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Updated November 2019
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Protein Info
Short Name:
CCDC108
Full Name:
Coiled-coil domain-containing protein 108
Alias:
CC108; coiled-coil domain containing 108; DKFZp434O0527; MGC35338
Type:
Mass (Da):
217232
Number AA:
1925
UniProt ID:
Q6ZU64
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
G
C
R
L
V
E
K
T
Q
K
V
E
N
P
S
Site 2
S20
T
Q
K
V
E
N
P
S
V
S
F
A
S
S
F
Site 3
S22
K
V
E
N
P
S
V
S
F
A
S
S
F
P
L
Site 4
S38
P
L
L
L
R
G
K
S
V
Q
K
K
Q
A
E
Site 5
S46
V
Q
K
K
Q
A
E
S
K
S
Q
I
K
L
H
Site 6
S48
K
K
Q
A
E
S
K
S
Q
I
K
L
H
T
Q
Site 7
S73
M
M
L
T
Q
A
P
S
S
V
V
R
S
R
N
Site 8
S74
M
L
T
Q
A
P
S
S
V
V
R
S
R
N
S
Site 9
S78
A
P
S
S
V
V
R
S
R
N
S
R
N
H
T
Site 10
S81
S
V
V
R
S
R
N
S
R
N
H
T
V
N
S
Site 11
T85
S
R
N
S
R
N
H
T
V
N
S
G
G
S
C
Site 12
S88
S
R
N
H
T
V
N
S
G
G
S
C
L
S
A
Site 13
S111
N
D
S
S
A
A
M
S
A
C
S
T
I
S
A
Site 14
S122
T
I
S
A
Q
P
A
S
S
M
D
T
Q
M
H
Site 15
S123
I
S
A
Q
P
A
S
S
M
D
T
Q
M
H
S
Site 16
T126
Q
P
A
S
S
M
D
T
Q
M
H
S
P
K
K
Site 17
S130
S
M
D
T
Q
M
H
S
P
K
K
Q
E
R
V
Site 18
Y180
L
K
L
Q
K
M
K
Y
R
P
P
K
T
K
F
Site 19
Y218
R
P
L
E
A
K
E
Y
M
D
Q
L
W
F
E
Site 20
T279
G
D
L
P
T
F
F
T
W
E
F
S
S
P
F
Site 21
S301
L
L
E
P
G
Q
A
S
Q
I
K
V
T
F
Q
Site 22
Y323
E
V
Q
A
T
C
W
Y
G
A
G
S
R
Q
R
Site 23
S327
T
C
W
Y
G
A
G
S
R
Q
R
S
S
I
Q
Site 24
S331
G
A
G
S
R
Q
R
S
S
I
Q
L
Q
A
V
Site 25
S332
A
G
S
R
Q
R
S
S
I
Q
L
Q
A
V
A
Site 26
S369
Q
K
L
L
Y
F
G
S
V
A
V
G
C
T
S
Site 27
S376
S
V
A
V
G
C
T
S
E
R
Q
I
R
L
H
Site 28
S386
Q
I
R
L
H
N
P
S
A
V
N
A
P
F
R
Site 29
S397
A
P
F
R
I
E
I
S
P
D
E
L
A
E
D
Site 30
S425
P
G
E
K
K
C
V
S
V
F
F
H
P
K
T
Site 31
T432
S
V
F
F
H
P
K
T
L
D
T
R
T
V
D
Site 32
T437
P
K
T
L
D
T
R
T
V
D
Y
C
S
I
M
Site 33
Y440
L
D
T
R
T
V
D
Y
C
S
I
M
P
S
G
Site 34
T560
L
F
L
D
L
M
G
T
C
H
S
D
S
T
K
Site 35
S563
D
L
M
G
T
C
H
S
D
S
T
K
P
A
I
Site 36
S565
M
G
T
C
H
S
D
S
T
K
P
A
I
L
K
Site 37
Y627
E
D
M
P
A
P
Q
Y
P
Y
I
P
P
M
T
Site 38
Y629
M
P
A
P
Q
Y
P
Y
I
P
P
M
T
E
F
Site 39
T699
S
D
C
P
F
W
V
T
P
E
S
C
D
V
P
Site 40
S702
P
F
W
V
T
P
E
S
C
D
V
P
P
L
K
Site 41
Y726
P
P
H
P
N
C
L
Y
T
V
E
L
E
A
F
Site 42
S741
A
I
Y
K
V
L
Q
S
Y
S
N
I
E
E
D
Site 43
S743
Y
K
V
L
Q
S
Y
S
N
I
E
E
D
C
T
Site 44
S765
T
V
R
A
R
G
H
S
Y
F
A
G
F
E
H
Site 45
Y766
V
R
A
R
G
H
S
Y
F
A
G
F
E
H
H
Site 46
Y777
F
E
H
H
I
P
Q
Y
S
L
D
V
P
K
L
Site 47
S789
P
K
L
F
P
A
V
S
S
G
E
P
T
Y
R
Site 48
Y795
V
S
S
G
E
P
T
Y
R
S
L
L
L
V
N
Site 49
S797
S
G
E
P
T
Y
R
S
L
L
L
V
N
K
D
Site 50
T809
N
K
D
C
K
L
L
T
F
S
L
A
P
Q
R
Site 51
S811
D
C
K
L
L
T
F
S
L
A
P
Q
R
G
S
Site 52
S818
S
L
A
P
Q
R
G
S
D
V
I
L
R
P
T
Site 53
S860
F
Y
L
Q
C
N
A
S
P
Q
Y
L
K
E
V
Site 54
Y863
Q
C
N
A
S
P
Q
Y
L
K
E
V
S
M
Y
Site 55
Y870
Y
L
K
E
V
S
M
Y
S
R
E
E
P
L
Q
Site 56
T882
P
L
Q
L
K
L
D
T
H
K
S
L
Y
F
K
Site 57
S885
L
K
L
D
T
H
K
S
L
Y
F
K
P
T
W
Site 58
Y887
L
D
T
H
K
S
L
Y
F
K
P
T
W
V
G
Site 59
T891
K
S
L
Y
F
K
P
T
W
V
G
C
S
S
T
Site 60
S897
P
T
W
V
G
C
S
S
T
S
P
F
T
F
R
Site 61
S899
W
V
G
C
S
S
T
S
P
F
T
F
R
N
P
Site 62
T902
C
S
S
T
S
P
F
T
F
R
N
P
S
R
L
Site 63
S907
P
F
T
F
R
N
P
S
R
L
P
L
Q
F
E
Site 64
S918
L
Q
F
E
W
R
V
S
E
Q
H
R
K
L
L
Site 65
S930
K
L
L
A
V
Q
P
S
R
G
L
I
Q
P
N
Site 66
T941
I
Q
P
N
E
R
L
T
L
T
W
T
F
S
P
Site 67
T943
P
N
E
R
L
T
L
T
W
T
F
S
P
L
E
Site 68
T945
E
R
L
T
L
T
W
T
F
S
P
L
E
E
T
Site 69
S947
L
T
L
T
W
T
F
S
P
L
E
E
T
K
Y
Site 70
Y954
S
P
L
E
E
T
K
Y
L
F
Q
V
G
M
W
Site 71
S968
W
V
W
E
A
G
L
S
P
N
A
N
P
A
A
Site 72
S991
V
G
V
G
L
T
S
S
L
S
A
K
E
K
E
Site 73
S993
V
G
L
T
S
S
L
S
A
K
E
K
E
L
A
Site 74
Y1025
N
D
G
N
C
T
L
Y
Y
R
L
Y
L
E
Q
Site 75
Y1026
D
G
N
C
T
L
Y
Y
R
L
Y
L
E
Q
G
Site 76
Y1029
C
T
L
Y
Y
R
L
Y
L
E
Q
G
S
P
E
Site 77
S1034
R
L
Y
L
E
Q
G
S
P
E
A
V
D
N
H
Site 78
T1050
L
A
L
Q
L
D
R
T
E
G
S
M
P
P
R
Site 79
S1053
Q
L
D
R
T
E
G
S
M
P
P
R
S
Q
D
Site 80
S1058
E
G
S
M
P
P
R
S
Q
D
T
I
C
L
T
Site 81
T1065
S
Q
D
T
I
C
L
T
A
C
P
K
Q
R
S
Site 82
Y1074
C
P
K
Q
R
S
Q
Y
S
W
T
I
T
Y
S
Site 83
S1075
P
K
Q
R
S
Q
Y
S
W
T
I
T
Y
S
L
Site 84
T1077
Q
R
S
Q
Y
S
W
T
I
T
Y
S
L
L
S
Site 85
T1079
S
Q
Y
S
W
T
I
T
Y
S
L
L
S
H
R
Site 86
S1084
T
I
T
Y
S
L
L
S
H
R
D
N
K
A
G
Site 87
S1118
L
D
V
S
S
M
G
S
A
E
G
I
T
R
K
Site 88
S1132
K
H
L
W
R
L
F
S
L
D
L
L
N
S
Y
Site 89
S1138
F
S
L
D
L
L
N
S
Y
L
E
R
D
P
T
Site 90
Y1139
S
L
D
L
L
N
S
Y
L
E
R
D
P
T
P
Site 91
T1145
S
Y
L
E
R
D
P
T
P
C
E
L
T
Y
K
Site 92
Y1151
P
T
P
C
E
L
T
Y
K
V
P
T
R
H
S
Site 93
S1158
Y
K
V
P
T
R
H
S
M
S
Q
I
P
P
V
Site 94
S1160
V
P
T
R
H
S
M
S
Q
I
P
P
V
L
T
Site 95
S1207
D
W
A
F
L
L
P
S
D
Q
R
I
D
V
E
Site 96
T1225
E
Q
A
E
L
N
S
T
E
L
H
Q
M
R
V
Site 97
S1239
V
Q
D
N
C
L
F
S
I
S
P
K
A
G
S
Site 98
S1241
D
N
C
L
F
S
I
S
P
K
A
G
S
L
S
Site 99
S1246
S
I
S
P
K
A
G
S
L
S
P
G
Q
E
Q
Site 100
S1248
S
P
K
A
G
S
L
S
P
G
Q
E
Q
M
V
Site 101
Y1259
E
Q
M
V
E
L
K
Y
S
H
L
F
I
G
T
Site 102
Y1296
T
V
K
P
E
Q
K
Y
V
H
F
T
S
T
T
Site 103
Y1321
T
L
P
P
R
Q
I
Y
E
L
Y
N
G
G
S
Site 104
Y1324
P
R
Q
I
Y
E
L
Y
N
G
G
S
V
P
V
Site 105
S1328
Y
E
L
Y
N
G
G
S
V
P
V
T
Y
E
V
Site 106
T1332
N
G
G
S
V
P
V
T
Y
E
V
Q
T
D
V
Site 107
S1341
E
V
Q
T
D
V
L
S
Q
V
Q
E
K
N
F
Site 108
S1366
K
G
E
I
Q
P
G
S
T
A
R
V
L
W
I
Site 109
Y1382
S
P
I
E
A
K
T
Y
T
V
D
V
P
I
H
Site 110
S1420
T
A
P
F
H
N
I
S
S
W
D
N
S
S
I
Site 111
S1425
N
I
S
S
W
D
N
S
S
I
H
S
R
L
V
Site 112
S1426
I
S
S
W
D
N
S
S
I
H
S
R
L
V
V
Site 113
S1429
W
D
N
S
S
I
H
S
R
L
V
V
P
G
Q
Site 114
S1441
P
G
Q
N
V
F
L
S
Q
S
H
I
S
L
G
Site 115
S1474
K
N
E
E
I
A
F
S
W
Q
P
S
P
L
D
Site 116
Y1524
A
D
L
V
C
K
L
Y
S
Q
Q
L
M
R
Q
Site 117
Y1532
S
Q
Q
L
M
R
Q
Y
H
K
E
L
Q
E
W
Site 118
T1551
V
R
Q
E
V
E
F
T
I
T
D
M
K
V
K
Site 119
T1553
Q
E
V
E
F
T
I
T
D
M
K
V
K
K
R
Site 120
Y1572
A
C
E
P
A
R
K
Y
K
T
L
P
P
I
K
Site 121
T1574
E
P
A
R
K
Y
K
T
L
P
P
I
K
N
Q
Site 122
S1583
P
P
I
K
N
Q
Q
S
V
S
R
P
A
S
W
Site 123
S1585
I
K
N
Q
Q
S
V
S
R
P
A
S
W
K
L
Site 124
S1589
Q
S
V
S
R
P
A
S
W
K
L
Q
T
P
K
Site 125
T1594
P
A
S
W
K
L
Q
T
P
K
E
E
V
S
W
Site 126
S1600
Q
T
P
K
E
E
V
S
W
P
C
P
Q
P
P
Site 127
S1608
W
P
C
P
Q
P
P
S
P
G
M
L
C
L
G
Site 128
S1653
R
K
A
P
R
E
E
S
E
T
S
E
E
K
S
Site 129
T1655
A
P
R
E
E
S
E
T
S
E
E
K
S
P
N
Site 130
S1656
P
R
E
E
S
E
T
S
E
E
K
S
P
N
K
Site 131
S1660
S
E
T
S
E
E
K
S
P
N
K
W
G
P
V
Site 132
S1668
P
N
K
W
G
P
V
S
K
Q
K
K
Q
L
L
Site 133
Y1706
S
L
V
E
Q
V
P
Y
F
R
Q
F
W
N
E
Site 134
S1735
M
P
I
L
P
V
P
S
S
S
W
E
D
G
K
Site 135
S1736
P
I
L
P
V
P
S
S
S
W
E
D
G
K
G
Site 136
S1737
I
L
P
V
P
S
S
S
W
E
D
G
K
G
K
Site 137
Y1754
K
E
D
R
P
E
H
Y
P
G
L
G
K
K
E
Site 138
T1785
E
E
E
E
E
E
E
T
E
E
E
E
L
G
K
Site 139
S1810
D
E
K
E
E
K
V
S
W
A
G
I
G
P
T
Site 140
T1817
S
W
A
G
I
G
P
T
P
Q
P
E
S
Q
E
Site 141
S1822
G
P
T
P
Q
P
E
S
Q
E
S
M
Q
W
Q
Site 142
T1883
S
R
G
E
V
V
L
T
S
R
P
R
V
I
A
Site 143
T1904
P
R
S
L
T
P
D
T
L
L
P
T
Q
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation