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Updated November 2019
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Protein Info
Short Name:
CMYA1
Full Name:
Xin actin-binding repeat-containing protein 1
Alias:
Cardiomyopathy associated protein 1; Cardiomyopathy-associated protein 1; DKFZp451D042; Xin; Xin A; Xin actin-binding repeat containing 1; XIRP1
Type:
Adhesion
Mass (Da):
198561
Number AA:
1843
UniProt ID:
Q702N8
International Prot ID:
IPI00793675
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
T
Q
T
Q
V
A
P
T
P
T
M
R
M
A
T
Site 2
T18
T
P
T
M
R
M
A
T
A
E
D
L
P
L
P
Site 3
S41
P
L
P
P
P
K
E
S
F
S
K
F
H
Q
Q
Site 4
S52
F
H
Q
Q
R
Q
A
S
E
L
R
R
L
Y
R
Site 5
Y58
A
S
E
L
R
R
L
Y
R
H
I
H
P
E
L
Site 6
S83
D
L
A
E
V
L
G
S
E
E
P
T
E
G
D
Site 7
T87
V
L
G
S
E
E
P
T
E
G
D
V
Q
C
M
Site 8
S127
C
G
D
V
Q
A
T
S
R
K
F
E
E
G
S
Site 9
S134
S
R
K
F
E
E
G
S
F
A
N
S
T
D
Q
Site 10
S138
E
E
G
S
F
A
N
S
T
D
Q
E
P
T
R
Site 11
T178
Q
A
K
E
L
E
A
T
V
R
E
P
A
A
S
Site 12
S185
T
V
R
E
P
A
A
S
G
D
V
Q
G
T
R
Site 13
T197
G
T
R
M
L
F
E
T
R
P
L
D
R
L
G
Site 14
S205
R
P
L
D
R
L
G
S
R
P
S
L
Q
E
Q
Site 15
S208
D
R
L
G
S
R
P
S
L
Q
E
Q
S
P
L
Site 16
S213
R
P
S
L
Q
E
Q
S
P
L
E
L
R
S
E
Site 17
S219
Q
S
P
L
E
L
R
S
E
I
Q
E
L
K
G
Site 18
T231
L
K
G
D
V
K
K
T
V
K
L
F
Q
T
E
Site 19
S263
A
C
R
E
E
I
Q
S
N
A
V
R
S
A
R
Site 20
S268
I
Q
S
N
A
V
R
S
A
R
W
L
F
E
T
Site 21
T275
S
A
R
W
L
F
E
T
R
P
L
D
A
I
N
Site 22
S286
D
A
I
N
Q
D
P
S
Q
V
R
V
I
R
G
Site 23
S295
V
R
V
I
R
G
I
S
L
E
E
G
A
R
P
Site 24
S305
E
G
A
R
P
D
V
S
A
T
R
W
I
F
E
Site 25
T313
A
T
R
W
I
F
E
T
Q
P
L
D
A
I
R
Site 26
S332
D
E
K
D
F
Q
P
S
P
D
L
I
P
P
G
Site 27
T381
V
P
G
D
V
R
S
T
L
W
L
F
E
T
K
Site 28
S415
Q
D
G
E
G
H
L
S
S
D
S
S
S
A
L
Site 29
S416
D
G
E
G
H
L
S
S
D
S
S
S
A
L
P
Site 30
S418
E
G
H
L
S
S
D
S
S
S
A
L
P
F
S
Site 31
S419
G
H
L
S
S
D
S
S
S
A
L
P
F
S
Q
Site 32
S420
H
L
S
S
D
S
S
S
A
L
P
F
S
Q
S
Site 33
S425
S
S
S
A
L
P
F
S
Q
S
A
P
Q
R
D
Site 34
S427
S
A
L
P
F
S
Q
S
A
P
Q
R
D
E
L
Site 35
T440
E
L
K
G
D
V
K
T
F
K
N
L
F
E
T
Site 36
S452
F
E
T
L
P
L
D
S
I
G
Q
G
E
V
L
Site 37
S463
G
E
V
L
A
H
G
S
P
S
R
E
E
G
T
Site 38
S472
S
R
E
E
G
T
D
S
A
G
Q
A
Q
G
I
Site 39
S481
G
Q
A
Q
G
I
G
S
P
V
Y
A
M
Q
D
Site 40
Y484
Q
G
I
G
S
P
V
Y
A
M
Q
D
S
K
G
Site 41
S489
P
V
Y
A
M
Q
D
S
K
G
R
L
H
A
L
Site 42
T497
K
G
R
L
H
A
L
T
S
V
S
R
E
Q
I
Site 43
S498
G
R
L
H
A
L
T
S
V
S
R
E
Q
I
V
Site 44
Y512
V
G
G
D
V
Q
G
Y
R
W
M
F
E
T
Q
Site 45
S527
P
L
D
Q
L
G
R
S
P
S
T
I
D
V
V
Site 46
S529
D
Q
L
G
R
S
P
S
T
I
D
V
V
R
G
Site 47
T556
T
A
R
W
L
F
E
T
Q
P
L
E
M
I
H
Site 48
S577
R
Q
K
E
E
G
K
S
Q
G
D
P
Q
P
E
Site 49
T593
P
P
K
G
D
V
Q
T
I
R
W
L
F
E
T
Site 50
S604
L
F
E
T
C
P
M
S
E
L
A
E
K
Q
G
Site 51
S612
E
L
A
E
K
Q
G
S
E
V
T
D
P
T
A
Site 52
S649
R
E
Q
H
L
Q
V
S
Q
V
P
A
G
E
R
Site 53
T658
V
P
A
G
E
R
Q
T
D
R
H
V
F
E
T
Site 54
T665
T
D
R
H
V
F
E
T
E
P
L
Q
A
S
G
Site 55
S671
E
T
E
P
L
Q
A
S
G
R
P
C
G
R
R
Site 56
Y682
C
G
R
R
P
V
R
Y
C
S
R
V
E
I
P
Site 57
S684
R
R
P
V
R
Y
C
S
R
V
E
I
P
S
G
Site 58
S690
C
S
R
V
E
I
P
S
G
Q
V
S
R
Q
K
Site 59
S694
E
I
P
S
G
Q
V
S
R
Q
K
E
V
F
Q
Site 60
S739
F
E
N
C
P
M
G
S
L
A
A
E
S
I
Q
Site 61
S757
L
L
E
E
Q
P
M
S
P
S
G
N
R
M
Q
Site 62
S766
S
G
N
R
M
Q
E
S
Q
E
T
A
A
E
G
Site 63
T769
R
M
Q
E
S
Q
E
T
A
A
E
G
T
L
R
Site 64
T781
T
L
R
T
L
H
A
T
P
G
I
L
H
H
G
Site 65
S808
C
L
A
K
Y
V
L
S
G
T
G
Q
G
H
P
Site 66
Y816
G
T
G
Q
G
H
P
Y
I
R
K
E
E
L
V
Site 67
T864
L
K
P
L
R
L
P
T
P
G
S
S
G
N
I
Site 68
S867
L
R
L
P
T
P
G
S
S
G
N
I
E
D
M
Site 69
T917
Y
S
L
Q
P
R
L
T
S
K
A
S
E
R
S
Site 70
S918
S
L
Q
P
R
L
T
S
K
A
S
E
R
S
S
Site 71
S921
P
R
L
T
S
K
A
S
E
R
S
S
V
Q
L
Site 72
S925
S
K
A
S
E
R
S
S
V
Q
L
L
A
S
C
Site 73
S931
S
S
V
Q
L
L
A
S
C
I
D
K
G
D
L
Site 74
S939
C
I
D
K
G
D
L
S
G
L
H
S
L
R
W
Site 75
S943
G
D
L
S
G
L
H
S
L
R
W
E
P
P
A
Site 76
S953
W
E
P
P
A
D
P
S
P
V
P
A
S
E
G
Site 77
S958
D
P
S
P
V
P
A
S
E
G
A
Q
S
L
H
Site 78
S963
P
A
S
E
G
A
Q
S
L
H
P
T
E
S
I
Site 79
T967
G
A
Q
S
L
H
P
T
E
S
I
I
H
V
P
Site 80
S969
Q
S
L
H
P
T
E
S
I
I
H
V
P
P
L
Site 81
S979
H
V
P
P
L
D
P
S
M
G
M
G
H
L
R
Site 82
S988
G
M
G
H
L
R
A
S
G
A
T
P
C
P
P
Site 83
T991
H
L
R
A
S
G
A
T
P
C
P
P
Q
A
I
Site 84
S1023
N
T
E
K
Q
E
D
S
H
S
G
Q
K
G
M
Site 85
S1025
E
K
Q
E
D
S
H
S
G
Q
K
G
M
A
V
Site 86
S1036
G
M
A
V
L
G
K
S
E
G
A
T
T
T
P
Site 87
T1040
L
G
K
S
E
G
A
T
T
T
P
P
G
P
G
Site 88
T1041
G
K
S
E
G
A
T
T
T
P
P
G
P
G
A
Site 89
T1042
K
S
E
G
A
T
T
T
P
P
G
P
G
A
P
Site 90
T1062
M
Q
S
L
R
M
A
T
A
E
A
Q
S
L
H
Site 91
T1081
N
K
H
K
Q
G
P
T
P
T
A
T
S
N
P
Site 92
T1085
Q
G
P
T
P
T
A
T
S
N
P
I
Q
D
G
Site 93
S1086
G
P
T
P
T
A
T
S
N
P
I
Q
D
G
L
Site 94
T1099
G
L
R
K
A
G
A
T
Q
S
N
I
R
P
G
Site 95
S1101
R
K
A
G
A
T
Q
S
N
I
R
P
G
G
G
Site 96
S1109
N
I
R
P
G
G
G
S
D
P
R
I
P
A
A
Site 97
S1121
P
A
A
P
R
K
V
S
R
E
E
Q
A
L
P
Site 98
Y1143
V
T
I
Q
D
G
I
Y
T
A
H
P
V
R
T
Site 99
T1144
T
I
Q
D
G
I
Y
T
A
H
P
V
R
T
F
Site 100
T1150
Y
T
A
H
P
V
R
T
F
D
P
P
G
G
V
Site 101
S1160
P
P
G
G
V
Q
L
S
Q
R
E
P
Q
S
R
Site 102
S1166
L
S
Q
R
E
P
Q
S
R
H
R
E
T
A
L
Site 103
T1171
P
Q
S
R
H
R
E
T
A
L
S
V
Q
A
P
Site 104
S1174
R
H
R
E
T
A
L
S
V
Q
A
P
R
P
L
Site 105
S1188
L
Q
G
G
P
G
Q
S
T
G
P
G
R
E
E
Site 106
S1246
G
P
Q
A
A
G
A
S
P
H
P
H
N
A
F
Site 107
S1294
L
K
D
P
L
L
H
S
H
S
S
P
A
G
Q
Site 108
S1296
D
P
L
L
H
S
H
S
S
P
A
G
Q
R
T
Site 109
S1297
P
L
L
H
S
H
S
S
P
A
G
Q
R
T
P
Site 110
T1303
S
S
P
A
G
Q
R
T
P
G
G
S
Q
T
K
Site 111
S1307
G
Q
R
T
P
G
G
S
Q
T
K
T
P
K
L
Site 112
T1309
R
T
P
G
G
S
Q
T
K
T
P
K
L
D
P
Site 113
T1311
P
G
G
S
Q
T
K
T
P
K
L
D
P
T
M
Site 114
T1317
K
T
P
K
L
D
P
T
M
P
P
K
K
K
P
Site 115
T1334
P
P
K
P
A
H
L
T
Q
S
H
P
P
Q
R
Site 116
S1336
K
P
A
H
L
T
Q
S
H
P
P
Q
R
L
P
Site 117
S1349
L
P
K
P
L
P
L
S
P
S
F
S
S
E
V
Site 118
S1351
K
P
L
P
L
S
P
S
F
S
S
E
V
G
Q
Site 119
S1353
L
P
L
S
P
S
F
S
S
E
V
G
Q
R
E
Site 120
S1354
P
L
S
P
S
F
S
S
E
V
G
Q
R
E
H
Site 121
T1368
H
Q
R
G
E
R
D
T
A
I
P
Q
P
A
K
Site 122
T1379
Q
P
A
K
V
P
T
T
V
D
Q
G
H
I
P
Site 123
S1392
I
P
L
A
R
C
P
S
G
H
S
Q
P
S
L
Site 124
S1395
A
R
C
P
S
G
H
S
Q
P
S
L
Q
H
G
Site 125
S1398
P
S
G
H
S
Q
P
S
L
Q
H
G
L
S
T
Site 126
S1404
P
S
L
Q
H
G
L
S
T
T
A
P
R
P
T
Site 127
T1405
S
L
Q
H
G
L
S
T
T
A
P
R
P
T
K
Site 128
T1411
S
T
T
A
P
R
P
T
K
N
Q
A
T
G
S
Site 129
S1418
T
K
N
Q
A
T
G
S
N
A
Q
S
S
E
P
Site 130
S1422
A
T
G
S
N
A
Q
S
S
E
P
P
K
L
N
Site 131
S1423
T
G
S
N
A
Q
S
S
E
P
P
K
L
N
A
Site 132
T1436
N
A
L
N
H
D
P
T
S
P
Q
W
G
P
G
Site 133
S1437
A
L
N
H
D
P
T
S
P
Q
W
G
P
G
P
Site 134
S1460
S
H
Q
G
A
P
E
S
P
D
S
L
Q
R
N
Site 135
S1463
G
A
P
E
S
P
D
S
L
Q
R
N
Q
K
E
Site 136
S1488
L
E
K
E
A
A
S
S
V
D
V
Q
A
L
R
Site 137
S1533
F
G
E
L
T
R
V
S
T
E
V
A
Q
L
K
Site 138
T1534
G
E
L
T
R
V
S
T
E
V
A
Q
L
K
E
Site 139
S1559
E
A
V
H
K
A
L
S
S
M
S
S
L
Q
P
Site 140
S1560
A
V
H
K
A
L
S
S
M
S
S
L
Q
P
E
Site 141
S1563
K
A
L
S
S
M
S
S
L
Q
P
E
A
S
A
Site 142
S1569
S
S
L
Q
P
E
A
S
A
R
G
H
F
Q
G
Site 143
S1582
Q
G
P
P
K
D
H
S
A
H
K
I
S
V
T
Site 144
S1587
D
H
S
A
H
K
I
S
V
T
V
S
S
S
A
Site 145
T1589
S
A
H
K
I
S
V
T
V
S
S
S
A
R
P
Site 146
S1591
H
K
I
S
V
T
V
S
S
S
A
R
P
S
G
Site 147
S1592
K
I
S
V
T
V
S
S
S
A
R
P
S
G
S
Site 148
S1593
I
S
V
T
V
S
S
S
A
R
P
S
G
S
G
Site 149
S1597
V
S
S
S
A
R
P
S
G
S
G
Q
E
V
G
Site 150
S1599
S
S
A
R
P
S
G
S
G
Q
E
V
G
G
Q
Site 151
T1631
Q
V
K
I
R
N
H
T
E
A
R
G
H
T
A
Site 152
T1637
H
T
E
A
R
G
H
T
A
S
T
A
P
S
T
Site 153
S1639
E
A
R
G
H
T
A
S
T
A
P
S
T
R
R
Site 154
S1643
H
T
A
S
T
A
P
S
T
R
R
Q
E
T
S
Site 155
T1644
T
A
S
T
A
P
S
T
R
R
Q
E
T
S
R
Site 156
T1649
P
S
T
R
R
Q
E
T
S
R
E
Y
L
C
P
Site 157
S1650
S
T
R
R
Q
E
T
S
R
E
Y
L
C
P
P
Site 158
Y1653
R
Q
E
T
S
R
E
Y
L
C
P
P
R
V
L
Site 159
S1662
C
P
P
R
V
L
P
S
S
R
D
S
P
S
S
Site 160
S1663
P
P
R
V
L
P
S
S
R
D
S
P
S
S
P
Site 161
S1666
V
L
P
S
S
R
D
S
P
S
S
P
T
F
I
Site 162
S1668
P
S
S
R
D
S
P
S
S
P
T
F
I
S
I
Site 163
S1669
S
S
R
D
S
P
S
S
P
T
F
I
S
I
Q
Site 164
T1671
R
D
S
P
S
S
P
T
F
I
S
I
Q
S
A
Site 165
S1674
P
S
S
P
T
F
I
S
I
Q
S
A
T
R
K
Site 166
S1677
P
T
F
I
S
I
Q
S
A
T
R
K
P
L
E
Site 167
T1685
A
T
R
K
P
L
E
T
P
S
F
K
G
N
P
Site 168
S1687
R
K
P
L
E
T
P
S
F
K
G
N
P
D
V
Site 169
S1695
F
K
G
N
P
D
V
S
V
K
S
T
Q
L
A
Site 170
T1699
P
D
V
S
V
K
S
T
Q
L
A
Q
D
I
G
Site 171
T1719
Q
K
G
V
Q
D
K
T
G
K
K
D
I
T
Q
Site 172
T1725
K
T
G
K
K
D
I
T
Q
C
S
V
Q
P
E
Site 173
S1728
K
K
D
I
T
Q
C
S
V
Q
P
E
P
A
P
Site 174
S1737
Q
P
E
P
A
P
P
S
A
S
P
L
P
R
G
Site 175
S1739
E
P
A
P
P
S
A
S
P
L
P
R
G
W
Q
Site 176
S1748
L
P
R
G
W
Q
K
S
V
L
E
L
Q
T
G
Site 177
T1754
K
S
V
L
E
L
Q
T
G
P
G
S
S
Q
H
Site 178
S1758
E
L
Q
T
G
P
G
S
S
Q
H
Y
G
A
M
Site 179
Y1762
G
P
G
S
S
Q
H
Y
G
A
M
R
T
V
T
Site 180
T1769
Y
G
A
M
R
T
V
T
E
Q
Y
E
E
V
D
Site 181
T1781
E
V
D
Q
F
G
N
T
V
L
M
S
S
T
T
Site 182
T1790
L
M
S
S
T
T
V
T
E
Q
A
E
P
P
R
Site 183
S1801
E
P
P
R
N
P
G
S
H
L
G
L
H
A
S
Site 184
S1808
S
H
L
G
L
H
A
S
P
L
L
R
Q
F
L
Site 185
S1817
L
L
R
Q
F
L
H
S
P
A
G
F
S
S
D
Site 186
S1823
H
S
P
A
G
F
S
S
D
L
T
E
A
E
T
Site 187
T1826
A
G
F
S
S
D
L
T
E
A
E
T
V
Q
V
Site 188
T1830
S
D
L
T
E
A
E
T
V
Q
V
S
C
S
Y
Site 189
S1834
E
A
E
T
V
Q
V
S
C
S
Y
S
Q
P
A
Site 190
S1836
E
T
V
Q
V
S
C
S
Y
S
Q
P
A
A
Q
Site 191
Y1837
T
V
Q
V
S
C
S
Y
S
Q
P
A
A
Q
_
Site 192
S1838
V
Q
V
S
C
S
Y
S
Q
P
A
A
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation