PhosphoNET

           
Protein Info 
   
Short Name:  RASGRP2
Full Name:  RAS guanyl-releasing protein 2
Alias:  Calcium and DAG-regulated guanine nucleotide exchange factor I; CALDAG-GEFI; CDC25L; GRP2; Guanine exchange factor MCG7; RAS guanyl nucleotide-releasing protein 2; RAS guanyl releasing protein 2; RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Type:  Intracellular, Plasma membrane, Cytoplasm, Cytosol, Synapse, Synaptosome, Cell projection, Cell junction protein
Mass (Da):  69248
Number AA:  609
UniProt ID:  Q7LDG7
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0030054  GO:0042995  GO:0005829 Uniprot OncoNet
Molecular Function:  GO:0005509  GO:0019992  GO:0005085 PhosphoSite+ KinaseNET
Biological Process:  GO:0007265  GO:0001558  GO:0051056 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T12LDLDKGCTVEELLRG
Site 2S50HPWYIPSSQLAAKLL
Site 3Y60AAKLLHIYQQSRKDN
Site 4S70SRKDNSNSLQVKTCH
Site 5S116QEGNRRHSSLIDIDS
Site 6S117EGNRRHSSLIDIDSV
Site 7S123SSLIDIDSVPTYKWK
Site 8Y127DIDSVPTYKWKRQVT
Site 9T134YKWKRQVTQRNPVGQ
Site 10S147GQKKRKMSLLFDHLE
Site 11Y164ELAEHLTYLEYRSFC
Site 12Y167EHLTYLEYRSFCKIL
Site 13Y178CKILFQDYHSFVTHG
Site 14S213WVQLMILSKPTAPQR
Site 15S253VVGGLSHSSISRLKE
Site 16S254VGGLSHSSISRLKET
Site 17S256GLSHSSISRLKETHS
Site 18T261SISRLKETHSHVSPE
Site 19S263SRLKETHSHVSPETI
Site 20S266KETHSHVSPETIKLW
Site 21T281EGLTELVTATGNYGN
Site 22Y289ATGNYGNYRRRLAAC
Site 23Y371LTVSLDQYQTEDELY
Site 24Y378YQTEDELYQLSLQRE
Site 25S381EDELYQLSLQREPRS
Site 26S388SLQREPRSKSSPTSP
Site 27S390QREPRSKSSPTSPTS
Site 28S391REPRSKSSPTSPTSC
Site 29T393PRSKSSPTSPTSCTP
Site 30S394RSKSSPTSPTSCTPP
Site 31T396KSSPTSPTSCTPPPR
Site 32S397SSPTSPTSCTPPPRP
Site 33T399PTSPTSCTPPPRPPV
Site 34S412PVLEEWTSAAKPKLD
Site 35S447VDGDGHISQEEFQII
Site 36S462RGNFPYLSAFGDLDQ
Site 37S482ISREEMVSYFLRSSS
Site 38Y483SREEMVSYFLRSSSV
Site 39S489SYFLRSSSVLGGRMG
Site 40S506HNFQESNSLRPVACR
Site 41S545KQCKDRLSVECRRRA
Site 42S554ECRRRAQSVSLEGSA
Site 43S556RRRAQSVSLEGSAPS
Site 44S560QSVSLEGSAPSPSPM
Site 45S563SLEGSAPSPSPMHSH
Site 46S565EGSAPSPSPMHSHHH
Site 47S569PSPSPMHSHHHRAFS
Site 48S576SHHHRAFSFSLPRPG
Site 49S578HHRAFSFSLPRPGRR
Site 50S587PRPGRRGSRPPEIRE
Site 51T599IREEEVQTVEDGVFD
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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