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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRPM8
Full Name:
Transient receptor potential cation channel subfamily M member 8
Alias:
Long transient receptor potential channel 6;Transient receptor potential p8
Type:
Mass (Da):
127685
Number AA:
1104
UniProt ID:
Q7Z2W7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
F
R
A
A
R
L
S
M
R
N
R
R
N
D
Site 2
T17
M
R
N
R
R
N
D
T
L
D
S
T
R
T
L
Site 3
S20
R
R
N
D
T
L
D
S
T
R
T
L
Y
S
S
Site 4
T21
R
N
D
T
L
D
S
T
R
T
L
Y
S
S
A
Site 5
T23
D
T
L
D
S
T
R
T
L
Y
S
S
A
S
R
Site 6
Y25
L
D
S
T
R
T
L
Y
S
S
A
S
R
S
T
Site 7
S26
D
S
T
R
T
L
Y
S
S
A
S
R
S
T
D
Site 8
S27
S
T
R
T
L
Y
S
S
A
S
R
S
T
D
L
Site 9
S29
R
T
L
Y
S
S
A
S
R
S
T
D
L
S
Y
Site 10
S31
L
Y
S
S
A
S
R
S
T
D
L
S
Y
S
E
Site 11
T32
Y
S
S
A
S
R
S
T
D
L
S
Y
S
E
S
Site 12
S35
A
S
R
S
T
D
L
S
Y
S
E
S
D
L
V
Site 13
Y36
S
R
S
T
D
L
S
Y
S
E
S
D
L
V
N
Site 14
S37
R
S
T
D
L
S
Y
S
E
S
D
L
V
N
F
Site 15
S39
T
D
L
S
Y
S
E
S
D
L
V
N
F
I
Q
Site 16
Y91
N
Q
S
E
K
W
N
Y
K
K
H
T
K
E
F
Site 17
T110
F
G
D
I
Q
F
E
T
L
G
K
K
G
K
Y
Site 18
Y117
T
L
G
K
K
G
K
Y
I
R
L
S
C
D
T
Site 19
S121
K
G
K
Y
I
R
L
S
C
D
T
D
A
E
I
Site 20
T124
Y
I
R
L
S
C
D
T
D
A
E
I
L
Y
E
Site 21
Y130
D
T
D
A
E
I
L
Y
E
L
L
T
Q
H
W
Site 22
T141
T
Q
H
W
H
L
K
T
P
N
L
V
I
S
V
Site 23
S147
K
T
P
N
L
V
I
S
V
T
G
G
A
K
N
Site 24
Y191
T
H
Y
G
L
M
K
Y
I
G
E
V
V
R
D
Site 25
T200
G
E
V
V
R
D
N
T
I
S
R
S
S
E
E
Site 26
S202
V
V
R
D
N
T
I
S
R
S
S
E
E
N
I
Site 27
S204
R
D
N
T
I
S
R
S
S
E
E
N
I
V
A
Site 28
S205
D
N
T
I
S
R
S
S
E
E
N
I
V
A
I
Site 29
T225
G
M
V
S
N
R
D
T
L
I
R
N
C
D
A
Site 30
Y235
R
N
C
D
A
E
G
Y
F
L
A
Q
Y
L
M
Site 31
Y240
E
G
Y
F
L
A
Q
Y
L
M
D
D
F
T
R
Site 32
T246
Q
Y
L
M
D
D
F
T
R
D
P
L
Y
I
L
Site 33
Y251
D
F
T
R
D
P
L
Y
I
L
D
N
N
H
T
Site 34
T272
N
G
C
H
G
H
P
T
V
E
A
K
L
R
N
Site 35
Y284
L
R
N
Q
L
E
K
Y
I
S
E
R
T
I
Q
Site 36
S286
N
Q
L
E
K
Y
I
S
E
R
T
I
Q
D
S
Site 37
T289
E
K
Y
I
S
E
R
T
I
Q
D
S
N
Y
G
Site 38
S293
S
E
R
T
I
Q
D
S
N
Y
G
G
K
I
P
Site 39
Y295
R
T
I
Q
D
S
N
Y
G
G
K
I
P
I
V
Site 40
T350
V
E
V
E
D
A
L
T
S
S
A
V
K
E
K
Site 41
T365
L
V
R
F
L
P
R
T
V
S
R
L
P
E
E
Site 42
S367
R
F
L
P
R
T
V
S
R
L
P
E
E
E
T
Site 43
T374
S
R
L
P
E
E
E
T
E
S
W
I
K
W
L
Site 44
S376
L
P
E
E
E
T
E
S
W
I
K
W
L
K
E
Site 45
Y413
N
A
I
S
Y
A
L
Y
K
A
F
S
T
S
E
Site 46
S417
Y
A
L
Y
K
A
F
S
T
S
E
Q
D
K
D
Site 47
S455
T
N
D
R
R
W
E
S
A
D
L
Q
E
V
M
Site 48
T464
D
L
Q
E
V
M
F
T
A
L
I
K
D
R
P
Site 49
S502
E
L
F
S
N
H
F
S
T
L
V
Y
R
N
L
Site 50
T503
L
F
S
N
H
F
S
T
L
V
Y
R
N
L
Q
Site 51
Y506
N
H
F
S
T
L
V
Y
R
N
L
Q
I
A
K
Site 52
S554
D
I
E
L
H
D
V
S
P
I
T
R
H
P
L
Site 53
T557
L
H
D
V
S
P
I
T
R
H
P
L
Q
A
L
Site 54
T588
W
E
Q
T
R
G
C
T
L
A
A
L
G
A
S
Site 55
T600
G
A
S
K
L
L
K
T
L
A
K
V
K
N
D
Site 56
T630
T
R
A
V
E
L
F
T
E
C
Y
S
S
D
E
Site 57
Y633
V
E
L
F
T
E
C
Y
S
S
D
E
D
L
A
Site 58
S635
L
F
T
E
C
Y
S
S
D
E
D
L
A
E
Q
Site 59
Y683
N
F
L
S
K
Q
W
Y
G
E
I
S
R
D
T
Site 60
T690
Y
G
E
I
S
R
D
T
K
N
W
K
I
I
L
Site 61
Y726
K
H
K
K
L
L
W
Y
Y
V
A
F
F
T
S
Site 62
S819
G
I
V
F
R
L
H
S
S
N
K
S
S
L
Y
Site 63
S820
I
V
F
R
L
H
S
S
N
K
S
S
L
Y
S
Site 64
S823
R
L
H
S
S
N
K
S
S
L
Y
S
G
R
V
Site 65
S824
L
H
S
S
N
K
S
S
L
Y
S
G
R
V
I
Site 66
Y826
S
S
N
K
S
S
L
Y
S
G
R
V
I
F
C
Site 67
S917
A
M
F
G
Q
V
P
S
D
V
D
G
T
T
Y
Site 68
T922
V
P
S
D
V
D
G
T
T
Y
D
F
A
H
C
Site 69
Y924
S
D
V
D
G
T
T
Y
D
F
A
H
C
T
F
Site 70
Y1005
R
Y
F
L
V
Q
E
Y
C
S
R
L
N
I
P
Site 71
Y1020
F
P
F
I
V
F
A
Y
F
Y
M
V
V
K
K
Site 72
Y1063
E
G
V
M
K
E
N
Y
L
V
K
I
N
T
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation