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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LARP4
Full Name:
La-related protein 4
Alias:
La ribonucleoprotein domain family, member 4; Mpl binding protein; PP13296
Type:
RNA binding protein
Mass (Da):
80596
Number AA:
724
UniProt ID:
Q71RC2
International Prot ID:
IPI00043638
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
A
P
G
N
T
D
A
T
P
V
T
H
G
T
E
Site 2
T36
N
T
D
A
T
P
V
T
H
G
T
E
S
S
W
Site 3
S41
P
V
T
H
G
T
E
S
S
W
H
E
I
A
A
Site 4
T49
S
W
H
E
I
A
A
T
S
G
A
H
P
E
G
Site 5
S61
P
E
G
N
A
E
L
S
E
D
I
C
K
E
Y
Site 6
Y68
S
E
D
I
C
K
E
Y
E
V
M
Y
S
S
S
Site 7
Y72
C
K
E
Y
E
V
M
Y
S
S
S
C
E
T
T
Site 8
S73
K
E
Y
E
V
M
Y
S
S
S
C
E
T
T
R
Site 9
S74
E
Y
E
V
M
Y
S
S
S
C
E
T
T
R
N
Site 10
S75
Y
E
V
M
Y
S
S
S
C
E
T
T
R
N
T
Site 11
T78
M
Y
S
S
S
C
E
T
T
R
N
T
T
G
I
Site 12
T79
Y
S
S
S
C
E
T
T
R
N
T
T
G
I
E
Site 13
T82
S
C
E
T
T
R
N
T
T
G
I
E
E
S
T
Site 14
T83
C
E
T
T
R
N
T
T
G
I
E
E
S
T
D
Site 15
S100
I
L
G
P
E
D
L
S
Y
Q
I
Y
D
V
S
Site 16
Y101
L
G
P
E
D
L
S
Y
Q
I
Y
D
V
S
G
Site 17
Y104
E
D
L
S
Y
Q
I
Y
D
V
S
G
E
S
N
Site 18
S107
S
Y
Q
I
Y
D
V
S
G
E
S
N
S
A
V
Site 19
T116
E
S
N
S
A
V
S
T
E
D
L
K
E
C
L
Site 20
S132
K
Q
L
E
F
C
F
S
R
E
N
L
S
K
D
Site 21
Y141
E
N
L
S
K
D
L
Y
L
I
S
Q
M
D
S
Site 22
S144
S
K
D
L
Y
L
I
S
Q
M
D
S
D
Q
F
Site 23
S195
K
G
E
K
V
R
P
S
H
K
R
C
I
V
I
Site 24
T209
I
L
R
E
I
P
E
T
T
P
I
E
E
V
K
Site 25
T210
L
R
E
I
P
E
T
T
P
I
E
E
V
K
G
Site 26
S221
E
V
K
G
L
F
K
S
E
N
C
P
K
V
I
Site 27
Y254
D
A
Q
Q
A
F
K
Y
L
R
E
E
V
K
T
Site 28
T261
Y
L
R
E
E
V
K
T
F
Q
G
K
P
I
M
Site 29
T276
A
R
I
K
A
I
N
T
F
F
A
K
N
G
Y
Site 30
S288
N
G
Y
R
L
M
D
S
S
I
Y
S
H
P
I
Site 31
S289
G
Y
R
L
M
D
S
S
I
Y
S
H
P
I
Q
Site 32
Y291
R
L
M
D
S
S
I
Y
S
H
P
I
Q
T
Q
Site 33
S292
L
M
D
S
S
I
Y
S
H
P
I
Q
T
Q
A
Site 34
Y301
P
I
Q
T
Q
A
Q
Y
A
S
P
V
F
M
Q
Site 35
S303
Q
T
Q
A
Q
Y
A
S
P
V
F
M
Q
P
V
Site 36
Y311
P
V
F
M
Q
P
V
Y
N
P
H
Q
Q
Y
S
Site 37
Y320
P
H
Q
Q
Y
S
V
Y
S
I
V
P
Q
S
W
Site 38
S326
V
Y
S
I
V
P
Q
S
W
S
P
N
P
T
P
Site 39
S328
S
I
V
P
Q
S
W
S
P
N
P
T
P
Y
F
Site 40
T332
Q
S
W
S
P
N
P
T
P
Y
F
E
T
P
L
Site 41
Y334
W
S
P
N
P
T
P
Y
F
E
T
P
L
A
P
Site 42
T337
N
P
T
P
Y
F
E
T
P
L
A
P
F
P
N
Site 43
S346
L
A
P
F
P
N
G
S
F
V
N
G
F
N
S
Site 44
S353
S
F
V
N
G
F
N
S
P
G
S
Y
K
T
N
Site 45
S356
N
G
F
N
S
P
G
S
Y
K
T
N
A
A
A
Site 46
Y357
G
F
N
S
P
G
S
Y
K
T
N
A
A
A
M
Site 47
T359
N
S
P
G
S
Y
K
T
N
A
A
A
M
N
M
Site 48
S381
R
V
K
P
Q
F
R
S
S
G
G
S
E
H
S
Site 49
S382
V
K
P
Q
F
R
S
S
G
G
S
E
H
S
T
Site 50
S385
Q
F
R
S
S
G
G
S
E
H
S
T
E
G
S
Site 51
S388
S
S
G
G
S
E
H
S
T
E
G
S
V
S
L
Site 52
T389
S
G
G
S
E
H
S
T
E
G
S
V
S
L
G
Site 53
S392
S
E
H
S
T
E
G
S
V
S
L
G
D
G
Q
Site 54
S394
H
S
T
E
G
S
V
S
L
G
D
G
Q
L
N
Site 55
Y403
G
D
G
Q
L
N
R
Y
S
S
R
N
F
P
A
Site 56
S404
D
G
Q
L
N
R
Y
S
S
R
N
F
P
A
E
Site 57
S405
G
Q
L
N
R
Y
S
S
R
N
F
P
A
E
R
Site 58
T424
V
T
G
H
Q
E
Q
T
Y
L
Q
K
E
T
S
Site 59
Y425
T
G
H
Q
E
Q
T
Y
L
Q
K
E
T
S
T
Site 60
Y441
Q
V
E
Q
N
G
D
Y
G
R
G
R
R
T
L
Site 61
T447
D
Y
G
R
G
R
R
T
L
F
R
G
R
R
R
Site 62
S461
R
R
E
D
D
R
I
S
R
P
H
P
S
T
A
Site 63
S466
R
I
S
R
P
H
P
S
T
A
E
S
K
A
P
Site 64
T467
I
S
R
P
H
P
S
T
A
E
S
K
A
P
T
Site 65
S470
P
H
P
S
T
A
E
S
K
A
P
T
P
K
F
Site 66
T474
T
A
E
S
K
A
P
T
P
K
F
D
L
L
A
Site 67
S482
P
K
F
D
L
L
A
S
N
F
P
P
L
P
G
Site 68
S490
N
F
P
P
L
P
G
S
S
S
R
M
P
G
E
Site 69
S491
F
P
P
L
P
G
S
S
S
R
M
P
G
E
L
Site 70
S492
P
P
L
P
G
S
S
S
R
M
P
G
E
L
V
Site 71
S505
L
V
L
E
N
R
M
S
D
V
V
K
G
V
Y
Site 72
S523
D
N
E
E
L
T
I
S
C
P
V
P
A
D
E
Site 73
T532
P
V
P
A
D
E
Q
T
E
C
T
S
A
Q
Q
Site 74
S543
S
A
Q
Q
L
N
M
S
T
S
S
P
C
A
A
Site 75
S545
Q
Q
L
N
M
S
T
S
S
P
C
A
A
E
L
Site 76
S546
Q
L
N
M
S
T
S
S
P
C
A
A
E
L
T
Site 77
S568
E
K
D
L
I
E
D
S
S
V
Q
K
D
G
L
Site 78
S569
K
D
L
I
E
D
S
S
V
Q
K
D
G
L
N
Site 79
T578
Q
K
D
G
L
N
Q
T
T
I
P
V
S
P
P
Site 80
T579
K
D
G
L
N
Q
T
T
I
P
V
S
P
P
S
Site 81
S583
N
Q
T
T
I
P
V
S
P
P
S
T
T
K
P
Site 82
S586
T
I
P
V
S
P
P
S
T
T
K
P
S
R
A
Site 83
T587
I
P
V
S
P
P
S
T
T
K
P
S
R
A
S
Site 84
T588
P
V
S
P
P
S
T
T
K
P
S
R
A
S
T
Site 85
S591
P
P
S
T
T
K
P
S
R
A
S
T
A
S
P
Site 86
S594
T
T
K
P
S
R
A
S
T
A
S
P
C
N
N
Site 87
T595
T
K
P
S
R
A
S
T
A
S
P
C
N
N
N
Site 88
S597
P
S
R
A
S
T
A
S
P
C
N
N
N
I
N
Site 89
T607
N
N
N
I
N
A
A
T
A
V
A
L
Q
E
P
Site 90
S618
L
Q
E
P
R
K
L
S
Y
A
E
V
C
Q
K
Site 91
S632
K
P
P
K
E
P
S
S
V
L
V
Q
P
L
R
Site 92
S643
Q
P
L
R
E
L
R
S
N
V
V
S
P
T
K
Site 93
S647
E
L
R
S
N
V
V
S
P
T
K
N
E
D
N
Site 94
T649
R
S
N
V
V
S
P
T
K
N
E
D
N
G
A
Site 95
S660
D
N
G
A
P
E
N
S
V
E
K
P
H
E
K
Site 96
S673
E
K
P
E
A
R
A
S
K
D
Y
S
G
F
R
Site 97
Y676
E
A
R
A
S
K
D
Y
S
G
F
R
G
N
I
Site 98
S677
A
R
A
S
K
D
Y
S
G
F
R
G
N
I
I
Site 99
S700
R
E
Q
R
R
Q
F
S
H
R
A
I
P
Q
G
Site 100
Y717
R
R
N
G
K
E
Q
Y
V
P
P
R
S
P
K
Site 101
S722
E
Q
Y
V
P
P
R
S
P
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation