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Updated November 2019
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Protein Info
Short Name:
DEPDC2
Full Name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
Alias:
DEP domain containing 2; DEP.2; DEPD2; FLJ12987; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2; Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2; PREX2; P-Rex2
Type:
Mass (Da):
182620
Number AA:
UniProt ID:
Q70Z35
International Prot ID:
IPI00425669
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0030675
GO:0030676
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007242
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
E
D
S
R
G
D
S
R
A
E
Site 2
S9
S
E
D
S
R
G
D
S
R
A
E
S
A
K
D
Site 3
S13
R
G
D
S
R
A
E
S
A
K
D
L
E
K
Q
Site 4
S29
R
L
R
V
C
V
L
S
E
L
Q
K
T
E
R
Site 5
T34
V
L
S
E
L
Q
K
T
E
R
D
Y
V
G
T
Site 6
Y38
L
Q
K
T
E
R
D
Y
V
G
T
L
E
F
L
Site 7
T69
D
K
N
V
T
E
E
T
V
K
M
L
F
S
N
Site 8
S75
E
T
V
K
M
L
F
S
N
I
E
D
I
L
A
Site 9
Y119
F
K
D
K
F
R
I
Y
D
E
Y
C
S
N
H
Site 10
Y122
K
F
R
I
Y
D
E
Y
C
S
N
H
E
K
A
Site 11
T158
L
L
G
G
R
K
N
T
D
V
P
L
E
G
Y
Site 12
T187
L
K
E
L
L
K
R
T
P
R
K
H
S
D
Y
Site 13
S192
K
R
T
P
R
K
H
S
D
Y
A
A
V
M
E
Site 14
Y194
T
P
R
K
H
S
D
Y
A
A
V
M
E
A
L
Site 15
T242
E
G
S
N
I
T
D
T
C
T
E
M
L
M
C
Site 16
Y274
L
F
D
N
L
L
V
Y
C
K
R
K
H
R
R
Site 17
S285
K
H
R
R
L
K
N
S
K
A
S
T
D
G
H
Site 18
T289
L
K
N
S
K
A
S
T
D
G
H
R
Y
L
F
Site 19
Y294
A
S
T
D
G
H
R
Y
L
F
R
G
R
I
N
Site 20
T302
L
F
R
G
R
I
N
T
E
V
M
E
V
E
N
Site 21
T314
V
E
N
V
D
D
G
T
A
D
F
H
S
S
G
Site 22
S319
D
G
T
A
D
F
H
S
S
G
H
I
V
V
N
Site 23
T374
K
L
G
M
E
Q
D
T
W
V
M
I
S
E
Q
Site 24
Y386
S
E
Q
G
E
K
L
Y
K
M
M
C
R
Q
G
Site 25
T404
K
D
R
K
R
K
L
T
T
F
P
K
C
F
L
Site 26
T405
D
R
K
R
K
L
T
T
F
P
K
C
F
L
G
Site 27
Y460
F
K
P
E
Q
M
L
Y
R
F
R
Y
D
D
G
Site 28
Y464
Q
M
L
Y
R
F
R
Y
D
D
G
T
F
Y
P
Site 29
Y470
R
Y
D
D
G
T
F
Y
P
R
N
E
M
Q
D
Site 30
S480
N
E
M
Q
D
V
I
S
K
G
V
R
L
Y
C
Site 31
T494
C
R
L
H
S
L
F
T
P
V
I
R
D
K
D
Site 32
Y502
P
V
I
R
D
K
D
Y
H
L
R
T
Y
K
S
Site 33
Y507
K
D
Y
H
L
R
T
Y
K
S
V
V
M
A
N
Site 34
S552
M
H
H
V
L
E
K
S
E
F
K
D
E
P
L
Site 35
S565
P
L
L
F
R
F
F
S
D
E
E
M
E
G
S
Site 36
S572
S
D
E
E
M
E
G
S
N
M
K
H
R
L
M
Site 37
S598
A
K
S
L
L
I
K
S
N
E
G
S
Y
G
F
Site 38
S602
L
I
K
S
N
E
G
S
Y
G
F
G
L
E
D
Site 39
S658
E
V
D
C
F
L
K
S
C
L
N
S
R
K
P
Site 40
S662
F
L
K
S
C
L
N
S
R
K
P
L
R
V
L
Site 41
S671
K
P
L
R
V
L
V
S
T
K
P
R
E
T
V
Site 42
T672
P
L
R
V
L
V
S
T
K
P
R
E
T
V
K
Site 43
T677
V
S
T
K
P
R
E
T
V
K
I
P
D
S
A
Site 44
S683
E
T
V
K
I
P
D
S
A
D
G
L
G
F
Q
Site 45
S728
K
V
N
G
I
N
V
S
K
E
T
H
A
S
V
Site 46
T740
A
S
V
I
A
H
V
T
A
C
R
K
Y
R
R
Site 47
Y745
H
V
T
A
C
R
K
Y
R
R
P
T
K
Q
D
Site 48
T749
C
R
K
Y
R
R
P
T
K
Q
D
S
I
Q
W
Site 49
S753
R
R
P
T
K
Q
D
S
I
Q
W
V
Y
N
S
Site 50
Y758
Q
D
S
I
Q
W
V
Y
N
S
I
E
S
A
Q
Site 51
S760
S
I
Q
W
V
Y
N
S
I
E
S
A
Q
E
D
Site 52
S771
A
Q
E
D
L
Q
K
S
H
S
K
P
P
G
D
Site 53
S773
E
D
L
Q
K
S
H
S
K
P
P
G
D
E
A
Site 54
S809
D
G
K
K
E
H
V
S
L
T
V
D
N
V
H
Site 55
T811
K
K
E
H
V
S
L
T
V
D
N
V
H
L
E
Site 56
Y819
V
D
N
V
H
L
E
Y
G
V
V
Y
E
Y
D
Site 57
Y823
H
L
E
Y
G
V
V
Y
E
Y
D
S
T
A
G
Site 58
Y825
E
Y
G
V
V
Y
E
Y
D
S
T
A
G
I
K
Site 59
S859
I
L
E
A
L
A
K
S
D
E
H
F
V
Q
N
Site 60
S869
H
F
V
Q
N
C
T
S
L
N
S
L
N
E
V
Site 61
T879
S
L
N
E
V
I
P
T
D
L
Q
S
K
F
S
Site 62
S886
T
D
L
Q
S
K
F
S
A
L
C
S
E
R
I
Site 63
S890
S
K
F
S
A
L
C
S
E
R
I
E
H
L
C
Site 64
S901
E
H
L
C
Q
R
I
S
S
Y
K
K
F
S
R
Site 65
S902
H
L
C
Q
R
I
S
S
Y
K
K
F
S
R
V
Site 66
Y903
L
C
Q
R
I
S
S
Y
K
K
F
S
R
V
L
Site 67
T917
L
K
N
R
A
W
P
T
F
K
Q
A
K
S
K
Site 68
S923
P
T
F
K
Q
A
K
S
K
I
S
P
L
H
S
Site 69
S926
K
Q
A
K
S
K
I
S
P
L
H
S
S
D
F
Site 70
S930
S
K
I
S
P
L
H
S
S
D
F
C
P
T
N
Site 71
S931
K
I
S
P
L
H
S
S
D
F
C
P
T
N
C
Site 72
Y947
V
N
V
M
E
V
S
Y
P
K
T
S
T
S
L
Site 73
T950
M
E
V
S
Y
P
K
T
S
T
S
L
G
S
A
Site 74
S951
E
V
S
Y
P
K
T
S
T
S
L
G
S
A
F
Site 75
T952
V
S
Y
P
K
T
S
T
S
L
G
S
A
F
G
Site 76
S953
S
Y
P
K
T
S
T
S
L
G
S
A
F
G
V
Site 77
S964
A
F
G
V
Q
L
D
S
R
K
H
N
S
H
D
Site 78
S976
S
H
D
K
E
N
K
S
S
E
Q
G
K
L
S
Site 79
S977
H
D
K
E
N
K
S
S
E
Q
G
K
L
S
P
Site 80
S983
S
S
E
Q
G
K
L
S
P
M
V
Y
I
Q
H
Site 81
Y1013
Q
D
G
H
G
L
R
Y
L
L
K
E
E
D
L
Site 82
T1022
L
K
E
E
D
L
E
T
Q
D
I
Y
Q
K
L
Site 83
Y1026
D
L
E
T
Q
D
I
Y
Q
K
L
L
G
K
L
Site 84
S1052
C
Q
I
D
D
L
L
S
S
I
T
Y
S
P
K
Site 85
S1053
Q
I
D
D
L
L
S
S
I
T
Y
S
P
K
L
Site 86
T1055
D
D
L
L
S
S
I
T
Y
S
P
K
L
E
R
Site 87
Y1056
D
L
L
S
S
I
T
Y
S
P
K
L
E
R
K
Site 88
S1057
L
L
S
S
I
T
Y
S
P
K
L
E
R
K
T
Site 89
T1064
S
P
K
L
E
R
K
T
S
E
G
I
I
P
T
Site 90
S1065
P
K
L
E
R
K
T
S
E
G
I
I
P
T
D
Site 91
S1073
E
G
I
I
P
T
D
S
D
N
E
K
G
E
R
Site 92
S1082
N
E
K
G
E
R
N
S
K
R
V
C
F
N
V
Site 93
S1097
A
G
D
E
Q
E
D
S
G
H
D
T
I
S
N
Site 94
T1101
Q
E
D
S
G
H
D
T
I
S
N
R
D
S
Y
Site 95
S1103
D
S
G
H
D
T
I
S
N
R
D
S
Y
S
D
Site 96
S1107
D
T
I
S
N
R
D
S
Y
S
D
C
N
S
N
Site 97
Y1108
T
I
S
N
R
D
S
Y
S
D
C
N
S
N
R
Site 98
S1109
I
S
N
R
D
S
Y
S
D
C
N
S
N
R
N
Site 99
S1113
D
S
Y
S
D
C
N
S
N
R
N
S
I
A
S
Site 100
S1117
D
C
N
S
N
R
N
S
I
A
S
F
T
S
I
Site 101
S1120
S
N
R
N
S
I
A
S
F
T
S
I
C
S
S
Site 102
T1122
R
N
S
I
A
S
F
T
S
I
C
S
S
Q
C
Site 103
S1127
S
F
T
S
I
C
S
S
Q
C
S
S
Y
F
H
Site 104
S1130
S
I
C
S
S
Q
C
S
S
Y
F
H
S
D
E
Site 105
Y1132
C
S
S
Q
C
S
S
Y
F
H
S
D
E
M
D
Site 106
S1135
Q
C
S
S
Y
F
H
S
D
E
M
D
S
G
D
Site 107
S1140
F
H
S
D
E
M
D
S
G
D
E
L
P
L
S
Site 108
S1147
S
G
D
E
L
P
L
S
V
R
I
S
H
D
K
Site 109
S1151
L
P
L
S
V
R
I
S
H
D
K
Q
D
K
I
Site 110
S1160
D
K
Q
D
K
I
H
S
C
L
E
H
L
F
S
Site 111
S1167
S
C
L
E
H
L
F
S
Q
V
D
S
I
T
N
Site 112
T1173
F
S
Q
V
D
S
I
T
N
L
L
K
G
Q
A
Site 113
T1188
V
V
R
A
F
D
Q
T
K
Y
L
T
P
G
R
Site 114
Y1190
R
A
F
D
Q
T
K
Y
L
T
P
G
R
G
L
Site 115
T1192
F
D
Q
T
K
Y
L
T
P
G
R
G
L
Q
E
Site 116
S1209
Q
E
M
E
P
K
L
S
C
P
K
R
L
R
L
Site 117
S1228
D
P
W
N
L
P
S
S
V
R
T
L
A
Q
N
Site 118
T1231
N
L
P
S
S
V
R
T
L
A
Q
N
I
R
K
Site 119
S1255
L
L
A
L
L
E
Y
S
D
S
E
T
Q
L
R
Site 120
S1257
A
L
L
E
Y
S
D
S
E
T
Q
L
R
R
D
Site 121
T1259
L
E
Y
S
D
S
E
T
Q
L
R
R
D
M
V
Site 122
S1325
F
H
F
Q
S
L
L
S
P
N
L
T
D
E
Q
Site 123
T1329
S
L
L
S
P
N
L
T
D
E
Q
A
M
L
E
Site 124
S1349
L
F
D
L
E
K
V
S
F
Y
F
K
P
S
E
Site 125
Y1351
D
L
E
K
V
S
F
Y
F
K
P
S
E
E
E
Site 126
S1355
V
S
F
Y
F
K
P
S
E
E
E
P
L
V
A
Site 127
T1367
L
V
A
N
V
P
L
T
Y
Q
A
E
G
S
R
Site 128
Y1380
S
R
Q
A
L
K
V
Y
F
Y
I
D
S
Y
H
Site 129
Y1382
Q
A
L
K
V
Y
F
Y
I
D
S
Y
H
F
E
Site 130
Y1386
V
Y
F
Y
I
D
S
Y
H
F
E
Q
L
P
Q
Site 131
Y1418
A
L
E
S
M
E
G
Y
Y
Y
R
D
N
V
S
Site 132
Y1419
L
E
S
M
E
G
Y
Y
Y
R
D
N
V
S
V
Site 133
Y1420
E
S
M
E
G
Y
Y
Y
R
D
N
V
S
V
E
Site 134
S1437
Q
A
Q
I
N
A
A
S
L
E
K
V
K
Q
Y
Site 135
Y1452
N
Q
K
L
R
A
F
Y
L
D
K
S
N
S
P
Site 136
S1456
R
A
F
Y
L
D
K
S
N
S
P
P
N
S
T
Site 137
S1458
F
Y
L
D
K
S
N
S
P
P
N
S
T
S
K
Site 138
S1462
K
S
N
S
P
P
N
S
T
S
K
A
A
Y
V
Site 139
Y1468
N
S
T
S
K
A
A
Y
V
D
K
L
M
R
P
Site 140
S1488
E
L
Y
R
L
V
A
S
F
I
R
S
K
R
T
Site 141
T1537
S
S
G
V
H
R
C
T
L
S
V
T
L
E
Q
Site 142
Y1558
S
H
G
L
P
P
R
Y
I
M
Q
A
T
D
V
Site 143
T1586
N
L
G
V
R
D
R
T
P
Q
S
A
P
R
L
Site 144
S1589
V
R
D
R
T
P
Q
S
A
P
R
L
Y
K
L
Site 145
Y1594
P
Q
S
A
P
R
L
Y
K
L
C
E
P
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation