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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNT2
Full Name:
Potassium channel subfamily T member 2
Alias:
Sequence like an intermediate conductance potassium channel subunit;Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1
Type:
Mass (Da):
130501
Number AA:
1135
UniProt ID:
Q6UVM3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
V
D
L
E
S
E
V
P
P
L
P
P
Site 2
Y15
V
P
P
L
P
P
R
Y
R
F
R
D
L
L
L
Site 3
Y38
D
R
V
Q
V
E
F
Y
M
N
E
N
T
F
K
Site 4
T43
E
F
Y
M
N
E
N
T
F
K
E
R
L
K
L
Site 5
S58
F
F
I
K
N
Q
R
S
S
L
R
I
R
L
F
Site 6
S59
F
I
K
N
Q
R
S
S
L
R
I
R
L
F
N
Site 7
S87
R
V
L
L
E
N
P
S
Q
G
N
E
W
S
H
Site 8
T191
L
H
R
A
I
Q
R
T
Q
S
A
M
F
N
Q
Site 9
S193
R
A
I
Q
R
T
Q
S
A
M
F
N
Q
V
L
Site 10
T249
T
V
G
F
G
D
V
T
P
E
T
W
S
S
K
Site 11
T252
F
G
D
V
T
P
E
T
W
S
S
K
L
F
V
Site 12
Y279
I
Q
F
E
Q
L
A
Y
L
W
M
E
R
Q
K
Site 13
S287
L
W
M
E
R
Q
K
S
G
G
N
Y
S
R
H
Site 14
Y291
R
Q
K
S
G
G
N
Y
S
R
H
R
A
Q
T
Site 15
S292
Q
K
S
G
G
N
Y
S
R
H
R
A
Q
T
E
Site 16
T298
Y
S
R
H
R
A
Q
T
E
K
H
V
V
L
C
Site 17
Y322
M
D
F
L
N
E
F
Y
A
H
P
R
L
Q
D
Site 18
Y359
M
W
S
Q
R
V
I
Y
L
Q
G
S
A
L
K
Site 19
S386
E
A
C
F
I
L
S
S
R
C
E
V
D
R
T
Site 20
T393
S
R
C
E
V
D
R
T
S
S
D
H
Q
T
I
Site 21
S394
R
C
E
V
D
R
T
S
S
D
H
Q
T
I
L
Site 22
S395
C
E
V
D
R
T
S
S
D
H
Q
T
I
L
R
Site 23
T399
R
T
S
S
D
H
Q
T
I
L
R
A
W
A
V
Site 24
S465
I
T
L
L
V
H
T
S
R
G
Q
E
G
Q
Q
Site 25
S473
R
G
Q
E
G
Q
Q
S
P
E
Q
W
Q
K
M
Site 26
Y481
P
E
Q
W
Q
K
M
Y
G
R
C
S
G
N
E
Site 27
Y490
R
C
S
G
N
E
V
Y
H
I
V
L
E
E
S
Site 28
T498
H
I
V
L
E
E
S
T
F
F
A
E
Y
E
G
Site 29
Y503
E
S
T
F
F
A
E
Y
E
G
K
S
F
T
Y
Site 30
T509
E
Y
E
G
K
S
F
T
Y
A
S
F
H
A
H
Site 31
Y510
Y
E
G
K
S
F
T
Y
A
S
F
H
A
H
K
Site 32
S512
G
K
S
F
T
Y
A
S
F
H
A
H
K
K
F
Site 33
Y542
L
L
N
P
G
P
R
Y
I
M
N
S
T
D
I
Site 34
S572
N
Q
D
Q
Q
R
K
S
N
V
S
R
S
F
Y
Site 35
S575
Q
Q
R
K
S
N
V
S
R
S
F
Y
H
G
P
Site 36
S577
R
K
S
N
V
S
R
S
F
Y
H
G
P
S
R
Site 37
Y579
S
N
V
S
R
S
F
Y
H
G
P
S
R
L
P
Site 38
S583
R
S
F
Y
H
G
P
S
R
L
P
V
H
S
I
Site 39
T604
V
A
I
D
L
Q
D
T
S
C
R
S
A
S
G
Site 40
S605
A
I
D
L
Q
D
T
S
C
R
S
A
S
G
P
Site 41
S608
L
Q
D
T
S
C
R
S
A
S
G
P
T
L
S
Site 42
S610
D
T
S
C
R
S
A
S
G
P
T
L
S
L
P
Site 43
S615
S
A
S
G
P
T
L
S
L
P
T
E
G
S
K
Site 44
S621
L
S
L
P
T
E
G
S
K
E
I
R
R
P
S
Site 45
S628
S
K
E
I
R
R
P
S
I
A
P
V
L
E
V
Site 46
S648
I
Q
T
C
D
L
L
S
D
Q
S
E
D
E
T
Site 47
S651
C
D
L
L
S
D
Q
S
E
D
E
T
T
P
D
Site 48
T655
S
D
Q
S
E
D
E
T
T
P
D
E
E
M
S
Site 49
T656
D
Q
S
E
D
E
T
T
P
D
E
E
M
S
S
Site 50
S663
T
P
D
E
E
M
S
S
N
L
E
Y
A
K
G
Site 51
Y667
E
M
S
S
N
L
E
Y
A
K
G
Y
P
P
Y
Site 52
Y671
N
L
E
Y
A
K
G
Y
P
P
Y
S
P
Y
I
Site 53
Y674
Y
A
K
G
Y
P
P
Y
S
P
Y
I
G
S
S
Site 54
S675
A
K
G
Y
P
P
Y
S
P
Y
I
G
S
S
P
Site 55
Y677
G
Y
P
P
Y
S
P
Y
I
G
S
S
P
T
F
Site 56
S680
P
Y
S
P
Y
I
G
S
S
P
T
F
C
H
L
Site 57
T683
P
Y
I
G
S
S
P
T
F
C
H
L
L
H
E
Site 58
Y707
D
K
S
C
Q
H
N
Y
Y
E
D
A
K
A
Y
Site 59
Y708
K
S
C
Q
H
N
Y
Y
E
D
A
K
A
Y
G
Site 60
Y742
F
I
V
P
L
R
A
Y
Y
R
P
K
K
E
L
Site 61
Y743
I
V
P
L
R
A
Y
Y
R
P
K
K
E
L
N
Site 62
S780
M
V
Y
Y
M
V
G
S
I
D
N
L
D
D
L
Site 63
S808
V
D
K
E
S
T
M
S
A
E
E
D
Y
M
A
Site 64
Y813
T
M
S
A
E
E
D
Y
M
A
D
A
K
T
I
Site 65
Y856
Q
F
R
A
K
D
C
Y
S
L
A
L
S
K
L
Site 66
S857
F
R
A
K
D
C
Y
S
L
A
L
S
K
L
E
Site 67
S861
D
C
Y
S
L
A
L
S
K
L
E
K
K
E
R
Site 68
S872
K
K
E
R
E
R
G
S
N
L
A
F
M
F
R
Site 69
Y898
S
M
L
D
T
L
L
Y
Q
S
F
V
K
D
Y
Site 70
Y905
Y
Q
S
F
V
K
D
Y
M
I
S
I
T
R
L
Site 71
S922
G
L
D
T
T
P
G
S
G
F
L
C
S
M
K
Site 72
S927
P
G
S
G
F
L
C
S
M
K
I
T
A
D
D
Site 73
Y940
D
D
L
W
I
R
T
Y
A
R
L
Y
Q
K
L
Site 74
Y944
I
R
T
Y
A
R
L
Y
Q
K
L
C
S
S
T
Site 75
S949
R
L
Y
Q
K
L
C
S
S
T
G
D
V
P
I
Site 76
S963
I
G
I
Y
R
T
E
S
Q
K
L
T
T
S
E
Site 77
T967
R
T
E
S
Q
K
L
T
T
S
E
S
Q
I
S
Site 78
S969
E
S
Q
K
L
T
T
S
E
S
Q
I
S
I
S
Site 79
S971
Q
K
L
T
T
S
E
S
Q
I
S
I
S
V
E
Site 80
S974
T
T
S
E
S
Q
I
S
I
S
V
E
E
W
E
Site 81
S976
S
E
S
Q
I
S
I
S
V
E
E
W
E
D
T
Site 82
T983
S
V
E
E
W
E
D
T
K
D
S
K
E
Q
G
Site 83
S986
E
W
E
D
T
K
D
S
K
E
Q
G
H
H
R
Site 84
S994
K
E
Q
G
H
H
R
S
N
H
R
N
S
T
S
Site 85
S999
H
R
S
N
H
R
N
S
T
S
S
D
Q
S
D
Site 86
T1000
R
S
N
H
R
N
S
T
S
S
D
Q
S
D
H
Site 87
S1001
S
N
H
R
N
S
T
S
S
D
Q
S
D
H
P
Site 88
S1002
N
H
R
N
S
T
S
S
D
Q
S
D
H
P
L
Site 89
S1005
N
S
T
S
S
D
Q
S
D
H
P
L
L
R
R
Site 90
S1014
H
P
L
L
R
R
K
S
M
Q
W
A
R
R
L
Site 91
S1022
M
Q
W
A
R
R
L
S
R
K
G
P
K
H
S
Site 92
Y1044
T
Q
Q
R
L
N
L
Y
R
R
S
E
R
Q
E
Site 93
S1047
R
L
N
L
Y
R
R
S
E
R
Q
E
L
A
E
Site 94
S1066
R
M
K
H
L
G
L
S
T
V
G
Y
D
E
M
Site 95
Y1070
L
G
L
S
T
V
G
Y
D
E
M
N
D
H
Q
Site 96
T1079
E
M
N
D
H
Q
S
T
L
S
Y
I
L
I
N
Site 97
S1081
N
D
H
Q
S
T
L
S
Y
I
L
I
N
P
S
Site 98
Y1082
D
H
Q
S
T
L
S
Y
I
L
I
N
P
S
P
Site 99
S1088
S
Y
I
L
I
N
P
S
P
D
T
R
I
E
L
Site 100
Y1109
I
R
P
D
P
L
A
Y
L
P
N
S
E
P
S
Site 101
S1113
P
L
A
Y
L
P
N
S
E
P
S
R
R
N
S
Site 102
S1116
Y
L
P
N
S
E
P
S
R
R
N
S
I
C
N
Site 103
S1120
S
E
P
S
R
R
N
S
I
C
N
V
T
G
Q
Site 104
S1129
C
N
V
T
G
Q
D
S
R
E
E
T
Q
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation