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Updated November 2019
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Protein Info
Short Name:
ITIH5L
Full Name:
Inter-alpha-trypsin inhibitor heavy chain H5-like protein
Alias:
Type:
Mass (Da):
143187
Number AA:
1313
UniProt ID:
Q6UXX5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
Q
G
P
P
V
P
A
S
S
S
T
K
L
L
M
Site 2
S31
G
P
P
V
P
A
S
S
S
T
K
L
L
M
T
Site 3
S32
P
P
V
P
A
S
S
S
T
K
L
L
M
T
S
Site 4
S39
S
T
K
L
L
M
T
S
Y
S
M
R
S
T
V
Site 5
S44
M
T
S
Y
S
M
R
S
T
V
V
S
R
Y
A
Site 6
T45
T
S
Y
S
M
R
S
T
V
V
S
R
Y
A
H
Site 7
S48
S
M
R
S
T
V
V
S
R
Y
A
H
T
L
V
Site 8
T116
E
A
H
Q
Q
G
K
T
A
A
H
V
G
I
R
Site 9
S127
V
G
I
R
D
R
E
S
E
K
F
R
I
S
T
Site 10
S133
E
S
E
K
F
R
I
S
T
S
L
A
A
G
T
Site 11
T134
S
E
K
F
R
I
S
T
S
L
A
A
G
T
E
Site 12
S135
E
K
F
R
I
S
T
S
L
A
A
G
T
E
V
Site 13
Y159
L
Q
R
H
Q
G
Q
Y
Q
L
V
V
S
L
R
Site 14
T179
K
R
L
S
I
E
V
T
V
S
E
R
T
G
I
Site 15
Y188
S
E
R
T
G
I
S
Y
V
H
I
P
P
L
R
Site 16
T201
L
R
T
G
R
L
R
T
N
A
H
A
S
E
V
Site 17
S206
L
R
T
N
A
H
A
S
E
V
D
S
P
P
S
Site 18
S210
A
H
A
S
E
V
D
S
P
P
S
T
R
I
E
Site 19
S213
S
E
V
D
S
P
P
S
T
R
I
E
R
G
E
Site 20
T214
E
V
D
S
P
P
S
T
R
I
E
R
G
E
T
Site 21
T221
T
R
I
E
R
G
E
T
C
V
R
I
T
Y
C
Site 22
Y227
E
T
C
V
R
I
T
Y
C
P
T
L
Q
D
Q
Site 23
T230
V
R
I
T
Y
C
P
T
L
Q
D
Q
S
S
I
Site 24
S235
C
P
T
L
Q
D
Q
S
S
I
S
G
S
G
I
Site 25
S236
P
T
L
Q
D
Q
S
S
I
S
G
S
G
I
M
Site 26
S238
L
Q
D
Q
S
S
I
S
G
S
G
I
M
A
D
Site 27
Y250
M
A
D
F
L
V
Q
Y
D
V
V
M
E
D
I
Site 28
Y267
D
V
Q
I
Y
D
D
Y
F
I
H
Y
F
A
P
Site 29
Y271
Y
D
D
Y
F
I
H
Y
F
A
P
R
G
L
P
Site 30
T297
V
S
S
S
M
F
G
T
K
M
E
Q
T
K
T
Site 31
T304
T
K
M
E
Q
T
K
T
A
M
N
V
I
L
S
Site 32
Y318
S
D
L
Q
A
N
D
Y
F
N
I
I
S
F
S
Site 33
T340
A
G
G
S
I
Q
A
T
I
Q
N
V
H
S
A
Site 34
Y350
N
V
H
S
A
K
D
Y
L
H
C
M
E
A
D
Site 35
S376
A
A
S
V
L
N
H
S
N
Q
E
P
G
R
G
Site 36
S385
Q
E
P
G
R
G
P
S
V
G
R
I
P
L
I
Site 37
T436
F
G
D
D
A
D
F
T
L
L
R
R
L
S
L
Site 38
Y453
R
G
I
A
R
R
I
Y
E
D
T
D
A
A
L
Site 39
T456
A
R
R
I
Y
E
D
T
D
A
A
L
Q
L
K
Site 40
S535
Q
L
L
V
A
H
H
S
E
G
A
T
N
N
S
Site 41
T539
A
H
H
S
E
G
A
T
N
N
S
Q
K
A
F
Site 42
S542
S
E
G
A
T
N
N
S
Q
K
A
F
G
C
P
Site 43
T582
A
H
F
Q
A
R
D
T
T
T
R
H
L
L
A
Site 44
T583
H
F
Q
A
R
D
T
T
T
R
H
L
L
A
A
Site 45
T624
S
E
E
T
R
R
Q
T
S
T
S
A
G
P
D
Site 46
S625
E
E
T
R
R
Q
T
S
T
S
A
G
P
D
T
Site 47
T626
E
T
R
R
Q
T
S
T
S
A
G
P
D
T
I
Site 48
S627
T
R
R
Q
T
S
T
S
A
G
P
D
T
I
M
Site 49
T632
S
T
S
A
G
P
D
T
I
M
P
S
S
S
S
Site 50
S636
G
P
D
T
I
M
P
S
S
S
S
R
H
G
L
Site 51
S637
P
D
T
I
M
P
S
S
S
S
R
H
G
L
G
Site 52
S638
D
T
I
M
P
S
S
S
S
R
H
G
L
G
V
Site 53
S639
T
I
M
P
S
S
S
S
R
H
G
L
G
V
S
Site 54
S658
A
L
V
P
K
V
I
S
P
K
S
R
P
V
K
Site 55
S661
P
K
V
I
S
P
K
S
R
P
V
K
P
K
F
Site 56
Y669
R
P
V
K
P
K
F
Y
L
S
S
T
T
T
A
Site 57
S671
V
K
P
K
F
Y
L
S
S
T
T
T
A
S
T
Site 58
S672
K
P
K
F
Y
L
S
S
T
T
T
A
S
T
K
Site 59
T673
P
K
F
Y
L
S
S
T
T
T
A
S
T
K
K
Site 60
T675
F
Y
L
S
S
T
T
T
A
S
T
K
K
M
L
Site 61
S677
L
S
S
T
T
T
A
S
T
K
K
M
L
S
S
Site 62
S683
A
S
T
K
K
M
L
S
S
K
E
L
E
P
L
Site 63
S684
S
T
K
K
M
L
S
S
K
E
L
E
P
L
G
Site 64
S693
E
L
E
P
L
G
E
S
P
H
T
L
S
M
P
Site 65
T696
P
L
G
E
S
P
H
T
L
S
M
P
T
Y
P
Site 66
S698
G
E
S
P
H
T
L
S
M
P
T
Y
P
K
A
Site 67
Y702
H
T
L
S
M
P
T
Y
P
K
A
K
I
P
A
Site 68
T715
P
A
Q
Q
D
S
G
T
L
A
Q
P
T
L
R
Site 69
T720
S
G
T
L
A
Q
P
T
L
R
T
K
P
T
I
Site 70
T726
P
T
L
R
T
K
P
T
I
L
V
P
S
N
S
Site 71
S743
L
L
P
L
K
P
G
S
L
S
H
Q
N
P
D
Site 72
S745
P
L
K
P
G
S
L
S
H
Q
N
P
D
I
L
Site 73
S756
P
D
I
L
P
T
N
S
R
T
Q
V
P
P
V
Site 74
S770
V
K
P
G
I
P
A
S
P
K
A
D
T
V
K
Site 75
T775
P
A
S
P
K
A
D
T
V
K
C
V
T
P
L
Site 76
T780
A
D
T
V
K
C
V
T
P
L
H
S
K
P
G
Site 77
S784
K
C
V
T
P
L
H
S
K
P
G
A
P
S
H
Site 78
S790
H
S
K
P
G
A
P
S
H
P
Q
L
G
A
L
Site 79
S799
P
Q
L
G
A
L
T
S
Q
A
P
K
G
L
P
Site 80
S808
A
P
K
G
L
P
Q
S
R
P
G
V
S
T
L
Site 81
S813
P
Q
S
R
P
G
V
S
T
L
Q
V
P
K
Y
Site 82
T814
Q
S
R
P
G
V
S
T
L
Q
V
P
K
Y
P
Site 83
Y820
S
T
L
Q
V
P
K
Y
P
L
H
T
R
P
R
Site 84
T833
P
R
V
P
A
P
K
T
R
N
N
M
P
H
L
Site 85
S855
K
T
P
K
I
L
L
S
L
K
P
S
A
P
P
Site 86
S866
S
A
P
P
H
Q
I
S
T
S
I
S
L
S
K
Site 87
S868
P
P
H
Q
I
S
T
S
I
S
L
S
K
P
E
Site 88
S870
H
Q
I
S
T
S
I
S
L
S
K
P
E
T
P
Site 89
S872
I
S
T
S
I
S
L
S
K
P
E
T
P
N
P
Site 90
T876
I
S
L
S
K
P
E
T
P
N
P
H
M
P
Q
Site 91
T884
P
N
P
H
M
P
Q
T
P
L
P
P
R
P
D
Site 92
S900
P
R
P
P
L
P
E
S
L
S
T
F
P
N
T
Site 93
S902
P
P
L
P
E
S
L
S
T
F
P
N
T
I
S
Site 94
T903
P
L
P
E
S
L
S
T
F
P
N
T
I
S
S
Site 95
T907
S
L
S
T
F
P
N
T
I
S
S
S
T
G
P
Site 96
S909
S
T
F
P
N
T
I
S
S
S
T
G
P
S
S
Site 97
S910
T
F
P
N
T
I
S
S
S
T
G
P
S
S
T
Site 98
S911
F
P
N
T
I
S
S
S
T
G
P
S
S
T
T
Site 99
T912
P
N
T
I
S
S
S
T
G
P
S
S
T
T
T
Site 100
S915
I
S
S
S
T
G
P
S
S
T
T
T
T
S
V
Site 101
S916
S
S
S
T
G
P
S
S
T
T
T
T
S
V
L
Site 102
T917
S
S
T
G
P
S
S
T
T
T
T
S
V
L
G
Site 103
T919
T
G
P
S
S
T
T
T
T
S
V
L
G
E
P
Site 104
T920
G
P
S
S
T
T
T
T
S
V
L
G
E
P
L
Site 105
S921
P
S
S
T
T
T
T
S
V
L
G
E
P
L
P
Site 106
T932
E
P
L
P
M
P
F
T
P
T
L
P
P
G
R
Site 107
T934
L
P
M
P
F
T
P
T
L
P
P
G
R
F
W
Site 108
Y944
P
G
R
F
W
H
Q
Y
D
L
L
P
G
P
Q
Site 109
S960
T
R
Q
V
L
G
P
S
R
P
G
V
P
T
M
Site 110
T966
P
S
R
P
G
V
P
T
M
S
L
L
N
S
S
Site 111
S968
R
P
G
V
P
T
M
S
L
L
N
S
S
R
P
Site 112
S972
P
T
M
S
L
L
N
S
S
R
P
T
P
E
G
Site 113
T976
L
L
N
S
S
R
P
T
P
E
G
S
P
P
N
Site 114
S980
S
R
P
T
P
E
G
S
P
P
N
L
P
I
L
Site 115
S1010
P
E
E
L
E
L
L
S
E
S
M
V
E
S
K
Site 116
S1016
L
S
E
S
M
V
E
S
K
F
V
E
S
L
N
Site 117
S1021
V
E
S
K
F
V
E
S
L
N
P
P
A
F
Y
Site 118
T1029
L
N
P
P
A
F
Y
T
F
L
T
P
D
E
D
Site 119
T1032
P
A
F
Y
T
F
L
T
P
D
E
D
G
S
P
Site 120
S1038
L
T
P
D
E
D
G
S
P
N
W
D
G
N
S
Site 121
S1045
S
P
N
W
D
G
N
S
E
E
I
L
G
G
A
Site 122
S1055
I
L
G
G
A
G
G
S
M
E
S
Q
G
S
S
Site 123
S1058
G
A
G
G
S
M
E
S
Q
G
S
S
V
G
L
Site 124
S1061
G
S
M
E
S
Q
G
S
S
V
G
L
A
K
G
Site 125
S1062
S
M
E
S
Q
G
S
S
V
G
L
A
K
G
T
Site 126
S1077
L
P
S
I
F
T
F
S
S
S
V
D
G
D
P
Site 127
S1078
P
S
I
F
T
F
S
S
S
V
D
G
D
P
H
Site 128
S1079
S
I
F
T
F
S
S
S
V
D
G
D
P
H
F
Site 129
T1100
S
E
E
K
I
C
F
T
L
N
G
H
P
G
D
Site 130
T1138
R
P
G
H
K
D
Q
T
R
T
Y
F
Q
I
I
Site 131
Y1141
H
K
D
Q
T
R
T
Y
F
Q
I
I
T
V
T
Site 132
T1146
R
T
Y
F
Q
I
I
T
V
T
T
D
K
P
R
Site 133
Y1155
T
T
D
K
P
R
A
Y
T
I
T
I
S
R
S
Site 134
T1156
T
D
K
P
R
A
Y
T
I
T
I
S
R
S
S
Site 135
T1158
K
P
R
A
Y
T
I
T
I
S
R
S
S
I
S
Site 136
S1160
R
A
Y
T
I
T
I
S
R
S
S
I
S
L
R
Site 137
S1162
Y
T
I
T
I
S
R
S
S
I
S
L
R
G
E
Site 138
S1163
T
I
T
I
S
R
S
S
I
S
L
R
G
E
G
Site 139
S1165
T
I
S
R
S
S
I
S
L
R
G
E
G
T
L
Site 140
T1171
I
S
L
R
G
E
G
T
L
R
L
S
W
D
Q
Site 141
S1175
G
E
G
T
L
R
L
S
W
D
Q
P
A
L
L
Site 142
Y1190
K
R
P
Q
L
E
L
Y
V
A
A
A
A
R
L
Site 143
Y1214
F
L
V
L
R
H
R
Y
R
H
P
S
T
L
Q
Site 144
S1218
R
H
R
Y
R
H
P
S
T
L
Q
L
P
H
L
Site 145
T1219
H
R
Y
R
H
P
S
T
L
Q
L
P
H
L
G
Site 146
S1233
G
F
Y
V
A
N
G
S
G
L
S
P
S
A
R
Site 147
S1238
N
G
S
G
L
S
P
S
A
R
G
L
I
G
Q
Site 148
S1282
G
K
R
L
L
K
D
S
P
R
L
L
P
R
W
Site 149
S1291
R
L
L
P
R
W
A
S
C
W
L
V
K
R
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation