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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA1267
Full Name:
MLL1/MLL complex subunit KIAA1267
Alias:
DKFZp686L2032; DKFZP727C091; K1267; Uncharacterized protein KIAA1267: Uncharacterized protein KIAA1267
Type:
Unknown function
Mass (Da):
120966
Number AA:
1105
UniProt ID:
Q7Z3B3
International Prot ID:
IPI00384972
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
R
F
K
L
A
P
P
S
S
T
L
S
P
G
S
Site 2
S27
F
K
L
A
P
P
S
S
T
L
S
P
G
S
A
Site 3
T28
K
L
A
P
P
S
S
T
L
S
P
G
S
A
E
Site 4
S30
A
P
P
S
S
T
L
S
P
G
S
A
E
N
N
Site 5
S33
S
S
T
L
S
P
G
S
A
E
N
N
G
N
A
Site 6
T49
I
L
I
A
A
N
G
T
K
R
K
A
I
A
A
Site 7
S60
A
I
A
A
E
D
P
S
L
D
F
R
N
N
P
Site 8
T88
S
Y
L
C
S
D
V
T
S
V
P
S
K
E
S
Site 9
S89
Y
L
C
S
D
V
T
S
V
P
S
K
E
S
L
Site 10
S103
L
K
L
Q
G
V
F
S
K
Q
T
V
L
K
S
Site 11
T106
Q
G
V
F
S
K
Q
T
V
L
K
S
H
P
L
Site 12
S110
S
K
Q
T
V
L
K
S
H
P
L
L
S
Q
S
Site 13
S115
L
K
S
H
P
L
L
S
Q
S
Y
E
L
R
A
Site 14
S117
S
H
P
L
L
S
Q
S
Y
E
L
R
A
E
L
Site 15
S134
R
Q
P
V
L
E
F
S
L
E
N
L
R
T
M
Site 16
T140
F
S
L
E
N
L
R
T
M
N
T
S
G
Q
T
Site 17
S144
N
L
R
T
M
N
T
S
G
Q
T
A
L
P
Q
Site 18
T162
N
G
L
A
K
K
L
T
K
S
S
T
H
S
D
Site 19
S164
L
A
K
K
L
T
K
S
S
T
H
S
D
H
D
Site 20
T166
K
K
L
T
K
S
S
T
H
S
D
H
D
N
S
Site 21
S168
L
T
K
S
S
T
H
S
D
H
D
N
S
T
S
Site 22
S173
T
H
S
D
H
D
N
S
T
S
L
N
G
G
K
Site 23
T174
H
S
D
H
D
N
S
T
S
L
N
G
G
K
R
Site 24
S175
S
D
H
D
N
S
T
S
L
N
G
G
K
R
A
Site 25
T184
N
G
G
K
R
A
L
T
S
S
A
L
H
G
G
Site 26
S185
G
G
K
R
A
L
T
S
S
A
L
H
G
G
E
Site 27
S186
G
K
R
A
L
T
S
S
A
L
H
G
G
E
M
Site 28
S196
H
G
G
E
M
G
G
S
E
S
G
D
L
K
G
Site 29
S198
G
E
M
G
G
S
E
S
G
D
L
K
G
G
M
Site 30
T206
G
D
L
K
G
G
M
T
N
C
T
L
P
H
R
Site 31
T209
K
G
G
M
T
N
C
T
L
P
H
R
S
L
D
Site 32
T220
R
S
L
D
V
E
H
T
T
L
Y
S
N
N
S
Site 33
T221
S
L
D
V
E
H
T
T
L
Y
S
N
N
S
T
Site 34
Y223
D
V
E
H
T
T
L
Y
S
N
N
S
T
A
N
Site 35
S227
T
T
L
Y
S
N
N
S
T
A
N
K
S
S
V
Site 36
T228
T
L
Y
S
N
N
S
T
A
N
K
S
S
V
N
Site 37
S232
N
N
S
T
A
N
K
S
S
V
N
S
M
E
Q
Site 38
S233
N
S
T
A
N
K
S
S
V
N
S
M
E
Q
P
Site 39
S236
A
N
K
S
S
V
N
S
M
E
Q
P
A
L
Q
Site 40
S245
E
Q
P
A
L
Q
G
S
S
R
L
S
P
G
T
Site 41
S249
L
Q
G
S
S
R
L
S
P
G
T
D
S
S
S
Site 42
T252
S
S
R
L
S
P
G
T
D
S
S
S
N
L
G
Site 43
S254
R
L
S
P
G
T
D
S
S
S
N
L
G
G
V
Site 44
S255
L
S
P
G
T
D
S
S
S
N
L
G
G
V
K
Site 45
S256
S
P
G
T
D
S
S
S
N
L
G
G
V
K
L
Site 46
S268
V
K
L
E
G
K
K
S
P
L
S
S
I
L
F
Site 47
S271
E
G
K
K
S
P
L
S
S
I
L
F
S
A
L
Site 48
S272
G
K
K
S
P
L
S
S
I
L
F
S
A
L
D
Site 49
S276
P
L
S
S
I
L
F
S
A
L
D
S
D
T
R
Site 50
S280
I
L
F
S
A
L
D
S
D
T
R
I
T
A
L
Site 51
T285
L
D
S
D
T
R
I
T
A
L
L
R
R
Q
A
Site 52
S296
R
R
Q
A
D
I
E
S
R
A
R
R
L
Q
K
Site 53
S330
G
F
L
E
K
T
L
S
K
L
P
N
L
E
S
Site 54
S337
S
K
L
P
N
L
E
S
L
R
P
R
S
Q
L
Site 55
S342
L
E
S
L
R
P
R
S
Q
L
M
L
T
R
K
Site 56
S359
A
A
L
R
K
A
A
S
E
T
T
T
S
E
G
Site 57
T362
R
K
A
A
S
E
T
T
T
S
E
G
L
S
N
Site 58
T363
K
A
A
S
E
T
T
T
S
E
G
L
S
N
F
Site 59
S364
A
A
S
E
T
T
T
S
E
G
L
S
N
F
L
Site 60
S368
T
T
T
S
E
G
L
S
N
F
L
K
S
N
S
Site 61
S373
G
L
S
N
F
L
K
S
N
S
I
S
E
E
L
Site 62
S375
S
N
F
L
K
S
N
S
I
S
E
E
L
E
R
Site 63
S377
F
L
K
S
N
S
I
S
E
E
L
E
R
F
T
Site 64
T384
S
E
E
L
E
R
F
T
A
S
G
I
A
N
L
Site 65
S386
E
L
E
R
F
T
A
S
G
I
A
N
L
R
C
Site 66
S394
G
I
A
N
L
R
C
S
E
Q
A
F
D
S
D
Site 67
S400
C
S
E
Q
A
F
D
S
D
V
T
D
S
S
S
Site 68
T403
Q
A
F
D
S
D
V
T
D
S
S
S
G
G
E
Site 69
S405
F
D
S
D
V
T
D
S
S
S
G
G
E
S
D
Site 70
S406
D
S
D
V
T
D
S
S
S
G
G
E
S
D
I
Site 71
S407
S
D
V
T
D
S
S
S
G
G
E
S
D
I
E
Site 72
S411
D
S
S
S
G
G
E
S
D
I
E
E
E
E
L
Site 73
T419
D
I
E
E
E
E
L
T
R
A
D
P
E
Q
R
Site 74
S434
H
V
P
L
R
R
R
S
E
W
K
W
A
A
D
Site 75
Y461
A
H
V
S
D
L
E
Y
R
I
R
Q
Q
T
D
Site 76
T467
E
Y
R
I
R
Q
Q
T
D
I
Y
K
Q
I
R
Site 77
Y470
I
R
Q
Q
T
D
I
Y
K
Q
I
R
A
N
K
Site 78
S499
T
D
L
F
L
P
L
S
S
E
V
K
T
D
H
Site 79
T504
P
L
S
S
E
V
K
T
D
H
G
T
D
K
L
Site 80
S514
G
T
D
K
L
I
E
S
V
S
Q
P
L
E
N
Site 81
S516
D
K
L
I
E
S
V
S
Q
P
L
E
N
H
G
Site 82
S531
A
P
I
I
G
H
I
S
E
S
L
S
T
K
S
Site 83
S535
G
H
I
S
E
S
L
S
T
K
S
C
G
A
L
Site 84
T536
H
I
S
E
S
L
S
T
K
S
C
G
A
L
R
Site 85
S538
S
E
S
L
S
T
K
S
C
G
A
L
R
P
V
Site 86
S564
A
D
H
I
P
G
D
S
S
D
A
E
E
Q
L
Site 87
S565
D
H
I
P
G
D
S
S
D
A
E
E
Q
L
H
Site 88
S581
K
Q
R
L
N
L
V
S
S
S
S
D
G
T
C
Site 89
S582
Q
R
L
N
L
V
S
S
S
S
D
G
T
C
V
Site 90
T587
V
S
S
S
S
D
G
T
C
V
A
A
R
T
R
Site 91
S598
A
R
T
R
P
V
L
S
C
K
K
R
R
L
V
Site 92
S609
R
R
L
V
R
P
N
S
I
V
P
L
S
K
K
Site 93
S614
P
N
S
I
V
P
L
S
K
K
V
H
R
N
S
Site 94
S621
S
K
K
V
H
R
N
S
T
I
R
P
G
C
D
Site 95
T622
K
K
V
H
R
N
S
T
I
R
P
G
C
D
V
Site 96
T643
C
G
S
G
S
I
N
T
M
P
P
E
I
H
Y
Site 97
Y650
T
M
P
P
E
I
H
Y
E
A
P
L
L
E
R
Site 98
T677
A
F
P
D
D
V
P
T
S
L
H
F
Q
S
M
Site 99
S678
F
P
D
D
V
P
T
S
L
H
F
Q
S
M
L
Site 100
S683
P
T
S
L
H
F
Q
S
M
L
K
S
Q
W
Q
Site 101
S714
H
R
A
P
M
P
G
S
L
P
D
S
A
R
K
Site 102
S718
M
P
G
S
L
P
D
S
A
R
K
D
R
H
K
Site 103
S728
K
D
R
H
K
L
V
S
S
F
L
T
T
A
K
Site 104
S729
D
R
H
K
L
V
S
S
F
L
T
T
A
K
L
Site 105
T732
K
L
V
S
S
F
L
T
T
A
K
L
S
H
H
Site 106
T733
L
V
S
S
F
L
T
T
A
K
L
S
H
H
Q
Site 107
T741
A
K
L
S
H
H
Q
T
R
P
D
R
T
H
R
Site 108
T764
V
P
M
V
E
R
V
T
A
P
K
A
E
R
L
Site 109
S792
K
M
R
L
R
D
H
S
S
E
R
S
E
V
L
Site 110
S793
M
R
L
R
D
H
S
S
E
R
S
E
V
L
K
Site 111
S796
R
D
H
S
S
E
R
S
E
V
L
K
H
H
T
Site 112
T803
S
E
V
L
K
H
H
T
D
M
S
S
S
S
Y
Site 113
S806
L
K
H
H
T
D
M
S
S
S
S
Y
L
A
A
Site 114
S807
K
H
H
T
D
M
S
S
S
S
Y
L
A
A
T
Site 115
S808
H
H
T
D
M
S
S
S
S
Y
L
A
A
T
H
Site 116
S809
H
T
D
M
S
S
S
S
Y
L
A
A
T
H
H
Site 117
Y810
T
D
M
S
S
S
S
Y
L
A
A
T
H
H
P
Site 118
T814
S
S
S
Y
L
A
A
T
H
H
P
P
H
S
P
Site 119
S820
A
T
H
H
P
P
H
S
P
L
V
R
Q
L
S
Site 120
S827
S
P
L
V
R
Q
L
S
T
S
S
D
S
P
A
Site 121
T828
P
L
V
R
Q
L
S
T
S
S
D
S
P
A
P
Site 122
S829
L
V
R
Q
L
S
T
S
S
D
S
P
A
P
A
Site 123
S830
V
R
Q
L
S
T
S
S
D
S
P
A
P
A
S
Site 124
S832
Q
L
S
T
S
S
D
S
P
A
P
A
S
S
S
Site 125
S837
S
D
S
P
A
P
A
S
S
S
S
Q
V
T
A
Site 126
S838
D
S
P
A
P
A
S
S
S
S
Q
V
T
A
S
Site 127
S840
P
A
P
A
S
S
S
S
Q
V
T
A
S
T
S
Site 128
T843
A
S
S
S
S
Q
V
T
A
S
T
S
Q
Q
P
Site 129
S845
S
S
S
Q
V
T
A
S
T
S
Q
Q
P
V
R
Site 130
S847
S
Q
V
T
A
S
T
S
Q
Q
P
V
R
R
R
Site 131
S858
V
R
R
R
R
G
E
S
S
F
D
I
N
N
I
Site 132
S859
R
R
R
R
G
E
S
S
F
D
I
N
N
I
V
Site 133
Y882
T
R
V
E
K
L
Q
Y
K
E
I
L
T
P
S
Site 134
T887
L
Q
Y
K
E
I
L
T
P
S
W
R
E
V
D
Site 135
S889
Y
K
E
I
L
T
P
S
W
R
E
V
D
L
Q
Site 136
S897
W
R
E
V
D
L
Q
S
L
K
G
S
P
D
E
Site 137
S901
D
L
Q
S
L
K
G
S
P
D
E
E
N
E
E
Site 138
S913
N
E
E
I
E
D
L
S
D
A
A
F
A
A
L
Site 139
T935
E
R
A
R
W
L
W
T
T
S
V
P
P
Q
R
Site 140
T936
R
A
R
W
L
W
T
T
S
V
P
P
Q
R
R
Site 141
S937
A
R
W
L
W
T
T
S
V
P
P
Q
R
R
G
Site 142
S945
V
P
P
Q
R
R
G
S
R
S
Y
R
S
S
D
Site 143
S947
P
Q
R
R
G
S
R
S
Y
R
S
S
D
G
R
Site 144
Y948
Q
R
R
G
S
R
S
Y
R
S
S
D
G
R
T
Site 145
S950
R
G
S
R
S
Y
R
S
S
D
G
R
T
T
P
Site 146
S951
G
S
R
S
Y
R
S
S
D
G
R
T
T
P
Q
Site 147
T955
Y
R
S
S
D
G
R
T
T
P
Q
L
G
S
A
Site 148
T956
R
S
S
D
G
R
T
T
P
Q
L
G
S
A
N
Site 149
S961
R
T
T
P
Q
L
G
S
A
N
P
S
T
P
Q
Site 150
S965
Q
L
G
S
A
N
P
S
T
P
Q
P
A
S
P
Site 151
T966
L
G
S
A
N
P
S
T
P
Q
P
A
S
P
D
Site 152
S971
P
S
T
P
Q
P
A
S
P
D
V
S
S
S
H
Site 153
S975
Q
P
A
S
P
D
V
S
S
S
H
S
L
S
E
Site 154
S976
P
A
S
P
D
V
S
S
S
H
S
L
S
E
Y
Site 155
S977
A
S
P
D
V
S
S
S
H
S
L
S
E
Y
S
Site 156
S979
P
D
V
S
S
S
H
S
L
S
E
Y
S
H
G
Site 157
S981
V
S
S
S
H
S
L
S
E
Y
S
H
G
Q
S
Site 158
Y983
S
S
H
S
L
S
E
Y
S
H
G
Q
S
P
R
Site 159
S984
S
H
S
L
S
E
Y
S
H
G
Q
S
P
R
S
Site 160
S988
S
E
Y
S
H
G
Q
S
P
R
S
P
I
S
P
Site 161
S991
S
H
G
Q
S
P
R
S
P
I
S
P
E
L
H
Site 162
S994
Q
S
P
R
S
P
I
S
P
E
L
H
S
A
P
Site 163
S999
P
I
S
P
E
L
H
S
A
P
L
T
P
V
A
Site 164
T1003
E
L
H
S
A
P
L
T
P
V
A
R
D
T
P
Site 165
T1009
L
T
P
V
A
R
D
T
P
R
H
L
A
S
E
Site 166
T1018
R
H
L
A
S
E
D
T
R
C
S
T
P
E
L
Site 167
S1021
A
S
E
D
T
R
C
S
T
P
E
L
G
L
D
Site 168
T1022
S
E
D
T
R
C
S
T
P
E
L
G
L
D
E
Site 169
S1031
E
L
G
L
D
E
Q
S
V
Q
P
W
E
R
R
Site 170
T1039
V
Q
P
W
E
R
R
T
F
P
L
A
H
S
P
Site 171
S1045
R
T
F
P
L
A
H
S
P
Q
A
E
C
E
D
Site 172
T1064
Q
E
R
A
A
R
C
T
R
R
T
S
G
S
K
Site 173
T1067
A
A
R
C
T
R
R
T
S
G
S
K
T
G
R
Site 174
S1068
A
R
C
T
R
R
T
S
G
S
K
T
G
R
E
Site 175
S1070
C
T
R
R
T
S
G
S
K
T
G
R
E
T
E
Site 176
T1072
R
R
T
S
G
S
K
T
G
R
E
T
E
A
A
Site 177
T1076
G
S
K
T
G
R
E
T
E
A
A
P
T
S
P
Site 178
T1081
R
E
T
E
A
A
P
T
S
P
P
I
V
P
L
Site 179
S1082
E
T
E
A
A
P
T
S
P
P
I
V
P
L
K
Site 180
T1098
R
H
L
V
A
A
A
T
A
Q
R
P
T
H
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation