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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMTC3
Full Name:
Transmembrane and TPR repeat-containing protein 3
Alias:
Protein SMILE
Type:
Mass (Da):
104009
Number AA:
915
UniProt ID:
Q6ZXV5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T46
N
K
D
L
H
P
S
T
P
L
K
T
L
F
Q
Site 2
T59
F
Q
N
D
F
W
G
T
P
M
S
E
E
R
S
Site 3
S62
D
F
W
G
T
P
M
S
E
E
R
S
H
K
S
Site 4
S66
T
P
M
S
E
E
R
S
H
K
S
Y
R
P
L
Site 5
S69
S
E
E
R
S
H
K
S
Y
R
P
L
T
V
L
Site 6
Y70
E
E
R
S
H
K
S
Y
R
P
L
T
V
L
T
Site 7
T74
H
K
S
Y
R
P
L
T
V
L
T
F
R
L
N
Site 8
S85
F
R
L
N
Y
L
L
S
E
L
K
P
M
S
Y
Site 9
Y159
F
L
A
A
F
L
S
Y
T
R
S
K
G
P
D
Site 10
T160
L
A
A
F
L
S
Y
T
R
S
K
G
P
D
N
Site 11
S162
A
F
L
S
Y
T
R
S
K
G
P
D
N
S
I
Site 12
S168
R
S
K
G
P
D
N
S
I
I
W
T
P
I
A
Site 13
S227
Q
F
L
R
G
K
G
S
I
P
F
S
M
L
Q
Site 14
S274
F
D
N
P
A
A
V
S
P
T
P
T
R
Q
L
Site 15
T276
N
P
A
A
V
S
P
T
P
T
R
Q
L
T
F
Site 16
T278
A
A
V
S
P
T
P
T
R
Q
L
T
F
N
Y
Site 17
T282
P
T
P
T
R
Q
L
T
F
N
Y
L
L
P
V
Site 18
Y285
T
R
Q
L
T
F
N
Y
L
L
P
V
N
A
W
Site 19
Y340
L
G
V
F
S
I
R
Y
S
G
D
S
S
K
T
Site 20
S341
G
V
F
S
I
R
Y
S
G
D
S
S
K
T
V
Site 21
S344
S
I
R
Y
S
G
D
S
S
K
T
V
L
M
A
Site 22
T398
H
G
W
Q
K
I
S
T
K
S
V
F
K
K
L
Site 23
S418
S
M
V
I
L
T
H
S
L
K
T
F
H
R
N
Site 24
Y432
N
W
D
W
E
S
E
Y
T
L
F
M
S
A
L
Site 25
Y468
N
F
E
R
A
L
K
Y
F
L
Q
A
T
H
V
Site 26
Y490
H
M
N
V
G
R
T
Y
K
N
L
N
R
T
K
Site 27
S502
R
T
K
E
A
E
E
S
Y
M
M
A
K
S
L
Site 28
Y503
T
K
E
A
E
E
S
Y
M
M
A
K
S
L
M
Site 29
Y519
Q
I
I
P
G
K
K
Y
A
A
R
I
A
P
N
Site 30
Y552
L
E
E
A
D
Q
L
Y
R
Q
A
I
S
M
R
Site 31
S557
Q
L
Y
R
Q
A
I
S
M
R
P
D
F
K
Q
Site 32
Y566
R
P
D
F
K
Q
A
Y
I
S
R
G
E
L
L
Site 33
S568
D
F
K
Q
A
Y
I
S
R
G
E
L
L
L
K
Site 34
Y601
R
N
N
A
D
L
W
Y
N
L
A
I
V
H
I
Site 35
S660
E
A
R
K
R
L
L
S
Y
I
N
E
E
P
L
Site 36
Y661
A
R
K
R
L
L
S
Y
I
N
E
E
P
L
D
Site 37
S714
F
N
L
A
L
L
Y
S
Q
T
A
K
E
L
K
Site 38
Y732
I
L
E
E
L
L
R
Y
Y
P
D
H
I
K
G
Site 39
Y733
L
E
E
L
L
R
Y
Y
P
D
H
I
K
G
L
Site 40
S770
R
I
L
E
M
D
P
S
N
V
Q
G
K
H
N
Site 41
Y782
K
H
N
L
C
V
V
Y
F
E
E
K
D
L
L
Site 42
S820
N
I
V
R
D
K
I
S
S
S
S
F
I
E
P
Site 43
S822
V
R
D
K
I
S
S
S
S
F
I
E
P
I
F
Site 44
S823
R
D
K
I
S
S
S
S
F
I
E
P
I
F
P
Site 45
S832
I
E
P
I
F
P
T
S
K
I
S
S
V
E
G
Site 46
S836
F
P
T
S
K
I
S
S
V
E
G
K
K
I
P
Site 47
S846
G
K
K
I
P
T
E
S
V
K
E
I
R
G
E
Site 48
S854
V
K
E
I
R
G
E
S
R
Q
T
Q
I
V
K
Site 49
T857
I
R
G
E
S
R
Q
T
Q
I
V
K
T
S
D
Site 50
T862
R
Q
T
Q
I
V
K
T
S
D
N
K
S
Q
S
Site 51
S863
Q
T
Q
I
V
K
T
S
D
N
K
S
Q
S
K
Site 52
S867
V
K
T
S
D
N
K
S
Q
S
K
S
N
K
Q
Site 53
S869
T
S
D
N
K
S
Q
S
K
S
N
K
Q
L
G
Site 54
S871
D
N
K
S
Q
S
K
S
N
K
Q
L
G
K
N
Site 55
T883
G
K
N
G
D
E
E
T
P
H
K
T
T
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation