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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NRK
Full Name:
Nik-related protein kinase
Alias:
DKFZp686A17109; EC 2.7.11.1
Type:
Protein-serine kinase, STE group, STE20 family, MSN subfamily
Mass (Da):
178479
Number AA:
1582
UniProt ID:
Q7Z2Y5
International Prot ID:
IPI00375682
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
GO:0005083
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
G
W
R
D
R
E
V
T
D
L
G
H
L
P
D
Site 2
T22
L
G
H
L
P
D
P
T
G
I
F
S
L
D
K
Site 3
Y40
L
G
T
Y
G
R
I
Y
L
G
L
H
E
K
T
Site 4
T61
K
V
M
N
A
R
K
T
P
L
P
E
I
G
R
Site 5
Y75
R
R
V
R
V
N
K
Y
Q
K
S
V
G
W
R
Site 6
S84
K
S
V
G
W
R
Y
S
D
E
E
E
D
L
R
Site 7
T92
D
E
E
E
D
L
R
T
E
L
N
L
L
R
K
Site 8
Y100
E
L
N
L
L
R
K
Y
S
F
H
K
N
I
V
Site 9
S101
L
N
L
L
R
K
Y
S
F
H
K
N
I
V
S
Site 10
S117
Y
G
A
F
F
K
L
S
P
P
G
Q
R
H
Q
Site 11
T144
V
T
D
V
V
R
M
T
S
N
Q
S
L
K
E
Site 12
S145
T
D
V
V
R
M
T
S
N
Q
S
L
K
E
D
Site 13
T186
K
G
Q
N
V
L
L
T
H
N
A
E
V
K
L
Site 14
S199
K
L
V
D
F
G
V
S
A
Q
V
S
R
T
N
Site 15
S203
F
G
V
S
A
Q
V
S
R
T
N
G
R
R
N
Site 16
S211
R
T
N
G
R
R
N
S
F
I
G
T
P
Y
W
Site 17
T215
R
R
N
S
F
I
G
T
P
Y
W
M
A
P
E
Site 18
S233
C
D
E
D
P
R
R
S
Y
D
Y
R
S
D
V
Site 19
Y234
D
E
D
P
R
R
S
Y
D
Y
R
S
D
V
W
Site 20
Y236
D
P
R
R
S
Y
D
Y
R
S
D
V
W
S
V
Site 21
S238
R
R
S
Y
D
Y
R
S
D
V
W
S
V
G
I
Site 22
S242
D
Y
R
S
D
V
W
S
V
G
I
T
A
I
E
Site 23
T276
I
L
R
E
S
A
P
T
V
K
S
S
G
W
S
Site 24
S279
E
S
A
P
T
V
K
S
S
G
W
S
R
K
F
Site 25
S280
S
A
P
T
V
K
S
S
G
W
S
R
K
F
H
Site 26
T303
K
N
F
L
F
R
P
T
S
A
N
M
L
Q
H
Site 27
S304
N
F
L
F
R
P
T
S
A
N
M
L
Q
H
P
Site 28
S325
N
E
R
H
V
V
E
S
L
T
R
H
L
T
G
Site 29
T331
E
S
L
T
R
H
L
T
G
I
I
K
K
R
Q
Site 30
Y356
E
E
A
I
K
E
Q
Y
T
V
R
R
F
R
G
Site 31
T357
E
A
I
K
E
Q
Y
T
V
R
R
F
R
G
P
Site 32
S365
V
R
R
F
R
G
P
S
C
T
H
E
L
L
R
Site 33
T367
R
F
R
G
P
S
C
T
H
E
L
L
R
L
P
Site 34
T375
H
E
L
L
R
L
P
T
S
S
R
C
R
P
L
Site 35
S376
E
L
L
R
L
P
T
S
S
R
C
R
P
L
R
Site 36
S377
L
L
R
L
P
T
S
S
R
C
R
P
L
R
V
Site 37
S390
R
V
L
H
G
E
P
S
Q
P
R
W
L
P
D
Site 38
S424
M
P
L
Q
A
L
D
S
A
P
K
P
L
K
G
Site 39
S495
P
R
L
L
Q
V
Q
S
Q
V
S
K
K
Q
Q
Site 40
T505
S
K
K
Q
Q
A
Q
T
Q
T
S
E
P
Q
D
Site 41
S580
T
E
A
E
E
P
E
S
L
R
V
N
A
Q
V
Site 42
S619
V
E
G
Q
T
E
G
S
P
Q
A
Q
A
W
T
Site 43
T626
S
P
Q
A
Q
A
W
T
L
E
P
P
Q
A
I
Site 44
S653
D
L
L
R
A
P
N
S
N
N
S
K
P
L
G
Site 45
S656
R
A
P
N
S
N
N
S
K
P
L
G
P
L
Q
Site 46
T664
K
P
L
G
P
L
Q
T
L
M
E
N
L
S
S
Site 47
S670
Q
T
L
M
E
N
L
S
S
N
R
F
Y
S
Q
Site 48
S671
T
L
M
E
N
L
S
S
N
R
F
Y
S
Q
P
Site 49
Y675
N
L
S
S
N
R
F
Y
S
Q
P
E
Q
A
R
Site 50
S676
L
S
S
N
R
F
Y
S
Q
P
E
Q
A
R
E
Site 51
S686
E
Q
A
R
E
K
K
S
K
V
S
T
L
R
Q
Site 52
T690
E
K
K
S
K
V
S
T
L
R
Q
A
L
A
K
Site 53
S700
Q
A
L
A
K
R
L
S
P
K
R
F
R
A
K
Site 54
S708
P
K
R
F
R
A
K
S
S
W
R
P
E
K
L
Site 55
S709
K
R
F
R
A
K
S
S
W
R
P
E
K
L
E
Site 56
S718
R
P
E
K
L
E
L
S
D
L
E
A
R
R
Q
Site 57
S753
D
K
D
K
E
D
E
S
S
D
N
D
E
V
F
Site 58
S754
K
D
K
E
D
E
S
S
D
N
D
E
V
F
H
Site 59
S777
E
P
L
K
P
Y
I
S
N
P
K
K
I
E
V
Site 60
S788
K
I
E
V
Q
E
R
S
P
S
V
P
N
N
Q
Site 61
S790
E
V
Q
E
R
S
P
S
V
P
N
N
Q
D
H
Site 62
S805
A
H
H
V
K
F
S
S
S
V
P
Q
R
S
L
Site 63
S806
H
H
V
K
F
S
S
S
V
P
Q
R
S
L
L
Site 64
S811
S
S
S
V
P
Q
R
S
L
L
E
Q
A
Q
K
Site 65
S826
P
I
D
I
R
Q
R
S
S
Q
N
R
Q
N
W
Site 66
S827
I
D
I
R
Q
R
S
S
Q
N
R
Q
N
W
L
Site 67
S837
R
Q
N
W
L
A
A
S
E
S
S
S
E
E
E
Site 68
S839
N
W
L
A
A
S
E
S
S
S
E
E
E
S
P
Site 69
S841
L
A
A
S
E
S
S
S
E
E
E
S
P
V
T
Site 70
S845
E
S
S
S
E
E
E
S
P
V
T
G
R
R
S
Site 71
T848
S
E
E
E
S
P
V
T
G
R
R
S
Q
S
S
Site 72
S852
S
P
V
T
G
R
R
S
Q
S
S
P
P
Y
S
Site 73
S854
V
T
G
R
R
S
Q
S
S
P
P
Y
S
T
I
Site 74
S855
T
G
R
R
S
Q
S
S
P
P
Y
S
T
I
D
Site 75
Y858
R
S
Q
S
S
P
P
Y
S
T
I
D
Q
K
L
Site 76
S859
S
Q
S
S
P
P
Y
S
T
I
D
Q
K
L
L
Site 77
Y885
G
K
I
S
P
P
V
Y
L
T
N
E
W
V
G
Site 78
T887
I
S
P
P
V
Y
L
T
N
E
W
V
G
Y
N
Site 79
Y893
L
T
N
E
W
V
G
Y
N
A
L
S
E
I
F
Site 80
T906
I
F
R
N
D
W
L
T
P
A
P
V
I
Q
P
Site 81
Y920
P
P
E
E
D
G
D
Y
V
E
L
Y
D
A
S
Site 82
Y924
D
G
D
Y
V
E
L
Y
D
A
S
A
D
T
D
Site 83
S938
D
G
D
D
D
D
E
S
N
D
T
F
E
D
T
Site 84
T941
D
D
D
E
S
N
D
T
F
E
D
T
Y
D
H
Site 85
Y946
N
D
T
F
E
D
T
Y
D
H
A
N
G
N
D
Site 86
Y984
V
D
D
V
N
N
N
Y
Y
E
A
P
S
C
P
Site 87
Y985
D
D
V
N
N
N
Y
Y
E
A
P
S
C
P
R
Site 88
S989
N
N
Y
Y
E
A
P
S
C
P
R
A
S
Y
G
Site 89
S994
A
P
S
C
P
R
A
S
Y
G
R
D
G
S
C
Site 90
Y995
P
S
C
P
R
A
S
Y
G
R
D
G
S
C
K
Site 91
S1000
A
S
Y
G
R
D
G
S
C
K
Q
D
G
Y
D
Site 92
Y1006
G
S
C
K
Q
D
G
Y
D
G
S
R
G
K
E
Site 93
S1009
K
Q
D
G
Y
D
G
S
R
G
K
E
E
A
Y
Site 94
Y1016
S
R
G
K
E
E
A
Y
R
G
Y
G
S
H
T
Site 95
Y1019
K
E
E
A
Y
R
G
Y
G
S
H
T
A
N
R
Site 96
S1021
E
A
Y
R
G
Y
G
S
H
T
A
N
R
S
H
Site 97
T1023
Y
R
G
Y
G
S
H
T
A
N
R
S
H
G
G
Site 98
S1027
G
S
H
T
A
N
R
S
H
G
G
S
A
A
S
Site 99
S1031
A
N
R
S
H
G
G
S
A
A
S
E
D
N
A
Site 100
S1034
S
H
G
G
S
A
A
S
E
D
N
A
A
I
G
Site 101
S1052
E
H
A
A
N
I
G
S
E
R
R
G
S
E
G
Site 102
S1057
I
G
S
E
R
R
G
S
E
G
D
G
G
K
G
Site 103
T1068
G
G
K
G
V
V
R
T
S
E
E
S
G
A
L
Site 104
S1069
G
K
G
V
V
R
T
S
E
E
S
G
A
L
G
Site 105
S1072
V
V
R
T
S
E
E
S
G
A
L
G
L
N
G
Site 106
S1084
L
N
G
E
E
N
C
S
E
T
D
G
P
G
L
Site 107
T1086
G
E
E
N
C
S
E
T
D
G
P
G
L
K
R
Site 108
S1096
P
G
L
K
R
P
A
S
Q
D
F
E
Y
L
Q
Site 109
Y1101
P
A
S
Q
D
F
E
Y
L
Q
E
E
P
G
G
Site 110
S1113
P
G
G
G
N
E
A
S
N
A
I
D
S
G
A
Site 111
S1118
E
A
S
N
A
I
D
S
G
A
A
P
S
A
P
Site 112
S1123
I
D
S
G
A
A
P
S
A
P
D
H
E
S
D
Site 113
S1129
P
S
A
P
D
H
E
S
D
N
K
D
I
S
E
Site 114
S1135
E
S
D
N
K
D
I
S
E
S
S
T
Q
S
D
Site 115
S1137
D
N
K
D
I
S
E
S
S
T
Q
S
D
F
S
Site 116
S1138
N
K
D
I
S
E
S
S
T
Q
S
D
F
S
A
Site 117
T1139
K
D
I
S
E
S
S
T
Q
S
D
F
S
A
N
Site 118
S1141
I
S
E
S
S
T
Q
S
D
F
S
A
N
H
S
Site 119
S1144
S
S
T
Q
S
D
F
S
A
N
H
S
S
P
S
Site 120
S1148
S
D
F
S
A
N
H
S
S
P
S
K
G
S
G
Site 121
S1149
D
F
S
A
N
H
S
S
P
S
K
G
S
G
M
Site 122
S1151
S
A
N
H
S
S
P
S
K
G
S
G
M
S
A
Site 123
S1178
F
V
E
V
P
E
E
S
P
K
Q
P
S
E
V
Site 124
S1183
E
E
S
P
K
Q
P
S
E
V
N
V
N
P
L
Site 125
Y1191
E
V
N
V
N
P
L
Y
V
S
P
A
C
K
K
Site 126
S1193
N
V
N
P
L
Y
V
S
P
A
C
K
K
P
L
Site 127
Y1204
K
K
P
L
I
H
M
Y
E
K
E
F
T
S
E
Site 128
S1228
N
L
L
L
G
T
R
S
N
L
Y
L
M
D
R
Site 129
Y1231
L
G
T
R
S
N
L
Y
L
M
D
R
S
G
K
Site 130
S1236
N
L
Y
L
M
D
R
S
G
K
A
D
I
T
K
Site 131
T1242
R
S
G
K
A
D
I
T
K
L
I
R
R
R
P
Site 132
T1264
E
P
L
N
L
L
I
T
I
S
G
H
K
N
R
Site 133
S1266
L
N
L
L
I
T
I
S
G
H
K
N
R
L
R
Site 134
Y1275
H
K
N
R
L
R
V
Y
H
L
T
W
L
R
N
Site 135
T1278
R
L
R
V
Y
H
L
T
W
L
R
N
K
I
L
Site 136
S1291
I
L
N
N
D
P
E
S
K
R
R
Q
E
E
M
Site 137
T1301
R
Q
E
E
M
L
K
T
E
E
A
C
K
A
I
Site 138
Y1327
L
Q
H
E
E
T
T
Y
I
A
I
A
L
K
S
Site 139
Y1339
L
K
S
S
I
H
L
Y
A
W
A
P
K
S
F
Site 140
S1345
L
Y
A
W
A
P
K
S
F
D
E
S
T
A
I
Site 141
T1350
P
K
S
F
D
E
S
T
A
I
K
V
C
I
D
Site 142
S1359
I
K
V
C
I
D
Q
S
A
D
S
E
G
D
Y
Site 143
S1362
C
I
D
Q
S
A
D
S
E
G
D
Y
M
S
Y
Site 144
Y1366
S
A
D
S
E
G
D
Y
M
S
Y
Q
A
Y
I
Site 145
Y1369
S
E
G
D
Y
M
S
Y
Q
A
Y
I
R
I
L
Site 146
T1405
L
K
L
K
V
F
P
T
L
D
H
K
P
V
T
Site 147
S1428
K
R
L
K
I
F
F
S
S
A
D
G
Y
H
L
Site 148
Y1433
F
F
S
S
A
D
G
Y
H
L
I
D
A
E
S
Site 149
S1440
Y
H
L
I
D
A
E
S
E
V
M
S
D
V
T
Site 150
S1444
D
A
E
S
E
V
M
S
D
V
T
L
P
K
N
Site 151
T1447
S
E
V
M
S
D
V
T
L
P
K
N
P
L
E
Site 152
S1482
T
F
N
A
E
A
L
S
V
E
A
N
E
Q
L
Site 153
T1509
S
S
I
A
F
E
C
T
Q
R
T
T
G
W
G
Site 154
S1538
E
S
E
L
K
R
R
S
I
K
K
L
R
F
L
Site 155
T1547
K
K
L
R
F
L
C
T
R
G
D
K
L
F
F
Site 156
T1555
R
G
D
K
L
F
F
T
S
T
L
R
N
H
H
Site 157
S1556
G
D
K
L
F
F
T
S
T
L
R
N
H
H
S
Site 158
T1557
D
K
L
F
F
T
S
T
L
R
N
H
H
S
R
Site 159
Y1566
R
N
H
H
S
R
V
Y
F
M
T
L
G
K
L
Site 160
T1569
H
S
R
V
Y
F
M
T
L
G
K
L
E
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation