KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DENND5B
Full Name:
DENN domain-containing protein 5B
Alias:
DENN/MADD domain containing 5B; Dennd5b; MGC24039
Type:
Membrane, Integral membrane protein
Mass (Da):
145020
Number AA:
1274
UniProt ID:
Q6ZUT9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
P
G
P
G
S
G
S
S
P
A
A
C
R
F
Site 2
S15
P
G
P
G
S
G
S
S
P
A
A
C
R
F
A
Site 3
S34
L
C
G
I
D
A
D
S
G
L
E
P
D
E
L
Site 4
S49
A
G
E
N
F
D
Q
S
P
L
R
R
T
F
K
Site 5
T54
D
Q
S
P
L
R
R
T
F
K
S
K
V
L
A
Site 6
S57
P
L
R
R
T
F
K
S
K
V
L
A
H
Y
P
Site 7
Y63
K
S
K
V
L
A
H
Y
P
Q
N
I
E
W
N
Site 8
S87
L
C
M
P
K
G
L
S
F
R
T
Q
T
D
N
Site 9
T92
G
L
S
F
R
T
Q
T
D
N
K
D
P
Q
F
Site 10
S101
N
K
D
P
Q
F
H
S
F
I
I
T
R
E
D
Site 11
T105
Q
F
H
S
F
I
I
T
R
E
D
G
S
R
T
Site 12
S110
I
I
T
R
E
D
G
S
R
T
Y
G
F
V
L
Site 13
Y113
R
E
D
G
S
R
T
Y
G
F
V
L
T
F
Y
Site 14
T118
R
T
Y
G
F
V
L
T
F
Y
E
E
V
T
S
Site 15
Y120
Y
G
F
V
L
T
F
Y
E
E
V
T
S
K
Q
Site 16
S146
H
N
A
E
H
Y
S
S
V
Y
A
S
S
S
C
Site 17
Y148
A
E
H
Y
S
S
V
Y
A
S
S
S
C
S
M
Site 18
S150
H
Y
S
S
V
Y
A
S
S
S
C
S
M
D
S
Site 19
S151
Y
S
S
V
Y
A
S
S
S
C
S
M
D
S
L
Site 20
S152
S
S
V
Y
A
S
S
S
C
S
M
D
S
L
A
Site 21
S154
V
Y
A
S
S
S
C
S
M
D
S
L
A
S
S
Site 22
S157
S
S
S
C
S
M
D
S
L
A
S
S
L
D
E
Site 23
S161
S
M
D
S
L
A
S
S
L
D
E
G
D
T
T
Site 24
T167
S
S
L
D
E
G
D
T
T
S
L
L
K
L
Q
Site 25
T168
S
L
D
E
G
D
T
T
S
L
L
K
L
Q
R
Site 26
S169
L
D
E
G
D
T
T
S
L
L
K
L
Q
R
Y
Site 27
Y176
S
L
L
K
L
Q
R
Y
N
S
Y
D
I
S
R
Site 28
S178
L
K
L
Q
R
Y
N
S
Y
D
I
S
R
D
T
Site 29
Y179
K
L
Q
R
Y
N
S
Y
D
I
S
R
D
T
L
Site 30
S182
R
Y
N
S
Y
D
I
S
R
D
T
L
Y
V
S
Site 31
T185
S
Y
D
I
S
R
D
T
L
Y
V
S
K
S
I
Site 32
Y187
D
I
S
R
D
T
L
Y
V
S
K
S
I
C
L
Site 33
Y212
K
K
F
L
I
Q
L
Y
K
A
V
T
S
Q
Q
Site 34
S217
Q
L
Y
K
A
V
T
S
Q
Q
P
P
P
L
P
Site 35
S227
P
P
P
L
P
L
E
S
Y
I
H
N
I
L
Y
Site 36
Y228
P
P
L
P
L
E
S
Y
I
H
N
I
L
Y
E
Site 37
Y234
S
Y
I
H
N
I
L
Y
E
V
P
L
P
P
P
Site 38
S244
P
L
P
P
P
G
R
S
L
K
F
Y
G
V
Y
Site 39
Y248
P
G
R
S
L
K
F
Y
G
V
Y
E
P
V
I
Site 40
Y251
S
L
K
F
Y
G
V
Y
E
P
V
I
C
Q
R
Site 41
S262
I
C
Q
R
P
G
P
S
E
L
P
L
S
D
Y
Site 42
S267
G
P
S
E
L
P
L
S
D
Y
P
L
R
E
A
Site 43
Y269
S
E
L
P
L
S
D
Y
P
L
R
E
A
F
E
Site 44
Y299
L
E
M
Q
I
L
L
Y
S
Q
D
Y
Q
R
L
Site 45
T308
Q
D
Y
Q
R
L
M
T
V
A
E
G
I
T
T
Site 46
S350
P
Y
L
M
G
L
Q
S
K
E
G
T
D
R
S
Site 47
T354
G
L
Q
S
K
E
G
T
D
R
S
K
L
E
L
Site 48
S357
S
K
E
G
T
D
R
S
K
L
E
L
P
Q
E
Site 49
S410
F
G
I
P
P
E
G
S
L
H
C
S
E
S
T
Site 50
S414
P
E
G
S
L
H
C
S
E
S
T
S
K
L
K
Site 51
S416
G
S
L
H
C
S
E
S
T
S
K
L
K
N
M
Site 52
S418
L
H
C
S
E
S
T
S
K
L
K
N
M
V
L
Site 53
Y445
C
T
N
N
I
S
M
Y
E
L
L
K
G
N
E
Site 54
T453
E
L
L
K
G
N
E
T
I
A
R
L
Q
A
L
Site 55
S474
A
V
E
K
M
D
L
S
A
S
L
G
E
K
D
Site 56
S476
E
K
M
D
L
S
A
S
L
G
E
K
D
K
D
Site 57
Y496
E
E
A
E
L
R
D
Y
Q
L
N
V
Q
L
R
Site 58
S545
M
Q
N
F
D
K
A
S
F
L
S
D
Q
P
E
Site 59
S548
F
D
K
A
S
F
L
S
D
Q
P
E
P
Y
L
Site 60
Y554
L
S
D
Q
P
E
P
Y
L
P
F
L
S
R
F
Site 61
S559
E
P
Y
L
P
F
L
S
R
F
I
E
T
Q
M
Site 62
Y599
R
I
D
K
I
R
L
Y
N
V
R
A
P
T
L
Site 63
T605
L
Y
N
V
R
A
P
T
L
R
T
S
I
Y
Q
Site 64
S609
R
A
P
T
L
R
T
S
I
Y
Q
K
C
S
T
Site 65
Y611
P
T
L
R
T
S
I
Y
Q
K
C
S
T
L
K
Site 66
S623
T
L
K
E
A
A
Q
S
I
E
Q
R
L
M
K
Site 67
T634
R
L
M
K
M
D
H
T
A
I
H
P
H
L
L
Site 68
Y650
M
K
I
G
Q
G
K
Y
E
Q
G
F
F
P
K
Site 69
S669
V
L
A
T
G
P
T
S
N
N
R
W
V
S
R
Site 70
S675
T
S
N
N
R
W
V
S
R
S
A
T
A
Q
R
Site 71
S677
N
N
R
W
V
S
R
S
A
T
A
Q
R
R
K
Site 72
T679
R
W
V
S
R
S
A
T
A
Q
R
R
K
E
R
Site 73
S691
K
E
R
L
R
Q
H
S
E
H
V
G
L
D
N
Site 74
Y704
D
N
D
L
R
E
K
Y
M
Q
E
A
R
S
L
Site 75
S710
K
Y
M
Q
E
A
R
S
L
G
K
N
L
R
Q
Site 76
S721
N
L
R
Q
P
K
L
S
D
L
S
P
A
V
I
Site 77
S724
Q
P
K
L
S
D
L
S
P
A
V
I
A
Q
T
Site 78
T747
L
K
E
C
R
M
K
T
K
R
M
L
V
E
K
Site 79
T770
G
H
G
E
A
N
I
T
G
L
E
E
N
T
L
Site 80
S780
E
E
N
T
L
I
A
S
L
C
D
L
L
E
R
Site 81
S790
D
L
L
E
R
I
W
S
H
G
L
Q
V
K
Q
Site 82
S800
L
Q
V
K
Q
G
K
S
A
L
W
S
H
L
I
Site 83
S822
K
Q
E
H
L
A
E
S
P
V
A
L
G
P
E
Site 84
S833
L
G
P
E
R
R
K
S
D
S
G
V
M
L
P
Site 85
S835
P
E
R
R
K
S
D
S
G
V
M
L
P
T
L
Site 86
T861
Q
N
M
S
E
I
K
T
D
V
G
R
A
R
A
Site 87
S873
A
R
A
W
I
R
L
S
L
E
K
K
L
L
S
Site 88
S880
S
L
E
K
K
L
L
S
Q
H
L
K
Q
L
L
Site 89
S888
Q
H
L
K
Q
L
L
S
N
Q
P
L
T
K
K
Site 90
Y897
Q
P
L
T
K
K
L
Y
K
R
Y
A
F
L
R
Site 91
Y914
E
E
R
E
Q
F
L
Y
H
L
L
S
L
N
A
Site 92
S962
S
N
P
W
I
C
V
S
G
E
L
G
D
T
G
Site 93
T968
V
S
G
E
L
G
D
T
G
V
M
Q
I
P
K
Site 94
T981
P
K
N
L
L
E
M
T
F
E
C
Q
N
L
G
Site 95
S1038
G
K
G
I
D
D
G
S
L
E
R
I
L
I
G
Site 96
S1052
G
E
L
M
T
S
A
S
D
E
D
L
V
K
Q
Site 97
T1062
D
L
V
K
Q
C
R
T
P
P
Q
Q
K
S
P
Site 98
S1068
R
T
P
P
Q
Q
K
S
P
T
T
A
R
R
L
Site 99
T1070
P
P
Q
Q
K
S
P
T
T
A
R
R
L
S
I
Site 100
T1071
P
Q
Q
K
S
P
T
T
A
R
R
L
S
I
T
Site 101
S1076
P
T
T
A
R
R
L
S
I
T
S
L
T
G
K
Site 102
T1078
T
A
R
R
L
S
I
T
S
L
T
G
K
N
N
Site 103
S1079
A
R
R
L
S
I
T
S
L
T
G
K
N
N
K
Site 104
S1116
K
P
E
K
E
R
G
S
L
T
V
L
L
C
G
Site 105
T1118
E
K
E
R
G
S
L
T
V
L
L
C
G
E
N
Site 106
Y1235
C
P
A
I
T
R
M
Y
E
E
S
A
L
L
R
Site 107
S1238
I
T
R
M
Y
E
E
S
A
L
L
R
D
R
M
Site 108
S1249
R
D
R
M
T
V
N
S
L
I
R
I
L
Q
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation