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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP45
Full Name:
Ubiquitin carboxyl-terminal hydrolase 45
Alias:
Deubiquitinating enzyme 45;Ubiquitin thiolesterase 45;Ubiquitin-specific-processing protease 45
Type:
Mass (Da):
91733
Number AA:
814
UniProt ID:
Q70EL2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
R
V
K
D
P
T
K
A
L
P
E
K
A
Site 2
S17
L
P
E
K
A
K
R
S
K
R
P
T
V
P
H
Site 3
T21
A
K
R
S
K
R
P
T
V
P
H
D
E
D
S
Site 4
S28
T
V
P
H
D
E
D
S
S
D
D
I
A
V
G
Site 5
S29
V
P
H
D
E
D
S
S
D
D
I
A
V
G
L
Site 6
S46
Q
H
V
S
H
A
I
S
V
N
H
V
K
R
A
Site 7
S63
E
N
L
W
S
V
C
S
E
C
L
K
E
R
R
Site 8
Y72
C
L
K
E
R
R
F
Y
D
G
Q
L
V
L
T
Site 9
S99
G
C
G
K
N
S
E
S
Q
H
S
L
K
H
F
Site 10
S102
K
N
S
E
S
Q
H
S
L
K
H
F
K
S
S
Site 11
S108
H
S
L
K
H
F
K
S
S
R
T
E
P
H
C
Site 12
T136
E
C
D
E
K
L
S
T
H
C
N
K
K
V
L
Site 13
S155
D
F
L
Q
K
H
A
S
K
T
Q
T
S
A
F
Site 14
T157
L
Q
K
H
A
S
K
T
Q
T
S
A
F
S
R
Site 15
T159
K
H
A
S
K
T
Q
T
S
A
F
S
R
I
M
Site 16
T175
L
C
E
E
K
C
E
T
D
E
I
Q
K
G
G
Site 17
S188
G
G
K
C
R
N
L
S
V
R
G
I
T
N
L
Site 18
T213
Q
N
L
A
Q
T
Y
T
L
T
D
L
M
N
E
Site 19
S233
T
K
L
K
I
F
P
S
S
D
S
Q
L
D
P
Site 20
S234
K
L
K
I
F
P
S
S
D
S
Q
L
D
P
L
Site 21
S246
D
P
L
V
V
E
L
S
R
P
G
P
L
T
S
Site 22
S261
A
L
F
L
F
L
H
S
M
K
E
T
E
K
G
Site 23
T265
F
L
H
S
M
K
E
T
E
K
G
P
L
S
P
Site 24
S271
E
T
E
K
G
P
L
S
P
K
V
L
F
N
Q
Site 25
S294
K
D
F
Q
Q
Q
D
S
Q
E
L
L
H
Y
L
Site 26
Y300
D
S
Q
E
L
L
H
Y
L
L
D
A
V
R
T
Site 27
T333
T
K
T
A
D
D
E
T
R
K
K
V
K
A
Y
Site 28
S381
K
D
P
F
I
D
I
S
L
P
I
I
E
E
R
Site 29
S390
P
I
I
E
E
R
V
S
K
P
L
L
W
G
R
Site 30
Y401
L
W
G
R
M
N
K
Y
R
S
L
R
E
T
D
Site 31
S403
G
R
M
N
K
Y
R
S
L
R
E
T
D
H
D
Site 32
T407
K
Y
R
S
L
R
E
T
D
H
D
R
Y
S
G
Site 33
Y412
R
E
T
D
H
D
R
Y
S
G
N
V
T
I
E
Site 34
S413
E
T
D
H
D
R
Y
S
G
N
V
T
I
E
N
Site 35
T417
D
R
Y
S
G
N
V
T
I
E
N
I
H
Q
P
Site 36
S432
R
A
A
K
K
H
S
S
S
K
D
K
S
Q
L
Site 37
S433
A
A
K
K
H
S
S
S
K
D
K
S
Q
L
I
Site 38
S437
H
S
S
S
K
D
K
S
Q
L
I
H
D
R
K
Site 39
S450
R
K
C
I
R
K
L
S
S
G
E
T
V
T
Y
Site 40
T454
R
K
L
S
S
G
E
T
V
T
Y
Q
K
N
E
Site 41
Y457
S
S
G
E
T
V
T
Y
Q
K
N
E
N
L
E
Site 42
S474
G
D
S
L
M
F
A
S
L
M
N
S
E
S
R
Site 43
S478
M
F
A
S
L
M
N
S
E
S
R
L
N
E
S
Site 44
S480
A
S
L
M
N
S
E
S
R
L
N
E
S
P
T
Site 45
S485
S
E
S
R
L
N
E
S
P
T
D
D
S
E
K
Site 46
T487
S
R
L
N
E
S
P
T
D
D
S
E
K
E
A
Site 47
S490
N
E
S
P
T
D
D
S
E
K
E
A
S
H
S
Site 48
S495
D
D
S
E
K
E
A
S
H
S
E
S
N
V
D
Site 49
S497
S
E
K
E
A
S
H
S
E
S
N
V
D
A
D
Site 50
S499
K
E
A
S
H
S
E
S
N
V
D
A
D
S
E
Site 51
S505
E
S
N
V
D
A
D
S
E
P
S
E
S
E
S
Site 52
S508
V
D
A
D
S
E
P
S
E
S
E
S
A
S
K
Site 53
S510
A
D
S
E
P
S
E
S
E
S
A
S
K
Q
T
Site 54
S512
S
E
P
S
E
S
E
S
A
S
K
Q
T
G
L
Site 55
S514
P
S
E
S
E
S
A
S
K
Q
T
G
L
F
R
Site 56
S522
K
Q
T
G
L
F
R
S
S
S
G
S
G
V
Q
Site 57
S523
Q
T
G
L
F
R
S
S
S
G
S
G
V
Q
P
Site 58
S524
T
G
L
F
R
S
S
S
G
S
G
V
Q
P
D
Site 59
S526
L
F
R
S
S
S
G
S
G
V
Q
P
D
G
P
Site 60
Y535
V
Q
P
D
G
P
L
Y
P
L
S
A
G
K
L
Site 61
T545
S
A
G
K
L
L
Y
T
K
E
T
D
S
G
D
Site 62
S550
L
Y
T
K
E
T
D
S
G
D
K
E
M
A
E
Site 63
S560
K
E
M
A
E
A
I
S
E
L
R
L
S
S
T
Site 64
S565
A
I
S
E
L
R
L
S
S
T
V
T
G
D
Q
Site 65
S566
I
S
E
L
R
L
S
S
T
V
T
G
D
Q
D
Site 66
T567
S
E
L
R
L
S
S
T
V
T
G
D
Q
D
F
Site 67
Y598
E
G
K
H
L
R
S
Y
S
P
Q
N
A
F
Q
Site 68
S599
G
K
H
L
R
S
Y
S
P
Q
N
A
F
Q
T
Site 69
T606
S
P
Q
N
A
F
Q
T
L
S
Q
S
Y
I
T
Site 70
S608
Q
N
A
F
Q
T
L
S
Q
S
Y
I
T
T
S
Site 71
S610
A
F
Q
T
L
S
Q
S
Y
I
T
T
S
K
E
Site 72
T614
L
S
Q
S
Y
I
T
T
S
K
E
C
S
I
Q
Site 73
S615
S
Q
S
Y
I
T
T
S
K
E
C
S
I
Q
S
Site 74
S622
S
K
E
C
S
I
Q
S
C
L
Y
Q
F
T
S
Site 75
Y651
C
T
K
N
K
Q
K
Y
Q
E
E
T
S
F
A
Site 76
S656
Q
K
Y
Q
E
E
T
S
F
A
E
K
K
V
E
Site 77
Y666
E
K
K
V
E
G
V
Y
T
N
A
R
K
Q
L
Site 78
T667
K
K
V
E
G
V
Y
T
N
A
R
K
Q
L
L
Site 79
S695
R
F
H
Q
A
G
L
S
L
R
K
V
N
R
H
Site 80
S741
G
I
V
E
H
S
G
S
M
R
E
G
H
Y
T
Site 81
T748
S
M
R
E
G
H
Y
T
A
Y
V
K
V
R
T
Site 82
Y750
R
E
G
H
Y
T
A
Y
V
K
V
R
T
P
S
Site 83
T755
T
A
Y
V
K
V
R
T
P
S
R
K
L
S
E
Site 84
S757
Y
V
K
V
R
T
P
S
R
K
L
S
E
H
N
Site 85
S761
R
T
P
S
R
K
L
S
E
H
N
T
K
K
K
Site 86
T765
R
K
L
S
E
H
N
T
K
K
K
N
V
P
G
Site 87
S778
P
G
L
K
A
A
D
S
E
S
A
G
Q
W
V
Site 88
S780
L
K
A
A
D
S
E
S
A
G
Q
W
V
H
V
Site 89
Y791
W
V
H
V
S
D
T
Y
L
Q
V
V
P
E
S
Site 90
S798
Y
L
Q
V
V
P
E
S
R
A
L
S
A
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation