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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYFIP1
Full Name:
Cytoplasmic FMR1-interacting protein 1
Alias:
CYFP1; Cytoplasmic FMR1 interacting protein 1; Cytoplasmic FMRP interacting protein 1; KIAA0068; P140SRA-1; Selective hybridizing clone; SHYC; Specifically Rac1-associated protein 1; Sra-1
Type:
Unknown function
Mass (Da):
145182
Number AA:
1253
UniProt ID:
Q7L576
International Prot ID:
IPI00644231
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
GO:0001726
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000902
GO:0007275
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
P
C
I
E
P
P
P
S
S
L
L
Y
Q
P
N
Site 2
S35
C
I
E
P
P
P
S
S
L
L
Y
Q
P
N
F
Site 3
Y38
P
P
P
S
S
L
L
Y
Q
P
N
F
N
T
N
Site 4
T54
E
D
R
N
A
F
V
T
G
I
A
R
Y
I
E
Site 5
T64
A
R
Y
I
E
Q
A
T
V
H
S
S
M
N
E
Site 6
S68
E
Q
A
T
V
H
S
S
M
N
E
M
L
E
E
Site 7
Y79
M
L
E
E
G
Q
E
Y
A
V
M
L
Y
T
W
Site 8
Y84
Q
E
Y
A
V
M
L
Y
T
W
R
S
C
S
R
Site 9
S90
L
Y
T
W
R
S
C
S
R
A
I
P
Q
V
K
Site 10
Y108
Q
P
N
R
V
E
I
Y
E
K
T
V
E
V
L
Site 11
T111
R
V
E
I
Y
E
K
T
V
E
V
L
E
P
E
Site 12
Y127
T
K
L
M
N
F
M
Y
F
Q
R
N
A
I
E
Site 13
S154
E
R
R
K
D
F
V
S
E
A
Y
L
I
T
L
Site 14
Y188
V
K
N
D
H
S
A
Y
K
R
A
A
Q
F
L
Site 15
S203
R
K
M
A
D
P
Q
S
I
Q
E
S
Q
N
L
Site 16
S207
D
P
Q
S
I
Q
E
S
Q
N
L
S
M
F
L
Site 17
Y249
V
N
L
C
V
D
Y
Y
E
N
R
M
Y
L
T
Site 18
Y254
D
Y
Y
E
N
R
M
Y
L
T
P
S
E
K
H
Site 19
T256
Y
E
N
R
M
Y
L
T
P
S
E
K
H
M
L
Site 20
Y282
D
G
S
V
S
N
I
Y
K
L
D
A
K
K
R
Site 21
S293
A
K
K
R
I
N
L
S
K
I
D
K
Y
F
K
Site 22
Y298
N
L
S
K
I
D
K
Y
F
K
Q
L
Q
V
V
Site 23
Y318
M
Q
I
E
L
A
R
Y
I
K
T
S
A
H
Y
Site 24
S322
L
A
R
Y
I
K
T
S
A
H
Y
E
E
N
K
Site 25
T333
E
E
N
K
S
R
W
T
C
T
S
S
G
S
S
Site 26
T335
N
K
S
R
W
T
C
T
S
S
G
S
S
P
Q
Site 27
S336
K
S
R
W
T
C
T
S
S
G
S
S
P
Q
Y
Site 28
S337
S
R
W
T
C
T
S
S
G
S
S
P
Q
Y
N
Site 29
S340
T
C
T
S
S
G
S
S
P
Q
Y
N
I
C
E
Site 30
Y343
S
S
G
S
S
P
Q
Y
N
I
C
E
Q
M
I
Site 31
S361
E
D
H
M
R
F
I
S
E
L
A
R
Y
S
N
Site 32
Y366
F
I
S
E
L
A
R
Y
S
N
S
E
V
V
T
Site 33
S367
I
S
E
L
A
R
Y
S
N
S
E
V
V
T
G
Site 34
S369
E
L
A
R
Y
S
N
S
E
V
V
T
G
S
G
Site 35
T373
Y
S
N
S
E
V
V
T
G
S
G
R
Q
E
A
Site 36
S375
N
S
E
V
V
T
G
S
G
R
Q
E
A
Q
K
Site 37
T383
G
R
Q
E
A
Q
K
T
D
A
E
Y
R
K
L
Site 38
Y387
A
Q
K
T
D
A
E
Y
R
K
L
F
D
L
A
Site 39
Y412
S
A
H
V
M
E
V
Y
S
W
K
L
V
H
P
Site 40
T420
S
W
K
L
V
H
P
T
D
K
Y
S
N
K
D
Site 41
Y423
L
V
H
P
T
D
K
Y
S
N
K
D
C
P
D
Site 42
S424
V
H
P
T
D
K
Y
S
N
K
D
C
P
D
S
Site 43
S431
S
N
K
D
C
P
D
S
A
E
E
Y
E
R
A
Site 44
Y435
C
P
D
S
A
E
E
Y
E
R
A
T
R
Y
N
Site 45
T439
A
E
E
Y
E
R
A
T
R
Y
N
Y
T
S
E
Site 46
Y441
E
Y
E
R
A
T
R
Y
N
Y
T
S
E
E
K
Site 47
Y443
E
R
A
T
R
Y
N
Y
T
S
E
E
K
F
A
Site 48
S445
A
T
R
Y
N
Y
T
S
E
E
K
F
A
L
V
Site 49
T479
F
N
H
A
I
R
H
T
V
Y
A
A
L
Q
D
Site 50
S488
Y
A
A
L
Q
D
F
S
Q
V
T
L
R
E
P
Site 51
T491
L
Q
D
F
S
Q
V
T
L
R
E
P
L
R
Q
Site 52
S509
K
K
K
N
V
I
Q
S
V
L
Q
A
I
R
K
Site 53
T517
V
L
Q
A
I
R
K
T
V
C
D
W
E
T
G
Site 54
S541
R
G
E
K
D
P
K
S
G
F
D
I
K
V
P
Site 55
S555
P
R
R
A
V
G
P
S
S
T
Q
L
Y
M
V
Site 56
S556
R
R
A
V
G
P
S
S
T
Q
L
Y
M
V
R
Site 57
Y560
G
P
S
S
T
Q
L
Y
M
V
R
T
M
L
E
Site 58
S568
M
V
R
T
M
L
E
S
L
I
A
D
K
S
G
Site 59
S574
E
S
L
I
A
D
K
S
G
S
K
K
T
L
R
Site 60
S576
L
I
A
D
K
S
G
S
K
K
T
L
R
S
S
Site 61
T579
D
K
S
G
S
K
K
T
L
R
S
S
L
E
G
Site 62
S582
G
S
K
K
T
L
R
S
S
L
E
G
P
T
I
Site 63
S583
S
K
K
T
L
R
S
S
L
E
G
P
T
I
L
Site 64
Y602
F
H
R
E
S
F
F
Y
T
H
L
I
N
F
S
Site 65
T603
H
R
E
S
F
F
Y
T
H
L
I
N
F
S
E
Site 66
T631
R
E
F
F
L
E
L
T
M
G
R
R
I
Q
F
Site 67
Y666
S
M
M
E
Y
V
L
Y
S
L
D
L
Y
N
D
Site 68
Y671
V
L
Y
S
L
D
L
Y
N
D
S
A
H
Y
A
Site 69
S674
S
L
D
L
Y
N
D
S
A
H
Y
A
L
T
R
Site 70
Y688
R
F
N
K
Q
F
L
Y
D
E
I
E
A
E
V
Site 71
S729
L
L
D
K
R
L
R
S
E
C
K
N
Q
G
A
Site 72
S743
A
T
I
H
L
P
P
S
N
R
Y
E
T
L
L
Site 73
T748
P
P
S
N
R
Y
E
T
L
L
K
Q
R
H
V
Site 74
S773
R
L
I
T
Q
R
V
S
A
A
M
Y
K
S
L
Site 75
T793
R
F
E
S
E
D
L
T
S
I
V
E
L
D
G
Site 76
T808
L
L
E
I
N
R
M
T
H
K
L
L
S
R
Y
Site 77
Y815
T
H
K
L
L
S
R
Y
L
T
L
D
G
F
D
Site 78
S833
R
E
A
N
H
N
V
S
A
P
Y
G
R
I
T
Site 79
Y836
N
H
N
V
S
A
P
Y
G
R
I
T
L
H
V
Site 80
Y855
N
Y
D
F
L
P
N
Y
C
Y
N
G
S
T
N
Site 81
Y857
D
F
L
P
N
Y
C
Y
N
G
S
T
N
R
F
Site 82
T867
S
T
N
R
F
V
R
T
V
L
P
F
S
Q
E
Site 83
S872
V
R
T
V
L
P
F
S
Q
E
F
Q
R
D
K
Site 84
Y887
Q
P
N
A
Q
P
Q
Y
L
H
G
S
K
A
L
Site 85
Y898
S
K
A
L
N
L
A
Y
S
S
I
Y
G
S
Y
Site 86
S899
K
A
L
N
L
A
Y
S
S
I
Y
G
S
Y
R
Site 87
S900
A
L
N
L
A
Y
S
S
I
Y
G
S
Y
R
N
Site 88
S904
A
Y
S
S
I
Y
G
S
Y
R
N
F
V
G
P
Site 89
Y967
C
R
L
P
R
H
E
Y
G
S
P
G
I
L
E
Site 90
S969
L
P
R
H
E
Y
G
S
P
G
I
L
E
F
F
Site 91
T991
V
E
Y
A
E
L
K
T
V
C
F
Q
N
L
R
Site 92
S1052
A
K
M
K
R
L
E
S
K
Y
A
P
L
H
L
Site 93
Y1054
M
K
R
L
E
S
K
Y
A
P
L
H
L
V
P
Site 94
T1068
P
L
I
E
R
L
G
T
P
Q
Q
I
A
I
A
Site 95
T1082
A
R
E
G
D
L
L
T
K
E
R
L
C
C
G
Site 96
T1148
P
V
G
T
H
E
F
T
V
E
Q
C
F
G
D
Site 97
Y1225
I
I
T
I
L
D
K
Y
L
K
S
G
D
G
E
Site 98
S1228
I
L
D
K
Y
L
K
S
G
D
G
E
G
T
P
Site 99
T1234
K
S
G
D
G
E
G
T
P
V
E
H
V
R
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation