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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INTS8
Full Name:
Integrator complex subunit 8
Alias:
C8orf52; FLJ20530; Int8; Integrator complex 8; KAONASHI 1; Kaonashi protein 1; MGC131633
Type:
RNA binding, snRNA transcription
Mass (Da):
113088
Number AA:
995
UniProt ID:
Q75QN2
International Prot ID:
IPI00375653
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0032039
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006396
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
D
R
E
A
A
T
S
S
R
P
C
T
P
P
Site 2
S14
D
R
E
A
A
T
S
S
R
P
C
T
P
P
Q
Site 3
T18
A
T
S
S
R
P
C
T
P
P
Q
T
C
W
F
Site 4
T22
R
P
C
T
P
P
Q
T
C
W
F
E
F
L
L
Site 5
S62
L
E
Q
A
S
K
P
S
V
N
E
Q
N
Q
V
Site 6
T153
Y
N
R
W
A
I
R
T
I
V
Q
S
S
F
P
Site 7
S158
I
R
T
I
V
Q
S
S
F
P
V
K
Q
A
K
Site 8
S172
K
P
G
P
P
Q
L
S
V
M
N
Q
M
Q
Q
Site 9
T184
M
Q
Q
E
K
E
L
T
E
N
I
L
K
V
L
Site 10
Y213
L
K
L
N
K
D
L
Y
V
H
T
M
R
T
L
Site 11
T234
P
G
M
V
N
G
E
T
E
S
S
T
A
G
L
Site 12
S237
V
N
G
E
T
E
S
S
T
A
G
L
K
V
K
Site 13
Y260
C
Y
D
L
G
A
A
Y
F
Q
Q
G
S
T
N
Site 14
T296
G
S
L
S
L
H
C
T
I
D
E
K
R
L
A
Site 15
S316
C
D
V
L
V
P
S
S
D
S
T
S
Q
Q
L
Site 16
S318
V
L
V
P
S
S
D
S
T
S
Q
Q
L
T
P
Site 17
T319
L
V
P
S
S
D
S
T
S
Q
Q
L
T
P
Y
Site 18
S320
V
P
S
S
D
S
T
S
Q
Q
L
T
P
Y
S
Site 19
T324
D
S
T
S
Q
Q
L
T
P
Y
S
Q
V
H
I
Site 20
Y326
T
S
Q
Q
L
T
P
Y
S
Q
V
H
I
C
L
Site 21
S327
S
Q
Q
L
T
P
Y
S
Q
V
H
I
C
L
R
Site 22
S353
I
E
D
N
L
T
L
S
L
P
V
Q
F
R
Q
Site 23
S361
L
P
V
Q
F
R
Q
S
V
L
R
E
L
F
K
Site 24
S423
D
F
L
L
E
V
C
S
R
S
V
N
L
E
K
Site 25
S425
L
L
E
V
C
S
R
S
V
N
L
E
K
A
S
Site 26
T467
S
S
H
E
L
F
I
T
L
L
K
D
E
E
R
Site 27
S485
V
D
Q
M
R
K
R
S
P
R
V
N
L
C
I
Site 28
S506
Y
D
I
P
A
S
A
S
V
N
I
G
Q
L
E
Site 29
S519
L
E
H
Q
L
I
L
S
V
D
P
W
R
I
R
Site 30
T543
T
S
E
R
Q
F
W
T
V
S
N
K
W
E
V
Site 31
T582
A
K
G
L
H
C
S
T
V
K
D
F
S
H
A
Site 32
S587
C
S
T
V
K
D
F
S
H
A
K
Q
L
F
A
Site 33
T622
M
L
L
L
D
I
H
T
H
E
A
G
T
G
Q
Site 34
S636
Q
A
G
E
R
P
P
S
D
L
I
S
R
V
R
Site 35
S640
R
P
P
S
D
L
I
S
R
V
R
G
Y
L
E
Site 36
Y645
L
I
S
R
V
R
G
Y
L
E
M
R
L
P
D
Site 37
S710
E
L
P
G
P
K
E
S
R
R
T
A
K
D
L
Site 38
T713
G
P
K
E
S
R
R
T
A
K
D
L
W
E
V
Site 39
S726
E
V
V
V
Q
I
C
S
V
S
S
Q
H
K
R
Site 40
S729
V
Q
I
C
S
V
S
S
Q
H
K
R
G
N
D
Site 41
S740
R
G
N
D
G
R
V
S
L
I
K
Q
R
E
S
Site 42
S747
S
L
I
K
Q
R
E
S
T
L
G
I
M
Y
R
Site 43
T748
L
I
K
Q
R
E
S
T
L
G
I
M
Y
R
S
Site 44
S759
M
Y
R
S
E
L
L
S
F
I
K
K
L
R
E
Site 45
S797
D
I
T
A
E
H
I
S
I
W
P
S
S
I
P
Site 46
S801
E
H
I
S
I
W
P
S
S
I
P
N
L
Q
S
Site 47
Y824
T
V
K
E
L
V
R
Y
T
L
S
I
N
P
N
Site 48
T825
V
K
E
L
V
R
Y
T
L
S
I
N
P
N
N
Site 49
S827
E
L
V
R
Y
T
L
S
I
N
P
N
N
H
S
Site 50
Y876
K
A
V
P
P
D
V
Y
T
D
Q
V
I
K
R
Site 51
T877
A
V
P
P
D
V
Y
T
D
Q
V
I
K
R
M
Site 52
Y909
Q
F
L
R
E
I
D
Y
K
T
A
F
K
S
L
Site 53
T911
L
R
E
I
D
Y
K
T
A
F
K
S
L
Q
E
Site 54
S915
D
Y
K
T
A
F
K
S
L
Q
E
Q
N
S
H
Site 55
S921
K
S
L
Q
E
Q
N
S
H
D
A
M
D
S
Y
Site 56
Y928
S
H
D
A
M
D
S
Y
Y
D
Y
I
W
D
V
Site 57
Y929
H
D
A
M
D
S
Y
Y
D
Y
I
W
D
V
T
Site 58
Y940
W
D
V
T
I
L
E
Y
L
T
Y
L
H
H
K
Site 59
Y943
T
I
L
E
Y
L
T
Y
L
H
H
K
R
G
E
Site 60
T951
L
H
H
K
R
G
E
T
D
K
R
Q
I
A
I
Site 61
S969
G
Q
T
E
L
N
A
S
N
P
E
E
V
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation