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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MED25
Full Name:
Mediator of RNA polymerase II transcription subunit 25
Alias:
Activator interaction domain-containing protein 1;Activator-recruited cofactor 92 kDa component;Mediator complex subunit 25;p78
Type:
Mass (Da):
78171
Number AA:
747
UniProt ID:
Q71SY5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y31
G
T
A
N
L
G
P
Y
F
E
G
L
R
K
H
Site 2
Y39
F
E
G
L
R
K
H
Y
L
L
P
A
I
E
Y
Site 3
T55
N
G
G
P
P
A
E
T
D
F
G
G
D
Y
G
Site 4
Y61
E
T
D
F
G
G
D
Y
G
G
T
Q
Y
S
L
Site 5
Y81
V
D
C
A
P
E
S
Y
V
Q
C
H
A
P
T
Site 6
Y161
P
A
V
E
S
T
T
Y
S
G
C
T
T
E
N
Site 7
S162
A
V
E
S
T
T
Y
S
G
C
T
T
E
N
L
Site 8
T166
T
T
Y
S
G
C
T
T
E
N
L
V
Q
Q
I
Site 9
S181
G
E
R
G
I
H
F
S
I
V
S
P
R
K
L
Site 10
T211
L
E
P
L
Q
P
P
T
D
V
S
Q
D
P
R
Site 11
S214
L
Q
P
P
T
D
V
S
Q
D
P
R
H
M
V
Site 12
S241
S
A
P
G
P
L
Q
S
K
Q
P
V
P
L
P
Site 13
S258
A
P
S
G
A
T
L
S
A
A
P
Q
Q
P
L
Site 14
Y272
L
P
P
V
P
P
Q
Y
Q
V
P
G
N
L
S
Site 15
S304
A
G
L
G
P
R
F
S
P
I
T
P
L
Q
Q
Site 16
T307
G
P
R
F
S
P
I
T
P
L
Q
Q
A
A
P
Site 17
S321
P
G
V
G
P
P
F
S
Q
A
P
A
P
Q
L
Site 18
S342
A
P
K
P
P
P
A
S
Q
P
S
L
V
S
T
Site 19
S345
P
P
P
A
S
Q
P
S
L
V
S
T
V
A
P
Site 20
T359
P
G
S
G
L
A
P
T
A
Q
P
G
A
P
S
Site 21
S380
P
G
G
V
S
G
P
S
P
A
Q
L
G
A
P
Site 22
S394
P
A
L
G
G
Q
Q
S
V
S
N
K
L
L
A
Site 23
S416
Q
E
K
P
K
P
A
S
V
D
A
N
T
K
L
Site 24
Y432
R
S
L
P
C
Q
V
Y
V
N
H
G
E
N
L
Site 25
T441
N
H
G
E
N
L
K
T
E
Q
W
P
Q
K
L
Site 26
Y487
L
E
S
L
K
G
L
Y
R
I
M
G
N
G
F
Site 27
S531
G
L
I
P
Y
D
Q
S
G
F
V
N
G
I
R
Site 28
S579
L
E
D
Q
A
R
P
S
Q
N
L
L
Q
L
R
Site 29
T595
P
Q
P
Q
P
Q
G
T
V
G
A
S
G
A
T
Site 30
T610
G
Q
P
Q
P
Q
G
T
A
Q
P
P
P
G
A
Site 31
S626
Q
G
P
P
G
A
A
S
G
P
P
P
P
G
P
Site 32
T658
L
N
P
P
P
P
Q
T
G
V
P
P
P
Q
A
Site 33
S666
G
V
P
P
P
Q
A
S
L
H
H
L
Q
P
P
Site 34
S703
L
H
P
P
P
A
Q
S
W
P
A
Q
L
P
P
Site 35
S736
P
Q
P
G
L
Q
P
S
V
M
E
D
D
I
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation