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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HDX
Full Name:
Highly divergent homeobox
Alias:
Type:
Mass (Da):
77206
Number AA:
690
UniProt ID:
Q7Z353
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
Q
Q
R
I
L
Q
R
Y
Y
E
N
G
M
T
N
Site 2
Y19
Q
R
I
L
Q
R
Y
Y
E
N
G
M
T
N
Q
Site 3
T24
R
Y
Y
E
N
G
M
T
N
Q
S
K
N
C
F
Site 4
S27
E
N
G
M
T
N
Q
S
K
N
C
F
Q
L
I
Site 5
S46
Q
E
T
K
L
D
F
S
V
V
R
T
W
V
G
Site 6
T50
L
D
F
S
V
V
R
T
W
V
G
N
K
R
R
Site 7
S60
G
N
K
R
R
K
M
S
S
K
N
S
E
S
G
Site 8
S61
N
K
R
R
K
M
S
S
K
N
S
E
S
G
T
Site 9
S64
R
K
M
S
S
K
N
S
E
S
G
T
A
T
T
Site 10
T68
S
K
N
S
E
S
G
T
A
T
T
G
T
S
L
Site 11
T70
N
S
E
S
G
T
A
T
T
G
T
S
L
S
A
Site 12
S74
G
T
A
T
T
G
T
S
L
S
A
P
D
I
T
Site 13
S76
A
T
T
G
T
S
L
S
A
P
D
I
T
V
R
Site 14
S92
V
V
N
I
A
R
P
S
S
Q
Q
S
S
W
T
Site 15
S93
V
N
I
A
R
P
S
S
Q
Q
S
S
W
T
S
Site 16
S96
A
R
P
S
S
Q
Q
S
S
W
T
S
A
N
N
Site 17
S97
R
P
S
S
Q
Q
S
S
W
T
S
A
N
N
D
Site 18
S100
S
Q
Q
S
S
W
T
S
A
N
N
D
V
I
V
Site 19
S115
T
G
I
Y
S
P
A
S
S
S
S
R
Q
G
T
Site 20
S116
G
I
Y
S
P
A
S
S
S
S
R
Q
G
T
N
Site 21
S117
I
Y
S
P
A
S
S
S
S
R
Q
G
T
N
K
Site 22
T122
S
S
S
S
R
Q
G
T
N
K
H
T
D
T
Q
Site 23
T128
G
T
N
K
H
T
D
T
Q
I
T
E
A
H
K
Site 24
S177
G
E
K
T
I
I
L
S
R
Q
T
S
V
L
N
Site 25
S188
S
V
L
N
A
G
N
S
V
F
N
H
A
K
K
Site 26
S200
A
K
K
N
Y
G
N
S
S
V
Q
A
S
E
M
Site 27
S201
K
K
N
Y
G
N
S
S
V
Q
A
S
E
M
T
Site 28
S205
G
N
S
S
V
Q
A
S
E
M
T
V
P
Q
K
Site 29
T208
S
V
Q
A
S
E
M
T
V
P
Q
K
P
S
V
Site 30
S230
E
P
V
G
I
Q
R
S
Y
K
P
E
H
T
G
Site 31
Y231
P
V
G
I
Q
R
S
Y
K
P
E
H
T
G
P
Site 32
Y254
K
P
T
I
R
D
P
Y
C
R
T
Q
N
L
E
Site 33
S288
N
A
P
Q
K
P
S
S
A
E
G
N
C
L
S
Site 34
S295
S
A
E
G
N
C
L
S
I
A
M
E
T
G
D
Site 35
Y307
T
G
D
A
E
D
E
Y
A
R
E
E
E
L
A
Site 36
S315
A
R
E
E
E
L
A
S
M
R
A
Q
I
P
S
Site 37
S322
S
M
R
A
Q
I
P
S
Y
S
R
F
Y
E
S
Site 38
Y323
M
R
A
Q
I
P
S
Y
S
R
F
Y
E
S
G
Site 39
S324
R
A
Q
I
P
S
Y
S
R
F
Y
E
S
G
S
Site 40
Y327
I
P
S
Y
S
R
F
Y
E
S
G
S
S
L
R
Site 41
S329
S
Y
S
R
F
Y
E
S
G
S
S
L
R
A
E
Site 42
S332
R
F
Y
E
S
G
S
S
L
R
A
E
N
Q
S
Site 43
S339
S
L
R
A
E
N
Q
S
T
T
L
P
G
P
G
Site 44
T340
L
R
A
E
N
Q
S
T
T
L
P
G
P
G
R
Site 45
T341
R
A
E
N
Q
S
T
T
L
P
G
P
G
R
N
Site 46
S352
P
G
R
N
M
P
N
S
Q
M
V
N
I
R
D
Site 47
Y366
D
M
S
D
N
V
L
Y
Q
N
R
N
Y
H
L
Site 48
Y371
V
L
Y
Q
N
R
N
Y
H
L
T
P
R
T
S
Site 49
T374
Q
N
R
N
Y
H
L
T
P
R
T
S
L
H
T
Site 50
S378
Y
H
L
T
P
R
T
S
L
H
T
A
S
S
T
Site 51
T381
T
P
R
T
S
L
H
T
A
S
S
T
M
Y
S
Site 52
S383
R
T
S
L
H
T
A
S
S
T
M
Y
S
N
T
Site 53
S384
T
S
L
H
T
A
S
S
T
M
Y
S
N
T
N
Site 54
T385
S
L
H
T
A
S
S
T
M
Y
S
N
T
N
P
Site 55
Y387
H
T
A
S
S
T
M
Y
S
N
T
N
P
L
R
Site 56
S388
T
A
S
S
T
M
Y
S
N
T
N
P
L
R
S
Site 57
T390
S
S
T
M
Y
S
N
T
N
P
L
R
S
N
F
Site 58
S395
S
N
T
N
P
L
R
S
N
F
S
P
H
F
A
Site 59
S398
N
P
L
R
S
N
F
S
P
H
F
A
S
S
N
Site 60
S404
F
S
P
H
F
A
S
S
N
Q
L
R
L
S
Q
Site 61
S410
S
S
N
Q
L
R
L
S
Q
N
Q
N
N
Y
Q
Site 62
Y416
L
S
Q
N
Q
N
N
Y
Q
I
S
G
N
L
T
Site 63
S443
L
Q
D
R
T
Q
F
S
D
R
D
L
A
T
L
Site 64
T449
F
S
D
R
D
L
A
T
L
K
K
Y
W
D
N
Site 65
Y453
D
L
A
T
L
K
K
Y
W
D
N
G
M
T
S
Site 66
S463
N
G
M
T
S
L
G
S
V
C
R
E
K
I
E
Site 67
T474
E
K
I
E
A
V
A
T
E
L
N
V
D
C
E
Site 68
Y494
I
G
N
R
R
R
K
Y
R
L
M
G
I
E
V
Site 69
S512
R
G
G
P
A
D
F
S
E
Q
P
E
S
G
S
Site 70
S517
D
F
S
E
Q
P
E
S
G
S
L
S
A
L
T
Site 71
S519
S
E
Q
P
E
S
G
S
L
S
A
L
T
P
G
Site 72
S521
Q
P
E
S
G
S
L
S
A
L
T
P
G
E
E
Site 73
T524
S
G
S
L
S
A
L
T
P
G
E
E
A
G
P
Site 74
S544
N
D
R
N
D
E
V
S
I
C
L
S
E
G
S
Site 75
S548
D
E
V
S
I
C
L
S
E
G
S
S
Q
E
E
Site 76
S551
S
I
C
L
S
E
G
S
S
Q
E
E
P
N
E
Site 77
S552
I
C
L
S
E
G
S
S
Q
E
E
P
N
E
V
Site 78
S590
E
I
I
D
D
E
E
S
D
M
I
S
N
S
E
Site 79
S594
D
E
E
S
D
M
I
S
N
S
E
V
E
Q
V
Site 80
S596
E
S
D
M
I
S
N
S
E
V
E
Q
V
N
S
Site 81
S603
S
E
V
E
Q
V
N
S
F
L
D
Y
K
N
E
Site 82
Y607
Q
V
N
S
F
L
D
Y
K
N
E
E
V
K
F
Site 83
Y626
L
E
I
Q
K
Q
K
Y
F
K
L
Q
T
F
V
Site 84
S653
E
Q
Q
Q
A
L
L
S
D
L
P
P
E
L
E
Site 85
S668
E
M
D
F
N
H
A
S
L
E
P
D
D
T
S
Site 86
T674
A
S
L
E
P
D
D
T
S
F
S
V
S
S
L
Site 87
S675
S
L
E
P
D
D
T
S
F
S
V
S
S
L
S
Site 88
S677
E
P
D
D
T
S
F
S
V
S
S
L
S
E
K
Site 89
S679
D
D
T
S
F
S
V
S
S
L
S
E
K
N
V
Site 90
S680
D
T
S
F
S
V
S
S
L
S
E
K
N
V
S
Site 91
S682
S
F
S
V
S
S
L
S
E
K
N
V
S
E
S
Site 92
S687
S
L
S
E
K
N
V
S
E
S
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation