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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LPPR4
Full Name:
Lipid phosphate phosphatase-related protein type 4
Alias:
KIAA0455
Type:
Cell development/differentiation; Phosphatase, lipid; EC 3.1.3.4
Mass (Da):
88410
Number AA:
814
UniProt ID:
Q7Z2D5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008195
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
Q
R
A
G
S
S
G
G
R
G
E
C
Site 2
S16
G
R
G
E
C
D
I
S
G
A
G
R
L
G
L
Site 3
S30
L
E
E
A
A
R
L
S
C
A
V
H
T
S
P
Site 4
S36
L
S
C
A
V
H
T
S
P
G
G
G
R
R
P
Site 5
S50
P
G
Q
A
A
G
M
S
A
K
E
R
P
K
G
Site 6
Y104
V
H
S
G
F
S
C
Y
D
R
S
L
S
M
P
Site 7
S107
G
F
S
C
Y
D
R
S
L
S
M
P
Y
I
E
Site 8
S109
S
C
Y
D
R
S
L
S
M
P
Y
I
E
P
T
Site 9
Y112
D
R
S
L
S
M
P
Y
I
E
P
T
Q
E
A
Site 10
T116
S
M
P
Y
I
E
P
T
Q
E
A
I
P
F
L
Site 11
S170
A
G
G
C
N
F
N
S
F
L
R
R
A
V
R
Site 12
Y206
S
T
G
Y
Q
A
P
Y
F
L
T
V
C
K
P
Site 13
T209
Y
Q
A
P
Y
F
L
T
V
C
K
P
N
Y
T
Site 14
S217
V
C
K
P
N
Y
T
S
L
N
V
S
C
K
E
Site 15
S226
N
V
S
C
K
E
N
S
Y
I
V
E
D
I
C
Site 16
T239
I
C
S
G
S
D
L
T
V
I
N
S
G
R
K
Site 17
S243
S
D
L
T
V
I
N
S
G
R
K
S
F
P
S
Site 18
S247
V
I
N
S
G
R
K
S
F
P
S
Q
H
A
T
Site 19
S250
S
G
R
K
S
F
P
S
Q
H
A
T
L
A
A
Site 20
S269
Y
V
S
M
Y
F
N
S
T
L
T
D
S
S
K
Site 21
T270
V
S
M
Y
F
N
S
T
L
T
D
S
S
K
L
Site 22
T272
M
Y
F
N
S
T
L
T
D
S
S
K
L
L
K
Site 23
S274
F
N
S
T
L
T
D
S
S
K
L
L
K
P
L
Site 24
S275
N
S
T
L
T
D
S
S
K
L
L
K
P
L
L
Site 25
T299
I
C
G
L
T
R
I
T
Q
Y
K
N
H
P
V
Site 26
S333
A
V
G
N
F
L
P
S
D
E
S
M
F
Q
H
Site 27
S336
N
F
L
P
S
D
E
S
M
F
Q
H
R
D
A
Site 28
S346
Q
H
R
D
A
L
R
S
L
T
D
L
N
Q
D
Site 29
T348
R
D
A
L
R
S
L
T
D
L
N
Q
D
P
N
Site 30
S359
Q
D
P
N
R
L
L
S
A
K
N
G
S
S
S
Site 31
S366
S
A
K
N
G
S
S
S
D
G
I
A
H
T
E
Site 32
S384
N
R
N
H
R
D
A
S
S
L
T
N
L
K
R
Site 33
S385
R
N
H
R
D
A
S
S
L
T
N
L
K
R
A
Site 34
T400
N
A
D
V
E
I
I
T
P
R
S
P
M
G
K
Site 35
S403
V
E
I
I
T
P
R
S
P
M
G
K
E
N
M
Site 36
T412
M
G
K
E
N
M
V
T
F
S
N
T
L
P
R
Site 37
S414
K
E
N
M
V
T
F
S
N
T
L
P
R
A
N
Site 38
T416
N
M
V
T
F
S
N
T
L
P
R
A
N
T
P
Site 39
T422
N
T
L
P
R
A
N
T
P
S
V
E
D
P
V
Site 40
S424
L
P
R
A
N
T
P
S
V
E
D
P
V
R
R
Site 41
S434
D
P
V
R
R
N
A
S
I
H
A
S
M
D
S
Site 42
S438
R
N
A
S
I
H
A
S
M
D
S
A
R
S
K
Site 43
S441
S
I
H
A
S
M
D
S
A
R
S
K
Q
L
L
Site 44
S457
Q
W
K
N
K
N
E
S
R
K
L
S
L
Q
V
Site 45
S461
K
N
E
S
R
K
L
S
L
Q
V
I
E
P
E
Site 46
S472
I
E
P
E
P
G
Q
S
P
P
R
S
I
E
M
Site 47
S476
P
G
Q
S
P
P
R
S
I
E
M
R
S
S
S
Site 48
S481
P
R
S
I
E
M
R
S
S
S
E
P
S
R
V
Site 49
S482
R
S
I
E
M
R
S
S
S
E
P
S
R
V
G
Site 50
S483
S
I
E
M
R
S
S
S
E
P
S
R
V
G
V
Site 51
S486
M
R
S
S
S
E
P
S
R
V
G
V
N
G
D
Site 52
Y501
H
H
G
P
G
N
Q
Y
L
K
I
Q
P
G
A
Site 53
S515
A
V
P
G
C
N
N
S
M
P
G
G
P
R
V
Site 54
S523
M
P
G
G
P
R
V
S
I
Q
S
R
P
G
S
Site 55
S526
G
P
R
V
S
I
Q
S
R
P
G
S
S
Q
L
Site 56
S530
S
I
Q
S
R
P
G
S
S
Q
L
V
H
I
P
Site 57
T540
L
V
H
I
P
E
E
T
Q
E
N
I
S
T
S
Site 58
S545
E
E
T
Q
E
N
I
S
T
S
P
K
S
S
S
Site 59
T546
E
T
Q
E
N
I
S
T
S
P
K
S
S
S
A
Site 60
S547
T
Q
E
N
I
S
T
S
P
K
S
S
S
A
R
Site 61
S550
N
I
S
T
S
P
K
S
S
S
A
R
A
K
W
Site 62
S551
I
S
T
S
P
K
S
S
S
A
R
A
K
W
L
Site 63
S552
S
T
S
P
K
S
S
S
A
R
A
K
W
L
K
Site 64
T564
W
L
K
A
A
E
K
T
V
A
C
N
R
S
N
Site 65
S572
V
A
C
N
R
S
N
S
Q
P
R
I
M
Q
V
Site 66
S591
K
Q
Q
G
V
L
Q
S
S
P
K
N
T
E
G
Site 67
S592
Q
Q
G
V
L
Q
S
S
P
K
N
T
E
G
S
Site 68
T596
L
Q
S
S
P
K
N
T
E
G
S
T
V
S
C
Site 69
S599
S
P
K
N
T
E
G
S
T
V
S
C
T
G
S
Site 70
T600
P
K
N
T
E
G
S
T
V
S
C
T
G
S
I
Site 71
S602
N
T
E
G
S
T
V
S
C
T
G
S
I
R
Y
Site 72
S606
S
T
V
S
C
T
G
S
I
R
Y
K
T
L
T
Site 73
T611
T
G
S
I
R
Y
K
T
L
T
D
H
E
P
S
Site 74
T613
S
I
R
Y
K
T
L
T
D
H
E
P
S
G
I
Site 75
S638
R
P
I
I
Q
I
P
S
T
E
G
E
G
S
G
Site 76
T639
P
I
I
Q
I
P
S
T
E
G
E
G
S
G
S
Site 77
S644
P
S
T
E
G
E
G
S
G
S
W
K
W
K
A
Site 78
S646
T
E
G
E
G
S
G
S
W
K
W
K
A
P
E
Site 79
S656
W
K
A
P
E
K
G
S
L
R
Q
T
Y
E
L
Site 80
T660
E
K
G
S
L
R
Q
T
Y
E
L
N
D
L
N
Site 81
Y661
K
G
S
L
R
Q
T
Y
E
L
N
D
L
N
R
Site 82
S670
L
N
D
L
N
R
D
S
E
S
C
E
S
L
K
Site 83
S672
D
L
N
R
D
S
E
S
C
E
S
L
K
D
S
Site 84
S675
R
D
S
E
S
C
E
S
L
K
D
S
F
G
S
Site 85
S679
S
C
E
S
L
K
D
S
F
G
S
G
D
R
K
Site 86
S682
S
L
K
D
S
F
G
S
G
D
R
K
R
S
N
Site 87
S688
G
S
G
D
R
K
R
S
N
I
D
S
N
E
H
Site 88
S692
R
K
R
S
N
I
D
S
N
E
H
H
H
H
G
Site 89
T702
H
H
H
H
G
I
T
T
I
R
V
T
P
V
E
Site 90
S715
V
E
G
S
E
I
G
S
E
T
L
S
I
S
S
Site 91
T717
G
S
E
I
G
S
E
T
L
S
I
S
S
S
R
Site 92
S719
E
I
G
S
E
T
L
S
I
S
S
S
R
D
S
Site 93
S721
G
S
E
T
L
S
I
S
S
S
R
D
S
T
L
Site 94
S722
S
E
T
L
S
I
S
S
S
R
D
S
T
L
R
Site 95
S723
E
T
L
S
I
S
S
S
R
D
S
T
L
R
R
Site 96
S726
S
I
S
S
S
R
D
S
T
L
R
R
K
G
N
Site 97
T727
I
S
S
S
R
D
S
T
L
R
R
K
G
N
I
Site 98
S741
I
I
L
I
P
E
R
S
N
S
P
E
N
T
R
Site 99
S743
L
I
P
E
R
S
N
S
P
E
N
T
R
N
I
Site 100
T747
R
S
N
S
P
E
N
T
R
N
I
F
Y
K
G
Site 101
Y752
E
N
T
R
N
I
F
Y
K
G
T
S
P
T
R
Site 102
S756
N
I
F
Y
K
G
T
S
P
T
R
A
Y
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation