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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BCoR
Full Name:
BCL-6 corepressor
Alias:
Bcl6 corepressor; KIAA1575
Type:
PcG protein complex, Nucleus protein
Mass (Da):
192189
Number AA:
1755
UniProt ID:
Q6W2J9
International Prot ID:
IPI00439548
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0031072
GO:0042826
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0007507
GO:0042476
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
R
V
R
M
C
G
A
S
E
D
R
K
I
L
V
Site 2
S98
S
S
L
C
G
L
G
S
E
K
G
R
E
A
A
Site 3
S107
K
G
R
E
A
A
T
S
T
L
G
G
L
G
F
Site 4
T108
G
R
E
A
A
T
S
T
L
G
G
L
G
F
S
Site 5
S115
T
L
G
G
L
G
F
S
S
E
R
N
P
E
M
Site 6
S116
L
G
G
L
G
F
S
S
E
R
N
P
E
M
Q
Site 7
T128
E
M
Q
F
K
P
N
T
P
E
T
V
E
A
S
Site 8
T131
F
K
P
N
T
P
E
T
V
E
A
S
A
V
S
Site 9
S146
G
K
P
P
N
G
F
S
A
I
Y
K
T
P
P
Site 10
Y149
P
N
G
F
S
A
I
Y
K
T
P
P
G
I
Q
Site 11
T151
G
F
S
A
I
Y
K
T
P
P
G
I
Q
K
S
Site 12
S158
T
P
P
G
I
Q
K
S
A
V
A
T
A
E
A
Site 13
S173
L
G
L
D
R
P
A
S
D
K
Q
S
P
L
N
Site 14
S177
R
P
A
S
D
K
Q
S
P
L
N
I
N
G
A
Site 15
Y195
R
L
P
W
V
N
P
Y
M
E
G
A
T
P
A
Site 16
T200
N
P
Y
M
E
G
A
T
P
A
I
Y
P
F
L
Site 17
Y204
E
G
A
T
P
A
I
Y
P
F
L
D
S
P
N
Site 18
S209
A
I
Y
P
F
L
D
S
P
N
K
Y
S
L
N
Site 19
Y213
F
L
D
S
P
N
K
Y
S
L
N
M
Y
K
A
Site 20
Y218
N
K
Y
S
L
N
M
Y
K
A
L
L
P
Q
Q
Site 21
S226
K
A
L
L
P
Q
Q
S
Y
S
L
A
Q
P
L
Site 22
Y227
A
L
L
P
Q
Q
S
Y
S
L
A
Q
P
L
Y
Site 23
S228
L
L
P
Q
Q
S
Y
S
L
A
Q
P
L
Y
S
Site 24
Y234
Y
S
L
A
Q
P
L
Y
S
P
V
C
T
N
G
Site 25
S235
S
L
A
Q
P
L
Y
S
P
V
C
T
N
G
E
Site 26
T239
P
L
Y
S
P
V
C
T
N
G
E
R
F
L
Y
Site 27
Y246
T
N
G
E
R
F
L
Y
L
P
P
P
H
Y
V
Site 28
Y252
L
Y
L
P
P
P
H
Y
V
G
P
H
I
P
S
Site 29
S259
Y
V
G
P
H
I
P
S
S
L
A
S
P
M
R
Site 30
S263
H
I
P
S
S
L
A
S
P
M
R
L
S
T
P
Site 31
S268
L
A
S
P
M
R
L
S
T
P
S
A
S
P
A
Site 32
T269
A
S
P
M
R
L
S
T
P
S
A
S
P
A
I
Site 33
S271
P
M
R
L
S
T
P
S
A
S
P
A
I
P
P
Site 34
S294
L
P
W
K
M
G
V
S
P
G
N
P
V
D
S
Site 35
S301
S
P
G
N
P
V
D
S
H
A
Y
P
H
I
Q
Site 36
Y304
N
P
V
D
S
H
A
Y
P
H
I
Q
N
S
K
Site 37
S310
A
Y
P
H
I
Q
N
S
K
Q
P
R
V
P
S
Site 38
S317
S
K
Q
P
R
V
P
S
A
K
A
V
T
S
G
Site 39
S336
T
A
L
L
L
P
P
S
P
R
P
S
P
R
V
Site 40
S340
L
P
P
S
P
R
P
S
P
R
V
H
L
P
T
Site 41
T347
S
P
R
V
H
L
P
T
Q
P
A
A
D
T
Y
Site 42
T353
P
T
Q
P
A
A
D
T
Y
S
E
F
H
K
H
Site 43
Y354
T
Q
P
A
A
D
T
Y
S
E
F
H
K
H
Y
Site 44
Y361
Y
S
E
F
H
K
H
Y
A
R
I
S
T
S
P
Site 45
S365
H
K
H
Y
A
R
I
S
T
S
P
S
V
A
L
Site 46
T366
K
H
Y
A
R
I
S
T
S
P
S
V
A
L
S
Site 47
S367
H
Y
A
R
I
S
T
S
P
S
V
A
L
S
K
Site 48
S369
A
R
I
S
T
S
P
S
V
A
L
S
K
P
Y
Site 49
S373
T
S
P
S
V
A
L
S
K
P
Y
M
T
V
S
Site 50
T378
A
L
S
K
P
Y
M
T
V
S
S
E
F
P
A
Site 51
S380
S
K
P
Y
M
T
V
S
S
E
F
P
A
A
R
Site 52
S389
E
F
P
A
A
R
L
S
N
G
K
Y
P
K
A
Site 53
Y393
A
R
L
S
N
G
K
Y
P
K
A
P
E
G
G
Site 54
T413
V
P
G
H
A
R
K
T
A
V
Q
D
R
K
D
Site 55
S422
V
Q
D
R
K
D
G
S
S
P
P
L
L
E
K
Site 56
S423
Q
D
R
K
D
G
S
S
P
P
L
L
E
K
Q
Site 57
T431
P
P
L
L
E
K
Q
T
V
T
K
D
V
T
D
Site 58
T433
L
L
E
K
Q
T
V
T
K
D
V
T
D
K
P
Site 59
T437
Q
T
V
T
K
D
V
T
D
K
P
L
D
L
S
Site 60
S444
T
D
K
P
L
D
L
S
S
K
V
V
D
V
D
Site 61
T464
H
M
K
K
M
A
P
T
V
L
V
H
S
R
A
Site 62
S469
A
P
T
V
L
V
H
S
R
A
G
S
G
L
V
Site 63
S473
L
V
H
S
R
A
G
S
G
L
V
L
S
G
S
Site 64
S478
A
G
S
G
L
V
L
S
G
S
E
I
P
K
E
Site 65
S480
S
G
L
V
L
S
G
S
E
I
P
K
E
T
L
Site 66
T486
G
S
E
I
P
K
E
T
L
S
P
P
G
N
G
Site 67
S488
E
I
P
K
E
T
L
S
P
P
G
N
G
C
A
Site 68
Y497
P
G
N
G
C
A
I
Y
R
S
E
I
I
S
T
Site 69
T504
Y
R
S
E
I
I
S
T
A
P
S
S
W
V
V
Site 70
S515
S
W
V
V
P
G
P
S
P
N
E
E
N
N
G
Site 71
S524
N
E
E
N
N
G
K
S
M
S
L
K
N
K
A
Site 72
S526
E
N
N
G
K
S
M
S
L
K
N
K
A
L
D
Site 73
S542
A
I
P
Q
Q
R
S
S
S
C
P
R
M
G
G
Site 74
S543
I
P
Q
Q
R
S
S
S
C
P
R
M
G
G
T
Site 75
S562
T
N
V
S
G
S
V
S
S
A
G
R
P
A
S
Site 76
S569
S
S
A
G
R
P
A
S
A
S
P
A
P
N
A
Site 77
S571
A
G
R
P
A
S
A
S
P
A
P
N
A
N
A
Site 78
T581
P
N
A
N
A
D
G
T
K
T
S
R
S
S
V
Site 79
T583
A
N
A
D
G
T
K
T
S
R
S
S
V
E
T
Site 80
S586
D
G
T
K
T
S
R
S
S
V
E
T
T
P
S
Site 81
S587
G
T
K
T
S
R
S
S
V
E
T
T
P
S
V
Site 82
T590
T
S
R
S
S
V
E
T
T
P
S
V
I
Q
H
Site 83
T591
S
R
S
S
V
E
T
T
P
S
V
I
Q
H
V
Site 84
S593
S
S
V
E
T
T
P
S
V
I
Q
H
V
G
Q
Site 85
T604
H
V
G
Q
P
P
A
T
P
A
K
H
S
S
S
Site 86
S609
P
A
T
P
A
K
H
S
S
S
T
S
S
K
G
Site 87
S610
A
T
P
A
K
H
S
S
S
T
S
S
K
G
A
Site 88
S611
T
P
A
K
H
S
S
S
T
S
S
K
G
A
K
Site 89
S613
A
K
H
S
S
S
T
S
S
K
G
A
K
A
S
Site 90
S614
K
H
S
S
S
T
S
S
K
G
A
K
A
S
N
Site 91
S620
S
S
K
G
A
K
A
S
N
P
E
P
S
F
K
Site 92
S625
K
A
S
N
P
E
P
S
F
K
A
N
E
N
G
Site 93
S636
N
E
N
G
L
P
P
S
S
I
F
L
S
P
N
Site 94
S637
E
N
G
L
P
P
S
S
I
F
L
S
P
N
E
Site 95
S641
P
P
S
S
I
F
L
S
P
N
E
A
F
R
S
Site 96
S648
S
P
N
E
A
F
R
S
P
P
I
P
Y
P
R
Site 97
Y653
F
R
S
P
P
I
P
Y
P
R
S
Y
L
P
Y
Site 98
S656
P
P
I
P
Y
P
R
S
Y
L
P
Y
P
A
P
Site 99
Y657
P
I
P
Y
P
R
S
Y
L
P
Y
P
A
P
E
Site 100
Y660
Y
P
R
S
Y
L
P
Y
P
A
P
E
G
I
A
Site 101
S669
A
P
E
G
I
A
V
S
P
L
S
L
H
G
K
Site 102
Y704
A
P
K
P
G
L
P
Y
G
L
P
T
G
R
P
Site 103
T708
G
L
P
Y
G
L
P
T
G
R
P
E
F
V
T
Site 104
T715
T
G
R
P
E
F
V
T
Y
Q
D
A
L
G
L
Site 105
Y716
G
R
P
E
F
V
T
Y
Q
D
A
L
G
L
G
Site 106
T733
H
P
M
L
I
P
H
T
P
I
E
I
T
K
E
Site 107
S747
E
E
K
P
E
R
R
S
R
S
H
E
R
A
R
Site 108
S749
K
P
E
R
R
S
R
S
H
E
R
A
R
Y
E
Site 109
Y755
R
S
H
E
R
A
R
Y
E
D
P
T
L
R
N
Site 110
T759
R
A
R
Y
E
D
P
T
L
R
N
R
F
S
E
Site 111
S765
P
T
L
R
N
R
F
S
E
I
L
E
T
S
S
Site 112
T770
R
F
S
E
I
L
E
T
S
S
T
K
L
H
P
Site 113
T773
E
I
L
E
T
S
S
T
K
L
H
P
D
V
P
Site 114
T796
P
N
W
N
Q
G
K
T
V
V
K
S
D
K
L
Site 115
S800
Q
G
K
T
V
V
K
S
D
K
L
V
Y
V
D
Site 116
Y805
V
K
S
D
K
L
V
Y
V
D
L
L
R
E
E
Site 117
T817
R
E
E
P
D
A
K
T
D
T
N
V
S
K
P
Site 118
T819
E
P
D
A
K
T
D
T
N
V
S
K
P
S
F
Site 119
S825
D
T
N
V
S
K
P
S
F
A
A
E
S
V
G
Site 120
S830
K
P
S
F
A
A
E
S
V
G
Q
S
A
E
P
Site 121
S834
A
A
E
S
V
G
Q
S
A
E
P
P
K
P
S
Site 122
S841
S
A
E
P
P
K
P
S
V
E
P
A
L
Q
Q
Site 123
S863
R
E
E
L
G
R
I
S
D
F
H
E
T
Y
T
Site 124
Y869
I
S
D
F
H
E
T
Y
T
F
K
Q
P
V
F
Site 125
T870
S
D
F
H
E
T
Y
T
F
K
Q
P
V
F
T
Site 126
S879
K
Q
P
V
F
T
V
S
K
D
S
V
L
A
G
Site 127
S897
E
N
L
G
L
P
V
S
T
P
F
L
E
P
P
Site 128
T913
G
S
D
G
P
A
V
T
F
G
K
T
Q
E
D
Site 129
T917
P
A
V
T
F
G
K
T
Q
E
D
P
K
P
F
Site 130
T936
A
P
P
S
V
D
V
T
P
T
Y
T
K
D
G
Site 131
Y939
S
V
D
V
T
P
T
Y
T
K
D
G
A
D
E
Site 132
S960
K
V
L
K
P
K
P
S
K
L
A
K
R
I
A
Site 133
S969
L
A
K
R
I
A
N
S
A
G
Y
V
G
D
R
Site 134
Y972
R
I
A
N
S
A
G
Y
V
G
D
R
F
K
C
Site 135
T981
G
D
R
F
K
C
V
T
T
E
L
Y
A
D
S
Site 136
Y985
K
C
V
T
T
E
L
Y
A
D
S
S
Q
L
S
Site 137
S988
T
T
E
L
Y
A
D
S
S
Q
L
S
R
E
Q
Site 138
S989
T
E
L
Y
A
D
S
S
Q
L
S
R
E
Q
R
Site 139
S992
Y
A
D
S
S
Q
L
S
R
E
Q
R
A
L
Q
Site 140
S1024
E
R
A
M
M
R
F
S
E
L
E
M
K
E
R
Site 141
T1038
R
E
G
G
H
P
A
T
K
D
S
E
M
C
K
Site 142
S1041
G
H
P
A
T
K
D
S
E
M
C
K
F
S
P
Site 143
S1047
D
S
E
M
C
K
F
S
P
A
D
W
E
R
L
Site 144
S1064
N
Q
D
K
K
P
K
S
V
T
L
E
E
A
I
Site 145
S1077
A
I
A
E
Q
N
E
S
E
R
C
E
Y
S
V
Site 146
Y1082
N
E
S
E
R
C
E
Y
S
V
G
N
K
H
R
Site 147
S1083
E
S
E
R
C
E
Y
S
V
G
N
K
H
R
D
Site 148
Y1105
K
D
L
P
V
E
K
Y
F
V
E
R
Q
P
V
Site 149
S1113
F
V
E
R
Q
P
V
S
E
P
P
A
D
Q
V
Site 150
S1122
P
P
A
D
Q
V
A
S
D
M
P
H
S
P
T
Site 151
S1127
V
A
S
D
M
P
H
S
P
T
L
R
V
D
R
Site 152
T1129
S
D
M
P
H
S
P
T
L
R
V
D
R
K
R
Site 153
S1139
V
D
R
K
R
K
V
S
G
D
S
S
H
T
E
Site 154
S1143
R
K
V
S
G
D
S
S
H
T
E
T
T
A
E
Site 155
T1147
G
D
S
S
H
T
E
T
T
A
E
E
V
P
E
Site 156
T1148
D
S
S
H
T
E
T
T
A
E
E
V
P
E
D
Site 157
S1166
K
A
K
R
R
R
V
S
K
D
D
W
P
E
R
Site 158
T1176
D
W
P
E
R
E
M
T
N
S
S
S
N
H
L
Site 159
S1178
P
E
R
E
M
T
N
S
S
S
N
H
L
E
D
Site 160
S1180
R
E
M
T
N
S
S
S
N
H
L
E
D
P
H
Site 161
Y1188
N
H
L
E
D
P
H
Y
S
E
L
T
N
L
K
Site 162
S1223
E
R
W
E
Q
Q
V
S
A
A
D
G
K
P
G
Site 163
S1233
D
G
K
P
G
R
Q
S
R
K
E
V
T
Q
A
Site 164
S1269
A
E
A
K
G
N
R
S
W
S
E
E
S
L
K
Site 165
S1271
A
K
G
N
R
S
W
S
E
E
S
L
K
P
S
Site 166
S1274
N
R
S
W
S
E
E
S
L
K
P
S
D
N
E
Site 167
S1278
S
E
E
S
L
K
P
S
D
N
E
Q
G
L
P
Site 168
S1288
E
Q
G
L
P
V
F
S
G
S
P
P
M
K
S
Site 169
S1290
G
L
P
V
F
S
G
S
P
P
M
K
S
L
S
Site 170
S1295
S
G
S
P
P
M
K
S
L
S
S
T
S
A
G
Site 171
S1297
S
P
P
M
K
S
L
S
S
T
S
A
G
G
K
Site 172
S1298
P
P
M
K
S
L
S
S
T
S
A
G
G
K
K
Site 173
T1299
P
M
K
S
L
S
S
T
S
A
G
G
K
K
Q
Site 174
S1310
G
K
K
Q
A
Q
P
S
C
A
P
A
S
R
P
Site 175
S1315
Q
P
S
C
A
P
A
S
R
P
P
A
K
Q
Q
Site 176
T1330
K
I
K
E
N
Q
K
T
D
V
L
C
A
D
E
Site 177
S1345
E
E
D
C
Q
A
A
S
L
L
Q
K
Y
T
D
Site 178
Y1350
A
A
S
L
L
Q
K
Y
T
D
N
S
E
K
P
Site 179
S1354
L
Q
K
Y
T
D
N
S
E
K
P
S
G
K
R
Site 180
S1358
T
D
N
S
E
K
P
S
G
K
R
L
C
K
T
Site 181
T1365
S
G
K
R
L
C
K
T
K
H
L
I
P
Q
E
Site 182
S1373
K
H
L
I
P
Q
E
S
R
R
G
L
P
L
T
Site 183
T1380
S
R
R
G
L
P
L
T
G
E
Y
Y
V
E
N
Site 184
Y1384
L
P
L
T
G
E
Y
Y
V
E
N
A
D
G
K
Site 185
T1393
E
N
A
D
G
K
V
T
V
R
R
F
R
K
R
Site 186
S1404
F
R
K
R
P
E
P
S
S
D
Y
D
L
S
P
Site 187
S1405
R
K
R
P
E
P
S
S
D
Y
D
L
S
P
A
Site 188
Y1407
R
P
E
P
S
S
D
Y
D
L
S
P
A
K
Q
Site 189
S1410
P
S
S
D
Y
D
L
S
P
A
K
Q
E
P
K
Site 190
S1429
L
Q
Q
L
L
P
A
S
Q
S
T
Q
L
P
C
Site 191
S1431
Q
L
L
P
A
S
Q
S
T
Q
L
P
C
S
S
Site 192
T1432
L
L
P
A
S
Q
S
T
Q
L
P
C
S
S
S
Site 193
S1437
Q
S
T
Q
L
P
C
S
S
S
P
Q
E
T
T
Site 194
S1438
S
T
Q
L
P
C
S
S
S
P
Q
E
T
T
Q
Site 195
S1439
T
Q
L
P
C
S
S
S
P
Q
E
T
T
Q
S
Site 196
T1443
C
S
S
S
P
Q
E
T
T
Q
S
R
P
M
P
Site 197
T1444
S
S
S
P
Q
E
T
T
Q
S
R
P
M
P
P
Site 198
S1446
S
P
Q
E
T
T
Q
S
R
P
M
P
P
E
A
Site 199
Y1475
Q
R
A
A
R
L
G
Y
E
E
V
V
L
Y
C
Site 200
Y1498
N
H
R
D
N
A
G
Y
C
A
L
H
E
A
C
Site 201
Y1519
I
V
R
H
L
L
E
Y
G
A
D
V
N
C
S
Site 202
S1526
Y
G
A
D
V
N
C
S
A
Q
D
G
T
R
P
Site 203
T1531
N
C
S
A
Q
D
G
T
R
P
L
H
D
A
V
Site 204
T1557
L
S
Y
G
A
D
P
T
L
A
T
Y
S
G
R
Site 205
T1560
G
A
D
P
T
L
A
T
Y
S
G
R
T
I
M
Site 206
S1562
D
P
T
L
A
T
Y
S
G
R
T
I
M
K
M
Site 207
T1580
E
L
M
E
K
F
L
T
D
Y
L
N
D
L
Q
Site 208
Y1582
M
E
K
F
L
T
D
Y
L
N
D
L
Q
G
R
Site 209
Y1601
A
S
G
T
W
D
F
Y
G
S
S
V
C
E
P
Site 210
S1612
V
C
E
P
D
D
E
S
G
Y
D
V
L
A
N
Site 211
Y1614
E
P
D
D
E
S
G
Y
D
V
L
A
N
P
P
Site 212
Y1633
Q
D
D
D
D
D
A
Y
S
D
V
F
E
F
E
Site 213
S1634
D
D
D
D
D
A
Y
S
D
V
F
E
F
E
F
Site 214
T1644
F
E
F
E
F
S
E
T
P
L
L
P
C
Y
N
Site 215
S1667
P
R
N
W
L
L
L
S
D
V
L
K
K
L
K
Site 216
S1676
V
L
K
K
L
K
M
S
S
R
I
F
R
C
N
Site 217
S1677
L
K
K
L
K
M
S
S
R
I
F
R
C
N
F
Site 218
Y1698
T
I
A
E
A
E
F
Y
R
Q
V
S
A
S
L
Site 219
T1735
E
F
T
N
E
I
Q
T
L
L
G
S
S
V
E
Site 220
S1739
E
I
Q
T
L
L
G
S
S
V
E
W
L
H
P
Site 221
S1747
S
V
E
W
L
H
P
S
D
L
A
S
D
N
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation