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Updated November 2019
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Protein Info
Short Name:
ANKRD12
Full Name:
Ankyrin repeat domain-containing protein 12
Alias:
ANCO2; ANCO-2; Ankyrin repeat domain 12; ANR12; FLJ20053; GAC-1; KIAA0874
Type:
Transcription, coactivator/corepressor
Mass (Da):
235652
Number AA:
2062
UniProt ID:
Q6UB98
International Prot ID:
IPI00448465
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
G
F
T
K
P
I
Q
S
E
N
S
D
S
D
S
Site 2
S15
K
P
I
Q
S
E
N
S
D
S
D
S
N
M
V
Site 3
S17
I
Q
S
E
N
S
D
S
D
S
N
M
V
E
K
Site 4
S19
S
E
N
S
D
S
D
S
N
M
V
E
K
P
Y
Site 5
Y26
S
N
M
V
E
K
P
Y
G
R
K
S
K
D
K
Site 6
S30
E
K
P
Y
G
R
K
S
K
D
K
I
A
S
Y
Site 7
S36
K
S
K
D
K
I
A
S
Y
S
K
T
P
K
I
Site 8
S38
K
D
K
I
A
S
Y
S
K
T
P
K
I
E
R
Site 9
T40
K
I
A
S
Y
S
K
T
P
K
I
E
R
S
D
Site 10
S46
K
T
P
K
I
E
R
S
D
V
S
K
E
M
K
Site 11
S49
K
I
E
R
S
D
V
S
K
E
M
K
E
K
S
Site 12
S56
S
K
E
M
K
E
K
S
S
M
K
R
K
L
P
Site 13
S57
K
E
M
K
E
K
S
S
M
K
R
K
L
P
F
Site 14
T65
M
K
R
K
L
P
F
T
I
S
P
S
R
N
E
Site 15
S67
R
K
L
P
F
T
I
S
P
S
R
N
E
E
R
Site 16
S69
L
P
F
T
I
S
P
S
R
N
E
E
R
D
S
Site 17
S76
S
R
N
E
E
R
D
S
D
T
D
S
D
P
G
Site 18
T78
N
E
E
R
D
S
D
T
D
S
D
P
G
H
T
Site 19
S80
E
R
D
S
D
T
D
S
D
P
G
H
T
S
E
Site 20
S95
N
W
G
E
R
L
I
S
S
Y
R
T
Y
S
E
Site 21
S96
W
G
E
R
L
I
S
S
Y
R
T
Y
S
E
K
Site 22
Y97
G
E
R
L
I
S
S
Y
R
T
Y
S
E
K
E
Site 23
T99
R
L
I
S
S
Y
R
T
Y
S
E
K
E
G
P
Site 24
Y100
L
I
S
S
Y
R
T
Y
S
E
K
E
G
P
E
Site 25
S101
I
S
S
Y
R
T
Y
S
E
K
E
G
P
E
K
Site 26
T111
E
G
P
E
K
K
K
T
K
K
E
A
G
N
K
Site 27
S120
K
E
A
G
N
K
K
S
T
P
V
S
I
L
F
Site 28
T121
E
A
G
N
K
K
S
T
P
V
S
I
L
F
G
Site 29
S124
N
K
K
S
T
P
V
S
I
L
F
G
Y
P
L
Site 30
Y129
P
V
S
I
L
F
G
Y
P
L
S
E
R
K
Q
Site 31
T144
M
A
L
L
M
Q
M
T
A
R
D
N
S
P
D
Site 32
S149
Q
M
T
A
R
D
N
S
P
D
S
T
P
N
H
Site 33
S152
A
R
D
N
S
P
D
S
T
P
N
H
P
S
Q
Site 34
T153
R
D
N
S
P
D
S
T
P
N
H
P
S
Q
T
Site 35
S158
D
S
T
P
N
H
P
S
Q
T
T
P
A
Q
K
Site 36
T161
P
N
H
P
S
Q
T
T
P
A
Q
K
K
T
P
Site 37
T167
T
T
P
A
Q
K
K
T
P
S
S
S
S
R
Q
Site 38
S169
P
A
Q
K
K
T
P
S
S
S
S
R
Q
K
D
Site 39
S170
A
Q
K
K
T
P
S
S
S
S
R
Q
K
D
K
Site 40
S171
Q
K
K
T
P
S
S
S
S
R
Q
K
D
K
V
Site 41
T187
K
R
N
E
R
G
E
T
P
L
H
M
A
A
I
Site 42
T253
T
Q
G
L
D
D
D
T
P
L
H
D
S
A
S
Site 43
S258
D
D
T
P
L
H
D
S
A
S
S
G
H
R
D
Site 44
S260
T
P
L
H
D
S
A
S
S
G
H
R
D
I
V
Site 45
S307
L
K
R
E
V
P
L
S
D
D
D
E
S
Y
T
Site 46
S312
P
L
S
D
D
D
E
S
Y
T
D
S
E
E
A
Site 47
Y313
L
S
D
D
D
E
S
Y
T
D
S
E
E
A
Q
Site 48
T314
S
D
D
D
E
S
Y
T
D
S
E
E
A
Q
S
Site 49
S316
D
D
E
S
Y
T
D
S
E
E
A
Q
S
V
N
Site 50
S321
T
D
S
E
E
A
Q
S
V
N
P
S
S
V
D
Site 51
S325
E
A
Q
S
V
N
P
S
S
V
D
E
N
I
D
Site 52
S326
A
Q
S
V
N
P
S
S
V
D
E
N
I
D
S
Site 53
S333
S
V
D
E
N
I
D
S
E
T
E
K
D
S
L
Site 54
T335
D
E
N
I
D
S
E
T
E
K
D
S
L
I
C
Site 55
S339
D
S
E
T
E
K
D
S
L
I
C
E
S
K
Q
Site 56
S344
K
D
S
L
I
C
E
S
K
Q
I
L
P
S
K
Site 57
S350
E
S
K
Q
I
L
P
S
K
T
P
L
P
S
A
Site 58
T352
K
Q
I
L
P
S
K
T
P
L
P
S
A
L
D
Site 59
Y361
L
P
S
A
L
D
E
Y
E
F
K
D
D
D
D
Site 60
T396
N
E
P
E
A
E
K
T
H
L
F
A
K
Q
E
Site 61
Y407
A
K
Q
E
K
A
F
Y
P
K
S
F
K
S
K
Site 62
S410
E
K
A
F
Y
P
K
S
F
K
S
K
K
Q
K
Site 63
S413
F
Y
P
K
S
F
K
S
K
K
Q
K
P
S
R
Site 64
S419
K
S
K
K
Q
K
P
S
R
V
L
Y
S
S
T
Site 65
Y423
Q
K
P
S
R
V
L
Y
S
S
T
E
S
S
D
Site 66
S424
K
P
S
R
V
L
Y
S
S
T
E
S
S
D
E
Site 67
S425
P
S
R
V
L
Y
S
S
T
E
S
S
D
E
E
Site 68
S428
V
L
Y
S
S
T
E
S
S
D
E
E
A
L
Q
Site 69
S429
L
Y
S
S
T
E
S
S
D
E
E
A
L
Q
N
Site 70
S440
A
L
Q
N
K
K
I
S
T
S
C
S
V
I
P
Site 71
S442
Q
N
K
K
I
S
T
S
C
S
V
I
P
E
T
Site 72
S444
K
K
I
S
T
S
C
S
V
I
P
E
T
S
N
Site 73
S452
V
I
P
E
T
S
N
S
D
M
Q
T
K
K
E
Site 74
T456
T
S
N
S
D
M
Q
T
K
K
E
Y
V
V
S
Site 75
Y460
D
M
Q
T
K
K
E
Y
V
V
S
G
E
H
K
Site 76
S463
T
K
K
E
Y
V
V
S
G
E
H
K
Q
K
G
Site 77
T501
G
K
E
N
T
R
I
T
N
L
T
V
N
T
G
Site 78
T504
N
T
R
I
T
N
L
T
V
N
T
G
L
D
C
Site 79
S512
V
N
T
G
L
D
C
S
E
K
T
R
E
E
G
Site 80
S524
E
E
G
N
F
R
K
S
F
S
P
K
D
D
T
Site 81
S526
G
N
F
R
K
S
F
S
P
K
D
D
T
S
L
Site 82
T531
S
F
S
P
K
D
D
T
S
L
H
L
F
H
I
Site 83
S532
F
S
P
K
D
D
T
S
L
H
L
F
H
I
S
Site 84
S539
S
L
H
L
F
H
I
S
T
G
K
S
P
K
H
Site 85
T540
L
H
L
F
H
I
S
T
G
K
S
P
K
H
S
Site 86
S543
F
H
I
S
T
G
K
S
P
K
H
S
C
G
L
Site 87
S547
T
G
K
S
P
K
H
S
C
G
L
S
E
K
Q
Site 88
S551
P
K
H
S
C
G
L
S
E
K
Q
S
T
P
L
Site 89
S555
C
G
L
S
E
K
Q
S
T
P
L
K
Q
E
H
Site 90
T556
G
L
S
E
K
Q
S
T
P
L
K
Q
E
H
T
Site 91
T563
T
P
L
K
Q
E
H
T
K
T
C
L
S
P
G
Site 92
T565
L
K
Q
E
H
T
K
T
C
L
S
P
G
S
S
Site 93
S568
E
H
T
K
T
C
L
S
P
G
S
S
E
M
S
Site 94
S571
K
T
C
L
S
P
G
S
S
E
M
S
L
Q
P
Site 95
S572
T
C
L
S
P
G
S
S
E
M
S
L
Q
P
D
Site 96
S575
S
P
G
S
S
E
M
S
L
Q
P
D
L
V
R
Site 97
Y583
L
Q
P
D
L
V
R
Y
D
N
T
E
S
E
F
Site 98
T586
D
L
V
R
Y
D
N
T
E
S
E
F
L
P
E
Site 99
S594
E
S
E
F
L
P
E
S
S
S
V
K
S
C
K
Site 100
S595
S
E
F
L
P
E
S
S
S
V
K
S
C
K
H
Site 101
S596
E
F
L
P
E
S
S
S
V
K
S
C
K
H
K
Site 102
S599
P
E
S
S
S
V
K
S
C
K
H
K
E
K
S
Site 103
S620
H
L
E
F
G
E
K
S
N
A
K
I
K
D
E
Site 104
S630
K
I
K
D
E
D
H
S
P
T
F
E
N
S
D
Site 105
T632
K
D
E
D
H
S
P
T
F
E
N
S
D
C
T
Site 106
S636
H
S
P
T
F
E
N
S
D
C
T
L
K
K
M
Site 107
T639
T
F
E
N
S
D
C
T
L
K
K
M
D
K
E
Site 108
T649
K
M
D
K
E
G
K
T
L
K
K
H
K
L
K
Site 109
Y676
I
E
G
E
K
E
K
Y
K
T
K
D
S
A
K
Site 110
T678
G
E
K
E
K
Y
K
T
K
D
S
A
K
E
L
Site 111
S681
E
K
Y
K
T
K
D
S
A
K
E
L
Q
R
S
Site 112
S688
S
A
K
E
L
Q
R
S
V
E
F
D
R
E
F
Site 113
S703
W
K
E
N
F
F
K
S
D
E
T
E
D
L
F
Site 114
T706
N
F
F
K
S
D
E
T
E
D
L
F
L
N
M
Site 115
T719
N
M
E
H
E
S
L
T
L
E
K
K
S
K
L
Site 116
S724
S
L
T
L
E
K
K
S
K
L
E
K
N
I
K
Site 117
S735
K
N
I
K
D
D
K
S
T
K
E
K
H
V
S
Site 118
S742
S
T
K
E
K
H
V
S
K
E
R
N
F
K
E
Site 119
S761
I
K
K
E
S
E
K
S
F
R
E
E
K
I
K
Site 120
T779
E
E
R
E
N
I
P
T
D
K
D
S
E
F
T
Site 121
S783
N
I
P
T
D
K
D
S
E
F
T
S
L
G
M
Site 122
S787
D
K
D
S
E
F
T
S
L
G
M
S
A
I
E
Site 123
T840
I
E
K
M
E
R
K
T
F
E
K
E
K
K
I
Site 124
S853
K
I
K
H
E
H
K
S
E
K
D
K
L
D
L
Site 125
S861
E
K
D
K
L
D
L
S
E
C
V
D
K
I
K
Site 126
Y874
I
K
E
K
D
K
L
Y
S
H
H
T
E
K
C
Site 127
S888
C
H
K
E
G
E
K
S
K
N
T
A
A
I
K
Site 128
T891
E
G
E
K
S
K
N
T
A
A
I
K
K
T
D
Site 129
T897
N
T
A
A
I
K
K
T
D
D
R
E
K
S
R
Site 130
S903
K
T
D
D
R
E
K
S
R
E
K
M
D
R
K
Site 131
S925
K
E
R
H
L
A
E
S
K
E
K
H
L
M
E
Site 132
S938
M
E
K
K
N
K
Q
S
D
N
S
E
Y
S
K
Site 133
S941
K
N
K
Q
S
D
N
S
E
Y
S
K
S
E
K
Site 134
Y943
K
Q
S
D
N
S
E
Y
S
K
S
E
K
G
K
Site 135
S944
Q
S
D
N
S
E
Y
S
K
S
E
K
G
K
N
Site 136
S946
D
N
S
E
Y
S
K
S
E
K
G
K
N
K
E
Site 137
S964
E
L
D
K
K
E
K
S
R
D
K
E
S
I
N
Site 138
T973
D
K
E
S
I
N
I
T
N
S
K
H
I
Q
E
Site 139
S984
H
I
Q
E
E
K
K
S
S
I
V
D
G
N
K
Site 140
S999
A
Q
H
E
K
P
L
S
L
K
E
K
T
K
D
Site 141
T1011
T
K
D
E
P
L
K
T
P
D
G
K
E
K
D
Site 142
Y1027
K
D
K
D
I
D
R
Y
K
E
R
D
K
H
K
Site 143
S1047
N
S
L
L
K
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F
Site 295
S1918
M
K
L
R
L
Q
H
S
I
E
R
E
K
L
I
Site 296
S1927
E
R
E
K
L
I
V
S
N
E
Q
E
V
L
R
Site 297
Y1937
Q
E
V
L
R
V
H
Y
R
A
A
R
T
L
A
Site 298
S1968
V
Y
N
V
P
L
D
S
Q
S
D
D
S
K
T
Site 299
S1970
N
V
P
L
D
S
Q
S
D
D
S
K
T
S
V
Site 300
S1973
L
D
S
Q
S
D
D
S
K
T
S
V
R
D
R
Site 301
T1975
S
Q
S
D
D
S
K
T
S
V
R
D
R
F
N
Site 302
S1976
Q
S
D
D
S
K
T
S
V
R
D
R
F
N
A
Site 303
T2034
L
Q
E
L
D
P
A
T
Y
K
S
I
S
I
Y
Site 304
Y2035
Q
E
L
D
P
A
T
Y
K
S
I
S
I
Y
E
Site 305
S2037
L
D
P
A
T
Y
K
S
I
S
I
Y
E
I
Q
Site 306
S2039
P
A
T
Y
K
S
I
S
I
Y
E
I
Q
E
F
Site 307
Y2041
T
Y
K
S
I
S
I
Y
E
I
Q
E
F
Y
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation