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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCM10
Full Name:
Protein MCM10 homolog
Alias:
CNA43; HsMCM10; MCM10 minichromosome maintenance deficient 10
Type:
DNA replication
Mass (Da):
98183
Number AA:
875
UniProt ID:
Q7L590
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
D
E
E
E
D
N
L
S
L
L
T
A
L
L
E
Site 2
S20
A
L
L
E
E
N
E
S
A
L
D
C
N
S
E
Site 3
S26
E
S
A
L
D
C
N
S
E
E
N
N
F
L
T
Site 4
S54
D
A
D
G
D
G
E
S
Y
T
E
E
A
D
D
Site 5
T67
D
D
G
E
T
G
E
T
R
D
E
K
E
N
L
Site 6
T76
D
E
K
E
N
L
A
T
L
F
G
D
M
E
D
Site 7
T85
F
G
D
M
E
D
L
T
D
E
E
E
V
P
A
Site 8
S93
D
E
E
E
V
P
A
S
Q
S
T
E
N
R
V
Site 9
T111
P
A
P
R
R
E
K
T
N
E
E
L
Q
E
E
Site 10
S143
T
T
I
K
Q
T
A
S
P
A
R
L
Q
K
S
Site 11
S150
S
P
A
R
L
Q
K
S
P
V
E
K
S
P
R
Site 12
S155
Q
K
S
P
V
E
K
S
P
R
P
P
L
K
E
Site 13
S171
R
V
Q
R
I
Q
E
S
T
C
F
S
A
E
L
Site 14
T172
V
Q
R
I
Q
E
S
T
C
F
S
A
E
L
D
Site 15
T186
D
V
P
A
L
P
R
T
K
R
V
A
R
T
P
Site 16
T192
R
T
K
R
V
A
R
T
P
K
A
S
P
P
D
Site 17
S196
V
A
R
T
P
K
A
S
P
P
D
P
K
S
S
Site 18
S202
A
S
P
P
D
P
K
S
S
S
S
R
M
T
S
Site 19
S203
S
P
P
D
P
K
S
S
S
S
R
M
T
S
A
Site 20
S204
P
P
D
P
K
S
S
S
S
R
M
T
S
A
P
Site 21
S205
P
D
P
K
S
S
S
S
R
M
T
S
A
P
S
Site 22
T208
K
S
S
S
S
R
M
T
S
A
P
S
Q
P
L
Site 23
S209
S
S
S
S
R
M
T
S
A
P
S
Q
P
L
Q
Site 24
S212
S
R
M
T
S
A
P
S
Q
P
L
Q
T
I
S
Site 25
T217
A
P
S
Q
P
L
Q
T
I
S
R
N
K
P
S
Site 26
S219
S
Q
P
L
Q
T
I
S
R
N
K
P
S
G
I
Site 27
T234
T
R
G
Q
I
V
G
T
P
G
S
S
G
E
T
Site 28
S237
Q
I
V
G
T
P
G
S
S
G
E
T
T
Q
P
Site 29
T242
P
G
S
S
G
E
T
T
Q
P
I
C
V
E
A
Site 30
S261
R
L
R
R
P
R
V
S
S
T
E
M
N
K
K
Site 31
S262
L
R
R
P
R
V
S
S
T
E
M
N
K
K
M
Site 32
S278
G
R
K
L
I
R
L
S
Q
I
K
E
K
M
A
Site 33
T305
G
V
I
L
K
K
V
T
P
Q
S
V
N
S
G
Site 34
S308
L
K
K
V
T
P
Q
S
V
N
S
G
K
T
F
Site 35
T314
Q
S
V
N
S
G
K
T
F
S
I
W
K
L
N
Site 36
S316
V
N
S
G
K
T
F
S
I
W
K
L
N
D
L
Site 37
S365
P
M
K
P
K
D
G
S
E
E
V
C
L
S
I
Site 38
S371
G
S
E
E
V
C
L
S
I
D
H
P
Q
K
V
Site 39
T401
K
K
N
G
E
P
C
T
Q
T
V
N
L
R
D
Site 40
T403
N
G
E
P
C
T
Q
T
V
N
L
R
D
C
E
Site 41
Y411
V
N
L
R
D
C
E
Y
C
Q
Y
H
V
Q
A
Site 42
S432
A
K
R
A
D
L
Q
S
T
F
S
G
G
R
I
Site 43
T433
K
R
A
D
L
Q
S
T
F
S
G
G
R
I
P
Site 44
S435
A
D
L
Q
S
T
F
S
G
G
R
I
P
K
K
Site 45
T448
K
K
F
A
R
R
G
T
S
L
K
E
R
L
C
Site 46
S449
K
F
A
R
R
G
T
S
L
K
E
R
L
C
Q
Site 47
Y460
R
L
C
Q
D
G
F
Y
Y
G
G
V
S
S
A
Site 48
Y461
L
C
Q
D
G
F
Y
Y
G
G
V
S
S
A
S
Site 49
S472
S
S
A
S
Y
A
A
S
I
A
A
A
V
A
P
Site 50
S512
K
L
G
I
P
Q
K
S
L
S
C
S
E
E
F
Site 51
S514
G
I
P
Q
K
S
L
S
C
S
E
E
F
K
E
Site 52
S516
P
Q
K
S
L
S
C
S
E
E
F
K
E
L
M
Site 53
T527
K
E
L
M
D
L
P
T
C
G
A
R
N
L
K
Site 54
S543
H
L
A
K
A
T
A
S
G
I
M
G
S
P
K
Site 55
S548
T
A
S
G
I
M
G
S
P
K
P
A
I
K
S
Site 56
S557
K
P
A
I
K
S
I
S
A
S
A
L
L
K
Q
Site 57
S559
A
I
K
S
I
S
A
S
A
L
L
K
Q
Q
K
Site 58
S577
L
E
M
R
R
R
K
S
E
E
I
Q
K
R
F
Site 59
S588
Q
K
R
F
L
Q
S
S
S
E
V
E
S
P
A
Site 60
S589
K
R
F
L
Q
S
S
S
E
V
E
S
P
A
V
Site 61
S593
Q
S
S
S
E
V
E
S
P
A
V
P
S
S
S
Site 62
S598
V
E
S
P
A
V
P
S
S
S
R
Q
P
P
A
Site 63
S599
E
S
P
A
V
P
S
S
S
R
Q
P
P
A
Q
Site 64
S600
S
P
A
V
P
S
S
S
R
Q
P
P
A
Q
P
Site 65
T610
P
P
A
Q
P
P
R
T
G
S
E
F
P
R
L
Site 66
S612
A
Q
P
P
R
T
G
S
E
F
P
R
L
E
G
Site 67
T623
R
L
E
G
A
P
A
T
M
T
P
K
L
G
R
Site 68
T625
E
G
A
P
A
T
M
T
P
K
L
G
R
G
V
Site 69
Y641
E
G
D
D
V
L
F
Y
D
E
S
P
P
P
R
Site 70
S644
D
V
L
F
Y
D
E
S
P
P
P
R
P
K
L
Site 71
S652
P
P
P
R
P
K
L
S
A
L
A
E
A
K
K
Site 72
T664
A
K
K
L
A
A
I
T
K
L
R
A
K
G
Q
Site 73
T676
K
G
Q
V
L
T
K
T
N
P
N
S
I
K
K
Site 74
S680
L
T
K
T
N
P
N
S
I
K
K
K
Q
K
D
Site 75
T702
K
E
R
V
E
K
N
T
M
F
S
S
Q
A
E
Site 76
S706
E
K
N
T
M
F
S
S
Q
A
E
D
E
L
E
Site 77
Y725
K
R
R
E
Q
L
A
Y
L
E
S
E
E
F
Q
Site 78
S739
Q
K
I
L
K
A
K
S
K
H
T
G
I
L
K
Site 79
Y756
E
A
E
M
Q
E
R
Y
F
E
P
L
V
K
K
Site 80
S824
P
C
G
N
R
S
I
S
L
D
R
L
P
N
K
Site 81
T851
D
G
M
L
K
E
K
T
G
P
K
I
G
G
E
Site 82
T859
G
P
K
I
G
G
E
T
L
L
P
R
G
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation