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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTHFD1L
Full Name:
Monofunctional C1-tetrahydrofolate synthase, mitochondrial
Alias:
Formyltetrahydrofolate synthetase
Type:
Mass (Da):
105790
Number AA:
978
UniProt ID:
Q6UB35
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
L
R
V
P
C
R
A
S
S
G
G
G
G
G
G
Site 2
S33
R
V
P
C
R
A
S
S
G
G
G
G
G
G
G
Site 3
S59
P
Q
D
G
Q
A
R
S
S
C
S
P
G
G
R
Site 4
S60
Q
D
G
Q
A
R
S
S
C
S
P
G
G
R
T
Site 5
S62
G
Q
A
R
S
S
C
S
P
G
G
R
T
P
A
Site 6
T67
S
C
S
P
G
G
R
T
P
A
A
R
D
S
I
Site 7
S73
R
T
P
A
A
R
D
S
I
V
R
E
V
I
Q
Site 8
S135
H
I
C
L
P
P
D
S
S
E
A
E
I
I
D
Site 9
S136
I
C
L
P
P
D
S
S
E
A
E
I
I
D
E
Site 10
S161
H
G
L
A
L
Q
I
S
E
N
L
F
S
N
K
Site 11
S166
Q
I
S
E
N
L
F
S
N
K
V
L
N
A
L
Site 12
T183
E
K
D
V
D
G
V
T
D
I
N
L
G
K
L
Site 13
T247
F
Q
R
K
G
S
M
T
M
S
I
Q
W
K
T
Site 14
T280
K
P
E
E
I
P
L
T
W
I
Q
P
G
T
T
Site 15
S292
G
T
T
V
L
N
C
S
H
D
F
L
S
G
K
Site 16
S297
N
C
S
H
D
F
L
S
G
K
V
G
C
G
S
Site 17
S304
S
G
K
V
G
C
G
S
P
R
I
H
F
G
G
Site 18
S332
L
R
I
Q
N
M
V
S
S
G
R
R
W
L
R
Site 19
S333
R
I
Q
N
M
V
S
S
G
R
R
W
L
R
E
Site 20
S357
C
L
K
L
Q
P
L
S
P
V
P
S
D
I
E
Site 21
S361
Q
P
L
S
P
V
P
S
D
I
E
I
S
R
G
Site 22
T370
I
E
I
S
R
G
Q
T
P
K
A
V
D
V
L
Site 23
Y391
L
A
D
E
I
E
I
Y
G
K
S
K
A
K
V
Site 24
S394
E
I
E
I
Y
G
K
S
K
A
K
V
R
L
S
Site 25
S401
S
K
A
K
V
R
L
S
V
L
E
R
L
K
D
Site 26
Y414
K
D
Q
A
D
G
K
Y
V
L
V
A
G
I
T
Site 27
S448
T
A
H
L
N
V
N
S
F
A
C
L
R
Q
P
Site 28
S456
F
A
C
L
R
Q
P
S
Q
G
P
T
F
G
V
Site 29
T460
R
Q
P
S
Q
G
P
T
F
G
V
K
G
G
A
Site 30
T514
I
L
H
E
N
T
Q
T
D
K
A
L
Y
N
R
Site 31
Y519
T
Q
T
D
K
A
L
Y
N
R
L
V
P
L
V
Site 32
S533
V
N
G
V
R
E
F
S
E
I
Q
L
A
R
L
Site 33
T548
K
K
L
G
I
N
K
T
D
P
S
T
L
T
E
Site 34
S551
G
I
N
K
T
D
P
S
T
L
T
E
E
E
V
Site 35
T552
I
N
K
T
D
P
S
T
L
T
E
E
E
V
S
Site 36
T554
K
T
D
P
S
T
L
T
E
E
E
V
S
K
F
Site 37
S569
A
R
L
D
I
D
P
S
T
I
T
W
Q
R
V
Site 38
T570
R
L
D
I
D
P
S
T
I
T
W
Q
R
V
L
Site 39
T579
T
W
Q
R
V
L
D
T
N
D
R
F
L
R
K
Site 40
T588
D
R
F
L
R
K
I
T
I
G
Q
G
N
T
E
Site 41
T594
I
T
I
G
Q
G
N
T
E
K
G
H
Y
R
Q
Site 42
Y599
G
N
T
E
K
G
H
Y
R
Q
A
Q
F
D
I
Site 43
S636
L
G
R
M
V
V
A
S
D
K
S
G
Q
P
V
Site 44
S639
M
V
V
A
S
D
K
S
G
Q
P
V
T
A
D
Site 45
T804
V
A
L
N
V
F
K
T
D
T
R
A
E
I
D
Site 46
Y829
A
F
D
A
V
P
C
Y
H
W
S
V
G
G
K
Site 47
S850
R
A
V
R
E
A
A
S
K
R
S
R
F
Q
F
Site 48
S853
R
E
A
A
S
K
R
S
R
F
Q
F
L
Y
D
Site 49
Y859
R
S
R
F
Q
F
L
Y
D
V
Q
V
P
I
V
Site 50
S885
G
A
K
D
I
E
L
S
P
E
A
Q
A
K
I
Site 51
Y895
A
Q
A
K
I
D
R
Y
T
Q
Q
G
F
G
N
Site 52
T896
Q
A
K
I
D
R
Y
T
Q
Q
G
F
G
N
L
Site 53
S913
C
M
A
K
T
H
L
S
L
S
H
Q
P
D
K
Site 54
S915
A
K
T
H
L
S
L
S
H
Q
P
D
K
K
G
Site 55
T969
F
Y
D
I
D
L
D
T
E
T
E
Q
V
K
G
Site 56
T971
D
I
D
L
D
T
E
T
E
Q
V
K
G
L
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation