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Updated November 2019
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Protein Info
Short Name:
UBN2
Full Name:
Ubinuclein-2
Alias:
K2030; KIAA2030; Loc254048
Type:
Phosphoprotein
Mass (Da):
146089
Number AA:
1347
UniProt ID:
Q6ZU65
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
R
R
V
A
F
I
S
L
S
P
V
R
R
R
Site 2
S13
R
V
A
F
I
S
L
S
P
V
R
R
R
E
A
Site 3
Y22
V
R
R
R
E
A
E
Y
P
G
P
E
R
E
P
Site 4
Y31
G
P
E
R
E
P
E
Y
P
R
E
P
P
R
L
Site 5
Y43
P
R
L
E
P
Q
P
Y
R
E
P
A
R
A
E
Site 6
S61
P
R
E
P
A
P
R
S
D
A
Q
P
P
S
R
Site 7
S67
R
S
D
A
Q
P
P
S
R
E
K
P
L
P
Q
Site 8
S78
P
L
P
Q
R
E
V
S
R
A
E
P
P
M
S
Site 9
S85
S
R
A
E
P
P
M
S
L
Q
R
E
P
P
R
Site 10
S112
Q
P
P
P
P
R
E
S
A
S
R
A
E
Q
P
Site 11
S114
P
P
P
R
E
S
A
S
R
A
E
Q
P
P
R
Site 12
T126
P
P
R
P
P
R
E
T
V
R
L
E
L
V
L
Site 13
T137
E
L
V
L
K
D
P
T
D
E
S
C
V
E
F
Site 14
S140
L
K
D
P
T
D
E
S
C
V
E
F
S
Y
P
Site 15
T162
Q
R
K
K
L
I
H
T
E
D
P
F
N
D
E
Site 16
Y187
A
K
K
F
E
M
K
Y
G
G
K
P
R
K
H
Site 17
T212
I
G
F
G
Y
D
E
T
D
P
F
I
D
N
S
Site 18
S219
T
D
P
F
I
D
N
S
E
A
Y
D
E
L
V
Site 19
S229
Y
D
E
L
V
P
A
S
L
T
T
K
Y
G
G
Site 20
Y234
P
A
S
L
T
T
K
Y
G
G
F
Y
I
N
T
Site 21
Y238
T
T
K
Y
G
G
F
Y
I
N
T
G
T
L
Q
Site 22
S250
T
L
Q
F
R
Q
A
S
D
T
E
E
D
D
I
Site 23
T252
Q
F
R
Q
A
S
D
T
E
E
D
D
I
T
D
Site 24
T258
D
T
E
E
D
D
I
T
D
N
Q
K
H
K
P
Site 25
S311
V
A
L
N
S
H
K
S
E
K
K
K
K
R
Y
Site 26
Y318
S
E
K
K
K
K
R
Y
K
D
S
L
S
L
A
Site 27
S321
K
K
K
R
Y
K
D
S
L
S
L
A
A
M
I
Site 28
S323
K
R
Y
K
D
S
L
S
L
A
A
M
I
R
K
Site 29
T349
S
N
P
K
V
P
V
T
L
S
T
P
S
L
N
Site 30
S351
P
K
V
P
V
T
L
S
T
P
S
L
N
K
P
Site 31
T352
K
V
P
V
T
L
S
T
P
S
L
N
K
P
P
Site 32
S354
P
V
T
L
S
T
P
S
L
N
K
P
P
C
A
Site 33
S375
D
V
P
D
L
N
L
S
S
G
D
P
D
L
P
Site 34
S376
V
P
D
L
N
L
S
S
G
D
P
D
L
P
I
Site 35
S386
P
D
L
P
I
F
V
S
T
N
E
H
E
L
F
Site 36
S416
D
R
L
L
D
A
A
S
D
G
S
P
L
S
E
Site 37
S419
L
D
A
A
S
D
G
S
P
L
S
E
S
G
G
Site 38
S422
A
S
D
G
S
P
L
S
E
S
G
G
E
N
G
Site 39
S424
D
G
S
P
L
S
E
S
G
G
E
N
G
T
T
Site 40
T430
E
S
G
G
E
N
G
T
T
T
Q
P
T
Y
T
Site 41
T431
S
G
G
E
N
G
T
T
T
Q
P
T
Y
T
S
Site 42
T432
G
G
E
N
G
T
T
T
Q
P
T
Y
T
S
Q
Site 43
Y436
G
T
T
T
Q
P
T
Y
T
S
Q
V
M
P
K
Site 44
S438
T
T
Q
P
T
Y
T
S
Q
V
M
P
K
V
V
Site 45
T480
E
G
R
K
K
F
F
T
Q
D
M
N
N
I
L
Site 46
S503
E
L
G
P
V
I
R
S
G
V
Y
S
H
L
E
Site 47
S548
Q
K
L
K
L
A
V
S
N
V
M
P
E
Q
L
Site 48
Y558
M
P
E
Q
L
F
K
Y
Q
E
D
C
Q
A
R
Site 49
S566
Q
E
D
C
Q
A
R
S
Q
A
K
C
A
K
L
Site 50
S584
E
E
R
E
K
N
G
S
E
E
D
D
D
E
K
Site 51
T611
H
W
D
D
T
I
R
T
L
L
C
N
L
V
E
Site 52
Y624
V
E
I
K
L
G
C
Y
E
L
E
P
N
K
S
Site 53
S631
Y
E
L
E
P
N
K
S
Q
S
A
E
D
Y
L
Site 54
Y637
K
S
Q
S
A
E
D
Y
L
K
S
F
M
E
T
Site 55
S640
S
A
E
D
Y
L
K
S
F
M
E
T
E
V
K
Site 56
T644
Y
L
K
S
F
M
E
T
E
V
K
P
L
W
P
Site 57
S666
M
L
F
K
E
S
R
S
V
H
N
H
L
T
S
Site 58
T672
R
S
V
H
N
H
L
T
S
A
P
A
K
K
K
Site 59
S700
V
K
T
L
P
L
H
S
F
P
T
M
L
K
E
Site 60
S709
P
T
M
L
K
E
C
S
P
K
K
D
Q
K
T
Site 61
T716
S
P
K
K
D
Q
K
T
P
T
S
L
V
A
S
Site 62
S719
K
D
Q
K
T
P
T
S
L
V
A
S
V
S
G
Site 63
S723
T
P
T
S
L
V
A
S
V
S
G
P
P
T
S
Site 64
S725
T
S
L
V
A
S
V
S
G
P
P
T
S
S
S
Site 65
S742
A
I
A
A
A
S
S
S
S
A
P
A
Q
E
T
Site 66
S755
E
T
I
C
L
D
D
S
L
D
E
D
L
S
F
Site 67
S761
D
S
L
D
E
D
L
S
F
H
S
P
S
L
D
Site 68
S764
D
E
D
L
S
F
H
S
P
S
L
D
L
V
S
Site 69
S766
D
L
S
F
H
S
P
S
L
D
L
V
S
E
A
Site 70
S788
N
K
G
P
P
V
G
S
R
I
S
M
P
T
T
Site 71
S791
P
P
V
G
S
R
I
S
M
P
T
T
K
P
R
Site 72
T794
G
S
R
I
S
M
P
T
T
K
P
R
P
G
L
Site 73
T795
S
R
I
S
M
P
T
T
K
P
R
P
G
L
R
Site 74
S808
L
R
E
E
K
L
A
S
I
M
S
K
L
P
L
Site 75
T817
M
S
K
L
P
L
A
T
P
K
K
L
D
S
T
Site 76
S823
A
T
P
K
K
L
D
S
T
Q
T
T
H
S
S
Site 77
T824
T
P
K
K
L
D
S
T
Q
T
T
H
S
S
S
Site 78
T826
K
K
L
D
S
T
Q
T
T
H
S
S
S
L
I
Site 79
T827
K
L
D
S
T
Q
T
T
H
S
S
S
L
I
A
Site 80
S831
T
Q
T
T
H
S
S
S
L
I
A
G
H
T
G
Site 81
T850
K
P
Q
D
L
A
H
T
G
I
S
S
G
L
I
Site 82
S861
S
G
L
I
A
G
S
S
I
Q
N
P
K
V
S
Site 83
S868
S
I
Q
N
P
K
V
S
L
E
P
L
P
A
R
Site 84
S884
L
Q
Q
G
L
Q
R
S
S
Q
I
H
T
S
S
Site 85
S885
Q
Q
G
L
Q
R
S
S
Q
I
H
T
S
S
S
Site 86
T889
Q
R
S
S
Q
I
H
T
S
S
S
S
Q
T
H
Site 87
S890
R
S
S
Q
I
H
T
S
S
S
S
Q
T
H
V
Site 88
S891
S
S
Q
I
H
T
S
S
S
S
Q
T
H
V
S
Site 89
S892
S
Q
I
H
T
S
S
S
S
Q
T
H
V
S
S
Site 90
S893
Q
I
H
T
S
S
S
S
Q
T
H
V
S
S
S
Site 91
T895
H
T
S
S
S
S
Q
T
H
V
S
S
S
S
Q
Site 92
S898
S
S
S
Q
T
H
V
S
S
S
S
Q
A
Q
I
Site 93
S901
Q
T
H
V
S
S
S
S
Q
A
Q
I
A
A
S
Site 94
S908
S
Q
A
Q
I
A
A
S
S
H
A
L
G
T
S
Site 95
S909
Q
A
Q
I
A
A
S
S
H
A
L
G
T
S
E
Site 96
S915
S
S
H
A
L
G
T
S
E
A
Q
D
A
S
S
Site 97
S922
S
E
A
Q
D
A
S
S
L
T
Q
V
T
K
V
Site 98
T924
A
Q
D
A
S
S
L
T
Q
V
T
K
V
H
Q
Site 99
Y939
H
S
A
V
Q
Q
N
Y
V
S
P
L
Q
A
T
Site 100
S941
A
V
Q
Q
N
Y
V
S
P
L
Q
A
T
I
S
Site 101
T946
Y
V
S
P
L
Q
A
T
I
S
K
S
Q
T
N
Site 102
S948
S
P
L
Q
A
T
I
S
K
S
Q
T
N
P
V
Site 103
S950
L
Q
A
T
I
S
K
S
Q
T
N
P
V
V
K
Site 104
T952
A
T
I
S
K
S
Q
T
N
P
V
V
K
L
S
Site 105
S959
T
N
P
V
V
K
L
S
N
N
P
Q
L
S
C
Site 106
S965
L
S
N
N
P
Q
L
S
C
S
S
S
L
I
K
Site 107
S967
N
N
P
Q
L
S
C
S
S
S
L
I
K
T
S
Site 108
S969
P
Q
L
S
C
S
S
S
L
I
K
T
S
D
K
Site 109
T973
C
S
S
S
L
I
K
T
S
D
K
P
L
M
Y
Site 110
S974
S
S
S
L
I
K
T
S
D
K
P
L
M
Y
R
Site 111
Y980
T
S
D
K
P
L
M
Y
R
L
P
L
S
T
P
Site 112
S985
L
M
Y
R
L
P
L
S
T
P
S
P
G
N
G
Site 113
T986
M
Y
R
L
P
L
S
T
P
S
P
G
N
G
S
Site 114
S988
R
L
P
L
S
T
P
S
P
G
N
G
S
Q
G
Site 115
S993
T
P
S
P
G
N
G
S
Q
G
S
H
P
L
V
Site 116
S996
P
G
N
G
S
Q
G
S
H
P
L
V
S
R
T
Site 117
T1003
S
H
P
L
V
S
R
T
V
P
S
T
T
T
S
Site 118
S1006
L
V
S
R
T
V
P
S
T
T
T
S
S
N
Y
Site 119
T1007
V
S
R
T
V
P
S
T
T
T
S
S
N
Y
L
Site 120
S1010
T
V
P
S
T
T
T
S
S
N
Y
L
A
K
A
Site 121
S1011
V
P
S
T
T
T
S
S
N
Y
L
A
K
A
M
Site 122
T1024
A
M
V
S
Q
I
S
T
Q
G
F
K
S
P
F
Site 123
S1029
I
S
T
Q
G
F
K
S
P
F
S
M
A
A
S
Site 124
S1032
Q
G
F
K
S
P
F
S
M
A
A
S
P
K
L
Site 125
S1042
A
S
P
K
L
A
A
S
P
K
P
A
T
S
P
Site 126
T1047
A
A
S
P
K
P
A
T
S
P
K
P
L
P
S
Site 127
S1048
A
S
P
K
P
A
T
S
P
K
P
L
P
S
P
Site 128
S1054
T
S
P
K
P
L
P
S
P
K
P
S
A
S
P
Site 129
S1058
P
L
P
S
P
K
P
S
A
S
P
K
P
S
L
Site 130
S1060
P
S
P
K
P
S
A
S
P
K
P
S
L
S
A
Site 131
S1064
P
S
A
S
P
K
P
S
L
S
A
K
P
S
V
Site 132
S1066
A
S
P
K
P
S
L
S
A
K
P
S
V
S
T
Site 133
S1070
P
S
L
S
A
K
P
S
V
S
T
K
L
I
S
Site 134
S1077
S
V
S
T
K
L
I
S
K
S
N
P
T
P
K
Site 135
S1079
S
T
K
L
I
S
K
S
N
P
T
P
K
P
T
Site 136
T1082
L
I
S
K
S
N
P
T
P
K
P
T
V
S
P
Site 137
T1086
S
N
P
T
P
K
P
T
V
S
P
S
S
S
S
Site 138
S1088
P
T
P
K
P
T
V
S
P
S
S
S
S
P
N
Site 139
S1090
P
K
P
T
V
S
P
S
S
S
S
P
N
A
L
Site 140
S1091
K
P
T
V
S
P
S
S
S
S
P
N
A
L
V
Site 141
S1092
P
T
V
S
P
S
S
S
S
P
N
A
L
V
A
Site 142
S1093
T
V
S
P
S
S
S
S
P
N
A
L
V
A
Q
Site 143
S1102
N
A
L
V
A
Q
G
S
H
S
S
T
N
S
P
Site 144
S1104
L
V
A
Q
G
S
H
S
S
T
N
S
P
V
H
Site 145
S1105
V
A
Q
G
S
H
S
S
T
N
S
P
V
H
K
Site 146
T1106
A
Q
G
S
H
S
S
T
N
S
P
V
H
K
Q
Site 147
S1108
G
S
H
S
S
T
N
S
P
V
H
K
Q
P
S
Site 148
S1115
S
P
V
H
K
Q
P
S
G
M
N
I
S
R
Q
Site 149
S1120
Q
P
S
G
M
N
I
S
R
Q
S
P
T
L
N
Site 150
S1123
G
M
N
I
S
R
Q
S
P
T
L
N
L
L
P
Site 151
T1125
N
I
S
R
Q
S
P
T
L
N
L
L
P
S
S
Site 152
S1131
P
T
L
N
L
L
P
S
S
R
T
S
G
L
P
Site 153
S1132
T
L
N
L
L
P
S
S
R
T
S
G
L
P
P
Site 154
S1135
L
L
P
S
S
R
T
S
G
L
P
P
T
K
N
Site 155
S1147
T
K
N
L
Q
A
P
S
K
L
T
N
S
S
S
Site 156
T1150
L
Q
A
P
S
K
L
T
N
S
S
S
T
G
T
Site 157
S1152
A
P
S
K
L
T
N
S
S
S
T
G
T
V
G
Site 158
S1154
S
K
L
T
N
S
S
S
T
G
T
V
G
K
N
Site 159
T1157
T
N
S
S
S
T
G
T
V
G
K
N
S
L
S
Site 160
S1162
T
G
T
V
G
K
N
S
L
S
G
I
A
M
N
Site 161
S1173
I
A
M
N
V
P
A
S
R
G
S
N
L
N
S
Site 162
S1176
N
V
P
A
S
R
G
S
N
L
N
S
S
G
A
Site 163
S1180
S
R
G
S
N
L
N
S
S
G
A
N
R
T
S
Site 164
S1181
R
G
S
N
L
N
S
S
G
A
N
R
T
S
L
Site 165
S1187
S
S
G
A
N
R
T
S
L
S
G
G
T
G
S
Site 166
S1189
G
A
N
R
T
S
L
S
G
G
T
G
S
G
T
Site 167
S1194
S
L
S
G
G
T
G
S
G
T
Q
G
A
T
K
Site 168
T1196
S
G
G
T
G
S
G
T
Q
G
A
T
K
P
L
Site 169
S1204
Q
G
A
T
K
P
L
S
T
P
H
R
P
S
T
Site 170
T1205
G
A
T
K
P
L
S
T
P
H
R
P
S
T
A
Site 171
S1210
L
S
T
P
H
R
P
S
T
A
S
G
S
S
V
Site 172
T1211
S
T
P
H
R
P
S
T
A
S
G
S
S
V
V
Site 173
S1213
P
H
R
P
S
T
A
S
G
S
S
V
V
T
A
Site 174
S1215
R
P
S
T
A
S
G
S
S
V
V
T
A
S
V
Site 175
S1242
S
P
L
T
L
M
T
S
P
L
S
V
T
N
Q
Site 176
S1245
T
L
M
T
S
P
L
S
V
T
N
Q
N
V
T
Site 177
T1285
T
D
T
A
G
V
T
T
T
S
G
S
T
S
A
Site 178
S1289
G
V
T
T
T
S
G
S
T
S
A
A
F
H
H
Site 179
S1291
T
T
T
S
G
S
T
S
A
A
F
H
H
S
L
Site 180
S1297
T
S
A
A
F
H
H
S
L
T
Q
N
L
L
K
Site 181
T1316
G
G
A
Q
H
A
A
T
L
S
H
S
P
L
P
Site 182
S1318
A
Q
H
A
A
T
L
S
H
S
P
L
P
A
H
Site 183
S1320
H
A
A
T
L
S
H
S
P
L
P
A
H
L
Q
Site 184
T1340
G
G
Q
S
K
G
D
T
K
L
P
R
K
S
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation