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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOL8
Full Name:
Nucleolar protein 8
Alias:
C9orf34; FLJ20736; Nop132; Nucleolar protein Nop132
Type:
RNA binding protein
Mass (Da):
131616
Number AA:
1167
UniProt ID:
Q76FK4
International Prot ID:
IPI00161085
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005730
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0030307
GO:0006259
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
K
V
N
R
E
T
K
R
L
Y
V
G
G
Site 2
Y11
N
R
E
T
K
R
L
Y
V
G
G
L
S
Q
D
Site 3
S16
R
L
Y
V
G
G
L
S
Q
D
I
S
E
A
D
Site 4
S20
G
G
L
S
Q
D
I
S
E
A
D
L
Q
N
Q
Site 5
S29
A
D
L
Q
N
Q
F
S
R
F
G
E
V
S
D
Site 6
S35
F
S
R
F
G
E
V
S
D
V
E
I
I
T
R
Site 7
Y55
N
P
Q
K
V
F
A
Y
I
N
I
S
V
A
E
Site 8
S59
V
F
A
Y
I
N
I
S
V
A
E
A
D
L
K
Site 9
S90
Q
I
Q
L
A
K
E
S
F
L
H
R
L
A
Q
Site 10
T133
H
M
K
A
V
P
G
T
E
V
P
G
H
K
N
Site 11
Y166
H
K
R
K
I
I
K
Y
D
P
S
K
Y
C
H
Site 12
Y171
I
K
Y
D
P
S
K
Y
C
H
N
L
K
K
I
Site 13
S183
K
K
I
G
E
D
F
S
N
T
I
P
I
S
S
Site 14
S189
F
S
N
T
I
P
I
S
S
L
T
W
E
L
E
Site 15
S190
S
N
T
I
P
I
S
S
L
T
W
E
L
E
G
Site 16
T192
T
I
P
I
S
S
L
T
W
E
L
E
G
G
N
Site 17
S203
E
G
G
N
D
P
M
S
K
K
R
R
G
E
F
Site 18
S211
K
K
R
R
G
E
F
S
D
F
H
G
P
P
K
Site 19
S228
I
K
V
Q
K
D
E
S
S
T
G
S
L
A
M
Site 20
S229
K
V
Q
K
D
E
S
S
T
G
S
L
A
M
S
Site 21
S232
K
D
E
S
S
T
G
S
L
A
M
S
T
R
P
Site 22
S236
S
T
G
S
L
A
M
S
T
R
P
R
R
V
I
Site 23
T249
V
I
E
R
P
P
L
T
Q
Q
Q
A
A
Q
K
Site 24
S261
A
Q
K
R
T
C
D
S
I
T
P
S
K
S
S
Site 25
T263
K
R
T
C
D
S
I
T
P
S
K
S
S
P
V
Site 26
S265
T
C
D
S
I
T
P
S
K
S
S
P
V
P
V
Site 27
S267
D
S
I
T
P
S
K
S
S
P
V
P
V
S
D
Site 28
S268
S
I
T
P
S
K
S
S
P
V
P
V
S
D
T
Site 29
S273
K
S
S
P
V
P
V
S
D
T
Q
K
L
K
N
Site 30
T275
S
P
V
P
V
S
D
T
Q
K
L
K
N
L
P
Site 31
T290
F
K
T
S
G
L
E
T
A
K
K
R
N
S
I
Site 32
S296
E
T
A
K
K
R
N
S
I
S
D
D
D
T
D
Site 33
S298
A
K
K
R
N
S
I
S
D
D
D
T
D
S
E
Site 34
T302
N
S
I
S
D
D
D
T
D
S
E
D
E
L
R
Site 35
S304
I
S
D
D
D
T
D
S
E
D
E
L
R
M
M
Site 36
T321
K
E
E
N
L
Q
R
T
T
Q
P
S
I
N
E
Site 37
T322
E
E
N
L
Q
R
T
T
Q
P
S
I
N
E
S
Site 38
S325
L
Q
R
T
T
Q
P
S
I
N
E
S
E
S
D
Site 39
S329
T
Q
P
S
I
N
E
S
E
S
D
P
F
E
V
Site 40
S331
P
S
I
N
E
S
E
S
D
P
F
E
V
V
R
Site 41
S343
V
V
R
D
D
F
K
S
G
V
H
K
L
H
S
Site 42
S361
L
G
I
K
N
R
V
S
C
H
D
S
D
D
D
Site 43
S365
N
R
V
S
C
H
D
S
D
D
D
I
M
R
N
Site 44
Y376
I
M
R
N
D
R
E
Y
D
S
G
D
T
D
E
Site 45
S378
R
N
D
R
E
Y
D
S
G
D
T
D
E
I
I
Site 46
T381
R
E
Y
D
S
G
D
T
D
E
I
I
A
M
K
Site 47
S397
N
V
A
K
V
K
N
S
T
E
F
S
Q
M
E
Site 48
S401
V
K
N
S
T
E
F
S
Q
M
E
K
S
T
K
Site 49
S406
E
F
S
Q
M
E
K
S
T
K
K
T
S
F
K
Site 50
S411
E
K
S
T
K
K
T
S
F
K
N
R
E
N
C
Site 51
S432
I
K
L
Q
K
R
K
S
N
V
E
S
A
L
S
Site 52
S436
K
R
K
S
N
V
E
S
A
L
S
H
G
L
K
Site 53
S439
S
N
V
E
S
A
L
S
H
G
L
K
S
L
N
Site 54
S444
A
L
S
H
G
L
K
S
L
N
R
K
S
P
S
Site 55
S449
L
K
S
L
N
R
K
S
P
S
H
S
S
S
S
Site 56
S451
S
L
N
R
K
S
P
S
H
S
S
S
S
E
D
Site 57
S453
N
R
K
S
P
S
H
S
S
S
S
E
D
A
D
Site 58
S455
K
S
P
S
H
S
S
S
S
E
D
A
D
S
A
Site 59
S456
S
P
S
H
S
S
S
S
E
D
A
D
S
A
S
Site 60
S461
S
S
S
E
D
A
D
S
A
S
E
L
A
D
S
Site 61
S463
S
E
D
A
D
S
A
S
E
L
A
D
S
E
G
Site 62
S468
S
A
S
E
L
A
D
S
E
G
G
E
E
Y
N
Site 63
Y474
D
S
E
G
G
E
E
Y
N
A
M
M
K
N
C
Site 64
S497
D
L
E
Q
L
A
G
S
D
L
K
V
P
N
E
Site 65
T506
L
K
V
P
N
E
D
T
K
S
D
G
P
E
T
Site 66
S508
V
P
N
E
D
T
K
S
D
G
P
E
T
T
T
Site 67
T515
S
D
G
P
E
T
T
T
Q
C
K
F
D
R
G
Site 68
S523
Q
C
K
F
D
R
G
S
K
S
P
K
T
P
T
Site 69
S525
K
F
D
R
G
S
K
S
P
K
T
P
T
G
L
Site 70
T528
R
G
S
K
S
P
K
T
P
T
G
L
R
R
G
Site 71
T530
S
K
S
P
K
T
P
T
G
L
R
R
G
R
Q
Site 72
S547
R
P
A
E
I
V
A
S
L
L
E
G
E
E
N
Site 73
Y580
F
K
G
V
G
C
L
Y
E
K
E
S
M
K
K
Site 74
S584
G
C
L
Y
E
K
E
S
M
K
K
S
L
K
D
Site 75
S588
E
K
E
S
M
K
K
S
L
K
D
S
V
A
S
Site 76
S592
M
K
K
S
L
K
D
S
V
A
S
N
N
K
D
Site 77
S602
S
N
N
K
D
Q
N
S
M
K
H
E
D
P
S
Site 78
S609
S
M
K
H
E
D
P
S
I
I
S
M
E
D
G
Site 79
S612
H
E
D
P
S
I
I
S
M
E
D
G
S
P
Y
Site 80
S617
I
I
S
M
E
D
G
S
P
Y
V
N
G
S
L
Site 81
Y619
S
M
E
D
G
S
P
Y
V
N
G
S
L
G
E
Site 82
S623
G
S
P
Y
V
N
G
S
L
G
E
V
T
P
C
Site 83
T628
N
G
S
L
G
E
V
T
P
C
Q
H
A
K
K
Site 84
Y641
K
K
A
N
G
P
N
Y
I
Q
P
Q
K
R
Q
Site 85
T649
I
Q
P
Q
K
R
Q
T
T
F
E
S
Q
D
R
Site 86
T650
Q
P
Q
K
R
Q
T
T
F
E
S
Q
D
R
K
Site 87
S653
K
R
Q
T
T
F
E
S
Q
D
R
K
A
V
S
Site 88
S660
S
Q
D
R
K
A
V
S
P
S
S
S
E
K
R
Site 89
S662
D
R
K
A
V
S
P
S
S
S
E
K
R
S
K
Site 90
S663
R
K
A
V
S
P
S
S
S
E
K
R
S
K
N
Site 91
S664
K
A
V
S
P
S
S
S
E
K
R
S
K
N
P
Site 92
S668
P
S
S
S
E
K
R
S
K
N
P
I
S
R
P
Site 93
S673
K
R
S
K
N
P
I
S
R
P
L
E
G
K
K
Site 94
S681
R
P
L
E
G
K
K
S
L
S
L
S
A
K
T
Site 95
S683
L
E
G
K
K
S
L
S
L
S
A
K
T
H
N
Site 96
S685
G
K
K
S
L
S
L
S
A
K
T
H
N
I
G
Site 97
S697
N
I
G
F
D
K
D
S
C
H
S
T
T
K
T
Site 98
T701
D
K
D
S
C
H
S
T
T
K
T
E
A
S
Q
Site 99
T704
S
C
H
S
T
T
K
T
E
A
S
Q
E
E
R
Site 100
S707
S
T
T
K
T
E
A
S
Q
E
E
R
S
D
S
Site 101
S712
E
A
S
Q
E
E
R
S
D
S
S
G
L
T
S
Site 102
S714
S
Q
E
E
R
S
D
S
S
G
L
T
S
L
K
Site 103
S715
Q
E
E
R
S
D
S
S
G
L
T
S
L
K
K
Site 104
T718
R
S
D
S
S
G
L
T
S
L
K
K
S
P
K
Site 105
S719
S
D
S
S
G
L
T
S
L
K
K
S
P
K
V
Site 106
S723
G
L
T
S
L
K
K
S
P
K
V
S
S
K
D
Site 107
S727
L
K
K
S
P
K
V
S
S
K
D
T
R
E
I
Site 108
T731
P
K
V
S
S
K
D
T
R
E
I
K
T
D
F
Site 109
T736
K
D
T
R
E
I
K
T
D
F
S
L
S
I
S
Site 110
S739
R
E
I
K
T
D
F
S
L
S
I
S
N
S
S
Site 111
S741
I
K
T
D
F
S
L
S
I
S
N
S
S
D
V
Site 112
S743
T
D
F
S
L
S
I
S
N
S
S
D
V
S
A
Site 113
S745
F
S
L
S
I
S
N
S
S
D
V
S
A
K
D
Site 114
S746
S
L
S
I
S
N
S
S
D
V
S
A
K
D
K
Site 115
S749
I
S
N
S
S
D
V
S
A
K
D
K
H
A
E
Site 116
T795
G
H
P
E
D
K
P
T
H
I
I
F
G
S
D
Site 117
S801
P
T
H
I
I
F
G
S
D
S
E
C
E
T
E
Site 118
S803
H
I
I
F
G
S
D
S
E
C
E
T
E
E
T
Site 119
T807
G
S
D
S
E
C
E
T
E
E
T
S
T
Q
E
Site 120
T810
S
E
C
E
T
E
E
T
S
T
Q
E
Q
S
H
Site 121
S811
E
C
E
T
E
E
T
S
T
Q
E
Q
S
H
P
Site 122
T812
C
E
T
E
E
T
S
T
Q
E
Q
S
H
P
G
Site 123
S816
E
T
S
T
Q
E
Q
S
H
P
G
E
E
W
V
Site 124
T830
V
K
E
S
M
G
K
T
S
G
K
L
F
D
S
Site 125
S837
T
S
G
K
L
F
D
S
S
D
D
D
E
S
D
Site 126
S838
S
G
K
L
F
D
S
S
D
D
D
E
S
D
S
Site 127
S843
D
S
S
D
D
D
E
S
D
S
E
D
D
S
N
Site 128
S845
S
D
D
D
E
S
D
S
E
D
D
S
N
R
F
Site 129
S849
E
S
D
S
E
D
D
S
N
R
F
K
I
K
P
Site 130
S871
Q
K
L
M
D
L
Q
S
H
F
G
T
D
D
R
Site 131
T875
D
L
Q
S
H
F
G
T
D
D
R
F
R
M
D
Site 132
S883
D
D
R
F
R
M
D
S
R
F
L
E
T
D
S
Site 133
T888
M
D
S
R
F
L
E
T
D
S
E
E
E
Q
E
Site 134
S890
S
R
F
L
E
T
D
S
E
E
E
Q
E
E
V
Site 135
S928
S
V
L
Q
I
N
L
S
N
S
T
N
R
G
S
Site 136
S930
L
Q
I
N
L
S
N
S
T
N
R
G
S
V
A
Site 137
T931
Q
I
N
L
S
N
S
T
N
R
G
S
V
A
A
Site 138
S935
S
N
S
T
N
R
G
S
V
A
A
K
K
F
K
Site 139
T956
P
T
K
Q
D
H
A
T
Y
E
R
K
R
D
D
Site 140
Y957
T
K
Q
D
H
A
T
Y
E
R
K
R
D
D
K
Site 141
Y990
P
E
V
S
K
E
M
Y
Y
N
I
A
M
D
L
Site 142
T1003
D
L
K
E
I
F
Q
T
T
K
Y
T
S
E
K
Site 143
Y1006
E
I
F
Q
T
T
K
Y
T
S
E
K
E
E
G
Site 144
T1014
T
S
E
K
E
E
G
T
P
W
N
E
D
C
G
Site 145
T1035
I
Q
D
P
A
A
L
T
S
D
A
E
Q
P
S
Site 146
S1036
Q
D
P
A
A
L
T
S
D
A
E
Q
P
S
G
Site 147
T1045
A
E
Q
P
S
G
F
T
F
S
F
F
D
S
D
Site 148
S1047
Q
P
S
G
F
T
F
S
F
F
D
S
D
T
K
Site 149
S1051
F
T
F
S
F
F
D
S
D
T
K
D
I
K
E
Site 150
T1053
F
S
F
F
D
S
D
T
K
D
I
K
E
E
T
Site 151
T1060
T
K
D
I
K
E
E
T
Y
R
V
E
T
V
K
Site 152
T1065
E
E
T
Y
R
V
E
T
V
K
P
G
K
I
V
Site 153
S1082
E
D
P
R
L
Q
D
S
S
S
E
E
E
D
V
Site 154
S1083
D
P
R
L
Q
D
S
S
S
E
E
E
D
V
T
Site 155
S1084
P
R
L
Q
D
S
S
S
E
E
E
D
V
T
E
Site 156
T1090
S
S
E
E
E
D
V
T
E
E
T
D
H
R
N
Site 157
T1093
E
E
D
V
T
E
E
T
D
H
R
N
S
S
P
Site 158
S1098
E
E
T
D
H
R
N
S
S
P
G
E
A
S
L
Site 159
S1099
E
T
D
H
R
N
S
S
P
G
E
A
S
L
L
Site 160
S1104
N
S
S
P
G
E
A
S
L
L
E
K
E
T
T
Site 161
T1111
S
L
L
E
K
E
T
T
R
F
F
F
F
S
K
Site 162
S1117
T
T
R
F
F
F
F
S
K
N
D
E
R
L
Q
Site 163
S1138
R
G
V
G
S
N
M
S
R
N
S
W
E
A
R
Site 164
S1141
G
S
N
M
S
R
N
S
W
E
A
R
T
T
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation