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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DPP8
Full Name:
Dipeptidyl peptidase 8
Alias:
DP8; DPRP1; DPRP-1; EC 3.4.14.5
Type:
Enzyme, dipeptidyl peptidase
Mass (Da):
103358
Number AA:
898
UniProt ID:
Q6V1X1
International Prot ID:
IPI00377128
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0008239
GO:0008236
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
D
C
E
E
N
I
E
S
Q
D
R
P
K
L
E
Site 2
Y52
R
P
K
L
E
P
F
Y
V
E
R
Y
S
W
S
Site 3
S57
P
F
Y
V
E
R
Y
S
W
S
Q
L
K
K
L
Site 4
S59
Y
V
E
R
Y
S
W
S
Q
L
K
K
L
L
A
Site 5
T68
L
K
K
L
L
A
D
T
R
K
Y
H
G
Y
M
Site 6
Y71
L
L
A
D
T
R
K
Y
H
G
Y
M
M
A
K
Site 7
Y74
D
T
R
K
Y
H
G
Y
M
M
A
K
A
P
H
Site 8
S96
N
D
P
D
G
P
H
S
D
R
I
Y
Y
L
A
Site 9
Y100
G
P
H
S
D
R
I
Y
Y
L
A
M
S
G
E
Site 10
Y101
P
H
S
D
R
I
Y
Y
L
A
M
S
G
E
N
Site 11
T112
S
G
E
N
R
E
N
T
L
F
Y
S
E
I
P
Site 12
S116
R
E
N
T
L
F
Y
S
E
I
P
K
T
I
N
Site 13
Y145
L
F
Q
A
T
L
D
Y
G
M
Y
S
R
E
E
Site 14
Y148
A
T
L
D
Y
G
M
Y
S
R
E
E
E
L
L
Site 15
S149
T
L
D
Y
G
M
Y
S
R
E
E
E
L
L
R
Site 16
T163
R
E
R
K
R
I
G
T
V
G
I
A
S
Y
D
Site 17
S168
I
G
T
V
G
I
A
S
Y
D
Y
H
Q
G
S
Site 18
Y169
G
T
V
G
I
A
S
Y
D
Y
H
Q
G
S
G
Site 19
Y171
V
G
I
A
S
Y
D
Y
H
Q
G
S
G
T
F
Site 20
S175
S
Y
D
Y
H
Q
G
S
G
T
F
L
F
Q
A
Site 21
T177
D
Y
H
Q
G
S
G
T
F
L
F
Q
A
G
S
Site 22
Y187
F
Q
A
G
S
G
I
Y
H
V
K
D
G
G
P
Site 23
T198
D
G
G
P
Q
G
F
T
Q
Q
P
L
R
P
N
Site 24
T209
L
R
P
N
L
V
E
T
S
C
P
N
I
R
M
Site 25
T250
T
R
E
E
R
R
L
T
Y
V
H
N
E
L
A
Site 26
Y251
R
E
E
R
R
L
T
Y
V
H
N
E
L
A
N
Site 27
S265
N
M
E
E
D
A
R
S
A
G
V
A
T
F
V
Site 28
T292
W
C
P
K
A
E
T
T
P
S
G
G
K
I
L
Site 29
S294
P
K
A
E
T
T
P
S
G
G
K
I
L
R
I
Site 30
Y303
G
K
I
L
R
I
L
Y
E
E
N
D
E
S
E
Site 31
S309
L
Y
E
E
N
D
E
S
E
V
E
I
I
H
V
Site 32
S318
V
E
I
I
H
V
T
S
P
M
L
E
T
R
R
Site 33
T323
V
T
S
P
M
L
E
T
R
R
A
D
S
F
R
Site 34
S328
L
E
T
R
R
A
D
S
F
R
Y
P
K
T
G
Site 35
Y331
R
R
A
D
S
F
R
Y
P
K
T
G
T
A
N
Site 36
T334
D
S
F
R
Y
P
K
T
G
T
A
N
P
K
V
Site 37
T342
G
T
A
N
P
K
V
T
F
K
M
S
E
I
M
Site 38
T384
Y
I
A
R
A
G
W
T
P
E
G
K
Y
A
W
Site 39
Y389
G
W
T
P
E
G
K
Y
A
W
S
I
L
L
D
Site 40
S398
W
S
I
L
L
D
R
S
Q
T
R
L
Q
I
V
Site 41
S428
E
R
Q
R
L
I
E
S
V
P
D
S
V
T
P
Site 42
T434
E
S
V
P
D
S
V
T
P
L
I
I
Y
E
E
Site 43
T442
P
L
I
I
Y
E
E
T
T
D
I
W
I
N
I
Site 44
T474
I
F
A
S
E
C
K
T
G
F
R
H
L
Y
K
Site 45
Y480
K
T
G
F
R
H
L
Y
K
I
T
S
I
L
K
Site 46
S484
R
H
L
Y
K
I
T
S
I
L
K
E
S
K
Y
Site 47
S489
I
T
S
I
L
K
E
S
K
Y
K
R
S
S
G
Site 48
Y491
S
I
L
K
E
S
K
Y
K
R
S
S
G
G
L
Site 49
S494
K
E
S
K
Y
K
R
S
S
G
G
L
P
A
P
Site 50
S495
E
S
K
Y
K
R
S
S
G
G
L
P
A
P
S
Site 51
S502
S
G
G
L
P
A
P
S
D
F
K
C
P
I
K
Site 52
S527
E
V
L
G
R
H
G
S
N
I
Q
V
D
E
V
Site 53
Y539
D
E
V
R
R
L
V
Y
F
E
G
T
K
D
S
Site 54
S546
Y
F
E
G
T
K
D
S
P
L
E
H
H
L
Y
Site 55
Y553
S
P
L
E
H
H
L
Y
V
V
S
Y
V
N
P
Site 56
Y557
H
H
L
Y
V
V
S
Y
V
N
P
G
E
V
T
Site 57
T567
P
G
E
V
T
R
L
T
D
R
G
Y
S
H
S
Site 58
Y571
T
R
L
T
D
R
G
Y
S
H
S
C
C
I
S
Site 59
S572
R
L
T
D
R
G
Y
S
H
S
C
C
I
S
Q
Site 60
Y588
C
D
F
F
I
S
K
Y
S
N
Q
K
N
P
H
Site 61
S598
Q
K
N
P
H
C
V
S
L
Y
K
L
S
S
P
Site 62
Y600
N
P
H
C
V
S
L
Y
K
L
S
S
P
E
D
Site 63
S604
V
S
L
Y
K
L
S
S
P
E
D
D
P
T
C
Site 64
T610
S
S
P
E
D
D
P
T
C
K
T
K
E
F
W
Site 65
T619
K
T
K
E
F
W
A
T
I
L
D
S
A
G
P
Site 66
Y630
S
A
G
P
L
P
D
Y
T
P
P
E
I
F
S
Site 67
T631
A
G
P
L
P
D
Y
T
P
P
E
I
F
S
F
Site 68
S637
Y
T
P
P
E
I
F
S
F
E
S
T
T
G
F
Site 69
Y647
S
T
T
G
F
T
L
Y
G
M
L
Y
K
P
H
Site 70
Y651
F
T
L
Y
G
M
L
Y
K
P
H
D
L
Q
P
Site 71
Y662
D
L
Q
P
G
K
K
Y
P
T
V
L
F
I
Y
Site 72
T664
Q
P
G
K
K
Y
P
T
V
L
F
I
Y
G
G
Site 73
Y686
N
R
F
K
G
V
K
Y
F
R
L
N
T
L
A
Site 74
S707
V
V
I
D
N
R
G
S
C
H
R
G
L
K
F
Site 75
Y720
K
F
E
G
A
F
K
Y
K
M
G
Q
I
E
I
Site 76
Y736
D
Q
V
E
G
L
Q
Y
L
A
S
R
Y
D
F
Site 77
S739
E
G
L
Q
Y
L
A
S
R
Y
D
F
I
D
L
Site 78
S755
R
V
G
I
H
G
W
S
Y
G
G
Y
L
S
L
Site 79
Y787
P
V
T
L
W
I
F
Y
D
T
G
Y
T
E
R
Site 80
Y806
P
D
Q
N
E
Q
G
Y
Y
L
G
S
V
A
M
Site 81
Y807
D
Q
N
E
Q
G
Y
Y
L
G
S
V
A
M
Q
Site 82
S810
E
Q
G
Y
Y
L
G
S
V
A
M
Q
A
E
K
Site 83
S820
M
Q
A
E
K
F
P
S
E
P
N
R
L
L
L
Site 84
Y855
L
V
R
A
G
K
P
Y
D
L
Q
I
Y
P
Q
Site 85
Y860
K
P
Y
D
L
Q
I
Y
P
Q
E
R
H
S
I
Site 86
S866
I
Y
P
Q
E
R
H
S
I
R
V
P
E
S
G
Site 87
S872
H
S
I
R
V
P
E
S
G
E
H
Y
E
L
H
Site 88
Y876
V
P
E
S
G
E
H
Y
E
L
H
L
L
H
Y
Site 89
Y883
Y
E
L
H
L
L
H
Y
L
Q
E
N
L
G
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation