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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D9
Full Name:
TBC1 domain family member 9
Alias:
KIAA0882; MDR1; TBC1 domain family member 9A; TBC1 domain family, member 9 (with GRAM domain); TBCD9
Type:
Intracellular protein
Mass (Da):
143229
Number AA:
1266
UniProt ID:
Q6ZT07
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
I
T
E
R
A
N
P
Y
F
I
L
Q
R
R
K
Site 2
T69
P
Y
R
I
L
Y
Q
T
P
D
S
L
V
Y
W
Site 3
T77
P
D
S
L
V
Y
W
T
I
A
C
G
G
S
R
Site 4
S103
Q
N
L
L
Q
T
L
S
I
F
E
N
E
N
D
Site 5
T112
F
E
N
E
N
D
I
T
T
F
V
R
G
K
I
Site 6
T113
E
N
E
N
D
I
T
T
F
V
R
G
K
I
Q
Site 7
T138
D
V
K
E
D
D
D
T
E
K
F
K
E
A
I
Site 8
Y163
E
E
E
K
L
V
N
Y
Y
S
C
S
Y
W
K
Site 9
Y164
E
E
K
L
V
N
Y
Y
S
C
S
Y
W
K
G
Site 10
T207
V
I
R
W
V
D
I
T
Q
L
E
K
N
A
T
Site 11
S224
L
P
D
V
I
K
V
S
T
R
S
S
E
H
F
Site 12
S228
I
K
V
S
T
R
S
S
E
H
F
F
S
V
F
Site 13
S233
R
S
S
E
H
F
F
S
V
F
L
N
I
N
E
Site 14
S267
E
G
F
E
Q
D
R
S
L
P
K
L
K
R
K
Site 15
S275
L
P
K
L
K
R
K
S
P
K
K
V
S
A
L
Site 16
S280
R
K
S
P
K
K
V
S
A
L
K
R
D
L
D
Site 17
S292
D
L
D
A
R
A
K
S
E
R
Y
R
A
L
F
Site 18
Y334
Q
M
F
V
S
T
N
Y
I
C
F
T
S
K
E
Site 19
S346
S
K
E
E
N
L
C
S
L
I
I
P
L
R
E
Site 20
S362
T
I
V
E
K
A
D
S
S
S
V
L
P
S
P
Site 21
S364
V
E
K
A
D
S
S
S
V
L
P
S
P
L
S
Site 22
S368
D
S
S
S
V
L
P
S
P
L
S
I
S
T
R
Site 23
S371
S
V
L
P
S
P
L
S
I
S
T
R
N
R
M
Site 24
S373
L
P
S
P
L
S
I
S
T
R
N
R
M
T
F
Site 25
T379
I
S
T
R
N
R
M
T
F
L
F
A
N
L
K
Site 26
S396
D
F
L
V
Q
R
I
S
D
F
L
Q
Q
T
T
Site 27
T402
I
S
D
F
L
Q
Q
T
T
S
K
I
Y
S
D
Site 28
S404
D
F
L
Q
Q
T
T
S
K
I
Y
S
D
K
E
Site 29
S408
Q
T
T
S
K
I
Y
S
D
K
E
F
A
G
S
Site 30
S415
S
D
K
E
F
A
G
S
Y
N
S
S
D
D
E
Site 31
S419
F
A
G
S
Y
N
S
S
D
D
E
V
Y
S
R
Site 32
Y424
N
S
S
D
D
E
V
Y
S
R
P
S
S
L
V
Site 33
S425
S
S
D
D
E
V
Y
S
R
P
S
S
L
V
S
Site 34
S428
D
E
V
Y
S
R
P
S
S
L
V
S
S
S
P
Site 35
S429
E
V
Y
S
R
P
S
S
L
V
S
S
S
P
Q
Site 36
S432
S
R
P
S
S
L
V
S
S
S
P
Q
R
S
T
Site 37
S433
R
P
S
S
L
V
S
S
S
P
Q
R
S
T
S
Site 38
S434
P
S
S
L
V
S
S
S
P
Q
R
S
T
S
S
Site 39
S438
V
S
S
S
P
Q
R
S
T
S
S
D
A
D
G
Site 40
T439
S
S
S
P
Q
R
S
T
S
S
D
A
D
G
E
Site 41
S440
S
S
P
Q
R
S
T
S
S
D
A
D
G
E
R
Site 42
S441
S
P
Q
R
S
T
S
S
D
A
D
G
E
R
Q
Site 43
S455
Q
F
N
L
N
G
N
S
V
P
T
A
T
Q
T
Site 44
T462
S
V
P
T
A
T
Q
T
L
M
T
M
Y
R
R
Site 45
Y467
T
Q
T
L
M
T
M
Y
R
R
R
S
P
E
E
Site 46
S471
M
T
M
Y
R
R
R
S
P
E
E
F
N
P
K
Site 47
Y503
Y
G
Q
G
I
C
M
Y
R
T
E
K
T
R
E
Site 48
Y541
E
K
A
T
H
P
G
Y
Y
E
D
L
V
E
K
Site 49
S549
Y
E
D
L
V
E
K
S
M
G
K
Y
N
L
A
Site 50
Y553
V
E
K
S
M
G
K
Y
N
L
A
T
E
E
I
Site 51
S567
I
E
R
D
L
H
R
S
L
P
E
H
P
A
F
Site 52
Y590
L
R
R
V
L
T
A
Y
A
F
R
N
P
N
I
Site 53
Y634
C
E
R
M
L
P
D
Y
Y
N
T
R
V
V
G
Site 54
Y635
E
R
M
L
P
D
Y
Y
N
T
R
V
V
G
A
Site 55
Y656
F
E
E
L
A
R
D
Y
V
P
Q
L
Y
D
C
Site 56
Y661
R
D
Y
V
P
Q
L
Y
D
C
M
Q
D
L
G
Site 57
T732
K
D
D
G
E
A
M
T
V
L
G
R
Y
L
D
Site 58
Y737
A
M
T
V
L
G
R
Y
L
D
S
V
T
N
K
Site 59
S740
V
L
G
R
Y
L
D
S
V
T
N
K
D
S
T
Site 60
T742
G
R
Y
L
D
S
V
T
N
K
D
S
T
L
P
Site 61
S746
D
S
V
T
N
K
D
S
T
L
P
P
I
P
H
Site 62
T747
S
V
T
N
K
D
S
T
L
P
P
I
P
H
L
Site 63
S756
P
P
I
P
H
L
H
S
L
L
S
D
D
V
E
Site 64
S759
P
H
L
H
S
L
L
S
D
D
V
E
P
Y
P
Site 65
Y765
L
S
D
D
V
E
P
Y
P
E
V
D
I
F
R
Site 66
Y778
F
R
L
I
R
T
S
Y
E
K
F
G
T
I
R
Site 67
T783
T
S
Y
E
K
F
G
T
I
R
A
D
L
I
E
Site 68
T803
Q
R
L
K
V
I
Q
T
L
E
D
T
T
K
R
Site 69
T815
T
K
R
N
V
V
R
T
I
V
T
E
T
S
F
Site 70
S821
R
T
I
V
T
E
T
S
F
T
I
D
E
L
E
Site 71
Y843
A
E
H
L
T
S
C
Y
W
G
G
S
S
N
A
Site 72
S857
A
L
D
R
H
D
P
S
L
P
Y
L
E
Q
Y
Site 73
Y860
R
H
D
P
S
L
P
Y
L
E
Q
Y
R
I
D
Site 74
Y864
S
L
P
Y
L
E
Q
Y
R
I
D
F
E
Q
F
Site 75
S887
P
W
A
C
G
T
H
S
D
V
L
A
S
R
L
Site 76
S904
L
L
D
E
N
G
D
S
L
I
N
F
R
E
F
Site 77
S941
H
V
L
P
E
P
S
S
D
Q
D
E
P
D
S
Site 78
S948
S
D
Q
D
E
P
D
S
A
F
E
A
T
Q
Y
Site 79
Y955
S
A
F
E
A
T
Q
Y
F
F
E
D
I
T
P
Site 80
S972
T
H
V
V
G
L
D
S
R
S
K
Q
G
A
D
Site 81
S974
V
V
G
L
D
S
R
S
K
Q
G
A
D
D
G
Site 82
T984
G
A
D
D
G
F
V
T
V
S
L
K
P
D
K
Site 83
S986
D
D
G
F
V
T
V
S
L
K
P
D
K
G
K
Site 84
S997
D
K
G
K
R
A
N
S
Q
E
N
R
N
Y
L
Site 85
Y1003
N
S
Q
E
N
R
N
Y
L
R
L
W
T
P
E
Site 86
T1008
R
N
Y
L
R
L
W
T
P
E
N
K
S
K
S
Site 87
S1013
L
W
T
P
E
N
K
S
K
S
K
N
A
K
D
Site 88
S1015
T
P
E
N
K
S
K
S
K
N
A
K
D
L
P
Site 89
Y1037
I
E
L
C
K
T
M
Y
N
M
F
S
E
D
P
Site 90
Y1050
D
P
N
E
Q
E
L
Y
H
A
T
A
A
V
T
Site 91
S1080
Q
P
A
K
E
G
G
S
G
G
S
G
P
S
C
Site 92
S1086
G
S
G
G
S
G
P
S
C
H
Q
G
I
P
G
Site 93
Y1105
K
K
G
P
G
Q
P
Y
V
V
E
S
V
E
P
Site 94
S1109
G
Q
P
Y
V
V
E
S
V
E
P
L
P
A
S
Site 95
S1116
S
V
E
P
L
P
A
S
L
A
P
D
S
E
E
Site 96
S1121
P
A
S
L
A
P
D
S
E
E
H
S
L
G
G
Site 97
S1125
A
P
D
S
E
E
H
S
L
G
G
Q
M
E
D
Site 98
S1138
E
D
I
K
L
E
D
S
S
P
R
D
N
G
A
Site 99
S1139
D
I
K
L
E
D
S
S
P
R
D
N
G
A
C
Site 100
S1147
P
R
D
N
G
A
C
S
S
M
L
I
S
D
D
Site 101
S1148
R
D
N
G
A
C
S
S
M
L
I
S
D
D
D
Site 102
S1152
A
C
S
S
M
L
I
S
D
D
D
T
K
D
D
Site 103
T1156
M
L
I
S
D
D
D
T
K
D
D
S
S
M
S
Site 104
S1160
D
D
D
T
K
D
D
S
S
M
S
S
Y
S
V
Site 105
S1161
D
D
T
K
D
D
S
S
M
S
S
Y
S
V
L
Site 106
S1163
T
K
D
D
S
S
M
S
S
Y
S
V
L
S
A
Site 107
S1164
K
D
D
S
S
M
S
S
Y
S
V
L
S
A
G
Site 108
Y1165
D
D
S
S
M
S
S
Y
S
V
L
S
A
G
S
Site 109
S1166
D
S
S
M
S
S
Y
S
V
L
S
A
G
S
H
Site 110
S1169
M
S
S
Y
S
V
L
S
A
G
S
H
E
E
D
Site 111
T1187
C
E
D
I
G
E
D
T
V
L
V
R
S
G
Q
Site 112
T1196
L
V
R
S
G
Q
G
T
A
A
L
P
R
S
T
Site 113
S1202
G
T
A
A
L
P
R
S
T
S
L
D
R
D
W
Site 114
T1203
T
A
A
L
P
R
S
T
S
L
D
R
D
W
A
Site 115
S1204
A
A
L
P
R
S
T
S
L
D
R
D
W
A
I
Site 116
T1212
L
D
R
D
W
A
I
T
F
E
Q
F
L
A
S
Site 117
T1254
R
M
M
G
K
P
L
T
S
A
S
D
Y
E
I
Site 118
S1255
M
M
G
K
P
L
T
S
A
S
D
Y
E
I
S
Site 119
S1257
G
K
P
L
T
S
A
S
D
Y
E
I
S
A
M
Site 120
Y1259
P
L
T
S
A
S
D
Y
E
I
S
A
M
S
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation