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Updated November 2019
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Protein Info
Short Name:
WDFY4
Full Name:
WD repeat- and FYVE domain-containing protein 4
Alias:
Type:
Mass (Da):
353610
Number AA:
3184
UniProt ID:
Q6ZS81
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
D
R
N
E
D
P
G
S
K
N
E
G
Q
L
A
Site 2
S37
D
V
P
H
G
G
Q
S
S
S
P
T
A
L
W
Site 3
S38
V
P
H
G
G
Q
S
S
S
P
T
A
L
W
D
Site 4
S39
P
H
G
G
Q
S
S
S
P
T
A
L
W
D
M
Site 5
T41
G
G
Q
S
S
S
P
T
A
L
W
D
M
L
E
Site 6
Y54
L
E
R
K
F
L
E
Y
Q
Q
L
T
H
K
S
Site 7
S61
Y
Q
Q
L
T
H
K
S
P
I
E
R
Q
K
S
Site 8
S68
S
P
I
E
R
Q
K
S
L
L
S
L
L
P
L
Site 9
S100
Q
R
L
A
E
D
V
S
D
Q
L
A
Q
Q
L
Site 10
Y138
G
D
V
D
Q
D
G
Y
L
L
L
K
S
V
Y
Site 11
T150
S
V
Y
V
L
T
G
T
D
S
E
T
L
G
R
Site 12
S152
Y
V
L
T
G
T
D
S
E
T
L
G
R
V
A
Site 13
T154
L
T
G
T
D
S
E
T
L
G
R
V
A
E
S
Site 14
S187
D
K
D
E
L
L
E
S
D
L
Q
V
Q
K
M
Site 15
S204
Q
M
L
L
N
I
C
S
D
S
Q
G
L
E
G
Site 16
S214
Q
G
L
E
G
L
L
S
G
S
E
L
Q
S
L
Site 17
S268
A
T
D
C
V
R
L
S
L
Q
N
L
S
R
L
Site 18
S273
R
L
S
L
Q
N
L
S
R
L
T
D
T
L
P
Site 19
T276
L
Q
N
L
S
R
L
T
D
T
L
P
A
P
E
Site 20
T278
N
L
S
R
L
T
D
T
L
P
A
P
E
V
S
Site 21
Y315
E
F
E
N
S
E
G
Y
P
L
L
L
K
V
L
Site 22
T329
L
L
R
Y
D
G
L
T
Q
S
E
V
D
P
H
Site 23
S331
R
Y
D
G
L
T
Q
S
E
V
D
P
H
L
E
Site 24
S360
S
E
L
K
V
F
D
S
I
T
Y
P
Q
L
E
Site 25
Y363
K
V
F
D
S
I
T
Y
P
Q
L
E
G
F
K
Site 26
S477
V
Q
H
L
I
K
E
S
P
G
P
S
C
T
L
Site 27
S481
I
K
E
S
P
G
P
S
C
T
L
M
A
L
Q
Site 28
T501
A
G
G
D
P
L
F
T
D
I
F
R
D
S
G
Site 29
S527
Q
A
K
I
M
R
K
S
G
N
K
V
S
T
P
Site 30
S532
R
K
S
G
N
K
V
S
T
P
G
V
Q
D
P
Site 31
T533
K
S
G
N
K
V
S
T
P
G
V
Q
D
P
E
Site 32
T544
Q
D
P
E
R
E
L
T
C
V
M
L
R
I
V
Site 33
S587
D
E
C
Y
R
E
A
S
L
S
I
L
E
Q
L
Site 34
S660
L
L
S
D
L
E
G
S
L
Q
E
P
P
L
Q
Site 35
S673
L
Q
A
W
G
A
V
S
P
R
Q
T
L
E
L
Site 36
Y700
H
W
D
P
V
N
G
Y
F
F
R
R
N
G
L
Site 37
S733
E
E
G
N
L
L
R
S
W
V
D
T
K
A
R
Site 38
T737
L
L
R
S
W
V
D
T
K
A
R
P
F
A
D
Site 39
S752
L
L
G
T
A
F
S
S
S
G
S
L
P
P
R
Site 40
S755
T
A
F
S
S
S
G
S
L
P
P
R
I
Q
S
Site 41
S787
L
R
G
D
L
K
E
S
L
R
T
K
Q
G
P
Site 42
S805
V
Q
K
G
E
T
G
S
D
P
Q
R
N
F
K
Site 43
Y845
V
R
L
L
P
R
L
Y
H
E
D
H
P
Q
L
Site 44
S853
H
E
D
H
P
Q
L
S
E
E
I
Q
C
S
L
Site 45
S859
L
S
E
E
I
Q
C
S
L
A
S
H
I
Q
S
Site 46
S866
S
L
A
S
H
I
Q
S
L
V
K
S
E
K
N
Site 47
S870
H
I
Q
S
L
V
K
S
E
K
N
R
Q
V
M
Site 48
T896
S
C
H
R
A
L
V
T
S
G
S
P
L
H
S
Site 49
S897
C
H
R
A
L
V
T
S
G
S
P
L
H
S
R
Site 50
S903
T
S
G
S
P
L
H
S
R
L
I
R
I
F
E
Site 51
S914
R
I
F
E
K
L
A
S
Q
A
I
E
P
D
V
Site 52
T937
I
P
S
S
L
S
A
T
T
K
I
L
D
S
S
Site 53
T946
K
I
L
D
S
S
H
T
H
R
G
N
P
G
C
Site 54
S954
H
R
G
N
P
G
C
S
G
S
Q
T
A
Q
G
Site 55
S956
G
N
P
G
C
S
G
S
Q
T
A
Q
G
L
A
Site 56
T958
P
G
C
S
G
S
Q
T
A
Q
G
L
A
E
G
Site 57
T980
A
G
L
H
P
G
V
T
Q
A
P
Q
P
L
G
Site 58
S989
A
P
Q
P
L
G
E
S
Q
D
S
T
T
A
L
Site 59
S992
P
L
G
E
S
Q
D
S
T
T
A
L
Q
T
A
Site 60
T993
L
G
E
S
Q
D
S
T
T
A
L
Q
T
A
L
Site 61
S1007
L
S
L
I
S
M
T
S
P
R
N
L
Q
P
Q
Site 62
S1047
L
S
T
V
M
G
T
S
T
E
Y
S
V
S
G
Site 63
T1048
S
T
V
M
G
T
S
T
E
Y
S
V
S
G
G
Site 64
S1051
M
G
T
S
T
E
Y
S
V
S
G
G
I
G
T
Site 65
S1053
T
S
T
E
Y
S
V
S
G
G
I
G
T
G
A
Site 66
T1085
I
S
R
H
G
A
A
T
E
G
H
P
L
R
F
Site 67
S1123
D
D
L
S
L
V
V
S
T
E
E
K
E
F
Q
Site 68
S1141
V
M
E
P
E
D
D
S
E
P
S
A
G
C
Q
Site 69
T1178
K
E
M
K
R
H
C
T
V
S
T
C
L
D
G
Site 70
T1220
D
V
Y
G
Y
I
A
T
P
R
V
W
K
Q
K
Site 71
S1228
P
R
V
W
K
Q
K
S
S
L
I
W
R
L
G
Site 72
S1229
R
V
W
K
Q
K
S
S
L
I
W
R
L
G
P
Site 73
Y1259
I
N
K
L
G
P
R
Y
C
G
N
F
Q
A
V
Site 74
S1275
V
Q
G
E
D
L
D
S
E
A
T
P
F
V
A
Site 75
T1278
E
D
L
D
S
E
A
T
P
F
V
A
E
E
R
Site 76
Y1307
V
A
D
I
R
N
A
Y
N
E
V
D
S
R
L
Site 77
S1322
I
A
K
E
M
N
I
S
S
R
D
N
A
M
P
Site 78
S1323
A
K
E
M
N
I
S
S
R
D
N
A
M
P
V
Site 79
S1341
R
N
C
A
G
H
L
S
G
S
L
R
T
I
G
Site 80
S1363
G
V
R
V
F
H
S
S
P
A
A
S
S
L
D
Site 81
S1368
H
S
S
P
A
A
S
S
L
D
F
I
G
G
P
Site 82
Y1392
A
T
D
D
H
T
M
Y
A
A
V
K
V
L
H
Site 83
S1454
V
E
L
G
F
R
S
S
A
I
T
N
T
G
V
Site 84
T1457
G
F
R
S
S
A
I
T
N
T
G
V
F
Q
H
Site 85
S1493
H
L
L
E
I
L
Q
S
P
R
E
G
P
R
N
Site 86
S1543
C
Q
L
R
G
H
F
S
T
Q
D
L
L
R
I
Site 87
T1544
Q
L
R
G
H
F
S
T
Q
D
L
L
R
I
G
Site 88
S1562
V
Y
T
L
K
P
S
S
V
N
E
R
Q
I
C
Site 89
S1577
M
D
G
A
L
D
P
S
L
P
A
G
S
Q
T
Site 90
S1582
D
P
S
L
P
A
G
S
Q
T
S
G
K
T
I
Site 91
S1611
S
S
P
Q
L
H
L
S
S
E
S
K
E
E
M
Site 92
S1612
S
P
Q
L
H
L
S
S
E
S
K
E
E
M
F
Site 93
S1655
L
Y
F
L
A
S
P
S
L
R
T
R
F
R
D
Site 94
S1668
R
D
G
L
C
A
G
S
W
V
E
R
S
T
E
Site 95
S1673
A
G
S
W
V
E
R
S
T
E
G
V
D
I
V
Site 96
T1674
G
S
W
V
E
R
S
T
E
G
V
D
I
V
M
Site 97
S1686
I
V
M
D
N
L
K
S
Q
S
P
L
P
E
Q
Site 98
S1688
M
D
N
L
K
S
Q
S
P
L
P
E
Q
S
P
Site 99
S1694
Q
S
P
L
P
E
Q
S
P
C
L
L
P
G
F
Site 100
T1731
F
F
L
Q
T
P
L
T
E
L
M
D
G
P
K
Site 101
S1740
L
M
D
G
P
K
D
S
L
D
A
M
L
Q
W
Site 102
S1779
E
M
L
K
A
T
M
S
Q
P
L
A
G
S
E
Site 103
T1793
E
D
G
A
W
A
Q
T
F
P
A
S
V
L
Q
Site 104
Y1809
L
S
L
V
H
R
T
Y
P
Q
D
P
A
W
R
Site 105
S1841
Q
K
G
V
G
A
E
S
T
R
N
T
S
S
P
Site 106
T1842
K
G
V
G
A
E
S
T
R
N
T
S
S
P
E
Site 107
T1845
G
A
E
S
T
R
N
T
S
S
P
E
A
A
A
Site 108
S1846
A
E
S
T
R
N
T
S
S
P
E
A
A
A
E
Site 109
S1847
E
S
T
R
N
T
S
S
P
E
A
A
A
E
G
Site 110
S1856
E
A
A
A
E
G
D
S
T
V
E
G
L
Q
A
Site 111
T1857
A
A
A
E
G
D
S
T
V
E
G
L
Q
A
P
Site 112
T1878
R
R
K
L
R
E
F
T
Q
L
L
L
R
E
L
Site 113
S1890
R
E
L
L
L
G
A
S
S
P
K
Q
W
L
P
Site 114
S1905
L
E
V
L
L
E
A
S
P
D
H
A
T
S
Q
Site 115
S1911
A
S
P
D
H
A
T
S
Q
Q
K
R
D
F
Q
Site 116
S1919
Q
Q
K
R
D
F
Q
S
E
V
L
L
S
A
M
Site 117
S1949
D
G
K
E
P
Q
P
S
A
E
A
A
A
A
P
Site 118
Y1973
Q
K
L
V
E
K
L
Y
S
G
M
F
S
A
D
Site 119
S1974
K
L
V
E
K
L
Y
S
G
M
F
S
A
D
P
Site 120
S1978
K
L
Y
S
G
M
F
S
A
D
P
R
H
I
L
Site 121
T2005
T
A
S
S
Q
R
D
T
V
L
S
T
L
Y
S
Site 122
S2008
S
Q
R
D
T
V
L
S
T
L
Y
S
S
L
N
Site 123
T2009
Q
R
D
T
V
L
S
T
L
Y
S
S
L
N
K
Site 124
Y2020
S
L
N
K
V
I
L
Y
C
L
S
K
P
Q
Q
Site 125
S2023
K
V
I
L
Y
C
L
S
K
P
Q
Q
S
L
S
Site 126
S2028
C
L
S
K
P
Q
Q
S
L
S
E
C
L
G
L
Site 127
S2030
S
K
P
Q
Q
S
L
S
E
C
L
G
L
L
S
Site 128
Y2075
L
L
L
N
E
R
S
Y
P
E
G
F
G
L
E
Site 129
S2088
L
E
P
K
P
R
M
S
T
Y
H
Q
V
F
L
Site 130
T2089
E
P
K
P
R
M
S
T
Y
H
Q
V
F
L
S
Site 131
Y2090
P
K
P
R
M
S
T
Y
H
Q
V
F
L
S
P
Site 132
S2096
T
Y
H
Q
V
F
L
S
P
N
E
D
V
K
E
Site 133
S2110
E
K
R
E
D
L
P
S
L
S
D
V
Q
H
N
Site 134
S2112
R
E
D
L
P
S
L
S
D
V
Q
H
N
I
Q
Site 135
T2121
V
Q
H
N
I
Q
K
T
V
Q
T
L
W
Q
Q
Site 136
T2136
L
V
A
Q
R
Q
Q
T
L
E
D
A
F
K
I
Site 137
S2146
D
A
F
K
I
D
L
S
V
K
P
G
E
R
E
Site 138
T2160
E
V
K
I
E
E
V
T
P
L
W
E
E
T
M
Site 139
S2177
A
W
Q
H
Y
L
A
S
E
K
K
S
L
A
S
Site 140
S2181
Y
L
A
S
E
K
K
S
L
A
S
R
S
N
V
Site 141
S2184
S
E
K
K
S
L
A
S
R
S
N
V
A
H
H
Site 142
S2186
K
K
S
L
A
S
R
S
N
V
A
H
H
S
K
Site 143
S2192
R
S
N
V
A
H
H
S
K
V
T
L
W
S
G
Site 144
S2198
H
S
K
V
T
L
W
S
G
S
L
S
S
A
M
Site 145
T2220
A
K
D
P
E
C
K
T
E
D
F
V
S
C
I
Site 146
Y2230
F
V
S
C
I
E
N
Y
R
R
R
G
Q
E
L
Site 147
Y2238
R
R
R
G
Q
E
L
Y
A
S
L
Y
K
D
H
Site 148
S2240
R
G
Q
E
L
Y
A
S
L
Y
K
D
H
V
Q
Site 149
Y2242
Q
E
L
Y
A
S
L
Y
K
D
H
V
Q
R
R
Site 150
S2275
F
G
E
L
G
L
W
S
Q
G
E
E
T
K
P
Site 151
T2280
L
W
S
Q
G
E
E
T
K
P
C
S
P
W
E
Site 152
S2284
G
E
E
T
K
P
C
S
P
W
E
L
D
W
R
Site 153
S2305
R
K
R
I
K
R
L
S
P
L
E
A
L
S
S
Site 154
S2311
L
S
P
L
E
A
L
S
S
G
R
H
K
E
S
Site 155
S2312
S
P
L
E
A
L
S
S
G
R
H
K
E
S
Q
Site 156
S2318
S
S
G
R
H
K
E
S
Q
D
K
N
D
H
I
Site 157
S2326
Q
D
K
N
D
H
I
S
Q
T
N
A
E
N
Q
Site 158
T2337
A
E
N
Q
D
E
L
T
L
R
E
A
E
G
E
Site 159
S2364
F
F
P
A
L
H
E
S
L
H
S
E
D
F
L
Site 160
S2367
A
L
H
E
S
L
H
S
E
D
F
L
E
L
C
Site 161
Y2431
L
S
P
T
G
D
V
Y
C
T
R
H
C
L
S
Site 162
S2450
P
F
I
F
N
L
C
S
K
D
R
S
T
D
H
Site 163
T2455
L
C
S
K
D
R
S
T
D
H
Y
S
C
Q
C
Site 164
Y2458
K
D
R
S
T
D
H
Y
S
C
Q
C
H
S
Y
Site 165
Y2498
Y
S
K
F
L
V
F
Y
N
N
D
R
S
K
A
Site 166
S2508
D
R
S
K
A
F
K
S
F
C
S
F
Q
P
S
Site 167
S2511
K
A
F
K
S
F
C
S
F
Q
P
S
L
K
G
Site 168
S2515
S
F
C
S
F
Q
P
S
L
K
G
K
A
T
S
Site 169
T2521
P
S
L
K
G
K
A
T
S
E
D
T
L
S
L
Site 170
S2522
S
L
K
G
K
A
T
S
E
D
T
L
S
L
R
Site 171
T2525
G
K
A
T
S
E
D
T
L
S
L
R
R
Y
P
Site 172
S2527
A
T
S
E
D
T
L
S
L
R
R
Y
P
G
S
Site 173
Y2531
D
T
L
S
L
R
R
Y
P
G
S
D
R
I
M
Site 174
S2534
S
L
R
R
Y
P
G
S
D
R
I
M
L
Q
K
Site 175
Y2552
R
D
I
S
N
F
E
Y
L
M
Y
L
N
T
A
Site 176
Y2555
S
N
F
E
Y
L
M
Y
L
N
T
A
A
G
R
Site 177
Y2567
A
G
R
T
C
N
D
Y
M
Q
Y
P
V
F
P
Site 178
S2582
W
V
L
A
D
Y
T
S
E
T
L
N
L
A
N
Site 179
S2597
P
K
I
F
R
D
L
S
K
P
M
G
A
Q
T
Site 180
T2604
S
K
P
M
G
A
Q
T
K
E
R
K
L
K
F
Site 181
T2621
R
F
K
E
V
E
K
T
E
G
D
M
T
V
Q
Site 182
S2672
V
A
D
R
M
F
H
S
V
K
S
T
W
E
S
Site 183
S2675
R
M
F
H
S
V
K
S
T
W
E
S
A
S
R
Site 184
T2676
M
F
H
S
V
K
S
T
W
E
S
A
S
R
E
Site 185
S2679
S
V
K
S
T
W
E
S
A
S
R
E
N
M
S
Site 186
S2681
K
S
T
W
E
S
A
S
R
E
N
M
S
D
V
Site 187
S2686
S
A
S
R
E
N
M
S
D
V
R
E
L
T
P
Site 188
T2692
M
S
D
V
R
E
L
T
P
E
F
F
Y
L
P
Site 189
Y2697
E
L
T
P
E
F
F
Y
L
P
E
F
L
T
N
Site 190
S2737
G
D
P
R
K
F
I
S
L
H
R
K
A
L
E
Site 191
S2745
L
H
R
K
A
L
E
S
D
F
V
S
A
N
L
Site 192
Y2762
W
I
D
L
I
F
G
Y
K
Q
Q
G
P
A
A
Site 193
Y2779
A
V
N
I
F
H
P
Y
F
Y
G
D
R
M
D
Site 194
S2788
Y
G
D
R
M
D
L
S
S
I
T
D
P
L
I
Site 195
S2789
G
D
R
M
D
L
S
S
I
T
D
P
L
I
K
Site 196
S2834
P
L
P
G
K
D
V
S
T
P
V
S
L
P
G
Site 197
T2835
L
P
G
K
D
V
S
T
P
V
S
L
P
G
H
Site 198
S2838
K
D
V
S
T
P
V
S
L
P
G
H
P
Q
P
Site 199
Y2848
G
H
P
Q
P
F
F
Y
S
L
Q
S
L
R
P
Site 200
S2849
H
P
Q
P
F
F
Y
S
L
Q
S
L
R
P
S
Site 201
S2852
P
F
F
Y
S
L
Q
S
L
R
P
S
Q
V
T
Site 202
S2856
S
L
Q
S
L
R
P
S
Q
V
T
V
K
D
M
Site 203
T2859
S
L
R
P
S
Q
V
T
V
K
D
M
Y
L
F
Site 204
S2867
V
K
D
M
Y
L
F
S
L
G
S
E
S
P
K
Site 205
S2872
L
F
S
L
G
S
E
S
P
K
G
A
I
G
H
Site 206
T2965
C
V
W
E
L
S
M
T
K
G
R
P
R
G
L
Site 207
Y2979
L
R
L
R
Q
A
L
Y
G
H
T
Q
A
V
T
Site 208
T3015
L
W
D
L
D
H
L
T
H
V
T
R
L
P
A
Site 209
T3061
G
Q
P
L
A
S
I
T
T
A
W
G
P
E
G
Site 210
S3084
E
G
P
A
W
D
T
S
Q
I
I
I
T
G
S
Site 211
T3101
G
M
V
R
V
W
K
T
E
D
V
K
M
S
V
Site 212
S3107
K
T
E
D
V
K
M
S
V
P
G
R
P
A
G
Site 213
S3123
E
P
P
A
Q
P
P
S
P
R
G
H
K
W
E
Site 214
T3146
L
D
V
S
I
A
L
T
G
K
P
S
K
T
S
Site 215
T3152
L
T
G
K
P
S
K
T
S
P
A
V
T
A
L
Site 216
S3153
T
G
K
P
S
K
T
S
P
A
V
T
A
L
A
Site 217
T3157
S
K
T
S
P
A
V
T
A
L
A
V
S
R
N
Site 218
T3166
L
A
V
S
R
N
H
T
K
L
L
V
G
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation