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Updated November 2019
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Protein Info
Short Name:
ANKRD11
Full Name:
Ankyrin repeat domain-containing protein 11
Alias:
ANCO1; ANCO-1; Ankyrin repeat domain-containing protein 11: Ankyrin repeat-containing cofactor 1: cDNA FLJ78738, highly similar to Homo sapiens ankyrin repeat-containing cofactor-1 (ANCO1) mRNA: Ankyrin repeat domain 11 variant: Nasopharyngeal carcinoma susceptibility protein LZ16; ANR11; LZ16; Nasopharyngeal carcinoma susceptibility protein; T13
Type:
Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
297941
Number AA:
2663
UniProt ID:
Q6UB99
International Prot ID:
IPI00002286
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
Q
Q
E
E
L
P
L
S
S
D
M
V
E
K
Q
Site 2
S35
K
K
D
K
D
K
V
S
L
T
K
T
P
K
L
Site 3
T37
D
K
D
K
V
S
L
T
K
T
P
K
L
E
R
Site 4
T39
D
K
V
S
L
T
K
T
P
K
L
E
R
G
D
Site 5
S56
K
E
V
R
E
R
A
S
K
R
K
L
P
F
T
Site 6
T63
S
K
R
K
L
P
F
T
A
G
A
N
G
E
Q
Site 7
S73
A
N
G
E
Q
K
D
S
D
T
E
K
Q
G
P
Site 8
T75
G
E
Q
K
D
S
D
T
E
K
Q
G
P
E
R
Site 9
T91
R
I
K
K
E
P
V
T
R
K
A
G
L
L
F
Site 10
Y109
L
S
G
I
R
A
G
Y
P
L
S
E
R
Q
Q
Site 11
S112
I
R
A
G
Y
P
L
S
E
R
Q
Q
V
A
L
Site 12
S131
T
A
E
E
S
A
N
S
P
V
D
T
T
P
K
Site 13
T135
S
A
N
S
P
V
D
T
T
P
K
H
P
S
Q
Site 14
T136
A
N
S
P
V
D
T
T
P
K
H
P
S
Q
S
Site 15
S141
D
T
T
P
K
H
P
S
Q
S
T
V
C
Q
K
Site 16
T144
P
K
H
P
S
Q
S
T
V
C
Q
K
G
T
P
Site 17
T150
S
T
V
C
Q
K
G
T
P
N
S
A
S
K
T
Site 18
S153
C
Q
K
G
T
P
N
S
A
S
K
T
K
D
K
Site 19
T157
T
P
N
S
A
S
K
T
K
D
K
V
N
K
R
Site 20
T170
K
R
N
E
R
G
E
T
R
L
H
R
A
A
I
Site 21
Y213
H
E
A
C
N
R
G
Y
Y
D
V
A
K
Q
L
Site 22
Y214
E
A
C
N
R
G
Y
Y
D
V
A
K
Q
L
L
Site 23
T236
T
K
G
L
D
D
D
T
P
L
H
D
A
A
N
Site 24
Y247
D
A
A
N
N
G
H
Y
K
V
V
K
L
L
L
Site 25
S263
Y
G
G
N
P
Q
Q
S
N
R
K
G
E
T
P
Site 26
T269
Q
S
N
R
K
G
E
T
P
L
K
V
A
N
S
Site 27
S276
T
P
L
K
V
A
N
S
P
T
M
V
N
L
L
Site 28
T288
N
L
L
L
G
K
G
T
Y
T
S
S
E
E
S
Site 29
Y289
L
L
L
G
K
G
T
Y
T
S
S
E
E
S
S
Site 30
T290
L
L
G
K
G
T
Y
T
S
S
E
E
S
S
T
Site 31
S291
L
G
K
G
T
Y
T
S
S
E
E
S
S
T
E
Site 32
S292
G
K
G
T
Y
T
S
S
E
E
S
S
T
E
S
Site 33
S295
T
Y
T
S
S
E
E
S
S
T
E
S
S
E
E
Site 34
S296
Y
T
S
S
E
E
S
S
T
E
S
S
E
E
E
Site 35
T297
T
S
S
E
E
S
S
T
E
S
S
E
E
E
D
Site 36
S299
S
E
E
S
S
T
E
S
S
E
E
E
D
A
P
Site 37
S300
E
E
S
S
T
E
S
S
E
E
E
D
A
P
S
Site 38
S307
S
E
E
E
D
A
P
S
F
A
P
S
S
S
V
Site 39
S311
D
A
P
S
F
A
P
S
S
S
V
D
G
N
N
Site 40
S312
A
P
S
F
A
P
S
S
S
V
D
G
N
N
T
Site 41
S313
P
S
F
A
P
S
S
S
V
D
G
N
N
T
D
Site 42
T319
S
S
V
D
G
N
N
T
D
S
E
F
E
K
G
Site 43
S321
V
D
G
N
N
T
D
S
E
F
E
K
G
L
K
Site 44
Y347
T
A
P
V
K
D
E
Y
E
F
D
E
D
D
E
Site 45
Y371
K
H
L
L
K
K
D
Y
R
K
E
T
K
S
N
Site 46
T375
K
K
D
Y
R
K
E
T
K
S
N
S
F
I
S
Site 47
S377
D
Y
R
K
E
T
K
S
N
S
F
I
S
I
P
Site 48
S379
R
K
E
T
K
S
N
S
F
I
S
I
P
K
M
Site 49
S390
I
P
K
M
E
V
K
S
Y
T
K
N
N
T
I
Site 50
Y391
P
K
M
E
V
K
S
Y
T
K
N
N
T
I
A
Site 51
T392
K
M
E
V
K
S
Y
T
K
N
N
T
I
A
P
Site 52
T396
K
S
Y
T
K
N
N
T
I
A
P
K
K
A
S
Site 53
S403
T
I
A
P
K
K
A
S
H
R
I
L
S
D
T
Site 54
S408
K
A
S
H
R
I
L
S
D
T
S
D
E
E
D
Site 55
T410
S
H
R
I
L
S
D
T
S
D
E
E
D
A
S
Site 56
S411
H
R
I
L
S
D
T
S
D
E
E
D
A
S
V
Site 57
S417
T
S
D
E
E
D
A
S
V
T
V
G
T
G
E
Site 58
T419
D
E
E
D
A
S
V
T
V
G
T
G
E
K
L
Site 59
S429
T
G
E
K
L
R
L
S
A
H
T
I
L
P
G
Site 60
T432
K
L
R
L
S
A
H
T
I
L
P
G
S
K
T
Site 61
S437
A
H
T
I
L
P
G
S
K
T
R
E
P
S
N
Site 62
T439
T
I
L
P
G
S
K
T
R
E
P
S
N
A
K
Site 63
S443
G
S
K
T
R
E
P
S
N
A
K
Q
Q
K
E
Site 64
S473
E
V
R
F
G
K
R
S
D
K
F
C
S
S
E
Site 65
S478
K
R
S
D
K
F
C
S
S
E
S
E
S
E
S
Site 66
S479
R
S
D
K
F
C
S
S
E
S
E
S
E
S
S
Site 67
S481
D
K
F
C
S
S
E
S
E
S
E
S
S
E
S
Site 68
S483
F
C
S
S
E
S
E
S
E
S
S
E
S
G
E
Site 69
S485
S
S
E
S
E
S
E
S
S
E
S
G
E
D
D
Site 70
S486
S
E
S
E
S
E
S
S
E
S
G
E
D
D
R
Site 71
S488
S
E
S
E
S
S
E
S
G
E
D
D
R
D
S
Site 72
S495
S
G
E
D
D
R
D
S
L
G
S
S
G
C
L
Site 73
S498
D
D
R
D
S
L
G
S
S
G
C
L
K
G
S
Site 74
S499
D
R
D
S
L
G
S
S
G
C
L
K
G
S
P
Site 75
S505
S
S
G
C
L
K
G
S
P
L
V
L
K
D
P
Site 76
S516
L
K
D
P
S
L
F
S
S
L
S
A
S
S
T
Site 77
S517
K
D
P
S
L
F
S
S
L
S
A
S
S
T
S
Site 78
S519
P
S
L
F
S
S
L
S
A
S
S
T
S
S
H
Site 79
S521
L
F
S
S
L
S
A
S
S
T
S
S
H
G
S
Site 80
S522
F
S
S
L
S
A
S
S
T
S
S
H
G
S
S
Site 81
T523
S
S
L
S
A
S
S
T
S
S
H
G
S
S
A
Site 82
S524
S
L
S
A
S
S
T
S
S
H
G
S
S
A
A
Site 83
S525
L
S
A
S
S
T
S
S
H
G
S
S
A
A
Q
Site 84
S528
S
S
T
S
S
H
G
S
S
A
A
Q
K
Q
N
Site 85
S529
S
T
S
S
H
G
S
S
A
A
Q
K
Q
N
P
Site 86
T543
P
S
H
T
D
Q
H
T
K
H
W
R
T
D
N
Site 87
S555
T
D
N
W
K
T
I
S
S
P
A
W
S
E
V
Site 88
S556
D
N
W
K
T
I
S
S
P
A
W
S
E
V
S
Site 89
S560
T
I
S
S
P
A
W
S
E
V
S
S
L
S
D
Site 90
S563
S
P
A
W
S
E
V
S
S
L
S
D
S
T
R
Site 91
S564
P
A
W
S
E
V
S
S
L
S
D
S
T
R
T
Site 92
S566
W
S
E
V
S
S
L
S
D
S
T
R
T
R
L
Site 93
S568
E
V
S
S
L
S
D
S
T
R
T
R
L
T
S
Site 94
T574
D
S
T
R
T
R
L
T
S
E
S
D
Y
S
S
Site 95
S575
S
T
R
T
R
L
T
S
E
S
D
Y
S
S
E
Site 96
S577
R
T
R
L
T
S
E
S
D
Y
S
S
E
G
S
Site 97
Y579
R
L
T
S
E
S
D
Y
S
S
E
G
S
S
V
Site 98
S580
L
T
S
E
S
D
Y
S
S
E
G
S
S
V
E
Site 99
S581
T
S
E
S
D
Y
S
S
E
G
S
S
V
E
S
Site 100
S584
S
D
Y
S
S
E
G
S
S
V
E
S
L
K
P
Site 101
S585
D
Y
S
S
E
G
S
S
V
E
S
L
K
P
V
Site 102
S588
S
E
G
S
S
V
E
S
L
K
P
V
R
K
R
Site 103
S603
Q
E
H
R
K
R
A
S
L
S
E
K
K
S
P
Site 104
S605
H
R
K
R
A
S
L
S
E
K
K
S
P
F
L
Site 105
S609
A
S
L
S
E
K
K
S
P
F
L
S
S
A
E
Site 106
S613
E
K
K
S
P
F
L
S
S
A
E
G
A
V
P
Site 107
S614
K
K
S
P
F
L
S
S
A
E
G
A
V
P
K
Site 108
S647
N
K
E
K
G
Q
C
S
I
S
Q
E
L
K
L
Site 109
S649
E
K
G
Q
C
S
I
S
Q
E
L
K
L
K
S
Site 110
S656
S
Q
E
L
K
L
K
S
F
T
Y
E
Y
E
D
Site 111
Y661
L
K
S
F
T
Y
E
Y
E
D
S
K
Q
K
S
Site 112
S664
F
T
Y
E
Y
E
D
S
K
Q
K
S
D
K
A
Site 113
S668
Y
E
D
S
K
Q
K
S
D
K
A
I
L
L
E
Site 114
S679
I
L
L
E
N
D
L
S
T
E
N
K
L
K
V
Site 115
S701
F
K
K
E
E
K
L
S
K
M
K
L
E
E
K
Site 116
S717
W
L
F
K
D
E
K
S
L
K
R
I
K
D
T
Site 117
T724
S
L
K
R
I
K
D
T
N
K
D
I
S
R
S
Site 118
S731
T
N
K
D
I
S
R
S
F
R
E
E
K
D
R
Site 119
S739
F
R
E
E
K
D
R
S
N
K
A
E
K
E
R
Site 120
S747
N
K
A
E
K
E
R
S
L
K
E
K
S
P
K
Site 121
S752
E
R
S
L
K
E
K
S
P
K
E
E
K
L
R
Site 122
Y761
K
E
E
K
L
R
L
Y
K
E
E
R
K
K
K
Site 123
S769
K
E
E
R
K
K
K
S
K
D
R
P
S
K
L
Site 124
S774
K
K
S
K
D
R
P
S
K
L
E
K
K
N
D
Site 125
S788
D
L
K
E
D
K
I
S
K
E
K
E
K
I
F
Site 126
S812
E
K
V
Y
R
E
D
S
A
F
D
E
Y
C
N
Site 127
Y817
E
D
S
A
F
D
E
Y
C
N
K
N
Q
F
L
Site 128
T829
Q
F
L
E
N
E
D
T
K
F
S
L
S
D
D
Site 129
S832
E
N
E
D
T
K
F
S
L
S
D
D
Q
R
D
Site 130
S834
E
D
T
K
F
S
L
S
D
D
Q
R
D
R
W
Site 131
S843
D
Q
R
D
R
W
F
S
D
L
S
D
S
S
F
Site 132
S846
D
R
W
F
S
D
L
S
D
S
S
F
D
F
K
Site 133
S848
W
F
S
D
L
S
D
S
S
F
D
F
K
G
E
Site 134
S849
F
S
D
L
S
D
S
S
F
D
F
K
G
E
D
Site 135
S857
F
D
F
K
G
E
D
S
W
D
S
P
V
T
D
Site 136
S860
K
G
E
D
S
W
D
S
P
V
T
D
Y
R
D
Site 137
T863
D
S
W
D
S
P
V
T
D
Y
R
D
M
K
S
Site 138
Y865
W
D
S
P
V
T
D
Y
R
D
M
K
S
D
S
Site 139
S870
T
D
Y
R
D
M
K
S
D
S
V
A
K
L
I
Site 140
S872
Y
R
D
M
K
S
D
S
V
A
K
L
I
L
E
Site 141
S885
L
E
T
V
K
E
D
S
K
E
R
R
R
D
S
Site 142
S892
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P
S
Site 294
S2355
S
K
Q
G
P
P
P
S
E
K
E
C
A
P
T
Site 295
T2362
S
E
K
E
C
A
P
T
P
A
P
V
T
R
A
Site 296
S2374
T
R
A
K
A
R
G
S
E
D
D
D
A
Q
A
Site 297
S2392
R
K
R
R
F
Q
R
S
T
Q
Q
L
Q
Q
Q
Site 298
T2393
K
R
R
F
Q
R
S
T
Q
Q
L
Q
Q
Q
L
Site 299
T2402
Q
L
Q
Q
Q
L
N
T
S
T
Q
Q
T
R
E
Site 300
T2407
L
N
T
S
T
Q
Q
T
R
E
V
I
Q
Q
T
Site 301
Y2430
K
L
D
A
I
E
P
Y
H
S
D
R
A
N
P
Site 302
S2432
D
A
I
E
P
Y
H
S
D
R
A
N
P
Y
F
Site 303
Y2438
H
S
D
R
A
N
P
Y
F
E
Y
L
Q
I
R
Site 304
Y2441
R
A
N
P
Y
F
E
Y
L
Q
I
R
K
K
I
Site 305
Y2469
A
P
Q
C
Y
A
E
Y
V
T
Y
T
G
S
Y
Site 306
Y2472
C
Y
A
E
Y
V
T
Y
T
G
S
Y
L
L
D
Site 307
S2475
E
Y
V
T
Y
T
G
S
Y
L
L
D
G
K
P
Site 308
S2496
P
V
I
A
P
P
P
S
L
A
E
P
L
K
E
Site 309
S2520
G
K
L
R
L
Q
H
S
I
E
R
E
K
L
I
Site 310
T2544
V
H
C
R
A
A
R
T
I
A
N
Q
A
V
P
Site 311
Y2564
M
L
L
D
S
E
V
Y
N
M
P
L
E
S
Q
Site 312
S2570
V
Y
N
M
P
L
E
S
Q
G
D
E
N
K
S
Site 313
S2577
S
Q
G
D
E
N
K
S
V
R
D
R
F
N
A
Site 314
Y2598
L
Q
D
V
D
D
K
Y
D
R
M
K
T
C
L
Site 315
S2638
L
D
P
A
G
H
K
S
L
C
V
N
E
V
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation