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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP27
Full Name:
Rho GTPase-activating protein 27
Alias:
CAMGAP1; CIN85-associated multi-domain-containing Rho GTPase-activating protein 1; FLJ43547; PP905; RHG27; Rho GTPase activating protein 27; Rho-type GTPase-activating protein 27; Similar to Rho GTPase activating protein 12
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
98387
Number AA:
889
UniProt ID:
Q6ZUM4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0030675
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0043089
GO:0006898
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
L
V
E
H
P
F
E
Y
T
G
K
D
G
R
R
Site 2
Y35
A
I
R
P
N
E
R
Y
R
L
L
R
R
S
T
Site 3
Y58
E
P
G
G
R
P
F
Y
L
P
A
Q
Y
V
R
Site 4
S84
A
P
P
G
P
H
P
S
P
A
A
P
E
P
L
Site 5
Y93
A
A
P
E
P
L
A
Y
D
Y
R
F
V
S
A
Site 6
Y95
P
E
P
L
A
Y
D
Y
R
F
V
S
A
A
A
Site 7
S113
P
D
G
A
P
E
E
S
G
G
R
A
S
S
L
Site 8
S118
E
E
S
G
G
R
A
S
S
L
C
G
P
A
Q
Site 9
S119
E
S
G
G
R
A
S
S
L
C
G
P
A
Q
R
Site 10
T130
P
A
Q
R
G
A
A
T
Q
R
S
S
L
A
P
Site 11
S133
R
G
A
A
T
Q
R
S
S
L
A
P
G
L
P
Site 12
S134
G
A
A
T
Q
R
S
S
L
A
P
G
L
P
A
Site 13
S156
A
P
V
R
P
A
Q
S
L
N
D
L
A
C
A
Site 14
S182
S
G
S
F
K
A
C
S
V
A
G
S
W
V
C
Site 15
S196
C
P
R
P
L
A
R
S
D
S
E
N
V
Y
E
Site 16
S198
R
P
L
A
R
S
D
S
E
N
V
Y
E
V
I
Site 17
Y202
R
S
D
S
E
N
V
Y
E
V
I
Q
D
L
H
Site 18
S216
H
V
P
P
P
E
E
S
A
E
Q
V
D
D
P
Site 19
Y228
D
D
P
P
E
P
V
Y
A
N
I
E
R
Q
P
Site 20
T238
I
E
R
Q
P
R
A
T
S
P
G
A
A
A
A
Site 21
S239
E
R
Q
P
R
A
T
S
P
G
A
A
A
A
P
Site 22
S249
A
A
A
A
P
L
P
S
P
V
W
E
T
H
T
Site 23
T256
S
P
V
W
E
T
H
T
D
A
G
T
G
R
P
Site 24
T260
E
T
H
T
D
A
G
T
G
R
P
Y
Y
Y
N
Site 25
Y264
D
A
G
T
G
R
P
Y
Y
Y
N
P
D
T
G
Site 26
Y265
A
G
T
G
R
P
Y
Y
Y
N
P
D
T
G
V
Site 27
Y266
G
T
G
R
P
Y
Y
Y
N
P
D
T
G
V
T
Site 28
T270
P
Y
Y
Y
N
P
D
T
G
V
T
T
W
E
S
Site 29
S277
T
G
V
T
T
W
E
S
P
F
E
A
A
E
G
Site 30
S287
E
A
A
E
G
A
A
S
P
A
T
S
P
A
S
Site 31
T290
E
G
A
A
S
P
A
T
S
P
A
S
V
D
S
Site 32
S291
G
A
A
S
P
A
T
S
P
A
S
V
D
S
H
Site 33
S294
S
P
A
T
S
P
A
S
V
D
S
H
V
S
L
Site 34
S297
T
S
P
A
S
V
D
S
H
V
S
L
E
T
E
Site 35
S300
A
S
V
D
S
H
V
S
L
E
T
E
W
G
Q
Site 36
Y308
L
E
T
E
W
G
Q
Y
W
D
E
E
S
R
R
Site 37
Y319
E
S
R
R
V
F
F
Y
N
P
L
T
G
E
T
Site 38
T323
V
F
F
Y
N
P
L
T
G
E
T
A
W
E
D
Site 39
S347
L
E
M
Q
P
G
L
S
P
G
S
P
G
D
P
Site 40
S350
Q
P
G
L
S
P
G
S
P
G
D
P
R
P
P
Site 41
T358
P
G
D
P
R
P
P
T
P
E
T
D
Y
P
E
Site 42
T361
P
R
P
P
T
P
E
T
D
Y
P
E
S
L
T
Site 43
Y363
P
P
T
P
E
T
D
Y
P
E
S
L
T
S
Y
Site 44
S366
P
E
T
D
Y
P
E
S
L
T
S
Y
P
E
E
Site 45
T368
T
D
Y
P
E
S
L
T
S
Y
P
E
E
D
Y
Site 46
S369
D
Y
P
E
S
L
T
S
Y
P
E
E
D
Y
S
Site 47
Y370
Y
P
E
S
L
T
S
Y
P
E
E
D
Y
S
P
Site 48
Y375
T
S
Y
P
E
E
D
Y
S
P
V
G
S
F
G
Site 49
S376
S
Y
P
E
E
D
Y
S
P
V
G
S
F
G
E
Site 50
S380
E
D
Y
S
P
V
G
S
F
G
E
P
G
P
T
Site 51
T387
S
F
G
E
P
G
P
T
S
P
L
T
T
P
P
Site 52
S388
F
G
E
P
G
P
T
S
P
L
T
T
P
P
G
Site 53
T391
P
G
P
T
S
P
L
T
T
P
P
G
W
S
C
Site 54
T392
G
P
T
S
P
L
T
T
P
P
G
W
S
C
H
Site 55
S397
L
T
T
P
P
G
W
S
C
H
V
S
Q
D
K
Site 56
Y408
S
Q
D
K
Q
M
L
Y
T
N
H
F
T
Q
E
Site 57
Y428
E
D
P
H
G
K
P
Y
F
Y
N
P
E
D
S
Site 58
Y430
P
H
G
K
P
Y
F
Y
N
P
E
D
S
S
V
Site 59
S435
Y
F
Y
N
P
E
D
S
S
V
R
W
E
L
P
Site 60
S436
F
Y
N
P
E
D
S
S
V
R
W
E
L
P
Q
Site 61
S451
V
P
V
P
A
P
R
S
I
H
K
S
S
Q
D
Site 62
S455
A
P
R
S
I
H
K
S
S
Q
D
G
D
T
P
Site 63
S456
P
R
S
I
H
K
S
S
Q
D
G
D
T
P
A
Site 64
T461
K
S
S
Q
D
G
D
T
P
A
Q
A
S
P
P
Site 65
S466
G
D
T
P
A
Q
A
S
P
P
E
E
K
V
P
Site 66
S481
A
E
L
D
E
V
G
S
W
E
E
V
S
P
A
Site 67
S486
V
G
S
W
E
E
V
S
P
A
T
A
A
V
R
Site 68
T508
G
V
L
H
R
T
K
T
A
D
K
G
K
R
L
Site 69
S521
R
L
R
K
K
H
W
S
A
S
W
T
V
L
E
Site 70
S523
R
K
K
H
W
S
A
S
W
T
V
L
E
G
G
Site 71
S538
V
L
T
F
F
K
D
S
K
T
S
A
A
G
G
Site 72
T540
T
F
F
K
D
S
K
T
S
A
A
G
G
L
R
Site 73
S550
A
G
G
L
R
Q
P
S
K
F
S
T
P
E
Y
Site 74
T554
R
Q
P
S
K
F
S
T
P
E
Y
T
V
E
L
Site 75
Y557
S
K
F
S
T
P
E
Y
T
V
E
L
R
G
A
Site 76
T558
K
F
S
T
P
E
Y
T
V
E
L
R
G
A
T
Site 77
T565
T
V
E
L
R
G
A
T
L
S
W
A
P
K
D
Site 78
S567
E
L
R
G
A
T
L
S
W
A
P
K
D
K
S
Site 79
S574
S
W
A
P
K
D
K
S
S
R
K
N
V
L
E
Site 80
S584
K
N
V
L
E
L
R
S
R
D
G
S
E
Y
L
Site 81
S588
E
L
R
S
R
D
G
S
E
Y
L
I
Q
H
D
Site 82
Y590
R
S
R
D
G
S
E
Y
L
I
Q
H
D
S
E
Site 83
S623
A
E
L
P
P
E
E
S
E
S
S
R
V
D
F
Site 84
S625
L
P
P
E
E
S
E
S
S
R
V
D
F
G
S
Site 85
S626
P
P
E
E
S
E
S
S
R
V
D
F
G
S
S
Site 86
S632
S
S
R
V
D
F
G
S
S
E
R
L
G
S
W
Site 87
S633
S
R
V
D
F
G
S
S
E
R
L
G
S
W
Q
Site 88
S638
G
S
S
E
R
L
G
S
W
Q
E
K
E
E
D
Site 89
S662
L
G
P
V
G
L
E
S
D
L
S
K
V
R
H
Site 90
S665
V
G
L
E
S
D
L
S
K
V
R
H
K
L
R
Site 91
T680
K
F
L
Q
R
R
P
T
L
Q
S
L
R
E
K
Site 92
S683
Q
R
R
P
T
L
Q
S
L
R
E
K
G
Y
I
Site 93
S708
A
L
C
E
R
E
R
S
R
V
P
R
F
V
Q
Site 94
S786
P
E
P
L
F
P
F
S
H
F
R
Q
F
I
A
Site 95
S804
L
Q
D
Q
A
R
R
S
R
C
V
R
D
L
V
Site 96
S813
C
V
R
D
L
V
R
S
L
P
A
P
N
H
D
Site 97
T821
L
P
A
P
N
H
D
T
L
R
M
L
F
Q
H
Site 98
S842
H
G
E
Q
N
R
M
S
V
Q
S
V
A
I
V
Site 99
T862
L
R
P
E
V
E
E
T
S
M
P
M
T
M
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation