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Updated November 2019
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Protein Info
Short Name:
FAM83H
Full Name:
Protein FAM83H
Alias:
family with sequence similarity 83, member H; FLJ46072
Type:
Unknown function
Mass (Da):
127101
Number AA:
1179
UniProt ID:
Q6ZRV2
International Prot ID:
IPI00394829
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0031214
GO:0009888
GO:0031214
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
R
R
S
Q
S
S
S
Q
G
D
Site 2
S7
_
M
A
R
R
S
Q
S
S
S
Q
G
D
N
P
Site 3
S8
M
A
R
R
S
Q
S
S
S
Q
G
D
N
P
L
Site 4
S9
A
R
R
S
Q
S
S
S
Q
G
D
N
P
L
A
Site 5
Y19
D
N
P
L
A
P
G
Y
L
P
P
H
Y
K
E
Site 6
Y24
P
G
Y
L
P
P
H
Y
K
E
Y
Y
R
L
A
Site 7
Y27
L
P
P
H
Y
K
E
Y
Y
R
L
A
V
D
A
Site 8
S40
D
A
L
A
E
G
G
S
E
A
Y
S
R
F
L
Site 9
S44
E
G
G
S
E
A
Y
S
R
F
L
A
T
E
G
Site 10
Y73
R
H
L
R
P
P
Q
Y
V
T
R
E
P
P
E
Site 11
T75
L
R
P
P
Q
Y
V
T
R
E
P
P
E
G
S
Site 12
Y95
M
D
G
S
S
G
T
Y
W
P
V
N
S
D
Q
Site 13
S100
G
T
Y
W
P
V
N
S
D
Q
A
V
P
E
L
Site 14
S133
V
Q
P
P
P
P
D
S
P
S
I
K
D
E
A
Site 15
S135
P
P
P
P
D
S
P
S
I
K
D
E
A
R
R
Site 16
S146
E
A
R
R
M
I
R
S
A
Q
Q
V
V
A
V
Site 17
Y216
R
T
V
A
G
P
T
Y
Y
C
R
T
G
K
S
Site 18
Y217
T
V
A
G
P
T
Y
Y
C
R
T
G
K
S
F
Site 19
S257
S
F
E
K
I
H
R
S
L
A
H
V
F
Q
G
Site 20
S269
F
Q
G
E
L
V
S
S
F
D
E
E
F
R
I
Site 21
Y297
A
L
A
R
M
D
A
Y
A
L
A
P
Y
A
G
Site 22
T318
V
P
G
V
G
A
P
T
P
F
S
F
P
K
R
Site 23
S321
V
G
A
P
T
P
F
S
F
P
K
R
A
H
L
Site 24
S342
E
E
G
L
G
F
P
S
F
L
D
P
D
R
H
Site 25
S352
D
P
D
R
H
F
L
S
A
F
R
R
E
E
P
Site 26
S377
H
A
G
L
R
P
L
S
R
R
L
E
A
E
A
Site 27
S411
M
D
A
F
K
R
H
S
F
A
T
E
G
A
G
Site 28
T414
F
K
R
H
S
F
A
T
E
G
A
G
A
V
E
Site 29
S430
F
A
A
A
R
Q
V
S
R
Q
T
F
L
S
H
Site 30
T433
A
R
Q
V
S
R
Q
T
F
L
S
H
G
D
D
Site 31
S436
V
S
R
Q
T
F
L
S
H
G
D
D
F
R
F
Site 32
Y454
H
F
H
R
D
Q
L
Y
Q
Q
Q
Y
Q
W
D
Site 33
Y458
D
Q
L
Y
Q
Q
Q
Y
Q
W
D
P
Q
L
T
Site 34
T465
Y
Q
W
D
P
Q
L
T
P
A
R
P
Q
G
L
Site 35
T490
F
A
D
P
D
D
F
T
L
G
A
G
P
R
F
Site 36
Y510
D
G
H
Q
R
L
D
Y
V
P
S
S
A
S
R
Site 37
S513
Q
R
L
D
Y
V
P
S
S
A
S
R
E
V
R
Site 38
S514
R
L
D
Y
V
P
S
S
A
S
R
E
V
R
H
Site 39
S516
D
Y
V
P
S
S
A
S
R
E
V
R
H
G
S
Site 40
S523
S
R
E
V
R
H
G
S
D
P
A
F
A
P
G
Site 41
S537
G
P
R
G
L
E
P
S
G
A
P
R
P
N
L
Site 42
T545
G
A
P
R
P
N
L
T
Q
R
F
P
C
Q
A
Site 43
S585
L
R
R
W
R
L
A
S
Y
L
S
G
C
H
G
Site 44
Y586
R
R
W
R
L
A
S
Y
L
S
G
C
H
G
E
Site 45
S588
W
R
L
A
S
Y
L
S
G
C
H
G
E
D
G
Site 46
S647
V
P
V
P
G
P
G
S
G
G
N
G
P
E
R
Site 47
S667
P
G
L
A
K
Q
D
S
F
R
S
R
L
N
P
Site 48
S679
L
N
P
L
V
Q
R
S
S
R
L
R
S
S
L
Site 49
S680
N
P
L
V
Q
R
S
S
R
L
R
S
S
L
I
Site 50
S684
Q
R
S
S
R
L
R
S
S
L
I
F
S
T
S
Site 51
S685
R
S
S
R
L
R
S
S
L
I
F
S
T
S
Q
Site 52
S689
L
R
S
S
L
I
F
S
T
S
Q
A
E
G
A
Site 53
S691
S
S
L
I
F
S
T
S
Q
A
E
G
A
A
G
Site 54
T703
A
A
G
A
A
A
A
T
E
K
V
Q
L
L
H
Site 55
T714
Q
L
L
H
K
E
Q
T
V
S
E
T
L
G
P
Site 56
S716
L
H
K
E
Q
T
V
S
E
T
L
G
P
G
G
Site 57
T718
K
E
Q
T
V
S
E
T
L
G
P
G
G
E
A
Site 58
S728
P
G
G
E
A
V
R
S
A
A
S
T
K
V
A
Site 59
S731
E
A
V
R
S
A
A
S
T
K
V
A
E
L
L
Site 60
T732
A
V
R
S
A
A
S
T
K
V
A
E
L
L
E
Site 61
Y741
V
A
E
L
L
E
K
Y
K
G
P
A
R
D
P
Site 62
T756
G
G
G
A
G
A
I
T
V
A
S
H
S
K
A
Site 63
S759
A
G
A
I
T
V
A
S
H
S
K
A
V
V
S
Site 64
S761
A
I
T
V
A
S
H
S
K
A
V
V
S
Q
A
Site 65
S766
S
H
S
K
A
V
V
S
Q
A
W
R
E
E
V
Site 66
S785
A
V
G
G
E
R
R
S
L
E
S
C
L
L
D
Site 67
S788
G
E
R
R
S
L
E
S
C
L
L
D
L
R
D
Site 68
S796
C
L
L
D
L
R
D
S
F
A
Q
Q
L
H
Q
Site 69
S813
E
R
Q
P
G
A
A
S
L
T
A
A
Q
L
L
Site 70
T822
T
A
A
Q
L
L
D
T
L
G
R
S
G
S
D
Site 71
S826
L
L
D
T
L
G
R
S
G
S
D
R
L
P
S
Site 72
S828
D
T
L
G
R
S
G
S
D
R
L
P
S
R
F
Site 73
S833
S
G
S
D
R
L
P
S
R
F
L
S
A
Q
S
Site 74
S837
R
L
P
S
R
F
L
S
A
Q
S
H
S
T
S
Site 75
S840
S
R
F
L
S
A
Q
S
H
S
T
S
P
Q
G
Site 76
S842
F
L
S
A
Q
S
H
S
T
S
P
Q
G
L
D
Site 77
S844
S
A
Q
S
H
S
T
S
P
Q
G
L
D
S
P
Site 78
S850
T
S
P
Q
G
L
D
S
P
L
P
L
E
G
S
Site 79
S857
S
P
L
P
L
E
G
S
G
A
H
Q
V
L
H
Site 80
S870
L
H
N
E
S
K
G
S
P
T
S
A
Y
P
E
Site 81
T872
N
E
S
K
G
S
P
T
S
A
Y
P
E
R
K
Site 82
S873
E
S
K
G
S
P
T
S
A
Y
P
E
R
K
G
Site 83
Y875
K
G
S
P
T
S
A
Y
P
E
R
K
G
S
P
Site 84
S881
A
Y
P
E
R
K
G
S
P
T
P
G
F
S
T
Site 85
T883
P
E
R
K
G
S
P
T
P
G
F
S
T
R
R
Site 86
S887
G
S
P
T
P
G
F
S
T
R
R
G
S
P
T
Site 87
T888
S
P
T
P
G
F
S
T
R
R
G
S
P
T
T
Site 88
S892
G
F
S
T
R
R
G
S
P
T
T
G
F
I
E
Site 89
T894
S
T
R
R
G
S
P
T
T
G
F
I
E
Q
K
Site 90
T895
T
R
R
G
S
P
T
T
G
F
I
E
Q
K
G
Site 91
S903
G
F
I
E
Q
K
G
S
P
T
S
A
Y
P
E
Site 92
T905
I
E
Q
K
G
S
P
T
S
A
Y
P
E
R
R
Site 93
S906
E
Q
K
G
S
P
T
S
A
Y
P
E
R
R
G
Site 94
Y908
K
G
S
P
T
S
A
Y
P
E
R
R
G
S
P
Site 95
S914
A
Y
P
E
R
R
G
S
P
V
P
P
V
P
E
Site 96
S924
P
P
V
P
E
R
R
S
S
P
V
P
P
V
P
Site 97
S925
P
V
P
E
R
R
S
S
P
V
P
P
V
P
E
Site 98
S936
P
V
P
E
R
R
G
S
L
T
L
T
I
S
G
Site 99
T938
P
E
R
R
G
S
L
T
L
T
I
S
G
E
S
Site 100
T940
R
R
G
S
L
T
L
T
I
S
G
E
S
P
K
Site 101
S942
G
S
L
T
L
T
I
S
G
E
S
P
K
A
G
Site 102
S945
T
L
T
I
S
G
E
S
P
K
A
G
P
A
E
Site 103
S956
G
P
A
E
E
G
P
S
G
P
M
E
V
L
R
Site 104
S966
M
E
V
L
R
K
G
S
L
R
L
R
Q
L
L
Site 105
S974
L
R
L
R
Q
L
L
S
P
K
G
E
R
R
M
Site 106
S998
Q
E
N
G
Q
P
E
S
P
R
R
L
S
L
G
Site 107
S1003
P
E
S
P
R
R
L
S
L
G
Q
G
D
S
T
Site 108
S1009
L
S
L
G
Q
G
D
S
T
E
A
A
T
E
E
Site 109
T1010
S
L
G
Q
G
D
S
T
E
A
A
T
E
E
R
Site 110
S1024
R
G
P
R
A
R
L
S
S
A
T
A
N
A
L
Site 111
S1025
G
P
R
A
R
L
S
S
A
T
A
N
A
L
Y
Site 112
T1027
R
A
R
L
S
S
A
T
A
N
A
L
Y
S
S
Site 113
Y1032
S
A
T
A
N
A
L
Y
S
S
N
L
R
D
D
Site 114
S1034
T
A
N
A
L
Y
S
S
N
L
R
D
D
T
K
Site 115
T1040
S
S
N
L
R
D
D
T
K
A
I
L
E
Q
I
Site 116
S1048
K
A
I
L
E
Q
I
S
A
H
G
Q
K
H
R
Site 117
S1061
H
R
A
V
P
A
P
S
P
G
P
T
H
N
S
Site 118
T1065
P
A
P
S
P
G
P
T
H
N
S
P
E
L
G
Site 119
S1068
S
P
G
P
T
H
N
S
P
E
L
G
R
P
P
Site 120
S1085
G
V
L
A
P
D
M
S
D
K
D
K
C
S
A
Site 121
S1091
M
S
D
K
D
K
C
S
A
I
F
R
S
D
S
Site 122
S1096
K
C
S
A
I
F
R
S
D
S
L
G
T
Q
G
Site 123
S1098
S
A
I
F
R
S
D
S
L
G
T
Q
G
R
L
Site 124
S1106
L
G
T
Q
G
R
L
S
R
T
L
P
A
S
A
Site 125
T1108
T
Q
G
R
L
S
R
T
L
P
A
S
A
E
E
Site 126
S1112
L
S
R
T
L
P
A
S
A
E
E
R
D
R
L
Site 127
S1125
R
L
L
R
R
M
E
S
M
R
K
E
K
R
V
Site 128
Y1133
M
R
K
E
K
R
V
Y
S
R
F
E
V
F
C
Site 129
S1134
R
K
E
K
R
V
Y
S
R
F
E
V
F
C
K
Site 130
S1146
F
C
K
K
E
E
A
S
S
P
G
A
G
E
G
Site 131
S1147
C
K
K
E
E
A
S
S
P
G
A
G
E
G
P
Site 132
T1159
E
G
P
A
E
E
G
T
R
D
S
K
V
G
K
Site 133
S1162
A
E
E
G
T
R
D
S
K
V
G
K
F
V
P
Site 134
T1174
F
V
P
K
I
L
G
T
F
K
S
K
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation