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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GVIN1
Full Name:
Interferon-induced very large GTPase 1
Alias:
FLJ13373; Gtpase, very large interferon inducible 1; Gvin1; Very large inducible GTPase 1; Vlig1; Vlig-1
Type:
Unknown function
Mass (Da):
279030
Number AA:
2422
UniProt ID:
Q7Z2Y8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005525
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
A
T
G
E
H
T
P
D
D
P
L
L
R
Site 2
Y34
E
V
G
L
D
V
E
Y
W
L
P
K
L
Q
E
Site 3
S64
N
N
L
K
K
L
K
S
Q
T
Q
H
P
W
E
Site 4
T66
L
K
K
L
K
S
Q
T
Q
H
P
W
E
K
L
Site 5
S77
W
E
K
L
L
N
L
S
H
S
K
S
L
S
A
Site 6
S81
L
N
L
S
H
S
K
S
L
S
A
L
L
Q
E
Site 7
S83
L
S
H
S
K
S
L
S
A
L
L
Q
E
S
Q
Site 8
S89
L
S
A
L
L
Q
E
S
Q
V
E
R
A
K
R
Site 9
T113
Q
E
L
R
D
L
L
T
E
G
K
Q
R
Q
E
Site 10
T125
R
Q
E
E
A
V
R
T
R
E
A
E
L
R
Q
Site 11
S143
I
P
E
E
Y
W
P
S
P
E
E
P
L
R
E
Site 12
S182
R
D
V
V
R
W
A
S
G
G
L
A
L
Q
G
Site 13
T200
A
S
H
Q
R
G
L
T
E
K
R
E
E
L
L
Site 14
S208
E
K
R
E
E
L
L
S
V
P
K
E
F
L
L
Site 15
T226
Q
Q
G
T
Q
M
K
T
K
E
F
T
S
P
Q
Site 16
S231
M
K
T
K
E
F
T
S
P
Q
A
E
F
M
F
Site 17
T239
P
Q
A
E
F
M
F
T
Q
M
V
E
K
L
G
Site 18
T250
E
K
L
G
F
R
L
T
T
S
A
K
D
G
N
Site 19
T251
K
L
G
F
R
L
T
T
S
A
K
D
G
N
W
Site 20
S252
L
G
F
R
L
T
T
S
A
K
D
G
N
W
G
Site 21
S261
K
D
G
N
W
G
F
S
L
E
A
G
L
D
H
Site 22
S269
L
E
A
G
L
D
H
S
K
H
P
E
S
K
E
Site 23
S274
D
H
S
K
H
P
E
S
K
E
T
Q
Q
S
S
Site 24
T277
K
H
P
E
S
K
E
T
Q
Q
S
S
S
E
N
Site 25
S280
E
S
K
E
T
Q
Q
S
S
S
E
N
S
Y
F
Site 26
S281
S
K
E
T
Q
Q
S
S
S
E
N
S
Y
F
C
Site 27
S282
K
E
T
Q
Q
S
S
S
E
N
S
Y
F
C
S
Site 28
S285
Q
Q
S
S
S
E
N
S
Y
F
C
S
T
K
F
Site 29
Y286
Q
S
S
S
E
N
S
Y
F
C
S
T
K
F
S
Site 30
S289
S
E
N
S
Y
F
C
S
T
K
F
S
Y
I
P
Site 31
S310
P
I
D
Q
L
Q
L
S
K
P
A
V
Q
E
L
Site 32
S325
K
C
I
E
E
L
L
S
Q
T
T
N
P
D
R
Site 33
T327
I
E
E
L
L
S
Q
T
T
N
P
D
R
F
S
Site 34
S334
T
T
N
P
D
R
F
S
L
L
R
H
R
I
I
Site 35
T373
A
I
S
E
G
Y
C
T
E
Q
L
A
E
V
R
Site 36
S409
V
A
A
G
V
N
V
S
D
S
H
S
K
T
A
Site 37
S411
A
G
V
N
V
S
D
S
H
S
K
T
A
T
Q
Site 38
S413
V
N
V
S
D
S
H
S
K
T
A
T
Q
T
K
Site 39
T415
V
S
D
S
H
S
K
T
A
T
Q
T
K
T
S
Site 40
T417
D
S
H
S
K
T
A
T
Q
T
K
T
S
Q
N
Site 41
S432
L
Q
T
K
V
Q
L
S
V
A
Q
T
G
G
P
Site 42
T436
V
Q
L
S
V
A
Q
T
G
G
P
P
E
A
D
Site 43
S477
P
V
W
D
I
I
L
S
S
H
R
S
N
F
K
Site 44
S481
I
I
L
S
S
H
R
S
N
F
K
D
P
L
Q
Site 45
S502
D
S
Y
T
A
L
T
S
I
T
A
Q
I
Q
N
Site 46
S515
Q
N
G
E
E
L
L
S
A
G
K
E
A
R
V
Site 47
S529
V
F
L
E
D
V
K
S
W
E
V
S
D
P
E
Site 48
S533
D
V
K
S
W
E
V
S
D
P
E
E
Q
L
K
Site 49
S550
I
N
F
M
K
M
L
S
Q
K
L
K
S
Y
D
Site 50
Y556
L
S
Q
K
L
K
S
Y
D
T
W
I
N
I
C
Site 51
T587
K
K
S
S
I
Y
K
T
K
C
I
K
S
H
L
Site 52
S592
Y
K
T
K
C
I
K
S
H
L
R
S
L
L
D
Site 53
S596
C
I
K
S
H
L
R
S
L
L
D
P
H
I
Y
Site 54
Y603
S
L
L
D
P
H
I
Y
R
V
T
N
F
P
Q
Site 55
S631
E
Q
E
Q
V
N
I
S
Q
F
S
Q
L
I
E
Site 56
S654
L
M
E
V
K
V
K
S
E
S
P
E
T
V
E
Site 57
S656
E
V
K
V
K
S
E
S
P
E
T
V
E
E
A
Site 58
T659
V
K
S
E
S
P
E
T
V
E
E
A
Q
R
K
Site 59
S667
V
E
E
A
Q
R
K
S
T
Y
E
V
S
L
A
Site 60
T668
E
E
A
Q
R
K
S
T
Y
E
V
S
L
A
L
Site 61
T690
Q
K
T
E
Q
T
D
T
Q
L
L
L
L
S
I
Site 62
Y733
M
Q
T
A
Q
N
K
Y
Q
E
L
K
N
I
C
Site 63
S741
Q
E
L
K
N
I
C
S
Y
R
A
Q
A
F
L
Site 64
T760
L
T
A
T
V
G
D
T
A
I
S
S
E
E
K
Site 65
S764
V
G
D
T
A
I
S
S
E
E
K
T
Q
R
M
Site 66
T768
A
I
S
S
E
E
K
T
Q
R
M
S
L
M
R
Site 67
S781
M
R
H
H
M
G
Q
S
L
S
K
E
V
A
H
Site 68
S783
H
H
M
G
Q
S
L
S
K
E
V
A
H
V
L
Site 69
Y814
R
L
L
I
N
G
D
Y
E
E
V
T
I
S
S
Site 70
S820
D
Y
E
E
V
T
I
S
S
L
Q
M
E
E
V
Site 71
S828
S
L
Q
M
E
E
V
S
K
Q
S
L
F
Y
G
Site 72
Y870
Q
H
L
G
L
E
H
Y
Y
P
K
K
L
S
K
Site 73
Y871
H
L
G
L
E
H
Y
Y
P
K
K
L
S
K
A
Site 74
Y889
L
I
Y
K
T
S
V
Y
N
T
Q
P
S
S
E
Site 75
T891
Y
K
T
S
V
Y
N
T
Q
P
S
S
E
Q
E
Site 76
S894
S
V
Y
N
T
Q
P
S
S
E
Q
E
L
P
F
Site 77
S895
V
Y
N
T
Q
P
S
S
E
Q
E
L
P
F
Y
Site 78
Y902
S
E
Q
E
L
P
F
Y
F
L
Q
K
L
L
M
Site 79
Y916
M
M
D
Y
E
L
R
Y
L
V
F
K
D
D
R
Site 80
Y944
E
D
E
A
F
D
P
Y
E
N
F
F
E
D
S
Site 81
S951
Y
E
N
F
F
E
D
S
D
S
P
T
K
S
S
Site 82
S953
N
F
F
E
D
S
D
S
P
T
K
S
S
S
T
Site 83
T955
F
E
D
S
D
S
P
T
K
S
S
S
T
E
P
Site 84
S957
D
S
D
S
P
T
K
S
S
S
T
E
P
S
P
Site 85
S958
S
D
S
P
T
K
S
S
S
T
E
P
S
P
H
Site 86
S959
D
S
P
T
K
S
S
S
T
E
P
S
P
H
I
Site 87
S963
K
S
S
S
T
E
P
S
P
H
I
H
P
V
D
Site 88
Y986
A
D
N
F
A
R
Q
Y
I
L
A
K
L
S
T
Site 89
S1013
C
T
S
Q
I
E
F
S
L
W
S
L
R
Q
I
Site 90
S1016
Q
I
E
F
S
L
W
S
L
R
Q
I
T
R
S
Site 91
T1021
L
W
S
L
R
Q
I
T
R
S
W
Q
E
A
R
Site 92
S1023
S
L
R
Q
I
T
R
S
W
Q
E
A
R
K
S
Site 93
S1030
S
W
Q
E
A
R
K
S
P
K
G
K
N
Y
Y
Site 94
Y1036
K
S
P
K
G
K
N
Y
Y
K
N
Q
Q
M
C
Site 95
Y1037
S
P
K
G
K
N
Y
Y
K
N
Q
Q
M
C
C
Site 96
S1060
V
R
V
G
N
G
L
S
A
S
K
S
Q
I
M
Site 97
S1062
V
G
N
G
L
S
A
S
K
S
Q
I
M
N
C
Site 98
S1134
K
E
H
E
Q
Q
L
S
F
L
K
E
V
S
T
Site 99
S1150
I
V
V
L
M
S
A
S
D
D
N
E
G
N
R
Site 100
T1182
D
D
K
E
A
T
M
T
N
I
S
G
Q
R
M
Site 101
T1202
N
R
N
E
A
E
L
T
E
E
L
T
T
T
I
Site 102
T1207
E
L
T
E
E
L
T
T
T
I
R
H
L
L
E
Site 103
S1221
E
L
S
D
T
A
L
S
L
E
D
C
S
Q
I
Site 104
S1226
A
L
S
L
E
D
C
S
Q
I
A
H
Q
Q
G
Site 105
S1263
F
L
G
K
M
K
L
S
Q
I
K
E
K
L
L
Site 106
Y1288
C
K
K
D
K
E
L
Y
H
L
R
E
K
G
N
Site 107
S1303
Q
S
I
E
Q
H
K
S
E
I
E
T
D
K
Q
Site 108
T1307
Q
H
K
S
E
I
E
T
D
K
Q
I
I
R
H
Site 109
S1329
P
L
N
D
L
M
Q
S
V
L
Q
F
L
Q
E
Site 110
T1342
Q
E
H
S
E
I
H
T
K
L
Y
F
L
Q
W
Site 111
Y1371
E
L
H
E
K
Q
K
Y
W
W
S
L
V
Q
T
Site 112
S1386
V
K
Q
K
A
P
N
S
H
S
L
I
C
L
Q
Site 113
S1388
Q
K
A
P
N
S
H
S
L
I
C
L
Q
S
E
Site 114
Y1421
I
R
E
V
G
Q
I
Y
E
A
L
E
E
A
S
Site 115
S1429
E
A
L
E
E
A
S
S
I
K
K
I
F
F
S
Site 116
T1528
Q
L
L
K
V
E
E
T
F
T
E
E
L
G
F
Site 117
T1530
L
K
V
E
E
T
F
T
E
E
L
G
F
D
F
Site 118
S1552
G
L
R
A
P
E
H
S
N
K
S
K
D
R
D
Site 119
S1555
A
P
E
H
S
N
K
S
K
D
R
D
N
E
L
Site 120
T1621
N
V
G
E
A
T
A
T
D
Q
T
M
D
G
R
Site 121
Y1667
F
D
V
N
T
H
V
Y
Y
F
A
H
L
W
D
Site 122
Y1686
M
A
P
P
N
P
R
Y
S
H
N
V
Q
Q
L
Site 123
S1687
A
P
P
N
P
R
Y
S
H
N
V
Q
Q
L
K
Site 124
S1695
H
N
V
Q
Q
L
K
S
R
I
L
M
T
A
T
Site 125
T1702
S
R
I
L
M
T
A
T
Q
E
S
R
G
N
I
Site 126
S1713
R
G
N
I
M
K
I
S
D
V
K
S
R
V
Q
Site 127
S1717
M
K
I
S
D
V
K
S
R
V
Q
D
L
W
R
Site 128
T1780
I
Q
N
G
K
I
Q
T
L
E
A
S
T
F
E
Site 129
Y1794
E
V
L
V
T
E
K
Y
E
V
V
K
Q
E
L
Site 130
Y1804
V
K
Q
E
L
E
K
Y
F
N
E
G
P
C
S
Site 131
S1834
V
L
K
E
K
L
I
S
D
S
K
R
Q
A
N
Site 132
S1836
K
E
K
L
I
S
D
S
K
R
Q
A
N
E
L
Site 133
S1845
R
Q
A
N
E
L
I
S
F
K
N
Q
S
Q
E
Site 134
S1850
L
I
S
F
K
N
Q
S
Q
E
R
L
N
K
K
Site 135
T1859
E
R
L
N
K
K
K
T
D
Y
E
K
E
L
L
Site 136
Y1861
L
N
K
K
K
T
D
Y
E
K
E
L
L
E
K
Site 137
S1869
E
K
E
L
L
E
K
S
R
K
L
A
L
T
V
Site 138
T1875
K
S
R
K
L
A
L
T
V
K
G
K
E
L
S
Site 139
S1882
T
V
K
G
K
E
L
S
E
E
E
L
H
E
K
Site 140
T1903
K
W
V
C
D
V
S
T
T
L
P
Q
V
T
E
Site 141
S1917
E
P
D
I
D
L
D
S
E
N
I
L
W
E
Y
Site 142
Y1924
S
E
N
I
L
W
E
Y
F
K
N
K
T
N
V
Site 143
Y1956
H
I
K
V
N
K
K
Y
N
H
I
P
M
T
L
Site 144
T1962
K
Y
N
H
I
P
M
T
L
T
V
F
E
K
E
Site 145
Y1977
F
I
N
M
T
T
D
Y
I
V
S
R
F
N
K
Site 146
Y2000
Q
C
G
Y
N
P
N
Y
F
H
E
I
L
K
T
Site 147
T2007
Y
F
H
E
I
L
K
T
I
E
E
E
V
K
S
Site 148
S2014
T
I
E
E
E
V
K
S
A
S
T
Q
K
R
Y
Site 149
T2022
A
S
T
Q
K
R
Y
T
F
T
N
T
F
I
I
Site 150
Y2059
R
A
N
D
P
V
N
Y
L
E
S
K
K
D
D
Site 151
T2069
S
K
K
D
D
F
F
T
S
F
K
I
S
C
Q
Site 152
S2070
K
K
D
D
F
F
T
S
F
K
I
S
C
Q
G
Site 153
S2133
L
E
K
H
I
L
F
S
L
A
E
E
E
N
F
Site 154
Y2143
E
E
E
N
F
D
N
Y
W
E
Y
L
H
N
S
Site 155
S2152
E
Y
L
H
N
S
K
S
F
F
R
S
Y
I
K
Site 156
S2156
N
S
K
S
F
F
R
S
Y
I
K
N
H
I
K
Site 157
Y2157
S
K
S
F
F
R
S
Y
I
K
N
H
I
K
R
Site 158
Y2165
I
K
N
H
I
K
R
Y
C
S
D
N
G
G
E
Site 159
T2176
N
G
G
E
K
M
K
T
F
F
E
K
S
L
I
Site 160
S2181
M
K
T
F
F
E
K
S
L
I
D
I
K
N
T
Site 161
S2191
D
I
K
N
T
I
L
S
A
I
H
E
S
T
S
Site 162
S2198
S
A
I
H
E
S
T
S
V
A
K
D
K
S
S
Site 163
S2204
T
S
V
A
K
D
K
S
S
T
A
S
E
W
L
Site 164
S2205
S
V
A
K
D
K
S
S
T
A
S
E
W
L
D
Site 165
S2208
K
D
K
S
S
T
A
S
E
W
L
D
L
F
C
Site 166
S2231
F
P
R
R
D
L
I
S
I
E
H
Q
E
I
K
Site 167
T2240
E
H
Q
E
I
K
H
T
E
F
L
K
E
A
M
Site 168
T2254
M
S
A
A
L
D
L
T
M
K
K
I
E
Q
N
Site 169
S2263
K
K
I
E
Q
N
Y
S
S
K
P
I
E
A
M
Site 170
S2272
K
P
I
E
A
M
V
S
K
I
E
K
M
L
S
Site 171
S2308
P
T
H
E
G
D
H
S
V
P
F
H
R
P
Q
Site 172
Y2356
R
N
F
P
F
K
N
Y
R
Q
A
G
G
D
Y
Site 173
Y2363
Y
R
Q
A
G
G
D
Y
A
M
W
S
I
T
P
Site 174
T2369
D
Y
A
M
W
S
I
T
P
D
T
S
I
Q
L
Site 175
Y2377
P
D
T
S
I
Q
L
Y
W
K
W
F
V
S
H
Site 176
Y2393
R
S
N
L
E
E
K
Y
Q
K
K
F
A
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation