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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAPN12
Full Name:
Calpain-12
Alias:
Calcium-activated neutral proteinase 12
Type:
Mass (Da):
81037
Number AA:
719
UniProt ID:
Q6ZSI9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
S
S
S
G
R
V
T
I
Q
L
V
D
E
E
Site 2
S31
L
Q
L
F
R
G
Q
S
Y
E
A
I
R
A
A
Site 3
Y50
G
I
L
F
R
D
P
Y
F
P
A
G
P
D
A
Site 4
Y60
A
G
P
D
A
L
G
Y
D
Q
L
G
P
D
S
Site 5
S67
Y
D
Q
L
G
P
D
S
E
K
A
K
G
V
K
Site 6
Y135
G
Q
D
F
Q
H
G
Y
A
G
V
F
H
F
Q
Site 7
Y185
A
P
L
L
E
K
A
Y
A
K
L
H
G
S
Y
Site 8
S191
A
Y
A
K
L
H
G
S
Y
E
V
M
R
G
G
Site 9
Y192
Y
A
K
L
H
G
S
Y
E
V
M
R
G
G
H
Site 10
Y216
G
G
V
G
E
V
L
Y
L
R
Q
N
S
M
G
Site 11
S244
L
V
G
A
T
A
L
S
D
R
G
E
Y
R
T
Site 12
Y249
A
L
S
D
R
G
E
Y
R
T
E
E
G
L
V
Site 13
T251
S
D
R
G
E
Y
R
T
E
E
G
L
V
K
G
Site 14
Y261
G
L
V
K
G
H
A
Y
S
I
T
G
T
H
K
Site 15
S262
L
V
K
G
H
A
Y
S
I
T
G
T
H
K
V
Site 16
T303
D
S
C
P
R
W
D
T
L
P
T
E
C
R
D
Site 17
T306
P
R
W
D
T
L
P
T
E
C
R
D
A
L
L
Site 18
S348
S
P
E
V
L
G
P
S
P
E
G
G
G
W
H
Site 19
S369
R
W
V
R
G
F
N
S
G
G
S
Q
P
N
A
Site 20
S372
R
G
F
N
S
G
G
S
Q
P
N
A
E
T
F
Site 21
T388
T
N
P
Q
F
R
L
T
L
L
E
P
D
E
E
Site 22
T421
G
P
A
R
G
G
R
T
P
K
C
T
V
L
L
Site 23
S429
P
K
C
T
V
L
L
S
L
I
Q
R
N
R
R
Site 24
S465
E
L
L
G
L
W
D
S
P
R
S
H
A
L
L
Site 25
S468
G
L
W
D
S
P
R
S
H
A
L
L
P
R
L
Site 26
S481
R
L
L
R
A
D
R
S
P
L
S
A
R
R
D
Site 27
S484
R
A
D
R
S
P
L
S
A
R
R
D
V
T
R
Site 28
T490
L
S
A
R
R
D
V
T
R
R
C
C
L
R
P
Site 29
T516
A
G
D
E
A
D
F
T
L
R
V
F
S
E
R
Site 30
S521
D
F
T
L
R
V
F
S
E
R
R
H
T
A
V
Site 31
T526
V
F
S
E
R
R
H
T
A
V
E
I
D
D
V
Site 32
S569
E
E
E
E
L
N
A
S
Q
L
Q
A
L
L
S
Site 33
T586
L
E
P
A
R
A
H
T
S
T
P
R
E
I
G
Site 34
S587
E
P
A
R
A
H
T
S
T
P
R
E
I
G
L
Site 35
T588
P
A
R
A
H
T
S
T
P
R
E
I
G
L
R
Site 36
T596
P
R
E
I
G
L
R
T
C
E
Q
L
L
Q
C
Site 37
T636
F
N
K
F
D
E
D
T
S
G
T
M
N
S
Y
Site 38
S637
N
K
F
D
E
D
T
S
G
T
M
N
S
Y
E
Site 39
S642
D
T
S
G
T
M
N
S
Y
E
L
R
L
A
L
Site 40
T661
F
H
L
N
N
Q
L
T
Q
T
L
T
S
R
Y
Site 41
T663
L
N
N
Q
L
T
Q
T
L
T
S
R
Y
R
D
Site 42
T665
N
Q
L
T
Q
T
L
T
S
R
Y
R
D
S
R
Site 43
S666
Q
L
T
Q
T
L
T
S
R
Y
R
D
S
R
L
Site 44
S671
L
T
S
R
Y
R
D
S
R
L
R
V
D
F
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation