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Updated November 2019
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Protein Info
Short Name:
FAM65A
Full Name:
Protein FAM65A
Alias:
DKFZp434D1416; FA65A; Family with sequence similarity 65, member A; FLJ13725; Protein FAM65A
Type:
Unknown function
Mass (Da):
132308
Number AA:
1223
UniProt ID:
Q6ZS17
International Prot ID:
IPI00418799
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0016020
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005488
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006163
GO:0006164
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
P
Q
R
R
L
L
S
A
R
V
N
R
S
Q
Site 2
S20
L
S
A
R
V
N
R
S
Q
S
F
A
G
V
L
Site 3
S22
A
R
V
N
R
S
Q
S
F
A
G
V
L
G
S
Site 4
S29
S
F
A
G
V
L
G
S
H
E
R
G
P
S
L
Site 5
S35
G
S
H
E
R
G
P
S
L
S
F
R
S
F
P
Site 6
S37
H
E
R
G
P
S
L
S
F
R
S
F
P
V
F
Site 7
S40
G
P
S
L
S
F
R
S
F
P
V
F
S
P
P
Site 8
S45
F
R
S
F
P
V
F
S
P
P
G
P
P
R
K
Site 9
S57
P
R
K
P
P
A
L
S
R
V
S
R
M
F
S
Site 10
S60
P
P
A
L
S
R
V
S
R
M
F
S
V
A
H
Site 11
S64
S
R
V
S
R
M
F
S
V
A
H
P
A
A
K
Site 12
Y82
P
E
R
L
D
L
V
Y
T
A
L
K
R
G
L
Site 13
T90
T
A
L
K
R
G
L
T
A
Y
L
E
V
H
Q
Site 14
Y92
L
K
R
G
L
T
A
Y
L
E
V
H
Q
Q
E
Site 15
S110
L
Q
G
Q
I
R
E
S
K
R
N
S
R
L
G
Site 16
S114
I
R
E
S
K
R
N
S
R
L
G
F
L
Y
D
Site 17
Y120
N
S
R
L
G
F
L
Y
D
L
D
K
Q
V
K
Site 18
S128
D
L
D
K
Q
V
K
S
I
E
R
F
L
R
R
Site 19
S141
R
R
L
E
F
H
A
S
K
I
D
E
L
Y
E
Site 20
Y147
A
S
K
I
D
E
L
Y
E
A
Y
C
V
Q
R
Site 21
Y161
R
R
L
R
D
G
A
Y
N
M
V
R
A
Y
T
Site 22
Y167
A
Y
N
M
V
R
A
Y
T
T
G
S
P
G
S
Site 23
T168
Y
N
M
V
R
A
Y
T
T
G
S
P
G
S
R
Site 24
S171
V
R
A
Y
T
T
G
S
P
G
S
R
E
A
R
Site 25
S180
G
S
R
E
A
R
D
S
L
A
E
A
T
R
G
Site 26
Y191
A
T
R
G
H
R
E
Y
T
E
S
M
C
L
L
Site 27
T192
T
R
G
H
R
E
Y
T
E
S
M
C
L
L
E
Site 28
S194
G
H
R
E
Y
T
E
S
M
C
L
L
E
S
E
Site 29
Y228
R
L
C
V
G
D
Q
Y
E
I
C
M
K
Y
G
Site 30
Y234
Q
Y
E
I
C
M
K
Y
G
R
Q
R
W
K
L
Site 31
S255
S
G
K
Q
V
W
D
S
E
E
T
I
F
L
P
Site 32
T319
I
K
L
S
L
E
V
T
W
S
P
F
D
K
D
Site 33
S321
L
S
L
E
V
T
W
S
P
F
D
K
D
D
Q
Site 34
S330
F
D
K
D
D
Q
P
S
A
A
S
S
V
N
K
Site 35
S334
D
Q
P
S
A
A
S
S
V
N
K
A
S
T
V
Site 36
S339
A
S
S
V
N
K
A
S
T
V
T
K
R
F
S
Site 37
T340
S
S
V
N
K
A
S
T
V
T
K
R
F
S
T
Site 38
T342
V
N
K
A
S
T
V
T
K
R
F
S
T
Y
S
Site 39
S346
S
T
V
T
K
R
F
S
T
Y
S
Q
S
P
P
Site 40
T347
T
V
T
K
R
F
S
T
Y
S
Q
S
P
P
D
Site 41
S349
T
K
R
F
S
T
Y
S
Q
S
P
P
D
T
P
Site 42
S351
R
F
S
T
Y
S
Q
S
P
P
D
T
P
S
L
Site 43
T355
Y
S
Q
S
P
P
D
T
P
S
L
R
E
Q
A
Site 44
S357
Q
S
P
P
D
T
P
S
L
R
E
Q
A
F
Y
Site 45
Y364
S
L
R
E
Q
A
F
Y
N
M
L
R
R
Q
E
Site 46
S380
L
E
N
G
T
A
W
S
L
S
S
E
S
S
D
Site 47
S382
N
G
T
A
W
S
L
S
S
E
S
S
D
D
S
Site 48
S383
G
T
A
W
S
L
S
S
E
S
S
D
D
S
S
Site 49
S385
A
W
S
L
S
S
E
S
S
D
D
S
S
S
P
Site 50
S386
W
S
L
S
S
E
S
S
D
D
S
S
S
P
Q
Site 51
S389
S
S
E
S
S
D
D
S
S
S
P
Q
L
S
G
Site 52
S390
S
E
S
S
D
D
S
S
S
P
Q
L
S
G
T
Site 53
S391
E
S
S
D
D
S
S
S
P
Q
L
S
G
T
A
Site 54
S395
D
S
S
S
P
Q
L
S
G
T
A
R
H
S
P
Site 55
T397
S
S
P
Q
L
S
G
T
A
R
H
S
P
A
P
Site 56
S401
L
S
G
T
A
R
H
S
P
A
P
R
P
L
V
Site 57
T425
V
A
F
R
R
P
E
T
P
S
S
G
P
L
D
Site 58
S427
F
R
R
P
E
T
P
S
S
G
P
L
D
E
E
Site 59
S428
R
R
P
E
T
P
S
S
G
P
L
D
E
E
G
Site 60
Y448
L
A
N
G
H
A
P
Y
S
R
T
L
S
H
I
Site 61
S449
A
N
G
H
A
P
Y
S
R
T
L
S
H
I
S
Site 62
T451
G
H
A
P
Y
S
R
T
L
S
H
I
S
E
A
Site 63
S453
A
P
Y
S
R
T
L
S
H
I
S
E
A
S
V
Site 64
S456
S
R
T
L
S
H
I
S
E
A
S
V
D
A
A
Site 65
S476
V
E
A
V
G
P
E
S
L
A
W
G
P
S
P
Site 66
S482
E
S
L
A
W
G
P
S
P
P
T
H
P
A
P
Site 67
T485
A
W
G
P
S
P
P
T
H
P
A
P
T
H
G
Site 68
S496
P
T
H
G
E
H
P
S
P
V
P
P
A
L
D
Site 69
S507
P
A
L
D
P
G
H
S
A
T
S
S
T
L
G
Site 70
S511
P
G
H
S
A
T
S
S
T
L
G
T
T
G
S
Site 71
T512
G
H
S
A
T
S
S
T
L
G
T
T
G
S
V
Site 72
T515
A
T
S
S
T
L
G
T
T
G
S
V
P
T
S
Site 73
S518
S
T
L
G
T
T
G
S
V
P
T
S
T
D
P
Site 74
S522
T
T
G
S
V
P
T
S
T
D
P
A
P
S
A
Site 75
T523
T
G
S
V
P
T
S
T
D
P
A
P
S
A
H
Site 76
S528
T
S
T
D
P
A
P
S
A
H
L
D
S
V
H
Site 77
S533
A
P
S
A
H
L
D
S
V
H
K
S
T
D
S
Site 78
S537
H
L
D
S
V
H
K
S
T
D
S
G
P
S
E
Site 79
S540
S
V
H
K
S
T
D
S
G
P
S
E
L
P
G
Site 80
S543
K
S
T
D
S
G
P
S
E
L
P
G
P
T
H
Site 81
T551
E
L
P
G
P
T
H
T
T
T
G
S
T
Y
S
Site 82
S558
T
T
T
G
S
T
Y
S
A
I
T
T
T
H
S
Site 83
T562
S
T
Y
S
A
I
T
T
T
H
S
A
P
S
P
Site 84
S565
S
A
I
T
T
T
H
S
A
P
S
P
L
T
H
Site 85
S568
T
T
T
H
S
A
P
S
P
L
T
H
T
T
T
Site 86
T571
H
S
A
P
S
P
L
T
H
T
T
T
G
S
T
Site 87
T573
A
P
S
P
L
T
H
T
T
T
G
S
T
H
K
Site 88
T575
S
P
L
T
H
T
T
T
G
S
T
H
K
P
I
Site 89
S604
G
P
V
Q
T
T
T
S
P
T
H
T
M
P
S
Site 90
T608
T
T
T
S
P
T
H
T
M
P
S
P
T
H
T
Site 91
S611
S
P
T
H
T
M
P
S
P
T
H
T
T
A
S
Site 92
T615
T
M
P
S
P
T
H
T
T
A
S
P
T
H
T
Site 93
S618
S
P
T
H
T
T
A
S
P
T
H
T
S
T
S
Site 94
T622
T
T
A
S
P
T
H
T
S
T
S
P
T
H
T
Site 95
S623
T
A
S
P
T
H
T
S
T
S
P
T
H
T
P
Site 96
S625
S
P
T
H
T
S
T
S
P
T
H
T
P
T
S
Site 97
T627
T
H
T
S
T
S
P
T
H
T
P
T
S
P
T
Site 98
T629
T
S
T
S
P
T
H
T
P
T
S
P
T
H
K
Site 99
S632
S
P
T
H
T
P
T
S
P
T
H
K
T
S
M
Site 100
T634
T
H
T
P
T
S
P
T
H
K
T
S
M
S
P
Site 101
T637
P
T
S
P
T
H
K
T
S
M
S
P
P
T
T
Site 102
S638
T
S
P
T
H
K
T
S
M
S
P
P
T
T
T
Site 103
S640
P
T
H
K
T
S
M
S
P
P
T
T
T
S
P
Site 104
T643
K
T
S
M
S
P
P
T
T
T
S
P
T
P
S
Site 105
T644
T
S
M
S
P
P
T
T
T
S
P
T
P
S
G
Site 106
S646
M
S
P
P
T
T
T
S
P
T
P
S
G
M
G
Site 107
T648
P
P
T
T
T
S
P
T
P
S
G
M
G
L
V
Site 108
S650
T
T
T
S
P
T
P
S
G
M
G
L
V
Q
T
Site 109
T657
S
G
M
G
L
V
Q
T
A
T
S
P
T
H
P
Site 110
T659
M
G
L
V
Q
T
A
T
S
P
T
H
P
T
T
Site 111
S660
G
L
V
Q
T
A
T
S
P
T
H
P
T
T
S
Site 112
T665
A
T
S
P
T
H
P
T
T
S
P
T
H
P
T
Site 113
T666
T
S
P
T
H
P
T
T
S
P
T
H
P
T
T
Site 114
S667
S
P
T
H
P
T
T
S
P
T
H
P
T
T
S
Site 115
T672
T
T
S
P
T
H
P
T
T
S
P
I
L
I
N
Site 116
S674
S
P
T
H
P
T
T
S
P
I
L
I
N
V
S
Site 117
T690
S
T
S
L
E
L
A
T
L
S
S
P
S
K
H
Site 118
S692
S
L
E
L
A
T
L
S
S
P
S
K
H
S
D
Site 119
S693
L
E
L
A
T
L
S
S
P
S
K
H
S
D
P
Site 120
S695
L
A
T
L
S
S
P
S
K
H
S
D
P
T
L
Site 121
S698
L
S
S
P
S
K
H
S
D
P
T
L
P
G
T
Site 122
T701
P
S
K
H
S
D
P
T
L
P
G
T
D
S
L
Site 123
T705
S
D
P
T
L
P
G
T
D
S
L
P
C
S
P
Site 124
S707
P
T
L
P
G
T
D
S
L
P
C
S
P
P
V
Site 125
S711
G
T
D
S
L
P
C
S
P
P
V
S
N
S
Y
Site 126
S715
L
P
C
S
P
P
V
S
N
S
Y
T
Q
A
D
Site 127
S717
C
S
P
P
V
S
N
S
Y
T
Q
A
D
P
M
Site 128
T719
P
P
V
S
N
S
Y
T
Q
A
D
P
M
A
P
Site 129
T728
A
D
P
M
A
P
R
T
P
H
P
S
P
A
H
Site 130
S732
A
P
R
T
P
H
P
S
P
A
H
S
S
R
K
Site 131
S736
P
H
P
S
P
A
H
S
S
R
K
P
L
T
S
Site 132
S737
H
P
S
P
A
H
S
S
R
K
P
L
T
S
P
Site 133
T742
H
S
S
R
K
P
L
T
S
P
A
P
D
P
S
Site 134
S743
S
S
R
K
P
L
T
S
P
A
P
D
P
S
E
Site 135
S749
T
S
P
A
P
D
P
S
E
S
T
V
Q
S
L
Site 136
S751
P
A
P
D
P
S
E
S
T
V
Q
S
L
S
P
Site 137
T752
A
P
D
P
S
E
S
T
V
Q
S
L
S
P
T
Site 138
S755
P
S
E
S
T
V
Q
S
L
S
P
T
P
S
P
Site 139
S757
E
S
T
V
Q
S
L
S
P
T
P
S
P
P
T
Site 140
T759
T
V
Q
S
L
S
P
T
P
S
P
P
T
P
A
Site 141
S761
Q
S
L
S
P
T
P
S
P
P
T
P
A
P
Q
Site 142
T764
S
P
T
P
S
P
P
T
P
A
P
Q
H
S
D
Site 143
S789
V
P
T
A
A
G
G
S
G
D
R
S
L
E
E
Site 144
S793
A
G
G
S
G
D
R
S
L
E
E
A
L
G
A
Site 145
Y808
L
M
A
A
L
D
D
Y
R
G
Q
F
P
E
L
Site 146
T823
Q
G
L
E
Q
E
V
T
R
L
E
S
L
L
M
Site 147
S827
Q
E
V
T
R
L
E
S
L
L
M
Q
R
Q
G
Site 148
T836
L
M
Q
R
Q
G
L
T
R
S
R
A
S
S
L
Site 149
S838
Q
R
Q
G
L
T
R
S
R
A
S
S
L
S
I
Site 150
S841
G
L
T
R
S
R
A
S
S
L
S
I
T
V
E
Site 151
S842
L
T
R
S
R
A
S
S
L
S
I
T
V
E
H
Site 152
S844
R
S
R
A
S
S
L
S
I
T
V
E
H
A
L
Site 153
T846
R
A
S
S
L
S
I
T
V
E
H
A
L
E
S
Site 154
S853
T
V
E
H
A
L
E
S
F
S
F
L
N
E
D
Site 155
S855
E
H
A
L
E
S
F
S
F
L
N
E
D
E
D
Site 156
S874
V
P
G
D
R
P
P
S
S
P
E
A
G
A
E
Site 157
S875
P
G
D
R
P
P
S
S
P
E
A
G
A
E
D
Site 158
S883
P
E
A
G
A
E
D
S
I
D
S
P
S
A
R
Site 159
S886
G
A
E
D
S
I
D
S
P
S
A
R
P
L
S
Site 160
S888
E
D
S
I
D
S
P
S
A
R
P
L
S
T
G
Site 161
S893
S
P
S
A
R
P
L
S
T
G
C
P
A
L
D
Site 162
T894
P
S
A
R
P
L
S
T
G
C
P
A
L
D
A
Site 163
S956
R
R
W
E
I
P
A
S
S
A
Q
E
V
V
Q
Site 164
S1005
N
Q
Y
G
A
R
L
S
L
R
Q
P
G
L
A
Site 165
T1041
P
G
P
G
E
Q
L
T
V
F
Q
F
W
S
F
Site 166
T1051
Q
F
W
S
F
V
E
T
L
D
S
P
T
M
E
Site 167
Y1060
D
S
P
T
M
E
A
Y
V
T
E
T
A
E
E
Site 168
T1062
P
T
M
E
A
Y
V
T
E
T
A
E
E
V
L
Site 169
S1103
R
D
G
L
R
A
L
S
S
L
L
V
H
G
N
Site 170
S1104
D
G
L
R
A
L
S
S
L
L
V
H
G
N
N
Site 171
S1125
S
T
Q
L
R
S
L
S
L
G
P
T
F
R
E
Site 172
T1129
R
S
L
S
L
G
P
T
F
R
E
R
A
L
L
Site 173
T1149
L
E
D
E
D
V
Q
T
R
V
A
G
C
L
A
Site 174
Y1171
E
G
I
E
P
L
V
Y
L
C
Q
T
D
T
E
Site 175
T1177
V
Y
L
C
Q
T
D
T
E
A
V
R
E
A
A
Site 176
S1187
V
R
E
A
A
R
Q
S
L
Q
Q
C
G
E
E
Site 177
S1197
Q
C
G
E
E
G
Q
S
A
H
R
R
L
E
E
Site 178
S1205
A
H
R
R
L
E
E
S
L
D
A
L
P
R
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation