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Updated November 2019
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Protein Info
Short Name:
VPS13C
Full Name:
Vacuolar protein sorting-associated protein 13C
Alias:
VP13C
Type:
Unknown function
Mass (Da):
422390
Number AA:
3753
UniProt ID:
Q709C8
International Prot ID:
IPI00465428
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0008104
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
L
N
R
F
L
G
D
Y
V
E
N
L
N
K
S
Site 2
S25
Y
V
E
N
L
N
K
S
Q
L
K
L
G
I
W
Site 3
S49
Q
I
K
E
N
A
L
S
E
L
D
V
P
F
K
Site 4
T66
A
G
Q
I
D
K
L
T
L
K
I
P
W
K
N
Site 5
Y98
V
P
G
A
S
I
K
Y
D
A
V
K
E
E
K
Site 6
S106
D
A
V
K
E
E
K
S
L
Q
D
V
K
Q
K
Site 7
Y144
Y
G
L
E
N
F
V
Y
K
D
I
K
P
G
R
Site 8
S170
P
F
K
G
L
D
R
S
K
D
K
P
K
E
A
Site 9
T181
P
K
E
A
K
K
D
T
F
V
E
K
L
A
T
Site 10
T188
T
F
V
E
K
L
A
T
Q
V
I
K
N
V
Q
Site 11
Y205
I
T
D
I
H
I
K
Y
E
D
D
V
T
D
P
Site 12
T210
I
K
Y
E
D
D
V
T
D
P
K
R
P
L
S
Site 13
S217
T
D
P
K
R
P
L
S
F
G
V
T
L
G
E
Site 14
T235
L
T
A
N
E
H
W
T
P
C
I
L
N
E
A
Site 15
S254
Y
K
L
I
R
L
D
S
L
S
A
Y
W
N
V
Site 16
Y258
R
L
D
S
L
S
A
Y
W
N
V
N
C
S
M
Site 17
Y267
N
V
N
C
S
M
S
Y
Q
R
S
R
E
Q
I
Site 18
S270
C
S
M
S
Y
Q
R
S
R
E
Q
I
L
D
Q
Site 19
S285
L
K
N
E
I
L
T
S
G
N
I
P
P
N
Y
Site 20
Y292
S
G
N
I
P
P
N
Y
Q
Y
I
F
Q
P
I
Site 21
Y306
I
S
A
S
A
K
L
Y
M
N
P
Y
A
E
S
Site 22
Y310
A
K
L
Y
M
N
P
Y
A
E
S
E
L
K
T
Site 23
T317
Y
A
E
S
E
L
K
T
P
K
L
D
C
N
I
Site 24
T334
Q
N
I
A
I
E
L
T
K
P
Q
Y
L
S
M
Site 25
S340
L
T
K
P
Q
Y
L
S
M
I
D
L
L
E
S
Site 26
Y350
D
L
L
E
S
V
D
Y
M
V
R
N
A
P
Y
Site 27
Y360
R
N
A
P
Y
R
K
Y
K
P
Y
L
P
L
H
Site 28
Y363
P
Y
R
K
Y
K
P
Y
L
P
L
H
T
N
G
Site 29
Y376
N
G
R
R
W
W
K
Y
A
I
D
S
V
L
E
Site 30
S407
K
H
R
Q
L
L
K
S
Y
K
I
A
Y
K
N
Site 31
T417
I
A
Y
K
N
K
L
T
Q
S
K
V
S
E
E
Site 32
S419
Y
K
N
K
L
T
Q
S
K
V
S
E
E
I
Q
Site 33
S463
G
Q
K
L
R
K
K
S
A
D
T
G
E
K
R
Site 34
T466
L
R
K
K
S
A
D
T
G
E
K
R
G
G
W
Site 35
S475
E
K
R
G
G
W
F
S
G
L
W
G
K
K
E
Site 36
S490
S
K
K
K
D
E
E
S
L
I
P
E
T
I
D
Site 37
T501
E
T
I
D
D
L
M
T
P
E
E
K
D
K
L
Site 38
S515
L
F
T
A
I
G
Y
S
E
S
T
H
N
L
T
Site 39
S517
T
A
I
G
Y
S
E
S
T
H
N
L
T
L
P
Site 40
T522
S
E
S
T
H
N
L
T
L
P
K
Q
Y
V
A
Site 41
S540
T
L
K
L
V
S
T
S
V
T
I
R
E
N
K
Site 42
T542
K
L
V
S
T
S
V
T
I
R
E
N
K
N
I
Site 43
S565
I
G
L
G
T
Q
V
S
Q
R
P
G
A
Q
A
Site 44
S595
R
Q
Q
D
I
V
P
S
L
V
A
S
I
G
D
Site 45
S606
S
I
G
D
T
T
S
S
L
L
K
I
K
F
E
Site 46
T614
L
L
K
I
K
F
E
T
N
P
E
D
S
P
A
Site 47
S619
F
E
T
N
P
E
D
S
P
A
D
Q
T
L
I
Site 48
T624
E
D
S
P
A
D
Q
T
L
I
V
Q
S
Q
P
Site 49
Y636
S
Q
P
V
E
V
I
Y
D
A
K
T
V
N
A
Site 50
T676
E
I
K
E
R
T
A
T
G
L
T
H
I
I
E
Site 51
Y698
R
I
N
L
K
P
S
Y
L
V
V
P
Q
T
G
Site 52
T704
S
Y
L
V
V
P
Q
T
G
F
H
H
E
K
S
Site 53
S711
T
G
F
H
H
E
K
S
D
L
L
I
L
D
F
Site 54
S725
F
G
T
F
Q
L
N
S
K
D
Q
G
L
Q
K
Site 55
T733
K
D
Q
G
L
Q
K
T
T
N
S
S
L
E
E
Site 56
T734
D
Q
G
L
Q
K
T
T
N
S
S
L
E
E
I
Site 57
S736
G
L
Q
K
T
T
N
S
S
L
E
E
I
M
D
Site 58
S737
L
Q
K
T
T
N
S
S
L
E
E
I
M
D
K
Site 59
Y746
E
E
I
M
D
K
A
Y
D
K
F
D
V
E
I
Site 60
S818
P
L
M
H
V
R
I
S
D
Q
K
M
K
D
V
Site 61
S831
D
V
L
Y
L
M
N
S
I
P
L
P
Q
K
S
Site 62
S838
S
I
P
L
P
Q
K
S
S
A
Q
S
P
E
R
Site 63
S839
I
P
L
P
Q
K
S
S
A
Q
S
P
E
R
Q
Site 64
S842
P
Q
K
S
S
A
Q
S
P
E
R
Q
V
S
S
Site 65
S848
Q
S
P
E
R
Q
V
S
S
I
P
I
I
S
G
Site 66
S849
S
P
E
R
Q
V
S
S
I
P
I
I
S
G
G
Site 67
T869
G
T
S
L
L
L
D
T
V
E
S
E
S
D
D
Site 68
S872
L
L
L
D
T
V
E
S
E
S
D
D
E
Y
F
Site 69
Y878
E
S
E
S
D
D
E
Y
F
D
A
E
D
G
E
Site 70
S891
G
E
P
Q
T
C
K
S
M
K
G
S
E
L
K
Site 71
S895
T
C
K
S
M
K
G
S
E
L
K
K
A
A
E
Site 72
T944
F
N
V
T
Q
L
G
T
E
A
T
M
R
T
F
Site 73
T947
T
Q
L
G
T
E
A
T
M
R
T
F
D
L
T
Site 74
T950
G
T
E
A
T
M
R
T
F
D
L
T
V
V
S
Site 75
T954
T
M
R
T
F
D
L
T
V
V
S
Y
L
K
K
Site 76
S957
T
F
D
L
T
V
V
S
Y
L
K
K
I
S
L
Site 77
S963
V
S
Y
L
K
K
I
S
L
D
Y
H
E
I
E
Site 78
Y966
L
K
K
I
S
L
D
Y
H
E
I
E
G
S
K
Site 79
S972
D
Y
H
E
I
E
G
S
K
R
K
P
L
H
L
Site 80
S981
R
K
P
L
H
L
I
S
S
S
D
K
P
G
L
Site 81
S982
K
P
L
H
L
I
S
S
S
D
K
P
G
L
D
Site 82
S983
P
L
H
L
I
S
S
S
D
K
P
G
L
D
L
Site 83
S1004
K
A
D
K
N
G
P
S
F
Q
T
A
F
G
K
Site 84
T1015
A
F
G
K
T
E
Q
T
V
K
V
A
F
S
S
Site 85
T1041
A
S
I
N
Y
L
T
T
I
I
P
S
D
D
Q
Site 86
S1049
I
I
P
S
D
D
Q
S
I
S
V
A
K
E
V
Site 87
S1051
P
S
D
D
Q
S
I
S
V
A
K
E
V
Q
I
Site 88
S1059
V
A
K
E
V
Q
I
S
T
E
K
Q
Q
K
N
Site 89
S1114
I
K
I
Q
G
L
D
S
S
L
S
L
Q
S
R
Site 90
S1115
K
I
Q
G
L
D
S
S
L
S
L
Q
S
R
K
Site 91
S1117
Q
G
L
D
S
S
L
S
L
Q
S
R
K
Q
S
Site 92
S1120
D
S
S
L
S
L
Q
S
R
K
Q
S
L
F
A
Site 93
S1124
S
L
Q
S
R
K
Q
S
L
F
A
R
L
E
N
Site 94
T1141
V
T
D
V
D
P
K
T
V
H
K
K
A
V
S
Site 95
Y1162
F
R
F
N
L
D
L
Y
P
D
A
T
E
G
D
Site 96
T1166
L
D
L
Y
P
D
A
T
E
G
D
L
Y
T
D
Site 97
Y1171
D
A
T
E
G
D
L
Y
T
D
M
S
K
V
D
Site 98
T1172
A
T
E
G
D
L
Y
T
D
M
S
K
V
D
G
Site 99
S1175
G
D
L
Y
T
D
M
S
K
V
D
G
V
L
S
Site 100
T1209
N
F
L
N
N
F
Q
T
A
K
E
S
L
S
A
Site 101
S1213
N
F
Q
T
A
K
E
S
L
S
A
A
T
A
Q
Site 102
T1227
Q
A
A
E
R
A
A
T
S
V
K
D
L
A
Q
Site 103
S1236
V
K
D
L
A
Q
R
S
F
R
V
S
I
N
I
Site 104
S1240
A
Q
R
S
F
R
V
S
I
N
I
D
L
K
A
Site 105
S1276
I
R
V
H
N
Q
F
S
L
V
S
D
E
D
Y
Site 106
S1279
H
N
Q
F
S
L
V
S
D
E
D
Y
L
N
P
Site 107
Y1283
S
L
V
S
D
E
D
Y
L
N
P
P
V
I
D
Site 108
Y1302
Q
L
T
K
L
T
L
Y
R
T
V
I
Q
P
G
Site 109
Y1336
R
N
L
A
A
S
W
Y
H
K
V
P
V
V
E
Site 110
S1350
E
I
K
G
H
L
D
S
M
N
V
S
L
N
Q
Site 111
S1354
H
L
D
S
M
N
V
S
L
N
Q
E
D
L
N
Site 112
S1398
I
K
E
P
L
E
I
S
I
S
Q
D
V
H
D
Site 113
S1400
E
P
L
E
I
S
I
S
Q
D
V
H
D
S
K
Site 114
S1406
I
S
Q
D
V
H
D
S
K
N
T
L
T
T
G
Site 115
T1437
E
I
K
E
V
V
V
T
L
M
K
K
S
E
K
Site 116
S1442
V
V
T
L
M
K
K
S
E
K
K
G
R
P
L
Site 117
T1469
K
V
K
T
Y
D
M
T
A
K
A
Y
L
K
K
Site 118
Y1473
Y
D
M
T
A
K
A
Y
L
K
K
I
S
M
Q
Site 119
T1485
S
M
Q
C
F
D
F
T
D
S
K
G
E
P
L
Site 120
S1497
E
P
L
H
I
I
N
S
S
N
V
T
D
E
P
Site 121
T1501
I
I
N
S
S
N
V
T
D
E
P
L
L
K
M
Site 122
T1511
P
L
L
K
M
L
L
T
K
A
D
S
D
G
P
Site 123
S1515
M
L
L
T
K
A
D
S
D
G
P
E
F
K
T
Site 124
T1522
S
D
G
P
E
F
K
T
I
H
D
S
T
K
Q
Site 125
S1526
E
F
K
T
I
H
D
S
T
K
Q
R
L
K
V
Site 126
S1561
L
S
S
A
A
P
F
S
E
P
S
S
S
E
K
Site 127
S1564
A
A
P
F
S
E
P
S
S
S
E
K
E
S
E
Site 128
S1565
A
P
F
S
E
P
S
S
S
E
K
E
S
E
L
Site 129
S1566
P
F
S
E
P
S
S
S
E
K
E
S
E
L
K
Site 130
S1570
P
S
S
S
E
K
E
S
E
L
K
P
L
V
G
Site 131
S1588
S
I
A
V
K
A
V
S
S
N
I
S
Q
K
D
Site 132
S1592
K
A
V
S
S
N
I
S
Q
K
D
V
F
D
L
Site 133
S1630
K
I
H
G
M
D
A
S
I
S
V
K
P
K
Q
Site 134
S1632
H
G
M
D
A
S
I
S
V
K
P
K
Q
T
D
Site 135
S1656
V
M
N
V
D
L
Q
S
I
H
K
K
A
V
S
Site 136
S1663
S
I
H
K
K
A
V
S
I
L
G
D
E
V
F
Site 137
T1675
E
V
F
R
F
Q
L
T
L
Y
P
D
A
T
E
Site 138
Y1677
F
R
F
Q
L
T
L
Y
P
D
A
T
E
G
E
Site 139
T1681
L
T
L
Y
P
D
A
T
E
G
E
A
Y
A
D
Site 140
Y1686
D
A
T
E
G
E
A
Y
A
D
M
S
K
V
D
Site 141
S1690
G
E
A
Y
A
D
M
S
K
V
D
G
K
L
S
Site 142
S1697
S
K
V
D
G
K
L
S
F
K
V
G
C
I
Q
Site 143
S1730
Q
T
A
K
E
A
L
S
T
A
T
V
Q
A
A
Site 144
S1742
Q
A
A
E
R
A
A
S
S
M
K
D
L
A
Q
Site 145
S1751
M
K
D
L
A
Q
K
S
F
R
L
L
M
D
I
Site 146
S1791
I
R
V
E
N
K
F
S
L
V
P
M
E
H
Y
Site 147
T1812
D
K
M
N
I
E
L
T
Q
L
K
L
S
R
T
Site 148
S1817
E
L
T
Q
L
K
L
S
R
T
I
L
Q
A
S
Site 149
T1876
A
L
S
E
D
D
L
T
V
L
M
K
I
L
L
Site 150
S1890
L
E
N
L
G
E
A
S
S
Q
P
S
P
T
Q
Site 151
S1891
E
N
L
G
E
A
S
S
Q
P
S
P
T
Q
S
Site 152
S1894
G
E
A
S
S
Q
P
S
P
T
Q
S
V
Q
E
Site 153
S1898
S
Q
P
S
P
T
Q
S
V
Q
E
T
V
R
V
Site 154
T1902
P
T
Q
S
V
Q
E
T
V
R
V
R
K
V
D
Site 155
S1911
R
V
R
K
V
D
V
S
S
V
P
D
H
L
K
Site 156
S1912
V
R
K
V
D
V
S
S
V
P
D
H
L
K
E
Site 157
T1924
L
K
E
Q
E
D
W
T
D
S
K
L
S
M
N
Site 158
S1929
D
W
T
D
S
K
L
S
M
N
Q
I
V
S
L
Site 159
Y1950
E
S
L
S
I
I
L
Y
N
N
D
I
N
Q
E
Site 160
S1966
G
V
A
F
H
N
D
S
F
Q
L
G
E
L
R
Site 161
S1979
L
R
L
H
L
M
A
S
S
G
K
M
F
K
D
Site 162
S1980
R
L
H
L
M
A
S
S
G
K
M
F
K
D
G
Site 163
S1988
G
K
M
F
K
D
G
S
M
N
V
S
V
K
L
Site 164
S1992
K
D
G
S
M
N
V
S
V
K
L
K
T
C
T
Site 165
T1999
S
V
K
L
K
T
C
T
L
D
D
L
R
E
G
Site 166
T2011
R
E
G
I
E
R
A
T
S
R
M
I
D
R
K
Site 167
S2012
E
G
I
E
R
A
T
S
R
M
I
D
R
K
N
Site 168
S2025
K
N
D
Q
D
N
N
S
S
M
I
D
I
S
Y
Site 169
Y2032
S
S
M
I
D
I
S
Y
K
Q
D
K
N
G
S
Site 170
S2071
F
I
K
A
V
P
Q
S
P
E
N
V
A
K
E
Site 171
T2086
T
Q
I
L
P
R
Q
T
A
T
G
K
V
K
I
Site 172
S2098
V
K
I
E
K
D
D
S
V
R
P
N
M
T
L
Site 173
S2137
A
S
F
Q
C
N
L
S
L
S
T
S
K
L
E
Site 174
S2139
F
Q
C
N
L
S
L
S
T
S
K
L
E
Q
M
Site 175
S2141
C
N
L
S
L
S
T
S
K
L
E
Q
M
M
E
Site 176
T2171
E
K
R
G
K
N
I
T
T
V
L
Q
P
C
S
Site 177
T2172
K
R
G
K
N
I
T
T
V
L
Q
P
C
S
L
Site 178
S2220
L
T
I
M
A
A
L
S
P
K
T
K
E
D
G
Site 179
T2223
M
A
A
L
S
P
K
T
K
E
D
G
S
K
D
Site 180
S2228
P
K
T
K
E
D
G
S
K
D
T
S
K
E
M
Site 181
S2232
E
D
G
S
K
D
T
S
K
E
M
E
N
L
W
Site 182
Y2247
G
I
K
S
I
N
D
Y
N
T
W
F
L
G
V
Site 183
S2263
T
A
T
E
I
T
E
S
F
K
G
I
E
H
S
Site 184
S2270
S
F
K
G
I
E
H
S
L
I
E
E
N
C
G
Site 185
T2286
V
V
E
S
I
Q
V
T
L
E
C
G
L
G
H
Site 186
S2314
G
N
I
K
N
W
T
S
L
M
A
A
V
A
D
Site 187
S2364
K
N
P
V
Q
D
K
S
L
L
P
G
D
D
F
Site 188
T2390
S
G
N
T
M
N
I
T
I
S
K
S
C
L
N
Site 189
S2407
N
N
L
A
K
G
F
S
E
G
T
A
S
T
F
Site 190
S2412
G
F
S
E
G
T
A
S
T
F
D
Y
S
L
K
Site 191
T2413
F
S
E
G
T
A
S
T
F
D
Y
S
L
K
D
Site 192
Y2416
G
T
A
S
T
F
D
Y
S
L
K
D
R
A
P
Site 193
Y2466
G
Q
N
L
E
L
E
Y
A
S
M
V
P
S
S
Site 194
S2468
N
L
E
L
E
Y
A
S
M
V
P
S
S
Q
G
Site 195
S2472
E
Y
A
S
M
V
P
S
S
Q
G
N
L
S
I
Site 196
S2473
Y
A
S
M
V
P
S
S
Q
G
N
L
S
I
L
Site 197
S2478
P
S
S
Q
G
N
L
S
I
L
S
R
Q
E
S
Site 198
S2481
Q
G
N
L
S
I
L
S
R
Q
E
S
S
F
F
Site 199
S2485
S
I
L
S
R
Q
E
S
S
F
F
T
L
T
I
Site 200
S2486
I
L
S
R
Q
E
S
S
F
F
T
L
T
I
V
Site 201
T2489
R
Q
E
S
S
F
F
T
L
T
I
V
P
H
G
Site 202
Y2513
A
R
P
G
R
R
L
Y
N
V
R
N
P
N
A
Site 203
S2521
N
V
R
N
P
N
A
S
H
S
D
S
V
L
V
Site 204
S2523
R
N
P
N
A
S
H
S
D
S
V
L
V
Q
I
Site 205
S2525
P
N
A
S
H
S
D
S
V
L
V
Q
I
D
A
Site 206
T2540
T
E
G
N
K
V
I
T
L
R
S
P
L
Q
I
Site 207
S2543
N
K
V
I
T
L
R
S
P
L
Q
I
K
N
H
Site 208
Y2602
A
G
I
L
E
H
Q
Y
K
E
S
T
T
Y
I
Site 209
Y2608
Q
Y
K
E
S
T
T
Y
I
S
W
K
E
E
L
Site 210
S2610
K
E
S
T
T
Y
I
S
W
K
E
E
L
H
R
Site 211
Y2650
A
L
P
D
E
L
S
Y
I
C
T
H
G
E
D
Site 212
Y2662
G
E
D
W
D
V
A
Y
I
I
H
L
Y
P
S
Site 213
Y2678
T
L
R
N
L
L
P
Y
S
L
R
Y
L
L
E
Site 214
S2697
T
H
E
L
A
E
G
S
T
A
D
V
L
H
S
Site 215
S2704
S
T
A
D
V
L
H
S
R
I
S
G
E
I
M
Site 216
Y2718
M
E
L
V
L
V
K
Y
Q
G
K
N
W
N
G
Site 217
T2732
G
H
F
R
I
R
D
T
L
P
E
F
F
P
V
Site 218
S2745
P
V
C
F
S
S
D
S
T
E
V
T
T
V
D
Site 219
T2749
S
S
D
S
T
E
V
T
T
V
D
L
S
V
H
Site 220
T2750
S
D
S
T
E
V
T
T
V
D
L
S
V
H
V
Site 221
S2821
N
K
V
Q
L
K
I
S
T
S
A
W
S
S
S
Site 222
T2822
K
V
Q
L
K
I
S
T
S
A
W
S
S
S
F
Site 223
S2823
V
Q
L
K
I
S
T
S
A
W
S
S
S
F
S
Site 224
S2826
K
I
S
T
S
A
W
S
S
S
F
S
L
D
T
Site 225
S2828
S
T
S
A
W
S
S
S
F
S
L
D
T
V
G
Site 226
S2830
S
A
W
S
S
S
F
S
L
D
T
V
G
S
Y
Site 227
S2889
L
E
V
G
E
I
A
S
D
G
S
M
P
T
N
Site 228
Y2900
M
P
T
N
K
W
N
Y
I
A
S
S
E
C
L
Site 229
S2928
R
V
V
G
C
E
G
S
S
K
P
F
F
Y
N
Site 230
Y2934
G
S
S
K
P
F
F
Y
N
R
Q
D
N
G
T
Site 231
T2941
Y
N
R
Q
D
N
G
T
L
L
S
L
E
D
L
Site 232
S2944
Q
D
N
G
T
L
L
S
L
E
D
L
N
G
G
Site 233
T2963
V
N
T
A
E
H
S
T
V
I
T
F
S
D
Y
Site 234
T2966
A
E
H
S
T
V
I
T
F
S
D
Y
H
E
G
Site 235
S2968
H
S
T
V
I
T
F
S
D
Y
H
E
G
S
A
Site 236
Y2970
T
V
I
T
F
S
D
Y
H
E
G
S
A
P
A
Site 237
T2989
H
T
P
W
D
I
L
T
Y
K
Q
S
G
S
P
Site 238
S2993
D
I
L
T
Y
K
Q
S
G
S
P
E
E
M
V
Site 239
S2995
L
T
Y
K
Q
S
G
S
P
E
E
M
V
L
L
Site 240
T3015
L
F
A
W
A
D
P
T
G
T
R
K
L
T
W
Site 241
T3021
P
T
G
T
R
K
L
T
W
T
Y
A
A
N
V
Site 242
T3023
G
T
R
K
L
T
W
T
Y
A
A
N
V
G
E
Site 243
Y3024
T
R
K
L
T
W
T
Y
A
A
N
V
G
E
H
Site 244
Y3043
D
G
C
G
Q
F
P
Y
D
A
N
I
Q
I
H
Site 245
Y3085
E
E
M
E
Q
A
D
Y
E
I
T
L
S
L
H
Site 246
T3088
E
Q
A
D
Y
E
I
T
L
S
L
H
S
L
G
Site 247
S3097
S
L
H
S
L
G
L
S
L
V
N
N
E
S
K
Site 248
S3103
L
S
L
V
N
N
E
S
K
Q
E
V
S
Y
I
Site 249
Y3109
E
S
K
Q
E
V
S
Y
I
G
I
T
S
S
G
Site 250
S3131
K
Q
K
W
K
P
F
S
Q
K
Q
I
I
L
L
Site 251
S3141
Q
I
I
L
L
E
Q
S
Y
Q
K
H
Q
I
S
Site 252
Y3142
I
I
L
L
E
Q
S
Y
Q
K
H
Q
I
S
R
Site 253
S3177
E
M
R
L
P
I
R
S
P
I
K
R
D
F
L
Site 254
S3185
P
I
K
R
D
F
L
S
G
I
Q
I
E
F
K
Site 255
S3194
I
Q
I
E
F
K
Q
S
S
H
Q
R
S
L
R
Site 256
S3195
Q
I
E
F
K
Q
S
S
H
Q
R
S
L
R
A
Site 257
S3199
K
Q
S
S
H
Q
R
S
L
R
A
R
L
Y
W
Site 258
Y3205
R
S
L
R
A
R
L
Y
W
L
Q
V
D
N
Q
Site 259
S3230
H
P
V
A
P
P
K
S
I
A
L
D
S
E
P
Site 260
S3235
P
K
S
I
A
L
D
S
E
P
K
P
F
I
D
Site 261
S3244
P
K
P
F
I
D
V
S
V
I
T
R
F
N
E
Site 262
Y3252
V
I
T
R
F
N
E
Y
S
K
V
L
Q
F
K
Site 263
T3288
I
A
L
F
T
P
T
T
D
P
E
A
E
R
R
Site 264
T3297
P
E
A
E
R
R
R
T
K
L
I
Q
Q
D
I
Site 265
S3320
E
T
S
M
T
D
M
S
I
L
S
F
F
E
H
Site 266
S3340
V
K
L
H
L
S
L
S
L
G
S
G
G
E
E
Site 267
S3348
L
G
S
G
G
E
E
S
D
K
E
K
Q
E
M
Site 268
Y3392
Y
E
I
R
Y
Q
F
Y
K
R
D
Q
L
I
W
Site 269
S3400
K
R
D
Q
L
I
W
S
V
V
R
H
Y
S
E
Site 270
Y3405
I
W
S
V
V
R
H
Y
S
E
Q
F
L
K
Q
Site 271
S3406
W
S
V
V
R
H
Y
S
E
Q
F
L
K
Q
M
Site 272
Y3498
A
I
T
M
D
K
E
Y
Q
Q
K
R
R
E
E
Site 273
S3507
Q
K
R
R
E
E
L
S
R
Q
P
R
D
F
G
Site 274
S3516
Q
P
R
D
F
G
D
S
L
A
R
G
G
K
G
Site 275
S3587
G
I
Q
R
A
A
E
S
T
E
E
V
S
S
L
Site 276
T3588
I
Q
R
A
A
E
S
T
E
E
V
S
S
L
R
Site 277
S3593
E
S
T
E
E
V
S
S
L
R
P
P
R
L
I
Site 278
Y3609
E
D
G
I
I
R
P
Y
D
R
Q
E
S
E
G
Site 279
S3614
R
P
Y
D
R
Q
E
S
E
G
S
D
L
L
E
Site 280
S3617
D
R
Q
E
S
E
G
S
D
L
L
E
N
H
I
Site 281
Y3632
K
K
L
E
G
E
T
Y
R
Y
H
C
A
I
P
Site 282
Y3634
L
E
G
E
T
Y
R
Y
H
C
A
I
P
G
S
Site 283
S3641
Y
H
C
A
I
P
G
S
K
K
T
I
L
M
V
Site 284
T3649
K
K
T
I
L
M
V
T
N
R
R
V
L
C
I
Site 285
S3681
E
D
F
V
F
P
P
S
V
S
E
N
V
L
K
Site 286
S3690
S
E
N
V
L
K
I
S
V
K
E
Q
G
L
F
Site 287
Y3712
Q
G
C
V
R
K
V
Y
L
K
D
T
A
T
A
Site 288
T3716
R
K
V
Y
L
K
D
T
A
T
A
E
R
A
C
Site 289
T3718
V
Y
L
K
D
T
A
T
A
E
R
A
C
N
A
Site 290
S3731
N
A
I
E
D
A
Q
S
T
R
Q
Q
Q
K
L
Site 291
S3743
Q
K
L
M
K
Q
S
S
V
R
L
L
R
P
Q
Site 292
S3753
L
L
R
P
Q
L
P
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation