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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC80
Full Name:
Coiled-coil domain-containing protein 80
Alias:
Down-regulated by oncogenes protein 1;Up-regulated in BRS-3 deficient mouse homolog
Type:
Mass (Da):
108174
Number AA:
950
UniProt ID:
Q76M96
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
S
E
P
H
P
H
A
T
I
R
G
S
H
G
G
Site 2
S32
P
H
A
T
I
R
G
S
H
G
G
R
K
V
P
Site 3
S42
G
R
K
V
P
L
V
S
P
D
S
S
R
P
A
Site 4
S45
V
P
L
V
S
P
D
S
S
R
P
A
R
F
L
Site 5
S46
P
L
V
S
P
D
S
S
R
P
A
R
F
L
R
Site 6
T55
P
A
R
F
L
R
H
T
G
R
S
R
G
I
E
Site 7
S58
F
L
R
H
T
G
R
S
R
G
I
E
R
S
T
Site 8
S64
R
S
R
G
I
E
R
S
T
L
E
E
P
N
L
Site 9
T65
S
R
G
I
E
R
S
T
L
E
E
P
N
L
Q
Site 10
S79
Q
P
L
Q
R
R
R
S
V
P
V
L
R
L
A
Site 11
T89
V
L
R
L
A
R
P
T
E
P
P
A
R
S
D
Site 12
S113
Q
R
P
A
A
R
G
S
P
R
E
M
I
R
D
Site 13
S123
E
M
I
R
D
E
G
S
S
A
R
S
R
M
L
Site 14
S124
M
I
R
D
E
G
S
S
A
R
S
R
M
L
R
Site 15
S127
D
E
G
S
S
A
R
S
R
M
L
R
F
P
S
Site 16
S134
S
R
M
L
R
F
P
S
G
S
S
S
P
N
I
Site 17
S138
R
F
P
S
G
S
S
S
P
N
I
L
A
S
F
Site 18
S144
S
S
P
N
I
L
A
S
F
A
G
K
N
R
V
Site 19
S155
K
N
R
V
W
V
I
S
A
P
H
A
S
E
G
Site 20
Y163
A
P
H
A
S
E
G
Y
Y
R
L
M
M
S
L
Site 21
Y164
P
H
A
S
E
G
Y
Y
R
L
M
M
S
L
L
Site 22
S169
G
Y
Y
R
L
M
M
S
L
L
K
D
D
V
Y
Site 23
Y176
S
L
L
K
D
D
V
Y
C
E
L
A
E
R
H
Site 24
T204
G
G
K
V
R
R
I
T
S
E
G
Q
I
L
E
Site 25
S205
G
K
V
R
R
I
T
S
E
G
Q
I
L
E
Q
Site 26
S217
L
E
Q
P
L
D
P
S
L
I
P
K
L
M
S
Site 27
T241
G
M
V
L
L
K
K
T
L
Q
V
E
E
R
Y
Site 28
Y248
T
L
Q
V
E
E
R
Y
P
Y
P
V
R
L
E
Site 29
Y250
Q
V
E
E
R
Y
P
Y
P
V
R
L
E
A
M
Site 30
Y258
P
V
R
L
E
A
M
Y
E
V
I
D
Q
G
P
Site 31
S305
G
G
G
A
G
R
P
S
L
G
S
E
K
K
K
Site 32
S308
A
G
R
P
S
L
G
S
E
K
K
K
E
D
P
Site 33
S326
Q
V
P
P
T
R
E
S
R
V
K
V
L
R
K
Site 34
S346
P
A
L
P
Q
P
P
S
T
P
R
A
T
T
L
Site 35
T347
A
L
P
Q
P
P
S
T
P
R
A
T
T
L
P
Site 36
T351
P
P
S
T
P
R
A
T
T
L
P
P
A
P
A
Site 37
T352
P
S
T
P
R
A
T
T
L
P
P
A
P
A
T
Site 38
T359
T
L
P
P
A
P
A
T
T
V
T
R
S
T
S
Site 39
T360
L
P
P
A
P
A
T
T
V
T
R
S
T
S
R
Site 40
T362
P
A
P
A
T
T
V
T
R
S
T
S
R
A
V
Site 41
T370
R
S
T
S
R
A
V
T
V
A
A
R
P
M
T
Site 42
T379
A
A
R
P
M
T
T
T
A
F
P
T
T
Q
R
Site 43
T384
T
T
T
A
F
P
T
T
Q
R
P
W
T
P
S
Site 44
T389
P
T
T
Q
R
P
W
T
P
S
P
S
H
R
P
Site 45
S391
T
Q
R
P
W
T
P
S
P
S
H
R
P
P
T
Site 46
S393
R
P
W
T
P
S
P
S
H
R
P
P
T
T
T
Site 47
T398
S
P
S
H
R
P
P
T
T
T
E
V
I
T
A
Site 48
T399
P
S
H
R
P
P
T
T
T
E
V
I
T
A
R
Site 49
T400
S
H
R
P
P
T
T
T
E
V
I
T
A
R
R
Site 50
T404
P
T
T
T
E
V
I
T
A
R
R
P
S
V
S
Site 51
S409
V
I
T
A
R
R
P
S
V
S
E
N
L
Y
P
Site 52
S411
T
A
R
R
P
S
V
S
E
N
L
Y
P
P
S
Site 53
Y415
P
S
V
S
E
N
L
Y
P
P
S
R
K
D
Q
Site 54
S418
S
E
N
L
Y
P
P
S
R
K
D
Q
H
R
E
Site 55
T429
Q
H
R
E
R
P
Q
T
T
R
R
P
S
K
A
Site 56
T430
H
R
E
R
P
Q
T
T
R
R
P
S
K
A
T
Site 57
S434
P
Q
T
T
R
R
P
S
K
A
T
S
L
E
S
Site 58
T437
T
R
R
P
S
K
A
T
S
L
E
S
F
T
N
Site 59
S438
R
R
P
S
K
A
T
S
L
E
S
F
T
N
A
Site 60
S441
S
K
A
T
S
L
E
S
F
T
N
A
P
P
T
Site 61
T448
S
F
T
N
A
P
P
T
T
I
S
E
P
S
T
Site 62
T449
F
T
N
A
P
P
T
T
I
S
E
P
S
T
R
Site 63
S451
N
A
P
P
T
T
I
S
E
P
S
T
R
A
A
Site 64
S454
P
T
T
I
S
E
P
S
T
R
A
A
G
P
G
Site 65
T455
T
T
I
S
E
P
S
T
R
A
A
G
P
G
R
Site 66
S503
K
A
Q
D
K
I
L
S
N
E
Y
E
E
K
Y
Site 67
Y510
S
N
E
Y
E
E
K
Y
D
L
S
R
P
T
A
Site 68
S513
Y
E
E
K
Y
D
L
S
R
P
T
A
S
Q
L
Site 69
T516
K
Y
D
L
S
R
P
T
A
S
Q
L
E
D
E
Site 70
S565
N
A
D
K
L
L
K
S
E
K
Q
M
K
K
S
Site 71
S572
S
E
K
Q
M
K
K
S
E
K
K
S
K
Q
E
Site 72
S576
M
K
K
S
E
K
K
S
K
Q
E
K
E
K
S
Site 73
S583
S
K
Q
E
K
E
K
S
K
K
K
K
G
G
K
Site 74
Y596
G
K
T
E
Q
D
G
Y
Q
K
P
T
N
K
H
Site 75
T605
K
P
T
N
K
H
F
T
Q
S
P
K
K
S
V
Site 76
S607
T
N
K
H
F
T
Q
S
P
K
K
S
V
A
D
Site 77
S611
F
T
Q
S
P
K
K
S
V
A
D
L
L
G
S
Site 78
S618
S
V
A
D
L
L
G
S
F
E
G
K
R
R
L
Site 79
T629
K
R
R
L
L
L
I
T
A
P
K
A
E
N
N
Site 80
Y638
P
K
A
E
N
N
M
Y
V
Q
Q
R
D
E
Y
Site 81
Y645
Y
V
Q
Q
R
D
E
Y
L
E
S
F
C
K
M
Site 82
S648
Q
R
D
E
Y
L
E
S
F
C
K
M
A
T
R
Site 83
S699
L
V
D
Q
R
L
I
S
E
L
R
K
E
Y
G
Site 84
Y705
I
S
E
L
R
K
E
Y
G
M
T
Y
N
D
F
Site 85
Y709
R
K
E
Y
G
M
T
Y
N
D
F
F
M
V
L
Site 86
Y726
V
D
L
R
V
K
Q
Y
Y
E
V
P
I
T
M
Site 87
Y727
D
L
R
V
K
Q
Y
Y
E
V
P
I
T
M
K
Site 88
T732
Q
Y
Y
E
V
P
I
T
M
K
S
V
F
D
L
Site 89
T742
S
V
F
D
L
I
D
T
F
Q
S
R
I
K
D
Site 90
S767
C
K
E
D
K
K
Q
S
L
E
N
F
L
S
R
Site 91
S773
Q
S
L
E
N
F
L
S
R
F
R
W
R
R
R
Site 92
S785
R
R
R
L
L
V
I
S
A
P
N
D
E
D
W
Site 93
Y794
P
N
D
E
D
W
A
Y
S
Q
Q
L
S
A
L
Site 94
S795
N
D
E
D
W
A
Y
S
Q
Q
L
S
A
L
S
Site 95
S799
W
A
Y
S
Q
Q
L
S
A
L
S
G
Q
A
C
Site 96
S838
L
F
P
I
N
G
S
S
V
V
E
R
E
D
V
Site 97
Y856
L
V
K
D
I
R
N
Y
F
Q
V
S
P
E
Y
Site 98
S860
I
R
N
Y
F
Q
V
S
P
E
Y
F
S
M
L
Site 99
Y918
M
R
C
P
E
D
E
Y
A
G
Y
G
Y
H
S
Site 100
Y921
P
E
D
E
Y
A
G
Y
G
Y
H
S
Y
H
Q
Site 101
Y923
D
E
Y
A
G
Y
G
Y
H
S
Y
H
Q
G
Y
Site 102
Y926
A
G
Y
G
Y
H
S
Y
H
Q
G
Y
Q
D
G
Site 103
Y934
H
Q
G
Y
Q
D
G
Y
Q
D
D
Y
R
H
H
Site 104
Y938
Q
D
G
Y
Q
D
D
Y
R
H
H
E
S
Y
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation