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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Thsd4
Full Name:
Thrombospondin type-1 domain-containing protein 4
Alias:
FLJ13710; Fvsy9334; Pro34005; Thrombospondin, type i, domain containing 4
Type:
Extracellular region, Proteinaceous extracellular matrix protein
Mass (Da):
112450
Number AA:
1018
UniProt ID:
Q6ZMP0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0004222
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
F
V
C
P
Q
P
S
T
Q
H
R
K
V
P
Q
Site 2
S68
P
W
S
A
C
S
R
S
C
S
G
G
V
M
E
Site 3
S70
S
A
C
S
R
S
C
S
G
G
V
M
E
Q
T
Site 4
T77
S
G
G
V
M
E
Q
T
R
P
C
L
P
R
S
Site 5
S84
T
R
P
C
L
P
R
S
Y
R
L
R
G
G
Q
Site 6
Y85
R
P
C
L
P
R
S
Y
R
L
R
G
G
Q
R
Site 7
T110
H
V
V
S
A
V
R
T
S
V
P
L
H
R
S
Site 8
S111
V
V
S
A
V
R
T
S
V
P
L
H
R
S
R
Site 9
S117
T
S
V
P
L
H
R
S
R
D
E
T
P
A
L
Site 10
T121
L
H
R
S
R
D
E
T
P
A
L
A
G
T
D
Site 11
T135
D
A
S
R
Q
G
P
T
V
L
R
G
S
R
H
Site 12
S140
G
P
T
V
L
R
G
S
R
H
P
Q
P
Q
G
Site 13
S156
E
V
T
G
D
R
R
S
R
T
R
G
T
I
G
Site 14
T158
T
G
D
R
R
S
R
T
R
G
T
I
G
P
G
Site 15
T161
R
R
S
R
T
R
G
T
I
G
P
G
K
Y
G
Site 16
Y167
G
T
I
G
P
G
K
Y
G
Y
G
K
A
P
Y
Site 17
Y169
I
G
P
G
K
Y
G
Y
G
K
A
P
Y
I
L
Site 18
Y174
Y
G
Y
G
K
A
P
Y
I
L
P
L
Q
T
D
Site 19
T185
L
Q
T
D
T
A
H
T
P
Q
R
L
R
R
Q
Site 20
S195
R
L
R
R
Q
K
L
S
S
R
H
S
R
S
Q
Site 21
S196
L
R
R
Q
K
L
S
S
R
H
S
R
S
Q
G
Site 22
S199
Q
K
L
S
S
R
H
S
R
S
Q
G
A
S
S
Site 23
S201
L
S
S
R
H
S
R
S
Q
G
A
S
S
A
R
Site 24
S205
H
S
R
S
Q
G
A
S
S
A
R
H
G
Y
S
Site 25
S206
S
R
S
Q
G
A
S
S
A
R
H
G
Y
S
S
Site 26
Y211
A
S
S
A
R
H
G
Y
S
S
P
A
H
Q
V
Site 27
S213
S
A
R
H
G
Y
S
S
P
A
H
Q
V
P
Q
Site 28
Y225
V
P
Q
H
G
P
L
Y
Q
S
D
S
G
P
R
Site 29
S227
Q
H
G
P
L
Y
Q
S
D
S
G
P
R
S
G
Site 30
S229
G
P
L
Y
Q
S
D
S
G
P
R
S
G
L
Q
Site 31
S233
Q
S
D
S
G
P
R
S
G
L
Q
A
A
E
A
Site 32
Y243
Q
A
A
E
A
P
I
Y
Q
L
P
L
T
H
D
Site 33
T248
P
I
Y
Q
L
P
L
T
H
D
Q
G
Y
P
A
Site 34
Y253
P
L
T
H
D
Q
G
Y
P
A
A
S
S
L
F
Site 35
S258
Q
G
Y
P
A
A
S
S
L
F
H
S
P
E
T
Site 36
S262
A
A
S
S
L
F
H
S
P
E
T
S
N
N
H
Site 37
S266
L
F
H
S
P
E
T
S
N
N
H
G
V
G
T
Site 38
T277
G
V
G
T
H
G
A
T
Q
S
F
S
Q
P
A
Site 39
S279
G
T
H
G
A
T
Q
S
F
S
Q
P
A
R
S
Site 40
S281
H
G
A
T
Q
S
F
S
Q
P
A
R
S
T
A
Site 41
S290
P
A
R
S
T
A
I
S
C
I
G
A
Y
R
Q
Site 42
Y295
A
I
S
C
I
G
A
Y
R
Q
Y
K
L
C
N
Site 43
Y298
C
I
G
A
Y
R
Q
Y
K
L
C
N
T
N
V
Site 44
S309
N
T
N
V
C
P
E
S
S
R
S
I
R
E
V
Site 45
S312
V
C
P
E
S
S
R
S
I
R
E
V
Q
C
A
Site 46
Y331
K
P
F
M
G
R
F
Y
E
W
E
P
F
A
E
Site 47
Y357
Q
A
M
G
Y
R
F
Y
V
R
Q
A
E
K
V
Site 48
T368
A
E
K
V
I
D
G
T
P
C
D
Q
N
G
T
Site 49
Y391
K
S
I
G
C
D
D
Y
L
G
S
D
K
V
V
Site 50
S394
G
C
D
D
Y
L
G
S
D
K
V
V
D
K
C
Site 51
Y451
E
M
Y
K
S
N
N
Y
L
A
L
R
S
R
S
Site 52
S456
N
N
Y
L
A
L
R
S
R
S
G
R
S
I
I
Site 53
S458
Y
L
A
L
R
S
R
S
G
R
S
I
I
N
G
Site 54
Y475
A
I
D
R
P
G
K
Y
E
G
G
G
T
M
F
Site 55
T483
E
G
G
G
T
M
F
T
Y
K
R
P
N
E
I
Site 56
Y484
G
G
G
T
M
F
T
Y
K
R
P
N
E
I
S
Site 57
S491
Y
K
R
P
N
E
I
S
S
T
A
G
E
S
F
Site 58
S492
K
R
P
N
E
I
S
S
T
A
G
E
S
F
L
Site 59
T493
R
P
N
E
I
S
S
T
A
G
E
S
F
L
A
Site 60
S497
I
S
S
T
A
G
E
S
F
L
A
E
G
P
T
Site 61
Y511
T
N
E
I
L
D
V
Y
M
I
H
Q
Q
P
N
Site 62
Y523
Q
P
N
P
G
V
H
Y
E
Y
V
I
M
G
T
Site 63
Y525
N
P
G
V
H
Y
E
Y
V
I
M
G
T
N
A
Site 64
S534
I
M
G
T
N
A
I
S
P
Q
V
P
P
H
R
Site 65
T553
P
F
N
G
Q
M
V
T
E
G
R
S
Q
E
E
Site 66
S583
E
A
P
E
M
F
T
S
E
S
A
Q
T
F
P
Site 67
T588
F
T
S
E
S
A
Q
T
F
P
V
R
H
P
D
Site 68
S598
V
R
H
P
D
R
F
S
P
H
R
P
D
N
L
Site 69
S616
A
P
Q
P
P
R
R
S
R
D
H
N
W
K
Q
Site 70
T626
H
N
W
K
Q
L
G
T
T
E
C
S
T
T
C
Site 71
T631
L
G
T
T
E
C
S
T
T
C
G
K
G
S
Q
Site 72
T632
G
T
T
E
C
S
T
T
C
G
K
G
S
Q
Y
Site 73
Y639
T
C
G
K
G
S
Q
Y
P
I
F
R
C
V
H
Site 74
S648
I
F
R
C
V
H
R
S
T
H
E
E
A
P
E
Site 75
T649
F
R
C
V
H
R
S
T
H
E
E
A
P
E
S
Site 76
S656
T
H
E
E
A
P
E
S
Y
C
D
S
S
M
K
Site 77
S660
A
P
E
S
Y
C
D
S
S
M
K
P
T
P
E
Site 78
S661
P
E
S
Y
C
D
S
S
M
K
P
T
P
E
E
Site 79
T665
C
D
S
S
M
K
P
T
P
E
E
E
P
C
N
Site 80
S711
R
Q
V
Y
A
N
R
S
L
T
V
Q
P
Y
R
Site 81
T713
V
Y
A
N
R
S
L
T
V
Q
P
Y
R
C
Q
Site 82
Y717
R
S
L
T
V
Q
P
Y
R
C
Q
H
L
E
K
Site 83
T727
Q
H
L
E
K
P
E
T
T
S
T
C
Q
L
K
Site 84
S729
L
E
K
P
E
T
T
S
T
C
Q
L
K
I
C
Site 85
T730
E
K
P
E
T
T
S
T
C
Q
L
K
I
C
S
Site 86
S807
T
E
W
S
E
R
C
S
A
E
C
G
A
G
V
Site 87
S818
G
A
G
V
R
T
R
S
V
V
C
M
T
N
H
Site 88
T843
N
N
R
P
A
E
A
T
P
C
D
N
G
P
C
Site 89
S865
A
G
S
W
S
Q
C
S
I
E
C
G
S
G
T
Site 90
T872
S
I
E
C
G
S
G
T
Q
Q
R
E
V
I
C
Site 91
T886
C
V
R
K
N
A
D
T
F
E
V
L
D
P
S
Site 92
S893
T
F
E
V
L
D
P
S
E
C
S
F
L
E
K
Site 93
S896
V
L
D
P
S
E
C
S
F
L
E
K
P
P
S
Site 94
S903
S
F
L
E
K
P
P
S
Q
Q
S
C
H
L
K
Site 95
S906
E
K
P
P
S
Q
Q
S
C
H
L
K
P
C
G
Site 96
S941
V
R
E
V
R
C
L
S
D
D
M
T
L
S
N
Site 97
T945
R
C
L
S
D
D
M
T
L
S
N
L
C
D
P
Site 98
S947
L
S
D
D
M
T
L
S
N
L
C
D
P
Q
L
Site 99
S961
L
K
P
E
E
R
E
S
C
N
P
Q
D
C
V
Site 100
Y979
D
E
N
C
K
D
K
Y
Y
N
C
N
V
V
V
Site 101
Y980
E
N
C
K
D
K
Y
Y
N
C
N
V
V
V
Q
Site 102
T1012
T
R
V
A
N
R
Q
T
G
F
L
G
S
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation