S797
P
S
K
S
Y
K
Y
S
P
K
T
P
P
R
W
Site 80
T800
S
Y
K
Y
S
P
K
T
P
P
R
W
A
E
D
Site 81
S810
R
W
A
E
D
Q
N
S
L
L
K
M
I
R
Q
Site 82
S833
M
Q
E
L
K
L
N
S
S
K
S
A
S
H
H
Site 83
S834
Q
E
L
K
L
N
S
S
K
S
A
S
H
H
R
Site 84
S836
L
K
L
N
S
S
K
S
A
S
H
H
R
W
P
Site 85
S838
L
N
S
S
K
S
A
S
H
H
R
W
P
T
E
Site 86
T844
A
S
H
H
R
W
P
T
E
N
Y
G
P
D
S
Site 87
Y847
H
R
W
P
T
E
N
Y
G
P
D
S
V
P
D
Site 88
S851
T
E
N
Y
G
P
D
S
V
P
D
G
Y
Q
G
Site 89
Y856
P
D
S
V
P
D
G
Y
Q
G
S
Q
T
F
H
Site 90
S859
V
P
D
G
Y
Q
G
S
Q
T
F
H
G
A
P
Site 91
T861
D
G
Y
Q
G
S
Q
T
F
H
G
A
P
L
T
Site 92
T871
G
A
P
L
T
V
A
T
T
G
P
S
V
Y
Y
Site 93
S875
T
V
A
T
T
G
P
S
V
Y
Y
S
Q
S
P
Site 94
Y877
A
T
T
G
P
S
V
Y
Y
S
Q
S
P
A
Y
Site 95
Y878
T
T
G
P
S
V
Y
Y
S
Q
S
P
A
Y
N
Site 96
S879
T
G
P
S
V
Y
Y
S
Q
S
P
A
Y
N
S
Site 97
S881
P
S
V
Y
Y
S
Q
S
P
A
Y
N
S
Q
Y
Site 98
Y884
Y
Y
S
Q
S
P
A
Y
N
S
Q
Y
L
L
R
Site 99
S886
S
Q
S
P
A
Y
N
S
Q
Y
L
L
R
P
A
Site 100
Y888
S
P
A
Y
N
S
Q
Y
L
L
R
P
A
A
N
Site 101
T897
L
R
P
A
A
N
V
T
P
T
K
G
S
S
N
Site 102
S902
N
V
T
P
T
K
G
S
S
N
T
E
F
K
S
Site 103
T905
P
T
K
G
S
S
N
T
E
F
K
S
T
K
E
Site 104
S909
S
S
N
T
E
F
K
S
T
K
E
G
F
S
I
Site 105
T910
S
N
T
E
F
K
S
T
K
E
G
F
S
I
P
Site 106
S915
K
S
T
K
E
G
F
S
I
P
V
S
A
D
G
Site 107
S919
E
G
F
S
I
P
V
S
A
D
G
F
K
F
G
Site 108
S928
D
G
F
K
F
G
I
S
E
P
G
N
Q
E
K
Site 109
S953
G
F
Q
A
Q
D
I
S
G
Q
K
N
G
R
G
Site 110
T971
G
Q
T
S
S
T
F
T
F
A
D
V
A
K
S
Site 111
S978
T
F
A
D
V
A
K
S
T
S
G
E
G
F
Q
Site 112
T979
F
A
D
V
A
K
S
T
S
G
E
G
F
Q
F
Site 113
S980
A
D
V
A
K
S
T
S
G
E
G
F
Q
F
G
Site 114
S1005
G
A
G
E
K
L
F
S
S
Q
C
G
K
M
A
Site 115
S1006
A
G
E
K
L
F
S
S
Q
C
G
K
M
A
N
Site 116
T1017
K
M
A
N
K
A
N
T
S
G
D
F
E
K
D
Site 117
S1018
M
A
N
K
A
N
T
S
G
D
F
E
K
D
D
Site 118
Y1028
F
E
K
D
D
D
A
Y
K
T
E
D
S
D
D
Site 119
T1030
K
D
D
D
A
Y
K
T
E
D
S
D
D
I
H
Site 120
S1033
D
A
Y
K
T
E
D
S
D
D
I
H
F
E
P
Site 121
Y1061
E
E
G
E
K
V
L
Y
S
Q
G
V
K
L
F
Site 122
S1062
E
G
E
K
V
L
Y
S
Q
G
V
K
L
F
R
Site 123
S1124
T
M
N
L
K
P
L
S
G
S
D
R
A
W
M
Site 124
S1126
N
L
K
P
L
S
G
S
D
R
A
W
M
W
S
Site 125
S1133
S
D
R
A
W
M
W
S
A
S
D
F
S
D
G
Site 126
S1135
R
A
W
M
W
S
A
S
D
F
S
D
G
D
A
Site 127
T1153
R
L
A
A
K
F
K
T
P
E
L
A
E
E
F
Site 128
T1178
L
L
D
I
P
L
Q
T
P
H
K
L
V
D
T
Site 129
T1185
T
P
H
K
L
V
D
T
G
R
A
A
K
L
I
Site 130
S1200
Q
R
A
E
E
M
K
S
G
L
K
D
F
K
T
Site 131
T1207
S
G
L
K
D
F
K
T
F
L
T
N
D
Q
T
Site 132
T1214
T
F
L
T
N
D
Q
T
K
V
T
E
E
E
N
Site 133
S1224
T
E
E
E
N
K
G
S
G
T
G
A
A
G
A
Site 134
T1235
A
A
G
A
S
D
T
T
I
K
P
N
P
E
N
Site 135
S1262
R
E
D
A
L
D
D
S
V
S
S
S
S
V
H
Site 136
S1264
D
A
L
D
D
S
V
S
S
S
S
V
H
A
S
Site 137
S1265
A
L
D
D
S
V
S
S
S
S
V
H
A
S
P
Site 138
S1266
L
D
D
S
V
S
S
S
S
V
H
A
S
P
L
Site 139
S1267
D
D
S
V
S
S
S
S
V
H
A
S
P
L
A
Site 140
S1271
S
S
S
S
V
H
A
S
P
L
A
S
S
P
V
Site 141
S1275
V
H
A
S
P
L
A
S
S
P
V
R
K
N
L
Site 142
S1276
H
A
S
P
L
A
S
S
P
V
R
K
N
L
F
Site 143
S1288
N
L
F
H
F
G
E
S
T
T
G
S
N
F
S
Site 144
T1289
L
F
H
F
G
E
S
T
T
G
S
N
F
S
F
Site 145
T1290
F
H
F
G
E
S
T
T
G
S
N
F
S
F
K
Site 146
S1292
F
G
E
S
T
T
G
S
N
F
S
F
K
S
A
Site 147
S1295
S
T
T
G
S
N
F
S
F
K
S
A
L
S
P
Site 148
S1298
G
S
N
F
S
F
K
S
A
L
S
P
S
K
S
Site 149
S1301
F
S
F
K
S
A
L
S
P
S
K
S
P
A
K
Site 150
S1303
F
K
S
A
L
S
P
S
K
S
P
A
K
L
N
Site 151
S1305
S
A
L
S
P
S
K
S
P
A
K
L
N
Q
S
Site 152
S1312
S
P
A
K
L
N
Q
S
G
T
S
V
G
T
D
Site 153
T1314
A
K
L
N
Q
S
G
T
S
V
G
T
D
E
E
Site 154
S1315
K
L
N
Q
S
G
T
S
V
G
T
D
E
E
S
Site 155
T1318
Q
S
G
T
S
V
G
T
D
E
E
S
D
V
T
Site 156
S1322
S
V
G
T
D
E
E
S
D
V
T
Q
E
E
E
Site 157
T1325
T
D
E
E
S
D
V
T
Q
E
E
E
R
D
G
Site 158
Y1334
E
E
E
R
D
G
Q
Y
F
E
P
V
V
P
L
Site 159
S1349
P
D
L
V
E
V
S
S
G
E
E
N
E
K
V
Site 160
S1359
E
N
E
K
V
V
F
S
H
R
A
E
L
Y
R
Site 161
Y1367
H
R
A
E
L
Y
R
Y
D
K
D
V
G
Q
W
Site 162
Y1388
D
I
K
I
L
Q
N
Y
D
N
K
Q
V
R
I
Site 163
T1412
L
C
A
N
H
T
I
T
P
D
M
S
L
Q
N
Site 164
S1416
H
T
I
T
P
D
M
S
L
Q
N
M
K
G
T
Site 165
T1423
S
L
Q
N
M
K
G
T
E
R
V
W
V
W
T
Site 166
S1456
K
L
Q
D
V
A
D
S
F
K
K
I
F
D
E
Site 167
S1472
K
T
A
Q
E
K
D
S
L
I
T
P
H
V
S
Site 168
T1475
Q
E
K
D
S
L
I
T
P
H
V
S
R
S
S
Site 169
S1479
S
L
I
T
P
H
V
S
R
S
S
T
P
R
E
Site 170
S1481
I
T
P
H
V
S
R
S
S
T
P
R
E
S
P
Site 171
S1482
T
P
H
V
S
R
S
S
T
P
R
E
S
P
C
Site 172
T1483
P
H
V
S
R
S
S
T
P
R
E
S
P
C
G
Site 173
S1487
R
S
S
T
P
R
E
S
P
C
G
K
I
A
V
Site 174
T1500
A
V
A
V
L
E
E
T
T
R
E
R
T
D
V
Site 175
T1505
E
E
T
T
R
E
R
T
D
V
I
Q
G
D
D
Site 176
S1518
D
D
V
A
D
A
A
S
E
V
E
V
S
S
T
Site 177
S1523
A
A
S
E
V
E
V
S
S
T
S
E
T
T
T
Site 178
T1525
S
E
V
E
V
S
S
T
S
E
T
T
T
K
A
Site 179
S1526
E
V
E
V
S
S
T
S
E
T
T
T
K
A
V
Site 180
T1528
E
V
S
S
T
S
E
T
T
T
K
A
V
V
S
Site 181
T1529
V
S
S
T
S
E
T
T
T
K
A
V
V
S
P
Site 182
T1530
S
S
T
S
E
T
T
T
K
A
V
V
S
P
P
Site 183
S1535
T
T
T
K
A
V
V
S
P
P
K
F
V
F
G
Site 184
S1543
P
P
K
F
V
F
G
S
E
S
V
K
R
I
F
Site 185
S1545
K
F
V
F
G
S
E
S
V
K
R
I
F
S
S
Site 186
S1551
E
S
V
K
R
I
F
S
S
E
K
S
K
P
F
Site 187
S1552
S
V
K
R
I
F
S
S
E
K
S
K
P
F
A
Site 188
S1555
R
I
F
S
S
E
K
S
K
P
F
A
F
G
N
Site 189
S1568
G
N
S
S
A
T
G
S
L
F
G
F
S
F
N
Site 190
S1577
F
G
F
S
F
N
A
S
L
K
S
N
N
S
E
Site 191
S1580
S
F
N
A
S
L
K
S
N
N
S
E
T
S
S
Site 192
S1583
A
S
L
K
S
N
N
S
E
T
S
S
V
A
Q
Site 193
T1585
L
K
S
N
N
S
E
T
S
S
V
A
Q
S
G
Site 194
S1587
S
N
N
S
E
T
S
S
V
A
Q
S
G
S
E
Site 195
S1591
E
T
S
S
V
A
Q
S
G
S
E
S
K
V
E
Site 196
S1593
S
S
V
A
Q
S
G
S
E
S
K
V
E
P
K
Site 197
S1595
V
A
Q
S
G
S
E
S
K
V
E
P
K
K
C
Site 198
S1605
E
P
K
K
C
E
L
S
K
N
S
D
I
E
Q
Site 199
S1608
K
C
E
L
S
K
N
S
D
I
E
Q
S
S
D
Site 200
S1614
N
S
D
I
E
Q
S
S
D
S
K
V
K
N
L
Site 201
S1616
D
I
E
Q
S
S
D
S
K
V
K
N
L
S
A
Site 202
S1622
D
S
K
V
K
N
L
S
A
S
F
P
M
E
E
Site 203
S1624
K
V
K
N
L
S
A
S
F
P
M
E
E
S
S
Site 204
Y1634
M
E
E
S
S
I
N
Y
T
F
K
T
P
E
K
Site 205
T1635
E
E
S
S
I
N
Y
T
F
K
T
P
E
K
E
Site 206
T1638
S
I
N
Y
T
F
K
T
P
E
K
E
P
P
L
Site 207
S1660
E
E
L
V
Q
K
L
S
S
T
T
K
S
A
D
Site 208
S1661
E
L
V
Q
K
L
S
S
T
T
K
S
A
D
H
Site 209
S1665
K
L
S
S
T
T
K
S
A
D
H
L
N
G
L
Site 210
S1692
E
Q
I
K
L
L
K
S
E
I
R
R
L
E
R
Site 211
S1706
R
N
Q
E
Q
E
E
S
A
A
N
V
E
H
L
Site 212
S1727
F
I
F
L
K
P
G
S
E
R
E
R
L
L
P
Site 213
S1743
I
N
T
M
L
Q
L
S
P
E
E
K
G
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation