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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARC
Full Name:
Activity-regulated cytoskeleton-associated protein
Alias:
ARC/ARG3.1;Activity-regulated gene 3.1 protein homolog
Type:
Mass (Da):
45316
Number AA:
396
UniProt ID:
Q7LC44
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
L
D
H
R
T
S
G
G
L
H
A
Y
P
Site 2
Y14
T
S
G
G
L
H
A
Y
P
G
P
R
G
G
Q
Site 3
T45
M
L
E
H
V
R
R
T
H
R
H
L
L
A
E
Site 4
S54
R
H
L
L
A
E
V
S
K
Q
V
E
R
E
L
Site 5
S67
E
L
K
G
L
H
R
S
V
G
K
L
E
S
N
Site 6
S73
R
S
V
G
K
L
E
S
N
L
D
G
Y
V
P
Site 7
Y78
L
E
S
N
L
D
G
Y
V
P
T
S
D
S
Q
Site 8
S82
L
D
G
Y
V
P
T
S
D
S
Q
R
W
K
K
Site 9
S84
G
Y
V
P
T
S
D
S
Q
R
W
K
K
S
I
Site 10
S132
R
W
A
D
R
L
E
S
T
G
G
K
Y
P
V
Site 11
Y137
L
E
S
T
G
G
K
Y
P
V
G
S
E
S
A
Site 12
S141
G
G
K
Y
P
V
G
S
E
S
A
R
H
T
V
Site 13
S143
K
Y
P
V
G
S
E
S
A
R
H
T
V
S
V
Site 14
T147
G
S
E
S
A
R
H
T
V
S
V
G
V
G
G
Site 15
S149
E
S
A
R
H
T
V
S
V
G
V
G
G
P
E
Site 16
S157
V
G
V
G
G
P
E
S
Y
C
H
E
A
D
G
Site 17
Y165
Y
C
H
E
A
D
G
Y
D
Y
T
V
S
P
Y
Site 18
Y167
H
E
A
D
G
Y
D
Y
T
V
S
P
Y
A
I
Site 19
T168
E
A
D
G
Y
D
Y
T
V
S
P
Y
A
I
T
Site 20
S170
D
G
Y
D
Y
T
V
S
P
Y
A
I
T
P
P
Site 21
T175
T
V
S
P
Y
A
I
T
P
P
P
A
A
G
E
Site 22
Y194
E
P
A
E
A
Q
Q
Y
Q
P
W
V
P
G
E
Site 23
S206
P
G
E
D
G
Q
P
S
P
G
V
D
T
Q
I
Site 24
S222
E
D
P
R
E
F
L
S
H
L
E
E
Y
L
R
Site 25
Y227
F
L
S
H
L
E
E
Y
L
R
Q
V
G
G
S
Site 26
S234
Y
L
R
Q
V
G
G
S
E
E
Y
W
L
S
Q
Site 27
Y274
F
K
K
E
F
L
Q
Y
S
E
G
T
L
S
R
Site 28
S275
K
K
E
F
L
Q
Y
S
E
G
T
L
S
R
E
Site 29
S280
Q
Y
S
E
G
T
L
S
R
E
A
I
Q
R
E
Site 30
Y309
L
W
R
K
R
D
L
Y
Q
T
L
Y
V
D
A
Site 31
T311
R
K
R
D
L
Y
Q
T
L
Y
V
D
A
D
E
Site 32
Y313
R
D
L
Y
Q
T
L
Y
V
D
A
D
E
E
E
Site 33
Y324
D
E
E
E
I
I
Q
Y
V
V
G
T
L
Q
P
Site 34
T344
L
R
H
P
L
P
K
T
L
E
Q
L
I
Q
R
Site 35
T378
P
V
E
D
E
A
E
T
L
T
P
A
P
N
S
Site 36
T380
E
D
E
A
E
T
L
T
P
A
P
N
S
E
S
Site 37
S385
T
L
T
P
A
P
N
S
E
S
V
A
S
D
R
Site 38
S387
T
P
A
P
N
S
E
S
V
A
S
D
R
T
Q
Site 39
S390
P
N
S
E
S
V
A
S
D
R
T
Q
P
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation