PhosphoNET

           
Protein Info 
   
Short Name:  HFE2
Full Name:  Hemojuvelin
Alias:  Hemochromatosis type 2 (juvenile); Hemochromatosis type 2 juvenile protein precursor isoform a; Hemojuvelin isoform a; Hfe2; Hfe2a; Hjv; Jh; Mgc23953; Rgmc
Type: 
Mass (Da):  45080
Number AA:  426
UniProt ID:  Q6ZVN8
International Prot ID:  Isoform a - IPI00329576
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0031225  GO:0005886   Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S7_MGEPGQSPSPRSSH
Site 2S9GEPGQSPSPRSSHGS
Site 3S12GQSPSPRSSHGSPPT
Site 4S13QSPSPRSSHGSPPTL
Site 5S16SPRSSHGSPPTLSTL
Site 6T19SSHGSPPTLSTLTLL
Site 7Y46ILRCNAEYVSSTLSL
Site 8S48RCNAEYVSSTLSLRG
Site 9S49CNAEYVSSTLSLRGG
Site 10T50NAEYVSSTLSLRGGG
Site 11S52EYVSSTLSLRGGGSS
Site 12S58LSLRGGGSSGALRGG
Site 13S59SLRGGGSSGALRGGG
Site 14Y86LCRALRSYALCTRRT
Site 15T93YALCTRRTARTCRGD
Site 16T96CTRRTARTCRGDLAF
Site 17S105RGDLAFHSAVHGIED
Site 18T125NCSRQGPTAPPPPRG
Site 19S140PALPGAGSGLPAPDP
Site 20Y150PAPDPCDYEGRFSRL
Site 21S155CDYEGRFSRLHGRPP
Site 22S169PGFLHCASFGDPHVR
Site 23T221ATATRKLTIIFKNMQ
Site 24S251PVAFEDGSINGGDRP
Site 25S261GGDRPGGSSLSIQTA
Site 26S262GDRPGGSSLSIQTAN
Site 27S264RPGGSSLSIQTANPG
Site 28S295RQTAGQLSFSIKVAE
Site 29S324CVGGCPPSQRLSRSE
Site 30S328CPPSQRLSRSERNRR
Site 31S330PSQRLSRSERNRRGA
Site 32T339RNRRGAITIDTARRL
Site 33T342RGAITIDTARRLCKE
Site 34S399EKLHLFPSDAGVPLS
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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