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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAXIP1
Full Name:
PAX-interacting protein 1
Alias:
CAGF28; CAGF29; PAX interacting (with transcription-activation domain) protein 1; PAXI1; PAXIP1L; PTIP; TNRC2
Type:
DNA repair
Mass (Da):
117690
Number AA:
1035
UniProt ID:
Q6ZW49
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
Q
A
G
A
L
C
W
S
L
P
E
L
S
Q
G
Site 2
S36
C
W
S
L
P
E
L
S
Q
G
E
V
G
K
G
Site 3
S58
K
H
R
D
H
L
P
S
S
D
P
V
L
M
Q
Site 4
S59
H
R
D
H
L
P
S
S
D
P
V
L
M
Q
A
Site 5
Y115
P
E
P
K
G
E
K
Y
E
C
A
L
K
R
A
Site 6
S123
E
C
A
L
K
R
A
S
I
K
I
V
T
P
D
Site 7
Y147
T
K
K
D
E
A
F
Y
H
P
R
L
I
I
Y
Site 8
Y154
Y
H
P
R
L
I
I
Y
E
E
E
E
E
E
E
Site 9
S174
V
E
N
E
E
Q
D
S
Q
N
E
G
S
T
D
Site 10
S179
Q
D
S
Q
N
E
G
S
T
D
E
K
S
S
P
Site 11
T180
D
S
Q
N
E
G
S
T
D
E
K
S
S
P
A
Site 12
S184
E
G
S
T
D
E
K
S
S
P
A
S
S
Q
E
Site 13
S185
G
S
T
D
E
K
S
S
P
A
S
S
Q
E
G
Site 14
S188
D
E
K
S
S
P
A
S
S
Q
E
G
S
P
S
Site 15
S189
E
K
S
S
P
A
S
S
Q
E
G
S
P
S
G
Site 16
S193
P
A
S
S
Q
E
G
S
P
S
G
D
Q
Q
F
Site 17
S195
S
S
Q
E
G
S
P
S
G
D
Q
Q
F
S
P
Site 18
S201
P
S
G
D
Q
Q
F
S
P
K
S
N
T
E
K
Site 19
S204
D
Q
Q
F
S
P
K
S
N
T
E
K
S
K
G
Site 20
S209
P
K
S
N
T
E
K
S
K
G
E
L
M
F
D
Site 21
S218
G
E
L
M
F
D
D
S
S
D
S
S
P
E
K
Site 22
S219
E
L
M
F
D
D
S
S
D
S
S
P
E
K
Q
Site 23
S221
M
F
D
D
S
S
D
S
S
P
E
K
Q
E
R
Site 24
S222
F
D
D
S
S
D
S
S
P
E
K
Q
E
R
N
Site 25
T233
Q
E
R
N
L
N
W
T
P
A
E
V
P
Q
L
Site 26
S287
A
A
G
Q
N
L
Q
S
S
E
R
S
E
M
I
Site 27
S288
A
G
Q
N
L
Q
S
S
E
R
S
E
M
I
A
Site 28
S291
N
L
Q
S
S
E
R
S
E
M
I
A
T
W
S
Site 29
T296
E
R
S
E
M
I
A
T
W
S
P
A
V
R
T
Site 30
S298
S
E
M
I
A
T
W
S
P
A
V
R
T
L
R
Site 31
T303
T
W
S
P
A
V
R
T
L
R
N
I
T
N
N
Site 32
T308
V
R
T
L
R
N
I
T
N
N
A
D
I
Q
Q
Site 33
S330
A
H
I
L
Q
T
L
S
A
P
T
K
N
L
E
Site 34
S343
L
E
Q
Q
V
N
H
S
Q
Q
G
H
T
N
A
Site 35
T361
L
F
S
Q
V
K
V
T
P
E
T
H
M
L
Q
Site 36
S402
Q
Q
Q
Q
Q
Q
I
S
Q
Q
P
Y
P
Q
Q
Site 37
Y406
Q
Q
I
S
Q
Q
P
Y
P
Q
Q
P
P
H
P
Site 38
S415
Q
Q
P
P
H
P
F
S
Q
Q
Q
Q
Q
Q
Q
Site 39
S430
Q
A
H
P
H
Q
F
S
Q
Q
Q
L
Q
F
P
Site 40
S488
A
Q
L
Q
Q
Q
H
S
L
L
Q
Q
Q
Q
Q
Site 41
S517
Q
Q
Q
Q
Q
M
Q
S
Q
T
A
P
H
L
S
Site 42
S524
S
Q
T
A
P
H
L
S
Q
T
S
Q
A
L
Q
Site 43
S551
Q
Q
Q
Q
P
P
P
S
P
Q
Q
H
Q
L
F
Site 44
Y582
C
V
F
A
I
A
D
Y
P
E
Q
M
S
D
K
Site 45
T609
H
G
G
T
V
D
P
T
F
T
S
R
C
T
H
Site 46
T611
G
T
V
D
P
T
F
T
S
R
C
T
H
L
L
Site 47
T615
P
T
F
T
S
R
C
T
H
L
L
C
E
S
Q
Site 48
S625
L
C
E
S
Q
V
S
S
A
Y
A
Q
A
I
R
Site 49
T639
R
E
R
K
R
C
V
T
A
H
W
L
N
T
V
Site 50
S673
P
P
G
G
K
P
C
S
Q
H
I
I
S
V
T
Site 51
S678
P
C
S
Q
H
I
I
S
V
T
G
F
V
D
S
Site 52
S685
S
V
T
G
F
V
D
S
D
R
D
D
L
K
L
Site 53
Y695
D
D
L
K
L
M
A
Y
L
A
G
A
K
Y
T
Site 54
Y701
A
Y
L
A
G
A
K
Y
T
G
Y
L
C
R
S
Site 55
Y704
A
G
A
K
Y
T
G
Y
L
C
R
S
N
T
V
Site 56
T710
G
Y
L
C
R
S
N
T
V
L
I
C
K
E
P
Site 57
Y722
K
E
P
T
G
L
K
Y
E
K
A
K
E
W
R
Site 58
Y754
E
A
L
R
Q
I
Q
Y
S
R
Y
T
A
F
S
Site 59
S755
A
L
R
Q
I
Q
Y
S
R
Y
T
A
F
S
L
Site 60
Y757
R
Q
I
Q
Y
S
R
Y
T
A
F
S
L
Q
D
Site 61
T758
Q
I
Q
Y
S
R
Y
T
A
F
S
L
Q
D
P
Site 62
S761
Y
S
R
Y
T
A
F
S
L
Q
D
P
F
A
P
Site 63
S812
V
A
N
V
Q
P
S
S
K
R
A
R
I
E
D
Site 64
T828
P
P
P
T
K
K
L
T
P
E
L
T
P
F
V
Site 65
S862
L
G
G
E
V
A
E
S
A
Q
K
C
T
H
L
Site 66
S925
A
E
V
L
F
S
F
S
L
E
E
S
L
K
R
Site 67
S929
F
S
F
S
L
E
E
S
L
K
R
A
H
V
S
Site 68
S936
S
L
K
R
A
H
V
S
P
L
F
K
A
K
Y
Site 69
Y943
S
P
L
F
K
A
K
Y
F
Y
I
T
P
G
I
Site 70
S970
C
A
G
G
K
V
L
S
K
Q
P
S
F
R
K
Site 71
S974
K
V
L
S
K
Q
P
S
F
R
K
L
M
E
H
Site 72
S986
M
E
H
K
Q
N
S
S
L
S
E
I
I
L
I
Site 73
S988
H
K
Q
N
S
S
L
S
E
I
I
L
I
S
C
Site 74
Y1005
D
L
H
L
C
R
E
Y
F
A
R
G
I
D
V
Site 75
T1026
L
T
G
V
L
T
Q
T
L
D
Y
E
S
Y
K
Site 76
Y1029
V
L
T
Q
T
L
D
Y
E
S
Y
K
F
N
_
Site 77
S1031
T
Q
T
L
D
Y
E
S
Y
K
F
N
_
_
_
Site 78
Y1032
Q
T
L
D
Y
E
S
Y
K
F
N
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation