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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DSTYK
Full Name:
Dual serine/threonine and tyrosine protein kinase
Alias:
Dusty PK; Dusty protein kinase; DustyPK; EC 2.7.11.1; KIAA0472; Receptor-interacting serine/threonine-protein kinase 5; RIP5; RIP-homologous kinase; RIPK5
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; Other-Unique family
Mass (Da):
105259
Number AA:
929
UniProt ID:
Q6XUX3
International Prot ID:
IPI00743336
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
D
G
V
P
W
G
S
E
P
V
S
G
P
G
Site 2
S14
P
W
G
S
E
P
V
S
G
P
G
P
G
G
G
Site 3
Y34
L
C
R
G
F
G
R
Y
R
R
Y
L
G
R
L
Site 4
Y37
G
F
G
R
Y
R
R
Y
L
G
R
L
R
Q
N
Site 5
T48
L
R
Q
N
L
R
E
T
Q
K
F
F
R
D
I
Site 6
T62
I
K
C
S
H
N
H
T
C
L
S
S
L
T
G
Site 7
S65
S
H
N
H
T
C
L
S
S
L
T
G
G
G
G
Site 8
S66
H
N
H
T
C
L
S
S
L
T
G
G
G
G
A
Site 9
S95
A
G
Q
L
S
C
I
S
F
P
P
K
E
E
K
Site 10
Y103
F
P
P
K
E
E
K
Y
L
Q
Q
I
V
D
C
Site 11
T140
G
V
Q
V
L
P
T
T
K
L
G
S
E
E
S
Site 12
S147
T
K
L
G
S
E
E
S
C
K
L
R
R
L
R
Site 13
T156
K
L
R
R
L
R
F
T
Y
G
T
Q
T
R
V
Site 14
Y157
L
R
R
L
R
F
T
Y
G
T
Q
T
R
V
S
Site 15
T159
R
L
R
F
T
Y
G
T
Q
T
R
V
S
L
A
Site 16
S164
Y
G
T
Q
T
R
V
S
L
A
L
P
G
Q
Y
Site 17
T176
G
Q
Y
E
L
V
H
T
L
V
A
H
Q
G
N
Site 18
S258
A
L
H
K
D
E
L
S
E
R
D
E
Q
E
L
Site 19
Y271
E
L
Q
E
I
R
K
Y
F
S
F
P
V
F
F
Site 20
S286
F
K
V
P
K
L
G
S
E
I
I
D
S
S
T
Site 21
S291
L
G
S
E
I
I
D
S
S
T
R
R
M
E
S
Site 22
S292
G
S
E
I
I
D
S
S
T
R
R
M
E
S
E
Site 23
T293
S
E
I
I
D
S
S
T
R
R
M
E
S
E
R
Site 24
S298
S
S
T
R
R
M
E
S
E
R
S
P
L
Y
R
Site 25
S301
R
R
M
E
S
E
R
S
P
L
Y
R
Q
L
I
Site 26
Y304
E
S
E
R
S
P
L
Y
R
Q
L
I
D
L
G
Site 27
Y312
R
Q
L
I
D
L
G
Y
L
S
S
S
H
W
N
Site 28
S315
I
D
L
G
Y
L
S
S
S
H
W
N
C
G
A
Site 29
T327
C
G
A
P
G
Q
D
T
K
A
Q
S
M
L
V
Site 30
S344
S
E
K
L
R
H
L
S
T
F
S
H
Q
V
L
Site 31
T345
E
K
L
R
H
L
S
T
F
S
H
Q
V
L
Q
Site 32
T387
M
Q
R
D
L
Q
I
T
P
K
R
L
E
Y
T
Site 33
Y393
I
T
P
K
R
L
E
Y
T
R
K
K
E
N
E
Site 34
Y402
R
K
K
E
N
E
L
Y
E
S
L
M
N
I
A
Site 35
S404
K
E
N
E
L
Y
E
S
L
M
N
I
A
N
R
Site 36
T436
E
E
L
L
D
D
A
T
N
M
E
F
K
D
V
Site 37
T454
E
N
G
E
P
V
G
T
R
E
I
K
C
C
I
Site 38
S483
V
A
N
K
L
I
S
S
V
D
Y
L
R
E
S
Site 39
S490
S
V
D
Y
L
R
E
S
F
V
G
T
L
E
R
Site 40
T494
L
R
E
S
F
V
G
T
L
E
R
C
L
Q
S
Site 41
S501
T
L
E
R
C
L
Q
S
L
E
K
S
Q
D
V
Site 42
S505
C
L
Q
S
L
E
K
S
Q
D
V
S
V
H
I
Site 43
S509
L
E
K
S
Q
D
V
S
V
H
I
T
S
N
Y
Site 44
T513
Q
D
V
S
V
H
I
T
S
N
Y
L
K
Q
I
Site 45
Y516
S
V
H
I
T
S
N
Y
L
K
Q
I
L
N
A
Site 46
S533
H
V
E
V
T
F
H
S
G
S
S
V
T
R
M
Site 47
S536
V
T
F
H
S
G
S
S
V
T
R
M
L
W
E
Site 48
S575
V
A
Q
E
A
I
E
S
L
S
A
S
K
L
A
Site 49
S577
Q
E
A
I
E
S
L
S
A
S
K
L
A
K
S
Site 50
S579
A
I
E
S
L
S
A
S
K
L
A
K
S
I
C
Site 51
S584
S
A
S
K
L
A
K
S
I
C
S
Q
F
R
T
Site 52
S587
K
L
A
K
S
I
C
S
Q
F
R
T
R
L
N
Site 53
T591
S
I
C
S
Q
F
R
T
R
L
N
S
S
H
E
Site 54
S595
Q
F
R
T
R
L
N
S
S
H
E
A
F
A
A
Site 55
S596
F
R
T
R
L
N
S
S
H
E
A
F
A
A
S
Site 56
S603
S
H
E
A
F
A
A
S
L
R
Q
L
E
A
G
Site 57
S612
R
Q
L
E
A
G
H
S
G
R
L
E
K
T
E
Site 58
T618
H
S
G
R
L
E
K
T
E
D
L
W
L
R
V
Site 59
S637
A
P
R
L
A
R
L
S
L
E
S
R
S
L
Q
Site 60
S642
R
L
S
L
E
S
R
S
L
Q
D
V
L
L
H
Site 61
Y663
Q
E
L
G
R
G
Q
Y
G
V
V
Y
L
C
D
Site 62
Y667
R
G
Q
Y
G
V
V
Y
L
C
D
N
W
G
G
Site 63
S682
H
F
P
C
A
L
K
S
V
V
P
P
D
E
K
Site 64
Y700
D
L
A
L
E
F
H
Y
M
R
S
L
P
K
H
Site 65
S703
L
E
F
H
Y
M
R
S
L
P
K
H
E
R
L
Site 66
S716
R
L
V
D
L
H
G
S
V
I
D
Y
N
Y
G
Site 67
Y720
L
H
G
S
V
I
D
Y
N
Y
G
G
G
S
S
Site 68
Y722
G
S
V
I
D
Y
N
Y
G
G
G
S
S
I
A
Site 69
Y742
E
R
L
H
R
D
L
Y
T
G
L
K
A
G
L
Site 70
T743
R
L
H
R
D
L
Y
T
G
L
K
A
G
L
T
Site 71
T750
T
G
L
K
A
G
L
T
L
E
T
R
L
Q
I
Site 72
S770
E
G
I
R
F
L
H
S
Q
G
L
V
H
R
D
Site 73
S808
P
E
A
M
M
S
G
S
I
V
G
T
P
I
H
Site 74
T812
M
S
G
S
I
V
G
T
P
I
H
M
A
P
E
Site 75
Y825
P
E
L
F
T
G
K
Y
D
N
S
V
D
V
Y
Site 76
S916
I
M
N
R
L
C
K
S
N
S
E
Q
P
N
R
Site 77
S918
N
R
L
C
K
S
N
S
E
Q
P
N
R
G
L
Site 78
S928
P
N
R
G
L
D
D
S
T
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation