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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UNC13D
Full Name:
Protein unc-13 homolog D
Alias:
FHL3; HLH3; HPLH3; Munc13-4; UN13D; unc-13 D; Unc-13 homolog D
Type:
Mass (Da):
123282
Number AA:
1090
UniProt ID:
Q70J99
International Prot ID:
IPI00456635
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070382
GO:0019898
GO:0005770
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006887
GO:0045921
GO:0043304
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S44
A
P
E
I
Q
P
P
S
H
H
F
S
P
E
Q
Site 2
S48
Q
P
P
S
H
H
F
S
P
E
Q
R
A
L
L
Site 3
Y56
P
E
Q
R
A
L
L
Y
E
D
A
L
Y
T
V
Site 4
Y61
L
L
Y
E
D
A
L
Y
T
V
L
H
R
L
G
Site 5
T62
L
Y
E
D
A
L
Y
T
V
L
H
R
L
G
H
Site 6
Y84
E
A
S
E
L
L
R
Y
L
Q
E
A
F
H
V
Site 7
T99
E
P
E
E
H
Q
Q
T
L
Q
R
V
R
E
L
Site 8
S129
G
I
L
G
K
D
V
S
G
F
S
D
P
Y
C
Site 9
S132
G
K
D
V
S
G
F
S
D
P
Y
C
L
L
G
Site 10
Y135
V
S
G
F
S
D
P
Y
C
L
L
G
I
E
Q
Site 11
S150
G
V
G
V
P
G
G
S
P
G
S
R
H
R
Q
Site 12
S153
V
P
G
G
S
P
G
S
R
H
R
Q
K
A
V
Site 13
T164
Q
K
A
V
V
R
H
T
I
P
E
E
E
T
H
Site 14
T173
P
E
E
E
T
H
R
T
Q
V
I
T
Q
T
L
Site 15
T177
T
H
R
T
Q
V
I
T
Q
T
L
N
P
V
W
Site 16
T179
R
T
Q
V
I
T
Q
T
L
N
P
V
W
D
E
Site 17
T187
L
N
P
V
W
D
E
T
F
I
L
E
F
E
D
Site 18
T209
L
D
M
W
D
L
D
T
V
E
S
V
R
Q
K
Site 19
S212
W
D
L
D
T
V
E
S
V
R
Q
K
L
G
E
Site 20
T221
R
Q
K
L
G
E
L
T
D
L
H
G
L
R
R
Site 21
Y261
R
C
R
E
D
Q
W
Y
P
L
E
P
R
T
E
Site 22
T269
P
L
E
P
R
T
E
T
Y
P
D
R
G
Q
C
Site 23
Y270
L
E
P
R
T
E
T
Y
P
D
R
G
Q
C
H
Site 24
T289
L
I
H
K
R
R
A
T
S
A
S
R
S
Q
P
Site 25
S290
I
H
K
R
R
A
T
S
A
S
R
S
Q
P
S
Site 26
S292
K
R
R
A
T
S
A
S
R
S
Q
P
S
Y
T
Site 27
S294
R
A
T
S
A
S
R
S
Q
P
S
Y
T
V
H
Site 28
S297
S
A
S
R
S
Q
P
S
Y
T
V
H
L
H
L
Site 29
Y298
A
S
R
S
Q
P
S
Y
T
V
H
L
H
L
L
Site 30
T299
S
R
S
Q
P
S
Y
T
V
H
L
H
L
L
Q
Site 31
S310
H
L
L
Q
Q
L
V
S
H
E
V
T
Q
H
E
Site 32
T314
Q
L
V
S
H
E
V
T
Q
H
E
A
G
S
T
Site 33
S320
V
T
Q
H
E
A
G
S
T
S
W
D
G
S
L
Site 34
T321
T
Q
H
E
A
G
S
T
S
W
D
G
S
L
S
Site 35
S322
Q
H
E
A
G
S
T
S
W
D
G
S
L
S
P
Site 36
S326
G
S
T
S
W
D
G
S
L
S
P
Q
A
A
T
Site 37
S328
T
S
W
D
G
S
L
S
P
Q
A
A
T
V
L
Site 38
S345
H
A
T
Q
K
D
L
S
D
F
H
Q
S
M
A
Site 39
Y357
S
M
A
Q
W
L
A
Y
S
R
L
Y
Q
S
L
Site 40
Y361
W
L
A
Y
S
R
L
Y
Q
S
L
E
F
P
S
Site 41
S363
A
Y
S
R
L
Y
Q
S
L
E
F
P
S
S
C
Site 42
Y380
H
P
I
T
S
I
E
Y
Q
W
I
Q
G
R
L
Site 43
S398
Q
Q
E
E
L
A
A
S
F
S
S
L
L
T
Y
Site 44
Y405
S
F
S
S
L
L
T
Y
G
L
S
L
I
R
R
Site 45
S420
F
R
S
V
F
P
L
S
V
S
D
S
P
A
R
Site 46
S422
S
V
F
P
L
S
V
S
D
S
P
A
R
L
Q
Site 47
S424
F
P
L
S
V
S
D
S
P
A
R
L
Q
S
L
Site 48
T464
L
V
T
E
A
L
Q
T
G
T
T
E
W
F
H
Site 49
T541
A
K
R
V
Q
D
H
T
T
V
V
G
D
V
V
Site 50
T542
K
R
V
Q
D
H
T
T
V
V
G
D
V
V
S
Site 51
S572
E
L
C
Q
L
R
M
S
S
S
E
R
D
G
V
Site 52
S573
L
C
Q
L
R
M
S
S
S
E
R
D
G
V
L
Site 53
S574
C
Q
L
R
M
S
S
S
E
R
D
G
V
L
A
Site 54
T600
I
P
S
W
L
Q
K
T
Y
N
E
A
L
A
R
Site 55
S629
E
L
T
K
H
S
T
S
A
V
D
L
S
T
C
Site 56
S641
S
T
C
F
A
Q
I
S
H
T
A
R
Q
L
D
Site 57
S685
K
A
R
A
R
E
L
S
S
G
Q
K
D
Q
G
Site 58
T740
E
Q
G
Q
L
Q
N
T
L
H
A
Q
L
Q
S
Site 59
T762
E
I
R
T
G
V
R
T
L
A
E
Q
L
E
V
Site 60
S839
A
A
A
S
Q
R
S
S
S
L
A
S
N
R
L
Site 61
S840
A
A
S
Q
R
S
S
S
L
A
S
N
R
L
K
Site 62
S843
Q
R
S
S
S
L
A
S
N
R
L
K
I
A
L
Site 63
T873
P
K
A
L
H
T
A
T
F
Q
A
L
Q
R
D
Site 64
S887
D
L
E
L
Q
A
A
S
S
R
E
L
I
R
K
Site 65
Y895
S
R
E
L
I
R
K
Y
F
C
S
R
I
Q
Q
Site 66
T915
S
E
E
L
G
A
V
T
V
K
A
S
Y
R
A
Site 67
S919
G
A
V
T
V
K
A
S
Y
R
A
S
E
Q
K
Site 68
S923
V
K
A
S
Y
R
A
S
E
Q
K
L
R
V
E
Site 69
S942
S
S
L
L
P
L
D
S
N
G
S
S
D
P
F
Site 70
S945
L
P
L
D
S
N
G
S
S
D
P
F
V
Q
L
Site 71
S946
P
L
D
S
N
G
S
S
D
P
F
V
Q
L
T
Site 72
T953
S
D
P
F
V
Q
L
T
L
E
P
R
H
E
F
Site 73
T968
P
E
L
A
A
R
E
T
Q
K
H
K
K
D
L
Site 74
Y1006
L
L
L
T
V
L
D
Y
D
T
L
G
A
D
D
Site 75
S1029
L
R
E
V
P
G
L
S
G
S
E
E
P
G
E
Site 76
S1031
E
V
P
G
L
S
G
S
E
E
P
G
E
V
P
Site 77
T1040
E
P
G
E
V
P
Q
T
R
L
P
L
T
Y
P
Site 78
T1045
P
Q
T
R
L
P
L
T
Y
P
A
P
N
G
D
Site 79
Y1046
Q
T
R
L
P
L
T
Y
P
A
P
N
G
D
P
Site 80
S1082
R
H
R
A
K
Q
A
S
Q
H
A
L
R
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation