KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LRIG3
Full Name:
Leucine-rich repeats and immunoglobulin-like domains protein 3
Alias:
FLJ90440; KIAA3016; Leucine-rich repeats and immunoglobulin-like domains 3; Leucine-rich repeats and immunoglobulin-like domains protein 3; LIG3; LIG-3
Type:
Unknown function
Mass (Da):
123434
Number AA:
1119
UniProt ID:
Q6UXM1
International Prot ID:
IPI00184265
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
A
P
S
L
R
A
R
A
A
G
Site 2
S27
V
L
G
R
A
G
R
S
D
S
G
G
R
G
E
Site 3
S29
G
R
A
G
R
S
D
S
G
G
R
G
E
L
G
Site 4
T49
A
A
E
R
P
C
P
T
T
C
R
C
L
G
D
Site 5
T50
A
E
R
P
C
P
T
T
C
R
C
L
G
D
L
Site 6
S61
L
G
D
L
L
D
C
S
R
K
R
L
A
R
L
Site 7
S74
R
L
P
E
P
L
P
S
W
V
A
R
L
D
L
Site 8
S87
D
L
S
H
N
R
L
S
F
I
K
A
S
S
M
Site 9
S92
R
L
S
F
I
K
A
S
S
M
S
H
L
Q
S
Site 10
S95
F
I
K
A
S
S
M
S
H
L
Q
S
L
R
E
Site 11
S99
S
S
M
S
H
L
Q
S
L
R
E
V
K
L
N
Site 12
S146
E
H
L
K
E
F
Q
S
L
E
T
L
D
L
S
Site 13
T149
K
E
F
Q
S
L
E
T
L
D
L
S
S
N
N
Site 14
S153
S
L
E
T
L
D
L
S
S
N
N
I
S
E
L
Site 15
S154
L
E
T
L
D
L
S
S
N
N
I
S
E
L
Q
Site 16
S158
D
L
S
S
N
N
I
S
E
L
Q
T
A
F
P
Site 17
Y171
F
P
A
L
Q
L
K
Y
L
Y
L
N
S
N
R
Site 18
Y173
A
L
Q
L
K
Y
L
Y
L
N
S
N
R
V
T
Site 19
S176
L
K
Y
L
Y
L
N
S
N
R
V
T
S
M
E
Site 20
T180
Y
L
N
S
N
R
V
T
S
M
E
P
G
Y
F
Site 21
S181
L
N
S
N
R
V
T
S
M
E
P
G
Y
F
D
Site 22
Y186
V
T
S
M
E
P
G
Y
F
D
N
L
A
N
T
Site 23
S205
K
L
N
R
N
R
I
S
A
I
P
P
K
M
F
Site 24
S243
Q
G
L
G
A
L
K
S
L
K
M
Q
R
N
G
Site 25
T276
Q
L
D
H
N
N
L
T
E
I
T
K
G
W
L
Site 26
S295
M
L
Q
E
L
H
L
S
Q
N
A
I
N
R
I
Site 27
T319
K
L
S
E
L
D
L
T
F
N
H
L
S
R
L
Site 28
S324
D
L
T
F
N
H
L
S
R
L
D
D
S
S
F
Site 29
S329
H
L
S
R
L
D
D
S
S
F
L
G
L
S
L
Site 30
Y349
I
G
N
N
R
V
S
Y
I
A
D
C
A
F
R
Site 31
T363
R
G
L
S
S
L
K
T
L
D
L
K
N
N
E
Site 32
S400
L
Q
G
N
R
I
R
S
I
T
K
K
A
F
T
Site 33
T402
G
N
R
I
R
S
I
T
K
K
A
F
T
G
L
Site 34
S431
S
L
Q
G
N
A
F
S
Q
M
K
K
L
Q
Q
Site 35
S444
Q
Q
L
H
L
N
T
S
S
L
L
C
D
C
Q
Site 36
S482
P
Q
L
L
K
G
R
S
I
F
A
V
S
P
D
Site 37
T502
D
F
P
K
P
Q
I
T
V
Q
P
E
T
Q
S
Site 38
S521
S
N
L
S
F
I
C
S
A
A
S
S
S
D
S
Site 39
S524
S
F
I
C
S
A
A
S
S
S
D
S
P
M
T
Site 40
S528
S
A
A
S
S
S
D
S
P
M
T
F
A
W
K
Site 41
T531
S
S
S
D
S
P
M
T
F
A
W
K
K
D
N
Site 42
Y549
H
D
A
E
M
E
N
Y
A
H
L
R
A
Q
G
Site 43
Y562
Q
G
G
E
V
M
E
Y
T
T
I
L
R
L
R
Site 44
Y579
E
F
A
S
E
G
K
Y
Q
C
V
I
S
N
H
Site 45
S590
I
S
N
H
F
G
S
S
Y
S
V
K
A
K
L
Site 46
S592
N
H
F
G
S
S
Y
S
V
K
A
K
L
T
V
Site 47
T598
Y
S
V
K
A
K
L
T
V
N
M
L
P
S
F
Site 48
T608
M
L
P
S
F
T
K
T
P
M
D
L
T
I
R
Site 49
T642
A
W
Q
K
D
G
G
T
D
F
P
A
A
R
E
Site 50
T677
D
I
G
V
Y
S
C
T
A
Q
N
S
A
G
S
Site 51
S681
Y
S
C
T
A
Q
N
S
A
G
S
I
S
A
N
Site 52
T707
L
R
P
L
L
D
R
T
V
T
K
G
E
T
A
Site 53
S723
L
Q
C
I
A
G
G
S
P
P
P
K
L
N
W
Site 54
T731
P
P
P
K
L
N
W
T
K
D
D
S
P
L
V
Site 55
S735
L
N
W
T
K
D
D
S
P
L
V
V
T
E
R
Site 56
T740
D
D
S
P
L
V
V
T
E
R
H
F
F
A
A
Site 57
Y765
D
V
S
D
A
G
K
Y
T
C
E
M
S
N
T
Site 58
T766
V
S
D
A
G
K
Y
T
C
E
M
S
N
T
L
Site 59
S770
G
K
Y
T
C
E
M
S
N
T
L
G
T
E
R
Site 60
T772
Y
T
C
E
M
S
N
T
L
G
T
E
R
G
N
Site 61
T775
E
M
S
N
T
L
G
T
E
R
G
N
V
R
L
Site 62
S783
E
R
G
N
V
R
L
S
V
I
P
T
P
T
C
Site 63
T787
V
R
L
S
V
I
P
T
P
T
C
D
S
P
Q
Site 64
S792
I
P
T
P
T
C
D
S
P
Q
M
T
A
P
S
Site 65
T796
T
C
D
S
P
Q
M
T
A
P
S
L
D
D
D
Site 66
S799
S
P
Q
M
T
A
P
S
L
D
D
D
G
W
A
Site 67
Y831
L
V
W
V
V
I
I
Y
H
T
R
R
R
N
E
Site 68
S841
R
R
R
N
E
D
C
S
I
T
N
T
D
E
T
Site 69
T845
E
D
C
S
I
T
N
T
D
E
T
N
L
P
A
Site 70
T848
S
I
T
N
T
D
E
T
N
L
P
A
D
I
P
Site 71
S856
N
L
P
A
D
I
P
S
Y
L
S
S
Q
G
T
Site 72
Y857
L
P
A
D
I
P
S
Y
L
S
S
Q
G
T
L
Site 73
S860
D
I
P
S
Y
L
S
S
Q
G
T
L
A
D
R
Site 74
T863
S
Y
L
S
S
Q
G
T
L
A
D
R
Q
D
G
Site 75
Y871
L
A
D
R
Q
D
G
Y
V
S
S
E
S
G
S
Site 76
S873
D
R
Q
D
G
Y
V
S
S
E
S
G
S
H
H
Site 77
S874
R
Q
D
G
Y
V
S
S
E
S
G
S
H
H
Q
Site 78
S876
D
G
Y
V
S
S
E
S
G
S
H
H
Q
F
V
Site 79
S878
Y
V
S
S
E
S
G
S
H
H
Q
F
V
T
S
Site 80
T884
G
S
H
H
Q
F
V
T
S
S
G
A
G
F
F
Site 81
S907
T
C
H
I
D
N
S
S
E
A
D
V
E
A
A
Site 82
Y930
L
G
S
T
G
P
M
Y
L
K
G
N
V
Y
G
Site 83
Y936
M
Y
L
K
G
N
V
Y
G
S
D
P
F
E
T
Site 84
S938
L
K
G
N
V
Y
G
S
D
P
F
E
T
Y
H
Site 85
Y944
G
S
D
P
F
E
T
Y
H
T
G
C
S
P
D
Site 86
T946
D
P
F
E
T
Y
H
T
G
C
S
P
D
P
R
Site 87
S949
E
T
Y
H
T
G
C
S
P
D
P
R
T
V
L
Site 88
T954
G
C
S
P
D
P
R
T
V
L
M
D
H
Y
E
Site 89
Y960
R
T
V
L
M
D
H
Y
E
P
S
Y
I
K
K
Site 90
Y964
M
D
H
Y
E
P
S
Y
I
K
K
K
E
C
Y
Site 91
Y971
Y
I
K
K
K
E
C
Y
P
C
S
H
P
S
E
Site 92
S974
K
K
E
C
Y
P
C
S
H
P
S
E
E
S
C
Site 93
S977
C
Y
P
C
S
H
P
S
E
E
S
C
E
R
S
Site 94
S980
C
S
H
P
S
E
E
S
C
E
R
S
F
S
N
Site 95
S984
S
E
E
S
C
E
R
S
F
S
N
I
S
W
P
Site 96
S986
E
S
C
E
R
S
F
S
N
I
S
W
P
S
H
Site 97
S989
E
R
S
F
S
N
I
S
W
P
S
H
V
R
K
Site 98
S992
F
S
N
I
S
W
P
S
H
V
R
K
L
L
N
Site 99
T1000
H
V
R
K
L
L
N
T
S
Y
S
H
N
E
G
Site 100
Y1002
R
K
L
L
N
T
S
Y
S
H
N
E
G
P
G
Site 101
S1003
K
L
L
N
T
S
Y
S
H
N
E
G
P
G
M
Site 102
S1018
K
N
L
C
L
N
K
S
S
L
D
F
S
A
N
Site 103
S1019
N
L
C
L
N
K
S
S
L
D
F
S
A
N
P
Site 104
S1023
N
K
S
S
L
D
F
S
A
N
P
E
P
A
S
Site 105
S1030
S
A
N
P
E
P
A
S
V
A
S
S
N
S
F
Site 106
S1033
P
E
P
A
S
V
A
S
S
N
S
F
M
G
T
Site 107
S1034
E
P
A
S
V
A
S
S
N
S
F
M
G
T
F
Site 108
S1036
A
S
V
A
S
S
N
S
F
M
G
T
F
G
K
Site 109
T1040
S
S
N
S
F
M
G
T
F
G
K
A
L
R
R
Site 110
Y1053
R
R
P
H
L
D
A
Y
S
S
F
G
Q
P
S
Site 111
S1054
R
P
H
L
D
A
Y
S
S
F
G
Q
P
S
D
Site 112
S1055
P
H
L
D
A
Y
S
S
F
G
Q
P
S
D
C
Site 113
S1060
Y
S
S
F
G
Q
P
S
D
C
Q
P
R
A
F
Site 114
Y1068
D
C
Q
P
R
A
F
Y
L
K
A
H
S
S
P
Site 115
S1073
A
F
Y
L
K
A
H
S
S
P
D
L
D
S
G
Site 116
S1074
F
Y
L
K
A
H
S
S
P
D
L
D
S
G
S
Site 117
S1079
H
S
S
P
D
L
D
S
G
S
E
E
D
G
K
Site 118
S1081
S
P
D
L
D
S
G
S
E
E
D
G
K
E
R
Site 119
T1099
Q
E
E
N
H
I
C
T
F
K
Q
T
L
E
N
Site 120
Y1107
F
K
Q
T
L
E
N
Y
R
T
P
N
F
Q
S
Site 121
T1109
Q
T
L
E
N
Y
R
T
P
N
F
Q
S
Y
D
Site 122
S1114
Y
R
T
P
N
F
Q
S
Y
D
L
D
T
_
_
Site 123
Y1115
R
T
P
N
F
Q
S
Y
D
L
D
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation