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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDZD4
Full Name:
PDZ domain-containing protein 4
Alias:
PDZ domain-containing RING finger protein 4-like protein
Type:
Mass (Da):
86171
Number AA:
769
UniProt ID:
Q76G19
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
G
K
E
L
S
K
L
S
Q
E
Q
T
L
Q
A
Site 2
T34
S
K
L
S
Q
E
Q
T
L
Q
A
L
R
S
S
Site 3
S40
Q
T
L
Q
A
L
R
S
S
K
E
P
L
V
I
Site 4
S41
T
L
Q
A
L
R
S
S
K
E
P
L
V
I
Q
Site 5
S53
V
I
Q
V
L
R
R
S
P
R
L
R
G
D
S
Site 6
S60
S
P
R
L
R
G
D
S
S
C
H
D
L
Q
L
Site 7
S61
P
R
L
R
G
D
S
S
C
H
D
L
Q
L
V
Site 8
S70
H
D
L
Q
L
V
D
S
G
T
Q
T
D
I
T
Site 9
T72
L
Q
L
V
D
S
G
T
Q
T
D
I
T
F
E
Site 10
T74
L
V
D
S
G
T
Q
T
D
I
T
F
E
H
I
Site 11
S103
I
L
E
P
P
P
I
S
H
E
Y
Y
D
P
A
Site 12
Y106
P
P
P
I
S
H
E
Y
Y
D
P
A
E
F
M
Site 13
Y107
P
P
I
S
H
E
Y
Y
D
P
A
E
F
M
E
Site 14
Y128
D
R
L
D
E
L
E
Y
E
E
V
E
L
Y
K
Site 15
Y134
E
Y
E
E
V
E
L
Y
K
S
S
H
R
D
K
Site 16
S136
E
E
V
E
L
Y
K
S
S
H
R
D
K
L
G
Site 17
S137
E
V
E
L
Y
K
S
S
H
R
D
K
L
G
L
Site 18
Y159
D
E
E
D
L
G
I
Y
V
G
E
V
N
P
N
Site 19
S167
V
G
E
V
N
P
N
S
I
A
A
K
D
G
R
Site 20
S200
E
E
A
V
A
I
L
S
Q
E
E
N
T
N
I
Site 21
S216
L
L
V
A
R
P
E
S
Q
L
A
K
R
W
K
Site 22
S225
L
A
K
R
W
K
D
S
D
R
D
D
F
L
D
Site 23
S236
D
F
L
D
D
F
G
S
E
N
E
G
E
L
R
Site 24
S249
L
R
A
R
K
L
K
S
P
P
A
Q
Q
P
G
Site 25
S271
P
D
A
G
P
G
L
S
N
S
Q
E
L
D
S
Site 26
S273
A
G
P
G
L
S
N
S
Q
E
L
D
S
G
V
Site 27
S278
S
N
S
Q
E
L
D
S
G
V
G
R
T
D
E
Site 28
S286
G
V
G
R
T
D
E
S
T
R
N
E
E
S
S
Site 29
T287
V
G
R
T
D
E
S
T
R
N
E
E
S
S
E
Site 30
S292
E
S
T
R
N
E
E
S
S
E
H
D
L
L
G
Site 31
S293
S
T
R
N
E
E
S
S
E
H
D
L
L
G
D
Site 32
S304
L
L
G
D
E
P
P
S
S
T
N
T
P
G
S
Site 33
S305
L
G
D
E
P
P
S
S
T
N
T
P
G
S
L
Site 34
T306
G
D
E
P
P
S
S
T
N
T
P
G
S
L
R
Site 35
T308
E
P
P
S
S
T
N
T
P
G
S
L
R
K
F
Site 36
S311
S
S
T
N
T
P
G
S
L
R
K
F
G
L
Q
Site 37
S330
Q
S
R
D
F
H
F
S
M
D
S
L
L
A
E
Site 38
T350
G
G
D
V
P
G
L
T
D
E
E
Y
E
R
Y
Site 39
Y354
P
G
L
T
D
E
E
Y
E
R
Y
R
E
L
L
Site 40
Y357
T
D
E
E
Y
E
R
Y
R
E
L
L
E
I
K
Site 41
S381
G
L
L
F
P
R
A
S
G
G
N
S
A
L
D
Site 42
S385
P
R
A
S
G
G
N
S
A
L
D
V
N
R
N
Site 43
S394
L
D
V
N
R
N
E
S
L
G
H
E
M
A
M
Site 44
Y441
L
L
E
E
E
S
L
Y
D
L
A
A
S
E
P
Site 45
S446
S
L
Y
D
L
A
A
S
E
P
K
K
H
E
L
Site 46
S454
E
P
K
K
H
E
L
S
D
I
S
E
L
P
E
Site 47
S457
K
H
E
L
S
D
I
S
E
L
P
E
K
S
D
Site 48
S463
I
S
E
L
P
E
K
S
D
K
D
S
T
S
A
Site 49
S467
P
E
K
S
D
K
D
S
T
S
A
Y
N
T
G
Site 50
S469
K
S
D
K
D
S
T
S
A
Y
N
T
G
E
S
Site 51
Y471
D
K
D
S
T
S
A
Y
N
T
G
E
S
C
R
Site 52
T473
D
S
T
S
A
Y
N
T
G
E
S
C
R
S
T
Site 53
S476
S
A
Y
N
T
G
E
S
C
R
S
T
P
L
L
Site 54
S479
N
T
G
E
S
C
R
S
T
P
L
L
V
E
P
Site 55
T480
T
G
E
S
C
R
S
T
P
L
L
V
E
P
L
Site 56
S490
L
V
E
P
L
P
E
S
P
L
R
R
A
M
A
Site 57
T505
G
N
S
N
L
N
R
T
P
P
G
P
A
V
A
Site 58
T513
P
P
G
P
A
V
A
T
P
A
K
A
A
P
P
Site 59
S523
K
A
A
P
P
P
G
S
P
A
K
F
R
S
L
Site 60
S529
G
S
P
A
K
F
R
S
L
S
R
D
P
E
A
Site 61
S531
P
A
K
F
R
S
L
S
R
D
P
E
A
G
R
Site 62
T552
R
G
R
R
N
P
K
T
G
L
T
L
E
R
V
Site 63
S563
L
E
R
V
G
P
E
S
S
P
Y
L
S
R
R
Site 64
S564
E
R
V
G
P
E
S
S
P
Y
L
S
R
R
H
Site 65
Y566
V
G
P
E
S
S
P
Y
L
S
R
R
H
R
G
Site 66
S568
P
E
S
S
P
Y
L
S
R
R
H
R
G
Q
G
Site 67
Y581
Q
G
Q
E
G
E
H
Y
H
S
C
V
Q
L
A
Site 68
S583
Q
E
G
E
H
Y
H
S
C
V
Q
L
A
P
T
Site 69
S602
E
L
G
H
G
P
L
S
L
A
G
G
P
R
V
Site 70
T617
G
G
V
A
A
A
A
T
E
A
P
R
M
E
W
Site 71
Y635
V
R
S
D
G
T
R
Y
V
A
K
R
P
V
R
Site 72
S658
L
K
I
R
E
E
R
S
G
M
T
T
D
D
D
Site 73
T661
R
E
E
R
S
G
M
T
T
D
D
D
A
V
S
Site 74
T662
E
E
R
S
G
M
T
T
D
D
D
A
V
S
E
Site 75
S668
T
T
D
D
D
A
V
S
E
M
K
M
G
R
Y
Site 76
Y675
S
E
M
K
M
G
R
Y
W
S
K
E
E
R
K
Site 77
S714
R
E
Q
Q
N
G
D
S
K
P
E
L
N
I
I
Site 78
S724
E
L
N
I
I
A
L
S
H
R
K
T
M
K
K
Site 79
T728
I
A
L
S
H
R
K
T
M
K
K
R
N
K
K
Site 80
Y760
S
A
D
G
K
R
V
Y
N
P
L
L
S
V
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation